Skip to content
Home
David I. Yule, Ph.D.

David I. Yule, Ph.D.

Looking for more Information?

Visit my lab website to learn more about my research, collaborators, latest news, etc.

Visit Research Lab Website

About Me

Faculty Appointments

Professor - Department of Pharmacology and Physiology (SMD)

Louis C. Lasagna Professorship in Experimental Therapeutics - Department of Pharmacology and Physiology (SMD)

Professor - Department of Medicine, Gastroenterology/Hepatology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

M.R.C. Secretory Control Group, Physiology Department, University of Liverpool. Supervisor: Prof. O.H. Petersen.

Department of Physiology, University of Michigan. Supervisor: Prof. J.A. Williams. 1990 - 1992

Education

PhD | UK-Univ of Liverpool. Physiology. 1989

BS | UK-Portsmouth Polytechnic. Pharmacology. 1985

Research

In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. Exposure of cells to neurotransmitters and hormones results in a rapid elevation of intracellular calcium. This increase in [Ca2+]i carries complex spatial and temporal infor...
In exocrine acinar cells regulation of intracellular calcium plays a pivotal role in controlling fluid and protein secretion. Exposure of cells to neurotransmitters and hormones results in a rapid elevation of intracellular calcium. This increase in [Ca2+]i carries complex spatial and temporal information important to the physiology of the acinar cell. Research in this laboratory focuses on gaining a better understanding of the mechanisms which underlie these signaling patterns with a primary goal of relating this knowledge to the physiology and pathophysiology of exocrine cells.
Although all Ca2+ mobilizing agonists in pancreatic acinar cells utilize the phosphoinositide-signaling (PI) pathway, stimulation by individual agents results in markedly different temporal and spatial patterns of Ca2+ signaling. One project is designed to understand at the molecular level how the cell effectively "knows" which PI-coupled agonist it is currently exposed to. Given that tremendous molecular diversity is expressed at all levels of this signaling pathway, our working hypothesis is that individual agonists do not couple to the signaling machinery in an identical fashion. This study involves precisely defining by molecular techniques the individual signaling proteins expressed in the acinar cell and then subsequently assessing if individual agonists utilize discrete and different elements of the PI-signaling pathway. We are utilizing fluorescence imaging techniques including high-speed confocal microscopy to monitor [Ca2+]i while manipulating the signaling pathway with neutralizing antibodies and antisense technology.

A further project relates to the organization and regulation of calcium release sites in exocrine cells. These organelles are defined by the expression of receptors for the second messenger Inositol 1,4,5-trisphosphate. In acinar cells the distribution of these receptors is tightly localized to an area associated with the actin cytoskeleton in the apical secretory pole of the cell. This distribution of receptors is the major factor in defining the spatial characteristics of the Ca2+ signal. The nature of the association with the cytoskeleton is being investigated. In addition the regulation of these receptors by phosphorylation and the consequences this may have for Ca2+ signaling are also being studied.

Publications

Journal Articles

Bcl-xL acts as an inhibitor of IPR channels, thereby antagonizing Ca-driven apoptosis.

Rosa N, Ivanova H, Wagner LE, Kale J, La Rovere R, Welkenhuyzen K, Louros N, Karamanou S, Shabardina V, Lemmens I, Vandermarliere E, Hamada K, Ando H, Rousseau F, Schymkowitz J, Tavernier J, Mikoshiba K, Economou A, Andrews DW, Parys JB, Yule DI, Bultynck G

Cell death and differentiation.. 2022 April 29 (4):788-805. Epub 11/08/2021.

Pivotal role of type-1 inositol 1,4,5-trisphosphate receptor for glucagon-induced gluconeogenesis.

Arige V, Yule DI

Cell calcium.. 2020 September 90 :102243. Epub 06/10/2020.

An inside job: Annexin 1A-Inositol 1,4,5-trisphosphate receptor interaction conveys endoplasmic reticulum luminal Ca sensitivity.

Wahl AM, Yule DI

Cell calcium.. 2020 September 90 :102250. Epub 07/08/2020.

Critical Role of Mortalin/GRP75 in Endothelial Cell Dysfunction Associated with Acute Lung Injury.

Leonard A, Su PY, Yule DI, Rahman A, Fazal F

Shock.. 2020 August 54 (2):245-255. Epub 1900 01 01.

Magnesium Acts as a Second Messenger in the Regulation of NMDA Receptor-Mediated CREB Signaling in Neurons.

Hou H, Wang L, Fu T, Papasergi M, Yule DI, Xia H

Molecular neurobiology.. 2020 June 57 (6):2539-2550. Epub 03/25/2020.

The native ORAI channel trio underlies the diversity of Ca signaling events.

Yoast RE, Emrich SM, Zhang X, Xin P, Johnson MT, Fike AJ, Walter V, Hempel N, Yule DI, Sneyd J, Gill DL, Trebak M

Nature communications.. 2020 May 1511 (1):2444. Epub 05/15/2020.

Bcl-2-Protein Family as Modulators of IP Receptors and Other Organellar Ca Channels.

Ivanova H, Vervliet T, Monaco G, Terry LE, Rosa N, Baker MR, Parys JB, Serysheva II, Yule DI, Bultynck G

Cold Spring Harbor perspectives in biology.. 2020 April 112 (4)Epub 04/01/2020.

A Multicellular Model of Primary Saliva Secretion in the Parotid Gland.

Vera-Sigüenza E, Pages N, Rugis J, Yule DI, Sneyd J

Bulletin of mathematical biology.. 2020 March 1182 (3):38. Epub 03/11/2020.

Fluoride exposure alters Ca signaling and mitochondrial function in enamel cells.

Aulestia FJ, Groeling J, Bomfim GHS, Costiniti V, Manikandan V, Chaloemtoem A, Concepcion AR, Li Y, Wagner LE, Idaghdour Y, Yule DI, Lacruz RS

Science signaling.. 2020 February 1813 (619)Epub 02/18/2020.

Bok regulates mitochondrial fusion and morphology.

Schulman JJ, Szczesniak LM, Bunker EN, Nelson HA, Roe MW, Wagner LE, Yule DI, Wojcikiewicz RJH

Cell death and differentiation.. 2019 December 26 (12):2682-2694. Epub 04/11/2019.

Bcl-2 and IP compete for the ligand-binding domain of IPRs modulating Ca signaling output.

Ivanova H, Wagner LE, Tanimura A, Vandermarliere E, Luyten T, Welkenhuyzen K, Alzayady KJ, Wang L, Hamada K, Mikoshiba K, De Smedt H, Martens L, Yule DI, Parys JB, Bultynck G

Cellular and molecular life sciences : CMLS.. 2019 October 76 (19):3843-3859. Epub 04/16/2019.

IP receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.

Bartok A, Weaver D, Golenár T, Nichtova Z, Katona M, Bánsághi S, Alzayady KJ, Thomas VK, Ando H, Mikoshiba K, Joseph SK, Yule DI, Csordás G, Hajnóczky G

Nature communications.. 2019 August 1910 (1):3726. Epub 08/19/2019.

A Model of [Formula: see text] Dynamics in an Accurate Reconstruction of Parotid Acinar Cells.

Pages N, Vera-Sigüenza E, Rugis J, Kirk V, Yule DI, Sneyd J

Bulletin of mathematical biology.. 2019 May 81 (5):1394-1426. Epub 01/14/2019.

Acetylcholine Inhibits Platelet Activation.

Bennett JA, Ture SK, Schmidt RA, Mastrangelo MA, Cameron SJ, Terry LE, Yule DI, Morrell CN, Lowenstein CJ

The Journal of pharmacology and experimental therapeutics.. 2019 May 369 (2):182-187. Epub 02/14/2019.

Expression of BK channels and Na-K pumps in the apical membrane of lacrimal acinar cells suggests a new molecular mechanism for primary tear-secretion.

Yule DI, Nánási PP, Magyar ZÉ, Márton I, Skaliczki M, Diszházi G, Almássy J

The ocular surface.. 2019 April 17 (2):272-277. Epub 01/24/2019.

A Mathematical Model of Fluid Transport in an Accurate Reconstruction of Parotid Acinar Cells.

Vera-Sigüenza E, Pages N, Rugis J, Yule DI, Sneyd J

Bulletin of mathematical biology.. 2019 March 81 (3):699-721. Epub 11/27/2018.

Selective Inactivation of Intracellular BiP/GRP78 Attenuates Endothelial Inflammation and Permeability in Acute Lung Injury.

Leonard A, Grose V, Paton AW, Paton JC, Yule DI, Rahman A, Fazal F

Scientific reports.. 2019 February 149 (1):2096. Epub 02/14/2019.

All three IP receptor isoforms generate Ca puffs that display similar characteristics.

Lock JT, Alzayady KJ, Yule DI, Parker I

Science signaling.. 2018 December 1811 (561)Epub 12/18/2018.

Redox regulation of type-I inositol trisphosphate receptors in intact mammalian cells.

Joseph SK, Young M, Alzayady K, Yule DI, Ali M, Booth DM, Hajnóczky G

The Journal of biological chemistry.. 2018 November 9293 (45):17464-17476. Epub 09/18/2018.

Differential regulation of ion channels function by proteolysis.

Wang L, Yule DI

Biochimica et biophysica acta. Molecular cell research.. 2018 November 1865 (11 Pt B):1698-1706. Epub 07/17/2018.

Carbohydrate Loading to Combat Acute Pancreatitis.

Vervliet T, Yule DI, Bultynck G

Trends in biochemical sciences.. 2018 October 43 (10):741-744. Epub 08/28/2018.

Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production.

de Rubio RG, Ransom RF, Malik S, Yule DI, Anantharam A, Smrcka AV

Science signaling.. 2018 September 1111 (547)Epub 09/11/2018.

Region-specific proteolysis differentially modulates type 2 and type 3 inositol 1,4,5-trisphosphate receptor activity in models of acute pancreatitis.

Wang L, Wagner LE, Alzayady KJ, Yule DI

The Journal of biological chemistry.. 2018 August 24293 (34):13112-13124. Epub 07/03/2018.

Inositol 1,4,5-trisphosphate Receptor Mutations associated with Human Disease.

Terry LE, Alzayady KJ, Furati E, Yule DI

Messenger.. 2018 June 6 (1-2):29-44. Epub 1900 01 01.

New saliva secretion model based on the expression of Na-K pump and K channels in the apical membrane of parotid acinar cells.

Almássy J, Siguenza E, Skaliczki M, Matesz K, Sneyd J, Yule DI, Nánási PP

Pflu?gers Archiv : European journal of physiology.. 2018 April 470 (4):613-621. Epub 01/17/2018.

Can pancreatitis be treated by inhibiting Ca signaling?

Williams JA, Yule DI

Annals of translational medicine.. 2018 April 6 (7):124. Epub 1900 01 01.

Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP.

Nurbaeva MK, Eckstein M, Devotta A, Saint-Jeannet JP, Yule DI, Hubbard MJ, Lacruz RS

Frontiers in physiology.. 2018 9 :801. Epub 07/02/2018.

Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity.

Wang L, Wagner LE, Alzayady KJ, Yule DI

The Journal of biological chemistry.. 2017 July 14292 (28):11714-11726. Epub 05/19/2017.

Resveratrol-induced autophagy is dependent on IPRs and on cytosolic Ca.

Luyten T, Welkenhuyzen K, Roest G, Kania E, Wang L, Bittremieux M, Yule DI, Parys JB, Bultynck G

Biochimica et biophysica acta. Molecular cell research.. 2017 June 1864 (6):947-956. Epub 02/28/2017.

Modeling calcium waves in an anatomically accurate three-dimensional parotid acinar cell.

Sneyd J, Means S, Zhu D, Rugis J, Won JH, Yule DI

Journal of theoretical biology.. 2017 April 21419 :383-393. Epub 05/04/2016.

DPB162-AE, an inhibitor of store-operated Ca entry, can deplete the endoplasmic reticulum Ca store.

Bittremieux M, Gerasimenko JV, Schuermans M, Luyten T, Stapleton E, Alzayady KJ, De Smedt H, Yule DI, Mikoshiba K, Vangheluwe P, Gerasimenko OV, Parys JB, Bultynck G

Cell calcium.. 2017 March 62 :60-70. Epub 02/01/2017.

On the dynamical structure of calcium oscillations.

Sneyd J, Han JM, Wang L, Chen J, Yang X, Tanimura A, Sanderson MJ, Kirk V, Yule DI

Proceedings of the National Academy of Sciences of the United States of America.. 2017 February 14114 (7):1456-1461. Epub 02/01/2017.

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.

Concepcion AR, Vaeth M, Wagner LE, Eckstein M, Hecht L, Yang J, Crottes D, Seidl M, Shin HP, Weidinger C, Cameron S, Turvey SE, Issekutz T, Meyts I, Lacruz RS, Cuk M, Yule DI, Feske S

The Journal of clinical investigation.. 2016 November 1126 (11):4303-4318. Epub 10/10/2016.

The trans-membrane domain of Bcl-2?, but not its hydrophobic cleft, is a critical determinant for efficient IP3 receptor inhibition.

Ivanova H, Ritane A, Wagner L, Luyten T, Shapovalov G, Welkenhuyzen K, Seitaj B, Monaco G, De Smedt H, Prevarskaya N, Yule DI, Parys JB, Bultynck G

Oncotarget.. 2016 August 237 (34):55704-55720. Epub 1900 01 01.

Proteolytic fragmentation of inositol 1,4,5-trisphosphate receptors: a novel mechanism regulating channel activity?

Wang L, Alzayady KJ, Yule DI

The Journal of physiology.. 2016 June 1594 (11):2867-76. Epub 12/07/2015.

Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome.

Gerber S, Alzayady KJ, Burglen L, Brémond-Gignac D, Marchesin V, Roche O, Rio M, Funalot B, Calmon R, Durr A, Gil-da-Silva-Lopes VL, Ribeiro Bittar MF, Orssaud C, Héron B, Ayoub E, Berquin P, Bahi-Buisson N, Bole C, Masson C, Munnich A, Simons M, Delous M, Dollfus H, Boddaert N, Lyonnet S, Kaplan J, Calvas P, Yule DI, Rozet JM, Fares Taie L

American journal of human genetics.. 2016 May 598 (5):971-980. Epub 04/21/2016.

Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.

Alzayady KJ, Wang L, Chandrasekhar R, Wagner LE, Van Petegem F, Yule DI

Science signaling.. 2016 April 59 (422):ra35. Epub 04/05/2016.

Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs.

Chandrasekhar R, Alzayady KJ, Wagner LE, Yule DI

The Journal of biological chemistry.. 2016 March 4291 (10):4846-60. Epub 01/11/2016.

IP3R deficit underlies loss of salivary fluid secretion in Sjögren's Syndrome.

Teos LY, Zhang Y, Cotrim AP, Swaim W, Won JH, Ambrus J, Shen L, Bebris L, Grisius M, Jang SI, Yule DI, Ambudkar IS, Alevizos I

Scientific reports.. 2015 September 145 :13953. Epub 09/14/2015.

The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²?-release channel.

Vervloessem T, Yule DI, Bultynck G, Parys JB

Biochimica et biophysica acta.. 2015 September 1853 (9):1992-2005. Epub 12/10/2014.

Tracing the Evolutionary History of Inositol, 1, 4, 5-Trisphosphate Receptor: Insights from Analyses of Capsaspora owczarzaki Ca2+ Release Channel Orthologs.

Alzayady KJ, Sebé-Pedrós A, Chandrasekhar R, Wang L, Ruiz-Trillo I, Yule DI

Molecular biology and evolution.. 2015 September 32 (9):2236-53. Epub 04/23/2015.

Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptors.

Chandrasekhar R, Alzayady KJ, Yule DI

Biochemical Society transactions.. 2015 June 43 (3):364-70. Epub 1900 01 01.

The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release.

Hedgepeth SC, Garcia MI, Wagner LE, Rodriguez AM, Chintapalli SV, Snyder RR, Hankins GD, Henderson BR, Brodie KM, Yule DI, van Rossum DB, Boehning D

The Journal of biological chemistry.. 2015 March 13290 (11):7304-13. Epub 02/02/2015.

Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp.

Wagner LE, Groom LA, Dirksen RT, Yule DI

Cell calcium.. 2014 August 56 (2):96-107. Epub 06/06/2014.

Cell Calcium. Special issue: Ca²? signaling and secretory function. Preface.

Yule DI

Cell calcium.. 2014 June 55 (6):281. Epub 04/18/2014.

Isoform- and species-specific control of inositol 1,4,5-trisphosphate (IP3) receptors by reactive oxygen species.

Bánsághi S, Golenár T, Madesh M, Csordás G, RamachandraRao S, Sharma K, Yule DI, Joseph SK, Hajnóczky G

The Journal of biological chemistry.. 2014 March 21289 (12):8170-81. Epub 01/27/2014.

Na+/Ca2+ exchangers regulate the migration and proliferation of human gastric myofibroblasts.

Kemény LV, Schnúr A, Czepán M, Rakonczay Z, Gál E, Lonovics J, Lázár G, Simonka Z, Venglovecz V, Maléth J, Judák L, Németh IB, Szabó K, Almássy J, Virág L, Geisz A, Tiszlavicz L, Yule DI, Wittmann T, Varró A, Hegyi P

American journal of physiology. Gastrointestinal and liver physiology.. 2013 October 15305 (8):G552-63. Epub 08/01/2013.

Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.

Alzayady KJ, Wagner LE, Chandrasekhar R, Monteagudo A, Godiska R, Tall GG, Joseph SK, Yule DI

The Journal of biological chemistry.. 2013 October 11288 (41):29772-84. Epub 08/16/2013.

Fragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels.

Alzayady KJ, Chandrasekhar R, Yule DI

The Journal of biological chemistry.. 2013 April 19288 (16):11122-34. Epub 03/11/2013.

Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity.

Wei-Lapierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W

The Journal of biological chemistry.. 2013 April 12288 (15):10567-77. Epub 03/01/2013.

Phospholipase C? hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV

Cell.. 2013 March 28153 (1):216-27. Epub 1900 01 01.

Photolysis of caged compounds: studying Ca(2+) signaling and activation of Ca(2+)-dependent ion channels.

Almassy J, Yule DI

Cold Spring Harbor protocols.. 2013 January 12013 (1)Epub 01/01/2013.

Studying the activation of epithelial ion channels using global whole-field photolysis.

Almassy J, Yule DI

Cold Spring Harbor protocols.. 2013 January 12013 (1)Epub 01/01/2013.

Investigating ion channel distribution using a combination of spatially limited photolysis, Ca(2+) imaging, and patch clamp recording.

Almassy J, Yule DI

Cold Spring Harbor protocols.. 2013 January 12013 (1)Epub 01/01/2013.

Analyzing Ca(2+) dynamics in intact epithelial cells using spatially limited flash photolysis.

Almassy J, Yule DI

Cold Spring Harbor protocols.. 2013 January 12013 (1)Epub 01/01/2013.

Manganese transport via the transferrin mechanism.

Gunter TE, Gerstner B, Gunter KK, Malecki J, Gelein R, Valentine WM, Aschner M, Yule DI

Neurotoxicology.. 2013 January 34 :118-27. Epub 11/09/2012.

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor.

Monaco G, Decrock E, Nuyts K, Wagner LE, Luyten T, Strelkov SV, Missiaen L, De Borggraeve WM, Leybaert L, Yule DI, De Smedt H, Parys JB, Bultynck G

PloS one.. 2013 8 (8):e73386. Epub 08/30/2013.

A quantitative analysis of electrolyte exchange in the salivary duct.

Patterson K, Catalán MA, Melvin JE, Yule DI, Crampin EJ, Sneyd J

American journal of physiology. Gastrointestinal and liver physiology.. 2012 November 15303 (10):G1153-63. Epub 08/16/2012.

Modelling the effects of calcium waves and oscillations on saliva secretion.

Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ

Journal of theoretical biology.. 2012 July 21305 :45-53. Epub 04/14/2012.

Differential regulation of the InsP? receptor type-1 and -2 single channel properties by InsP?, Ca²? and ATP.

Wagner LE, Yule DI

The Journal of physiology.. 2012 July 15590 (14):3245-59. Epub 04/30/2012.

Distinct contributions by ionotropic purinoceptor subtypes to ATP-evoked calcium signals in mouse parotid acinar cells.

Bhattacharya S, Verrill DS, Carbone KM, Brown S, Yule DI, Giovannucci DR

The Journal of physiology.. 2012 June 1590 (11):2721-37. Epub 03/25/2012.

Apical Ca2+-activated potassium channels in mouse parotid acinar cells.

Almassy J, Won JH, Begenisich TB, Yule DI

The Journal of general physiology.. 2012 February 139 (2):121-33. Epub 1900 01 01.

Regulation of Ca²? release through inositol 1,4,5-trisphosphate receptors by adenine nucleotides in parotid acinar cells.

Park HS, Betzenhauser MJ, Zhang Y, Yule DI

American journal of physiology. Gastrointestinal and liver physiology.. 2012 January 1302 (1):G97-G104. Epub 09/29/2011.

Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis.

Won JH, Zhang Y, Ji B, Logsdon CD, Yule DI

Molecular biology of the cell.. 2011 February 122 (3):421-36. Epub 1900 01 01.

InsP3R-associated cGMP kinase substrate determines inositol 1,4,5-trisphosphate receptor susceptibility to phosphoregulation by cyclic nucleotide-dependent kinases.

Masuda W, Betzenhauser MJ, Yule DI

The Journal of biological chemistry.. 2010 November 26285 (48):37927-38. Epub 09/27/2010.

Pancreatic acinar cells: molecular insight from studies of signal-transduction using transgenic animals.

Yule DI

The international journal of biochemistry & cell biology.. 2010 November 42 (11):1757-61. Epub 07/15/2010.

A dynamic model of saliva secretion.

Palk L, Sneyd J, Shuttleworth TJ, Yule DI, Crampin EJ

Journal of theoretical biology.. 2010 October 21266 (4):625-40. Epub 06/25/2010.

Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.

Yule DI, Betzenhauser MJ, Joseph SK

Cell calcium.. 2010 June 47 (6):469-79. Epub 05/26/2010.

Impaired TNF-alpha control of IP3R-mediated Ca2+ release in Alzheimer's disease mouse neurons.

Park KM, Yule DI, Bowers WJ

Cellular signalling.. 2010 March 22 (3):519-26. Epub 1900 01 01.

Protein kinase A regulation of P2X(4) receptors: requirement for a specific motif in the C-terminus.

Brown DA, Yule DI

Biochimica et biophysica acta.. 2010 February 1803 (2):275-87. Epub 12/21/2009.

Extracellular ATP and P2Y2 receptors mediate intercellular Ca(2+) waves induced by mechanical stimulation in submandibular gland cells: Role of mitochondrial regulation of store operated Ca(2+) entry.

Ryu SY, Peixoto PM, Won JH, Yule DI, Kinnally KW

Cell calcium.. 2010 January 47 (1):65-76. Epub 01/06/2010.

Regulation of inositol 1,4,5-trisphosphate receptors by phosphorylation and adenine nucleotides.

Betzenhauser MJ, Yule DI

Current topics in membranes.. 2010 66 :273-98. Epub 07/25/2010.

Tumor necrosis factor-alpha-mediated regulation of the inositol 1,4,5-trisphosphate receptor promoter.

Park KM, Yule DI, Bowers WJ

The Journal of biological chemistry.. 2009 October 2284 (40):27557-66. Epub 08/07/2009.

Protein kinase A increases type-2 inositol 1,4,5-trisphosphate receptor activity by phosphorylation of serine 937.

Betzenhauser MJ, Fike JL, Wagner LE, Yule DI

The Journal of biological chemistry.. 2009 September 11284 (37):25116-25. Epub 07/16/2009.

Inositol trisphosphate receptor and ion channel models based on single-channel data.

Gin E, Wagner LE, Yule DI, Sneyd J

Chaos.. 2009 September 19 (3):037104. Epub 1900 01 01.

ATP regulation of type-1 inositol 1,4,5-trisphosphate receptor activity does not require walker A-type ATP-binding motifs.

Betzenhauser MJ, Wagner LE, Park HS, Yule DI

The Journal of biological chemistry.. 2009 June 12284 (24):16156-16163. Epub 04/22/2009.

A kinetic model of the inositol trisphosphate receptor based on single-channel data.

Gin E, Falcke M, Wagner LE, Yule DI, Sneyd J

Biophysical journal.. 2009 May 2096 (10):4053-62. Epub 1900 01 01.

Markov chain Monte Carlo fitting of single-channel data from inositol trisphosphate receptors.

Gin E, Falcke M, Wagner LE, Yule DI, Sneyd J

Journal of theoretical biology.. 2009 April 7257 (3):460-74. Epub 12/30/2008.

Tumor necrosis factor-alpha potentiates intraneuronal Ca2+ signaling via regulation of the inositol 1,4,5-trisphosphate receptor.

Park KM, Yule DI, Bowers WJ

The Journal of biological chemistry.. 2008 November 28283 (48):33069-79. Epub 10/06/2008.

Studying isoform-specific inositol 1,4,5-trisphosphate receptor function and regulation.

Betzenhauser MJ, Wagner LE, Won JH, Yule DI

Methods : a companion to Methods in enzymology.. 2008 November 46 (3):177-82. Epub 10/16/2008.

The type 2 inositol (1,4,5)-trisphosphate (InsP3) receptor determines the sensitivity of InsP3-induced Ca2+ release to ATP in pancreatic acinar cells.

Park HS, Betzenhauser MJ, Won JH, Chen J, Yule DI

The Journal of biological chemistry.. 2008 September 19283 (38):26081-8. Epub 07/24/2008.

Visualizing form and function in organotypic slices of the adult mouse parotid gland.

Warner JD, Peters CG, Saunders R, Won JH, Betzenhauser MJ, Gunning WT, Yule DI, Giovannucci DR

American journal of physiology. Gastrointestinal and liver physiology.. 2008 September 295 (3):G629-40. Epub 07/31/2008.

ATP modulation of Ca2+ release by type-2 and type-3 inositol (1, 4, 5)-triphosphate receptors. Differing ATP sensitivities and molecular determinants of action.

Betzenhauser MJ, Wagner LE, Iwai M, Michikawa T, Mikoshiba K, Yule DI

The Journal of biological chemistry.. 2008 August 1283 (31):21579-87. Epub 05/27/2008.

Regulation of single inositol 1,4,5-trisphosphate receptor channel activity by protein kinase A phosphorylation.

Wagner LE, Joseph SK, Yule DI

The Journal of physiology.. 2008 August 1586 (15):3577-96. Epub 06/05/2008.

Molecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment.

Schug ZT, da Fonseca PC, Bhanumathy CD, Wagner L, Zhang X, Bailey B, Morris EP, Yule DI, Joseph SK

The Journal of biological chemistry.. 2008 February 1283 (5):2939-48. Epub 11/19/2007.

Ca2+ release dynamics in parotid and pancreatic exocrine acinar cells evoked by spatially limited flash photolysis.

Won JH, Cottrell WJ, Foster TH, Yule DI

American journal of physiology. Gastrointestinal and liver physiology.. 2007 December 293 (6):G1166-77. Epub 09/27/2007.

A mathematical model of fluid secretion from a parotid acinar cell.

Gin E, Crampin EJ, Brown DA, Shuttleworth TJ, Yule DI, Sneyd J

Journal of theoretical biology.. 2007 September 7248 (1):64-80. Epub 05/03/2007.

Protein kinase C regulation of P2X3 receptors is unlikely to involve direct receptor phosphorylation.

Brown DA, Yule DI

Biochimica et biophysica acta.. 2007 February 1773 (2):166-75. Epub 09/19/2006.

Measurement of Ca2+ signaling dynamics in exocrine cells with total internal reflection microscopy.

Won JH, Yule DI

American journal of physiology. Gastrointestinal and liver physiology.. 2006 July 291 (1):G146-55. Epub 02/16/2006.

ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A.

Wagner LE, Betzenhauser MJ, Yule DI

The Journal of biological chemistry.. 2006 June 23281 (25):17410-17419. Epub 04/18/2006.

Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptors.

Khan MT, Wagner L, Yule DI, Bhanumathy C, Joseph SK

The Journal of biological chemistry.. 2006 February 10281 (6):3731-7. Epub 12/06/2005.

A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations.

Sneyd J, Tsaneva-Atanasova K, Reznikov V, Bai Y, Sanderson MJ, Yule DI

Proceedings of the National Academy of Sciences of the United States of America.. 2006 February 7103 (6):1675-80. Epub 01/30/2006.

Spatiotemporal analysis of exocytosis in mouse parotid acinar cells.

Chen Y, Warner JD, Yule DI, Giovannucci DR

American journal of physiology. Cell physiology.. 2005 November 289 (5):C1209-19. Epub 07/06/2005.

Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells.

Mignen O, Thompson JL, Yule DI, Shuttleworth TJ

The Journal of physiology.. 2005 May 1564 (Pt 3):791-801. Epub 03/10/2005.

Calcium oscillations in a triplet of pancreatic acinar cells.

Tsaneva-Atanasova K, Yule DI, Sneyd J

Biophysical journal.. 2005 March 88 (3):1535-51. Epub 12/13/2004.

Functional consequences of phosphomimetic mutations at key cAMP-dependent protein kinase phosphorylation sites in the type 1 inositol 1,4,5-trisphosphate receptor.

Wagner LE, Li WH, Joseph SK, Yule DI

The Journal of biological chemistry.. 2004 October 29279 (44):46242-52. Epub 08/11/2004.

cAMP potentiates ATP-evoked calcium signaling in human parotid acinar cells.

Brown DA, Bruce JI, Straub SV, Yule DI

The Journal of biological chemistry.. 2004 September 17279 (38):39485-94. Epub 07/19/2004.

Calcium and mitochondria.

Gunter TE, Yule DI, Gunter KK, Eliseev RA, Salter JD

FEBS letters.. 2004 June 1567 (1):96-102. Epub 1900 01 01.

Modulation of [Ca2+]i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells.

Bruce JI, Giovannucci DR, Blinder G, Shuttleworth TJ, Yule DI

The Journal of biological chemistry.. 2004 March 26279 (13):12909-17. Epub 12/29/2003.

Control of calcium oscillations by membrane fluxes.

Yule DI, Sneyd J, Thompson JL, Tsaneva-Atanasova K, Shuttleworth TJ, Yule DI, Thompson JL, Shuttleworth TJ

Proceedings of the National Academy of Sciences of the United States of America.. 2004 February 3101 (5):1392-6. Epub 01/20/2004.

Modulation of cytosolic calcium signaling by protein kinase A-mediated phosphorylation of inositol 1,4,5-trisphosphate receptors.

Straub SV, Wagner LE, Bruce JI, Yule DI

Biological research.. 2004 37 (4):593-602. Epub 1900 01 01.

Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.

Bruce JI, Straub SV, Yule DI

Cell calcium.. 2003 December 34 (6):431-44. Epub 1900 01 01.

Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: a mutational analysis of the functionally important sites in the S2+ and S2- splice variants.

Wagner LE, Li WH, Yule DI

The Journal of biological chemistry.. 2003 November 14278 (46):45811-7. Epub 08/25/2003.

Critical role for NHE1 in intracellular pH regulation in pancreatic acinar cells.

Brown DA, Melvin JE, Yule DI

American journal of physiology. Gastrointestinal and liver physiology.. 2003 November 285 (5):G804-12. Epub 07/03/2003.

Modulation of Ca2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptors.

Yule DI, Straub SV, Bruce JI

Biochemical Society transactions.. 2003 October 31 (Pt 5):954-7. Epub 1900 01 01.

A model of calcium waves in pancreatic and parotid acinar cells.

Sneyd J, Tsaneva-Atanasova K, Bruce JI, Straub SV, Giovannucci DR, Yule DI

Biophysical journal.. 2003 September 85 (3):1392-405. Epub 1900 01 01.

Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells.

Bruce JI, Yule DI, Shuttleworth TJ

The Journal of biological chemistry.. 2002 December 13277 (50):48172-81. Epub 10/03/2002.

A role for phosphorylation of inositol 1,4,5-trisphosphate receptors in defining calcium signals induced by Peptide agonists in pancreatic acinar cells.

Straub SV, Giovannucci DR, Bruce JI, Yule DI

The Journal of biological chemistry.. 2002 August 30277 (35):31949-56. Epub 06/13/2002.

Cytosolic Ca(2+) and Ca(2+)-activated Cl(-) current dynamics: insights from two functionally distinct mouse exocrine cells.

Giovannucci DR, Bruce JI, Straub SV, Arreola J, Sneyd J, Shuttleworth TJ, Yule DI

The Journal of physiology.. 2002 April 15540 (Pt 2):469-84. Epub 1900 01 01.

Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.

Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI

The Journal of biological chemistry.. 2002 January 11277 (2):1340-8. Epub 11/01/2001.

Identification of a ryanodine receptor in rat heart mitochondria.

Beutner G, Sharma VK, Giovannucci DR, Yule DI, Sheu SS

The Journal of biological chemistry.. 2001 June 15276 (24):21482-8. Epub 04/10/2001.

Subtype-specific regulation of inositol 1,4,5-trisphosphate receptors: controlling calcium signals in time and space.

Yule DI

The Journal of general physiology.. 2001 May 117 (5):431-4. Epub 1900 01 01.

Targeted phosphorylation of inositol 1,4,5-trisphosphate receptors selectively inhibits localized Ca2+ release and shapes oscillatory Ca2+ signals.

Giovannucci DR, Groblewski GE, Sneyd J, Yule DI

The Journal of biological chemistry.. 2000 October 27275 (43):33704-11. Epub 1900 01 01.

Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria.

Straub SV, Giovannucci DR, Yule DI

The Journal of general physiology.. 2000 October 116 (4):547-60. Epub 1900 01 01.

Modulation of InsP3 receptor properties by phosphorylation: targeting of PKA to InsP3 receptors shapes oscillatory calcium signals in pancreatic acinar cells.

Giovannucci DR, Sneyd J, Groblewski GE, Yule DI

Journal of Korean medical science.. 2000 August 15 Suppl (Suppl):S55-6. Epub 1900 01 01.

Agonist-dependent phosphorylation of the inositol 1,4,5-trisphosphate receptor: A possible mechanism for agonist-specific calcium oscillations in pancreatic acinar cells.

LeBeau AP, Yule DI, Groblewski GE, Sneyd J

The Journal of general physiology.. 1999 June 113 (6):851-72. Epub 1900 01 01.

Secretagogues cause ubiquitination and down-regulation of inositol 1, 4,5-trisphosphate receptors in rat pancreatic acinar cells.

Wojcikiewicz RJ, Ernst SA, Yule DI

Gastroenterology.. 1999 May 116 (5):1194-201. Epub 1900 01 01.

Calcium signaling in rat pancreatic acinar cells: a role for Galphaq, Galpha11, and Galpha14.

Yule DI, Baker CW, Williams JA

The American journal of physiology.. 1999 January 276 (1):G271-9. Epub 1900 01 01.

Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cells.

Giovannucci DR, Yule DI, Stuenkel EL

American journal of physiology. Cell physiology.. 1998 September 1275 (3):C732-C739. Epub 1900 01 01.

Optical measurement of stimulus-evoked membrane dynamics in single pancreatic acinar cells.

Giovannucci DR, Yule DI, Stuenkel EL

The American journal of physiology.. 1998 September 275 (3):C732-9. Epub 1900 01 01.

Overexpression of Rab3D enhances regulated amylase secretion from pancreatic acini of transgenic mice.

Ohnishi H, Samuelson LC, Yule DI, Ernst SA, Williams JA

The Journal of clinical investigation.. 1997 December 15100 (12):3044-52. Epub 1900 01 01.

Heterotrimeric G-protein Gq/11 localized on pancreatic zymogen granules is involved in calcium-regulated amylase secretion.

Ohnishi H, Ernst SA, Yule DI, Baker CW, Williams JA

The Journal of biological chemistry.. 1997 June 20272 (25):16056-61. Epub 1900 01 01.

Endothelin-activated calcium signaling in enteric glia derived from neonatal guinea pig.

Zhang W, Sarosi G, Barnhart D, Yule DI, Mulholland MW

The American journal of physiology.. 1997 May 272 (5 Pt 1):G1175-85. Epub 1900 01 01.

Evidence that zymogen granules are not a physiologically relevant calcium pool. Defining the distribution of inositol 1,4,5-trisphosphate receptors in pancreatic acinar cells.

Yule DI, Ernst SA, Ohnishi H, Wojcikiewicz RJ

The Journal of biological chemistry.. 1997 April 4272 (14):9093-8. Epub 1900 01 01.

Ultrastructure and cell-cell coupling of cardiac myocytes differentiating in embryonic stem cell cultures.

Westfall MV, Pasyk KA, Yule DI, Samuelson LC, Metzger JM

Cell motility and the cytoskeleton.. 1997 36 (1):43-54. Epub 1900 01 01.

Stimulus-secretion coupling of pancreatic digestive enzyme secretion.

Williams JA, Groblewski GE, Ohnishi H, Yule DI

Digestion.. 1997 58 Suppl 1 :42-5. Epub 1900 01 01.

Intercellular calcium waves in rat pancreatic acini: mechanism of transmission.

Yule DI, Stuenkel E, Williams JA

The American journal of physiology.. 1996 October 271 (4 Pt 1):C1285-94. Epub 1900 01 01.

Intra- and intercellular calcium signaling in human neuroepithelioma cells.

Palmer RK, Yule DI, McEwen EL, Williams JA, Fisher SK

Journal of lipid mediators and cell signalling. 1996 September 14 (1-3):169-74. Epub 1900 01 01.

Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells.

Palmer RK, Yule DI, Shewach DS, Williams JA, Fisher SK

The American journal of physiology.. 1996 July 271 (1 Pt 1):C43-53. Epub 1900 01 01.

Extracellular ATP mediates Ca2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism.

Kimball BC, Yule DI, Mulholland MW

The American journal of physiology.. 1996 April 270 (4 Pt 1):G587-93. Epub 1900 01 01.

Caffeine- and ryanodine-sensitive Ca2+ stores in cultured guinea pig myenteric neurons.

Kimball BC, Yule DI, Mulholland MW

The American journal of physiology.. 1996 April 270 (4 Pt 1):G594-603. Epub 1900 01 01.

Halothane and octanol block Ca2+ oscillations in pancreatic acini by multiple mechanisms.

Deutsch DE, Williams JA, Yule DI

The American journal of physiology.. 1995 November 269 (5 Pt 1):G779-88. Epub 1900 01 01.

Mutation of carboxyl-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization.

Yang J, Williams JA, Yule DI, Logsdon CD

Molecular pharmacology.. 1995 September 48 (3):477-85. Epub 1900 01 01.

Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms.

Massa E, Kelly KM, Yule DI, MacDonald RL, Uhler MD

Molecular pharmacology.. 1995 April 47 (4):707-16. Epub 1900 01 01.

Ca2+ signaling through secretagogue and growth factor receptors on pancreatic AR42J cells.

Simeone DM, Yule DI, Logsdon CD, Williams JA

Regulatory peptides.. 1995 January 2655 (2):197-206. Epub 1900 01 01.

Agonist-specific calcium signaling and phosphoinositide hydrolysis in human SK-N-MCIXC neuroepithelioma cells.

Palmer RK, Yule DI, McEwen EL, Williams JA, Fisher SK

Journal of neurochemistry.. 1994 December 63 (6):2099-107. Epub 1900 01 01.

Spontaneous calcium oscillations in clonal endocrine pancreatic glucagon-secreting cells.

Bode HP, Yule DI, Fehmann HC, Göke B, Williams JA

Biochemical and biophysical research communications.. 1994 November 30205 (1):435-40. Epub 1900 01 01.

Tyrosine kinase inhibitors attenuate "capacitative" Ca2+ influx in rat pancreatic acinar cells.

Yule DI, Kim ET, Williams JA

Biochemical and biophysical research communications.. 1994 August 15202 (3):1697-704. Epub 1900 01 01.

Characterization of cholecystokininA receptor agonist activity by a family of cholecystokininB receptor antagonists.

Blevins GT, van de Westerlo EM, Yule DI, Williams JA

The Journal of pharmacology and experimental therapeutics.. 1994 June 269 (3):911-6. Epub 1900 01 01.

Multiple inhibitory effects of genistein on stimulus-secretion coupling in rat pancreatic acini.

Duan RD, Wagner AC, Yule DI, Williams JA

The American journal of physiology.. 1994 February 266 (2 Pt 1):G303-10. Epub 1900 01 01.

CCK antagonists reveal that CCK-8 and JMV-180 interact with different sites on the rat pancreatic acinar cell CCKA receptor.

Yule DI, Williams JA

Peptides.. 1994 15 (6):1045-51. Epub 1900 01 01.

A cloned CCK-A receptor transduces multiple signals in response to full and partial agonists.

Yule DI, Tseng MJ, Williams JA, Logdson CD

The American journal of physiology.. 1993 November 265 (5 Pt 1):G999-1004. Epub 1900 01 01.

Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells.

Yule DI, Wu D, Essington TE, Shayman JA, Williams JA

The Journal of biological chemistry.. 1993 June 15268 (17):12353-8. Epub 1900 01 01.

Pilocarpine and carbachol exhibit markedly different patterns of Ca2+ signaling in rat pancreatic acinar cells.

Yule DI, Essington TE, Williams JA

The American journal of physiology.. 1993 April 264 (4 Pt 1):G786-91. Epub 1900 01 01.

Effects of okadaic acid indicate a role for dephosphorylation in pancreatic stimulus-secretion coupling.

Wagner AC, Wishart MJ, Yule DI, Williams JA

The American journal of physiology.. 1992 December 263 (6 Pt 1):C1172-80. Epub 1900 01 01.

Endothelin increases [Ca2+]i in rat pancreatic acinar cells by intracellular release but fails to increase amylase secretion.

Yule DI, Blevins GT, Wagner AC, Williams JA

Biochimica et biophysica acta.. 1992 August 121136 (2):175-80. Epub 1900 01 01.

U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.

Yule DI, Williams JA

The Journal of biological chemistry.. 1992 July 15267 (20):13830-5. Epub 1900 01 01.

Discordance and concordance of dementia of the Alzheimer type (DAT) in monozygotic twins indicate heritable and sporadic forms of Alzheimer's disease.

Rapoport SI, Pettigrew KD, Schapiro MB

Neurology.. 1991 October 41 (10):1549-53. Epub 1900 01 01.

Mastoparan induces oscillations of cytosolic Ca2+ in rat pancreatic acinar cells.

Yule DI, Williams JA

Biochemical and biophysical research communications.. 1991 May 31177 (1):159-65. Epub 1900 01 01.

Chronic renal failure: causes, diagnosis, and therapy.

Campistol JM, Montoliu J

Comprehensive therapy.. 1991 February 17 (2):51-62. Epub 1900 01 01.

Receptor-activated cytoplasmic Ca2+ oscillations in pancreatic acinar cells: generation and spreading of Ca2+ signals.

Petersen OH, Gallacher DV, Wakui M, Yule DI, Petersen CC, Toescu EC

Cell calcium.. 1991 12 (2-3):135-44. Epub 1900 01 01.

Acetylcholine and cholecystokinin induce different patterns of oscillating calcium signals in pancreatic acinar cells.

Yule DI, Lawrie AM, Gallacher DV

Cell calcium.. 1991 12 (2-3):145-51. Epub 1900 01 01.

Effects of alanine on insulin-secreting cells: patch-clamp and single cell intracellular Ca2+ measurements.

Dunne MJ, Yule DI, Gallacher DV, Petersen OH

Biochimica et biophysica acta.. 1990 November 121055 (2):157-64. Epub 1900 01 01.

Substance P and bombesin elevate cytosolic Ca2+ by different molecular mechanisms in a rat pancreatic acinar cell line.

Gallacher DV, Hanley MR, Petersen OH, Roberts ML, Squire-Pollard LG, Yule DI

The Journal of physiology.. 1990 July 426 :193-207. Epub 1900 01 01.

Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G-protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent Cl- current recording in single pancreatic acinar cells.

Osipchuk YV, Wakui M, Yule DI, Gallacher DV, Petersen OH

The EMBO journal.. 1990 March 9 (3):697-704. Epub 1900 01 01.

Comparative study of the effects of cromakalim (BRL 34915) and diazoxide on membrane potential, [Ca2+]i and ATP-sensitive potassium currents in insulin-secreting cells.

Dunne MJ, Yule DI, Gallacher DV, Petersen OH

The Journal of membrane biology.. 1990 March 114 (1):53-60. Epub 1900 01 01.

Stimulant-evoked depolarization and increase in [Ca2+]i in insulin-secreting cells is dependent on external Na+.

Dunne MJ, Yule DI, Gallacher DV, Petersen OH

The Journal of membrane biology.. 1990 February 113 (2):131-8. Epub 1900 01 01.

Vasopressin directly closes ATP-sensitive potassium channels evoking membrane depolarization and an increase in the free intracellular Ca2+ concentration in insulin-secreting cells.

Martin SC, Yule DI, Dunne MJ, Gallacher DV, Petersen OH

The EMBO journal.. 1989 December 18 (12):3595-9. Epub 1900 01 01.

Cromakalim (BRL 34915) and diazoxide activate ATP-regulated potassium channels in insulin-secreting cells.

Dunne MJ, Yule DI, Gallacher DV, Petersen OH

Pflu?gers Archiv : European journal of physiology.. 1989 414 Suppl 1 :S154-5. Epub 1900 01 01.

Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine.

Yule DI, Gallacher DV

FEBS letters.. 1988 November 7239 (2):358-62. Epub 1900 01 01.

Books

Physiology of the Gastrointestinal Tract, Two Volume Set (2012)

Chapter: Stimulus-secretion Coupling in Pancreatic Acinar Cells

Authors: Williams, John A., and Yule, David I.

Publisher: Elsevier 2012

Physiology of the Gastrointestinal Tract (2006)

Chapter: Stimulus-Secretion Coupling in the Pancreatic Acinus.

Authors: Williams, JA; and Yule, DI

Publisher: Raven Press 2006

Physiology of the Gastrointestinal Tract (1994)

Chapter: Stimulus-secretion coupling in the pancreatic acinus.

Authors: Yule, DI; and Williams, JA

Publisher: Raven Press 1994

Pancreas: Biology, Pathobiology and Disease (1993)

Chapter: Stimulus-secretion coupling in rat pancreatic acinar cells.

Authors: Williams, JA; Yule, DI; Go, VLW; Dimagn, EP

Publisher: Raven Press, New York 1993