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Terry W. Wright, Ph.D.

Terry W. Wright, Ph.D.

Contact

Office (585) 275-4246

About Me

Faculty Appointments

Associate Professor - Department of Pediatrics, Infectious Diseases (SMD)

Associate Professor - Department of Microbiology and Immunology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Pediatrics Postdoctoral Training, Division of Neonatology, University of Rochester School of Medicine and Dentistry, Rochester, NY 1995 - 1997

Education

PhD | University of Rochester School of Medicine and Dentistry. Microbiology and Immunology. 1995

MS | University of Rochester School of Medicine and Dentistry. Microbiology and Immunology. 1992

BS | Rochester Institute of Technology. Biotechnology. 1990

Awards

American Society for Microbiology Sustaining Membership Travel Award. 1994

Research

Dr. Wright's research interests are:

1) Pneumocystis carinii biology
2) Pathogenesis of lung injury during Pneumocystis carinii pneumonia.

The rapid clearance of bacterial and fungal pathogens is essential to preserve the delicate structure and critical function of the lung. The...
Dr. Wright's research interests are:

1) Pneumocystis carinii biology
2) Pathogenesis of lung injury during Pneumocystis carinii pneumonia.

The rapid clearance of bacterial and fungal pathogens is essential to preserve the delicate structure and critical function of the lung. The opportunistic pathogen, Pneumocystis carinii, colonizes the alveolar epithelium of patients suffering from a variety of immunodeficiencies, including AIDS. Dr. Wright's laboratory uses an immunologically-reconstituted scid mouse model of Pneumocystis carinii pneumonia (PCP) to study the host response to infection. Scid mice lack functional lymphocytes and therefore develop active P. carinii infections. However, the adoptive transfer of congenic spleen cells, including CD4+ T lymphocytes, to P. carinii-infected scid mice results in inflammatory cell recruitment to sites of infection and organism clearance. They are now examining the earliest molecular signals (including cytokine and chemokine expression) produced at epithelial sites of P. carinii colonization, to determine which cell types and which soluble mediators are involved in targeting inflammatory cell recruitment. These studies will not only further our understanding of PCP, but may also provide insight into general mechanisms of lung defense.

In addition, they are examining the role of pulmonary inflammation in the pathology of PCP. As stated above, an intense CD4+ T lymphocyte-dependent inflammatory response is mounted at sites of infection in reconstituted scid mice. In many cases this inflammatory response is productive, and serves to resolve the infection. However, under certain circumstances the inflammatory response may actually contribute to the pulmonary injury and respiratory impairment observed in P. carinii pneumonia. They have begun studies using physiological and molecular measurements of lung injury to assess the in vivo role of P. carinii driven inflammation in PCP. They also plan to test specific anti-inflammatory agents to manipulate various aspects of the inflammatory response to determine the effect on lung injury. These studies will help define the role of inflammation in PCP, and further our understanding of pulmonary immunology.

Patents

Polypeptides and Immunogenic Conjugates Capable of Inducing Antibodies Against Pathogens, and Uses Thereof

Issue date: October 19, 2010

Optimized Antigens of Pneumocystis and Use Thereof

Issue date: December 06, 2016

Publications

Journal Articles

Intrinsic Programming of Alveolar Macrophages for Protective Antifungal Innate Immunity Against Infection.

Bhagwat SP, Gigliotti F, Wang J, Wang Z, Notter RH, Murphy PS, Rivera-Escalera F, Malone J, Jordan MB, Elliott MR, Wright TW

Frontiers in immunology.. 2018 9 :2131. Epub 09/19/2018.

Neither classical nor alternative macrophage activation is required for Pneumocystis clearance during immune reconstitution inflammatory syndrome.

Zhang ZQ, Wang J, Hoy Z, Keegan A, Gigliotti F, Wright T

Infection and immunity.. 2015 December 83 (12):4594-603. Epub 09/14/2015.

MyD88 signaling regulates both host defense and immunopathogenesis during pneumocystis infection.

Bello-Irizarry SN, Wang J, Johnston CJ, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 January 1192 (1):282-92. Epub 11/29/2013.

Selective ablation of lung epithelial IKK2 impairs pulmonary Th17 responses and delays the clearance of Pneumocystis.

Perez-Nazario N, Rangel-Moreno J, O'Reilly MA, Pasparakis M, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2013 November 1191 (9):4720-30. Epub 09/27/2013.

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.

Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ

PloS one.. 2013 8 (5):e63798. Epub 05/31/2013.

The alveolar epithelial cell chemokine response to pneumocystis requires adaptor molecule MyD88 and interleukin-1 receptor but not toll-like receptor 2 or 4.

Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW

Infection and immunity.. 2012 November 80 (11):3912-20. Epub 08/27/2012.

Pneumocystis: where does it live?

Gigliotti F, Wright TW

PLoS pathogens.. 2012 8 (11):e1003025. Epub 11/29/2012.

Ablation of TNF-RI/RII expression in Alzheimer's disease mice leads to an unexpected enhancement of pathology: implications for chronic pan-TNF-? suppressive therapeutic strategies in the brain.

Montgomery SL, Mastrangelo MA, Habib D, Narrow WC, Burrell SA, Wright TW, Bowers WJ

The American journal of pathology.. 2011 October 179 (4):2053-70. Epub 08/09/2011.

Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia.

Wang J, Wright TW, Gigliotti F

Interdisciplinary perspectives on infectious diseases. 2011 2011 :918038. Epub 08/29/2011.

Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia.

Wang J, Gigliotti F, Bhagwat SP, George TC, Wright TW

PLoS pathogens.. 2010 August 196 (8):e1001058. Epub 08/19/2010.

Murine mechanical ventilation stimulates alveolar epithelial cell proliferation.

Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ

Experimental lung research.. 2010 August 36 (6):331-41. Epub 1900 01 01.

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.

Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB

Virology.. 2010 May 10400 (2):224-32. Epub 02/25/2010.

Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumonia.

Bhagwat SP, Wright TW, Gigliotti F

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 January 1184 (1):497-502. Epub 11/30/2009.

Parenchymal cell TNF receptors contribute to inflammatory cell recruitment and respiratory failure in Pneumocystis carinii-induced pneumonia.

Pryhuber GS, Huyck HL, Bhagwat S, O'Reilly MA, Finkelstein JN, Gigliotti F, Wright TW

The Journal of immunology : official journal of the American Association of Immunologists.. 2008 July 15181 (2):1409-19. Epub 1900 01 01.

Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism.

Wang J, Gigliotti F, Bhagwat SP, Maggirwar SB, Wright TW

American journal of physiology. Lung cellular and molecular physiology.. 2007 June 292 (6):L1495-505. Epub 02/16/2007.

Contribution of T cell subsets to the pathophysiology of Pneumocystis-related immunorestitution disease.

Bhagwat SP, Gigliotti F, Xu H, Wright TW

American journal of physiology. Lung cellular and molecular physiology.. 2006 December 291 (6):L1256-66. Epub 08/04/2006.

Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development.

Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2006 November 291 (5):L1101-11. Epub 07/21/2006.

Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia.

Gigliotti F, Crow EL, Bhagwat SP, Wright TW

Infection and immunity.. 2006 November 74 (11):6310-6. Epub 08/28/2006.

p21Cip1 protection against hyperoxia requires Bcl-XL and is uncoupled from its ability to suppress growth.

Vitiello PF, Staversky RJ, Gehen SC, Johnston CJ, Finkelstein JN, Wright TW, O'Reilly MA

The American journal of pathology.. 2006 June 168 (6):1838-47. Epub 1900 01 01.

Active immunization against Pneumocystis carinii with a recombinant P. carinii antigen.

Wells J, Haidaris CG, Wright TW, Gigliotti F

Infection and immunity.. 2006 April 74 (4):2446-8. Epub 1900 01 01.

Complement and Fc function are required for optimal antibody prophylaxis against Pneumocystis carinii pneumonia.

Wells J, Haidaris CG, Wright TW, Gigliotti F

Infection and immunity.. 2006 January 74 (1):390-3. Epub 1900 01 01.

Immunopathogenesis of Pneumocystis carinii pneumonia.

Gigliotti F, Wright TW

Expert reviews in molecular medicine.. 2005 November 147 (26):1-16. Epub 11/14/2005.

Inhibition of surfactant activity by Pneumocystis carinii organisms and components in vitro.

Wang Z, Foye A, Chang Y, Chess PR, Wright TW, Bhagwat S, Gigliotti F, Notter RH

American journal of physiology. Lung cellular and molecular physiology.. 2005 June 288 (6):L1124-31. Epub 1900 01 01.

Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells.

Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW

Infection and immunity.. 2005 May 73 (5):2766-77. Epub 1900 01 01.

Activity of Hoechst 33258 against Pneumocystis carinii f. sp. muris, Candida albicans, and Candida dubliniensis.

Disney MD, Stephenson R, Wright TW, Haidaris CG, Turner DH, Gigliotti F

Antimicrobial agents and chemotherapy.. 2005 April 49 (4):1326-30. Epub 1900 01 01.

Neither neutrophils nor reactive oxygen species contribute to tissue damage during Pneumocystis pneumonia in mice.

Swain SD, Wright TW, Degel PM, Gigliotti F, Harmsen AG

Infection and immunity.. 2004 October 72 (10):5722-32. Epub 1900 01 01.

TNF receptor signaling contributes to chemokine secretion, inflammation, and respiratory deficits during Pneumocystis pneumonia.

Wright TW, Pryhuber GS, Chess PR, Wang Z, Notter RH, Gigliotti F

The Journal of immunology : official journal of the American Association of Immunologists.. 2004 February 15172 (4):2511-21. Epub 1900 01 01.

Characterization of transmission of Pneumocystis carinii f. sp. muris through immunocompetent BALB/c mice.

Gigliotti F, Harmsen AG, Wright TW

Infection and immunity.. 2003 July 71 (7):3852-6. Epub 1900 01 01.

Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1).

Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA

The American journal of pathology.. 2002 October 161 (4):1383-93. Epub 1900 01 01.

Passive intranasal monoclonal antibody prophylaxis against murine Pneumocystis carinii pneumonia.

Gigliotti F, Haidaris CG, Wright TW, Harmsen AG

Infection and immunity.. 2002 March 70 (3):1069-74. Epub 1900 01 01.

Pulmonary inflammation disrupts surfactant function during Pneumocystis carinii pneumonia.

Wright TW, Notter RH, Wang Z, Harmsen AG, Gigliotti F

Infection and immunity.. 2001 February 69 (2):758-64. Epub 1900 01 01.

Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii.

Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG

Gene.. 2000 January 25242 (1-2):141-50. Epub 1900 01 01.

Immune-mediated inflammation directly impairs pulmonary function, contributing to the pathogenesis of Pneumocystis carinii pneumonia.

Wright TW, Gigliotti F, Finkelstein JN, McBride JT, An CL, Harmsen AG

The Journal of clinical investigation.. 1999 November 104 (9):1307-17. Epub 1900 01 01.

Chemokine gene expression during Pneumocystis carinii-driven pulmonary inflammation.

Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN

Infection and immunity.. 1999 July 67 (7):3452-60. Epub 1900 01 01.

Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia.

Simpson-Haidaris PJ, Courtney MA, Wright TW, Goss R, Harmsen A, Gigliotti F

Infection and immunity.. 1998 September 66 (9):4431-9. Epub 1900 01 01.

Inflammatory and epithelial responses in mouse strains that differ in sensitivity to hyperoxic injury.

Johnston CJ, Stripp BR, Piedbeouf B, Wright TW, Mango GW, Reed CK, Finkelstein JN

Experimental lung research.. 1998 24 (2):189-202. Epub 1900 01 01.

Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and -sensitive mice after thoracic irradiation.

Johnston CJ, Wright TW, Rubin P, Finkelstein JN

Experimental lung research.. 1998 24 (3):321-37. Epub 1900 01 01.

Chemokine mRNA alterations in newborn and adult mouse lung during acute hyperoxia.

D'Angio CT, Johnston CJ, Wright TW, Reed CK, Finkelstein JN

Experimental lung research.. 1998 24 (5):685-702. Epub 1900 01 01.

Analysis of cytokine mRNA profiles in the lungs of Pneumocystis carinii-infected mice.

Wright TW, Johnston CJ, Harmsen AG, Finkelstein JN

American journal of respiratory cell and molecular biology.. 1997 October 17 (4):491-500. Epub 1900 01 01.

Comparison of adult and newborn pulmonary cytokine mRNA expression after hyperoxia.

Johnston CJ, Wright TW, Reed CK, Finkelstein JN

Experimental lung research.. 1997 23 (6):537-52. Epub 1900 01 01.

Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA.

Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ

Gene.. 1995 December 29167 (1-2):185-9. Epub 1900 01 01.

Cloning and characterization of a lung-specific cDNA corresponding to the gamma chain of hepatic fibrinogen.

Simpson-Haidaris PJ, Wright TW, Earnest BJ, Hui Z, Neroni LA, Courtney MA

Gene.. 1995 December 29167 (1-2):273-8. Epub 1900 01 01.

Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii.

Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ

DNA research : an international journal for rapid publication of

Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species.

Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG

Infection and immunity.. 1994 May 62 (5):1513-9. Epub 1900 01 01.

Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma.

Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ

Blood.. 1993 October 1582 (8):2406-13. Epub 1900 01 01.

Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction.

Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR

The Journal of infectious diseases.. 1993 July 168 (1):191-4. Epub 1900 01 01.

In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene.

Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG

Molecular microbiology.. 1993 March 7 (5):647-56. Epub 1900 01 01.

Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii.

Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG

The Journal of infectious diseases.. 1992 November 166 (5):1113-23. Epub 1900 01 01.

Antigenic variation of a major surface glycoprotein of Pneumocystis carinii.

Gigliotti F

The Journal of protozoology. 1991 38 (6):4S-5S. Epub 1900 01 01.

Molecular cloning and characterization of ferret Pneumocystis carinii gp120.

Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ

The Journal of protozoology. 1991 38 (6):5S-6S. Epub 1900 01 01.

Books

Pneumocystis carinii Pneumonia (2005)

Chapter: Mechanisms of lung damage

Pneumocystis carinii Pneumonia (2005)

Chapter: Antibodies and other non-T cell defenses

Principles and Practice of Pediatric Infectious Diseases (2003)

Chapter: Pneumocystis carinii