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Stephanos Kyrkanides, D.D.S., M.S., Ph.D.

Contact

Appointment (585) 341-7177
Office (585) 275-5012
Fax (585) 273-1233
Administrative (585) 273-3340

About Me

Faculty Appointments

Adjunct Professor - Department of Neuroscience (SMD)

Credentials

Education

Post-Doc | University of Rochester School of Medicine & Dentistry. Molecular Medicine & Gene Therapy. 2000

Ph.D. | University of Rochester School of Medicine & Dentistry. Neurobiology & Anatomy. 1999

Certificate | Eastman Dental Center. Advanced Education in General Dentistry. 1999

M.S. | University of Rochester School of Medicine & Dentistry. Neurobiology & Anatomy. 1997

Certificate | Eastman Dental Center. Temporomandibular Joint Disorders. 1995

Certificate | Eastman Dental Center. Orthodontics & Craniofacial Orthopedics. 1994

DDS | National University of Athens. Dentistry. 1991

Awards

Orthodontic Faculty Development Fellowship Award, American Association of Orthodontists Foundation 2002

Orthodontic Faculty Development Fellowship Award, American Association of Orthodontists Foundation 2001

Mentored Clinician Scientist Award, NIH/NIDCR K08 DE/NS00471 "Neuronal function in craniofacial development 2001 - 2005

Training fellowship, NIH/NIEHS T32 ES07026, "Training in Environmental Toxicology 2000

Training fellowship, NIH/NIA T32 AG00107, "Training in Neurobiology of Aging & Geriatrics 1999

1998 Biomedical Research Award, American Association of Orthodontists Foundation, "The role of COX-2 and NSAIDs in tooth movement 1998

Research Award, Eastman Orthodontic Foundation. "The action of non-steroidal anti-inflammatory drugs in tissue remodeling during orthodontic tooth movement 1997

1997 Dean's Merit Award, Office of Graduate Studies, University of Rochester School of Medicine & Dentistry, Rochester NY 1997

Basil G. Bibby Research Fellowship, Eastman Dental Center 1997

Michael G. Buonocore Award, American Association for Dental Research-Rochester Section. "Trigeminal nuclear complex of the New Zealand white rabbit brain stem: Anatomical and immunohistochemical studies 1996

Basil G. Bibby Research Fellowship, Eastman Dental Center. 1995

Research Fellowship, Eastman Dental Center, Rochester, NY. "Retrograde transport of horseradish peroxidase in the trigeminal nerve of the New Zealand white rabbit 1994

Research Award, Northeastern Society of Orthodontists Research. "Asymmetry of the upper lip and nose in Unilateral Cleft Lip & Palate 1993

Publications

Journal Articles

The cranial base in craniofacial development: a gene therapy study.

Kyrkanides S, Kambylafkas P, Miller JH, Tallents RH, Puzas JE

Journal of dental research.. 2007 October 86 (10):956-61. Epub 1900 01 01.

Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration.

Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 August 2927 (35):9301-9. Epub 1900 01 01.

Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism.

Brouxhon S, Kyrkanides S, O'Banion MK, Johnson R, Pearce DA, Centola GM, Miller JN, McGrath KH, Erdle B, Scott G, Schneider S, VanBuskirk J, Pentland AP

Cancer research.. 2007 August 1567 (16):7654-64. Epub 1900 01 01.

Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype.

Kyrkanides S, Miller JN, Tallents RH, Brouxhon SM, Centola GM, Olschowka JA

Journal of neuroimmunology.. 2007 August 188 (1-2):39-47. Epub 06/18/2007.

Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint.

Kyrkanides S, Fiorentino PM, Miller JN, Gan Y, Lai YC, Shaftel SS, Puzas JE, Piancino MG, O'Banion MK, Tallents RH

Arthritis and rheumatism.. 2007 June 56 (6):2038-48. Epub 1900 01 01.

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology.

Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK

The Journal of clinical investigation.. 2007 June 117 (6):1595-604. Epub 1900 01 01.

Comparison of Doppler sonography to magnetic resonance imaging and clinical examination for disc displacement.

Puri P, Kambylafkas P, Kyrkanides S, Katzberg R, Tallents RH

The Angle orthodontist.. 2006 September 76 (5):824-9. Epub 1900 01 01.

Validity of panoramic radiographs for measuring mandibular asymmetry.

Kambylafkas P, Murdock E, Gilda E, Tallents RH, Kyrkanides S

The Angle orthodontist.. 2006 May 76 (3):388-93. Epub 1900 01 01.

beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration.

Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff HJ

Brain research. Molecular brain research.. 2005 February 18133 (2):286-98. Epub 1900 01 01.

The relationship of distinct craniofacial features between Turner syndrome females and their parents.

Perkiömäki MR, Kyrkanides S, Niinimaa A, Alvesalo L

European journal of orthodontics.. 2005 February 27 (1):48-52. Epub 1900 01 01.

Mandibular asymmetry in adult patients with unilateral degenerative joint disease.

Kambylafkas P, Kyrkanides S, Tallents RH.

Angle Orthodontist. 2005; 75: 297-302.

Intra-articular induction of chronic IL-1beta expression in the adult mouse results in an osteoarthritis-like phenotype accompanied by pain.

Lai Y-C, Shaftel SS, Miller JH, Tallents RH, Chang Y, Olschowka JA, Pinkert CA, Puzas JE, Dickerson IA, O'Banion MK, Stephanos Kyrkanides S.

Arthritis Rheumatism. 2005; 54: 1184-1197.

Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral disk displacement without reduction.

Gidarakou IK, Tallents RH, Kyrkanides S, Stein S, Moss ME

The Angle orthodontist.. 2004 October 74 (5):684-90. Epub 1900 01 01.

Abnormal PGE(2) regulation of monocyte TNF-alpha levels in trauma patients parallels development of a more macrophage-like phenotype.

Laudanski K, De A, Brouxhon S, Kyrkanides S, Miller-Graziano C

Shock.. 2004 September 22 (3):204-12. Epub 1900 01 01.

The effect of esthetic consultation methods on acceptance of diastema-closure treatment plan: a pilot study.

Almog D, Sanchez Marin C, Proskin HM, Cohen MJ, Kyrkanides S, Malmstrom H

The Journal of the American Dental Association.. 2004 July 135 (7):875-81; quiz 1035-6, 1038. Epub 1900 01 01.

Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement with reduction.

Gidarakou IK, Tallents RH, Stein S, Kyrkanides S, Moss ME

The Angle orthodontist.. 2004 April 74 (2):212-9. Epub 1900 01 01.

Non-primate lentiviral vector administration in the TMJ.

Kyrkanides S, Kambylafkas P, Miller JH, Tallents RH

Journal of dental research.. 2004 January 83 (1):65-70. Epub 1900 01 01.

Retrospective revelations: 20 long-term orthodontically treated unilateral cleft lip and palate individuals.

Subtelny JD and Kyrkanides S.

World Journal of Orthodontics. 2004; 5: 153-163.

The effect of esthetic consultation methods on acceptance of diastema-closure plan: A pilot study.

Almog D, Sanchez-Marin C, Proskin HM, Cohen MJ, Kyrkanides S, Malmstrom H.

Journal of American Dental Association . 2004; 135: 875-881.

Retrospective revelations: twenty orthodontically treated individuals with unilateral cleft lip and palate.

Subtelny JD, Kyrkanides S

World journal of orthodontics.. 2004 5 (2):152-63. Epub 1900 01 01.

Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons.

Kyrkanides S, Miller JH, Federoff HJ

Brain research. Molecular brain research.. 2003 November 6119 (1):1-9. Epub 1900 01 01.

Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system.

Kyrkanides S, Miller JH, Bowers WJ, Federoff HJ

Molecular therapy : the journal of the American Society of Gene Therapy.. 2003 November 8 (5):790-5. Epub 1900 01 01.

Association of nasomaxillary asymmetry in children with unilateral cleft lip and palate and their parents.

Yoon YJ, Perkiomaki MR, Tallents RH, Barillas I, Herrera-Guido R, Fong CT, Kyrkanides S

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 2003 September 40 (5):493-7. Epub 1900 01 01.

Association of distinct craniofacial features in nonsyndromic cleft lip and palate family members.

Perkiomaki MR, Yoon YJ, Tallents RH, Barillas I, Herrera-Guido R, Moss ME, Fong CT, Kyrkanides S

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 2003 July 40 (4):397-402. Epub 1900 01 01.

Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with normal temporomandibular joints.

Gidarakou IK, Tallents RH, Kyrkanides S, Stein S, Moss ME

The Angle orthodontist.. 2003 April 73 (2):116-20. Epub 1900 01 01.

Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with unilateral disk displacement without reduction.

Gidarakou IK, Tallents RH, Kyrkanides S, Stein S, Moss ME

The Angle orthodontist.. 2003 April 73 (2):121-7. Epub 1900 01 01.

Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral degenerative joint disease.

Gidarakou IK, Tallents RH, Kyrkanides S, Stein S, Moss M

The Angle orthodontist.. 2003 February 73 (1):71-8. Epub 1900 01 01.

Transverse craniofacial features and their genetic predisposition in non-syndromic unilateral cleft lip and palate families.

Yoon Y-J, Perkiomaki MR, Tallents RH, Barillas I, Herrera-Guido R, Fong C-T, Kyrkanides S.

Cleft Palate Craniofacial Journal. 2003; 41: 256-61.

Comparison of skeletal and dental morphology in asymptomatic volunteers and symptomatic patients with bilateral disk displacement with reduction.

Gidarakou IK, Tallents RH, Kyrkanides S, Stein S, Moss ME

The Angle orthodontist.. 2002 December 72 (6):541-6. Epub 1900 01 01.

Mandibular asymmetry and antigonial notching in individuals with unilateral cleft lip and palate.

Kyrkanides S, Richter L

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 2002 January 39 (1):30-5. Epub 1900 01 01.

Prevalence of Missing Posterior Teeth & Intra-articular Temporomandibular Disorders.

Tallents RH, Macher DJ, Kyrkanides S, Katzberg RW, Moss ME.

Journal of Prosthodontics. 2002; 87: 45-50.

The role of Cyclooxygenase-2 in modulating CNS inflammation following brain radiation injury.

Kyrkanides S, Olschowka JA, Williams JP, Hansen JT, O'Banion MK.

Molecular Brain Research, . 2002; 104: 159-169.

Selective inhibition of cyclooxygenase-2 attenuates expression of inflammation-related genes in CNS injury.

O'Banion MK, Kyrkanides S, Olschowka JA

Advances in experimental medicine and biology.. 2002 507 :155-60. Epub 1900 01 01.

Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury.

Kyrkanides S, O'Banion MK, Whiteley PE, Daeschner JC, Olschowka JA

Journal of neuroimmunology.. 2001 October 1119 (2):269-77. Epub 1900 01 01.

Microtia associated with the Kabuki (Niikawa-Kuroki) syndrome.

Fong C-T, Wang M, Carter EC, Hogan CA, Tallents RH, Kyrkanides S, Liptak GS, Sanger JA, Frisina RB.

Otolaryngol Head Neck Surgery. 2001; 125(5): 557-558.

Temporomandibular joint sound evaluation with an electronic device and clinical evaluation.

Tanzilli RA, Tallents RH, Katzberg RW, Kyrkanides S, Moss ME.

Clinical Orthodontic Research. 2001; 4: 72-78.

Cranial base and facial skeleton asymmetries in individuals with unilateral cleft lip and palate.

Kyrkanides S, Klambani M, Subtelny JD

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 2000 November 37 (6):556-61. Epub 1900 01 01.

Non-steroidal anti-inflammatory drugs in orthodontic tooth movement: Metalloproteinase activity and collagen synthesis by endothelial cells.

Kyrkanides S; O'Banion MK; Subtelny JD.

American Journal of Orthodontics & Dentofacial Orthopedics. 2000; 118: 203-209.

Temporomandibular joint disorders: effects of capsaicin on substance P immunoreactivity in the rabbit brain stem.

Kyrkanides S; Tallents RH; Macher DJ; Olschowka JA; Steven SY.

Journal Orofac Pain. 2000; 16: 225-239.

Condyle position as a predictor of temporomandibular joint internal derangement.

Bonilla-Aragon H, Tallents RH, Katzberg RW, Kyrkanides S, Moss ME

The Journal of prosthetic dentistry.. 1999 August 82 (2):205-8. Epub 1900 01 01.

TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury.

Kyrkanides S, Olschowka JA, Williams JP, Hansen JT, O'Banion MK

Journal of neuroimmunology.. 1999 March 195 (1-2):95-106. Epub 1900 01 01.

The effect of surgically induced anterior disc displacement of the temporomandibular joint on the midface and cranial base.

Qadan S, Macher DJ, Tallents RH, Kyrkanides S, Moss ME.

Clinical Orthodontics & Research. 1999; 2: 124-32.

Growth retardation, distinct oriental-like faces, glaucoma, brachydactyly, ventricular septal defect and speech disorder. An unknown entity.

Dakou-Voutetakis C, Bazopoulou E, Kyrkanides S., Pagalos C, Apostolakis A.

Genetic Counceling. 1999; 10: 245-250.

Mandibular asymmetry in noncleft and unilateral cleft lip and palate individuals.

Laspos CP, Kyrkanides S, Tallents RH, Moss ME, Subtelny JD

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 1997 September 34 (5):410-6. Epub 1900 01 01.

Mandibular and maxillary asymmetry in individuals with unilateral cleft lip and palate.

Laspos CP, Kyrkanides S, Tallents RH, Moss ME, Subtelny JD

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 1997 May 34 (3):232-9. Epub 1900 01 01.

ICAM-1 induction in the mouse CNS following irradiation.

Olschowka JA, Kyrkanides S, Harvey BK, Williams JP, Rubin P; Hansen JT.

Brain Behavior & Immunity. 1997; 11: 273-285.

Unilateral osteochondroma of the mandibular condyle: Imaging findings.

Ribeiro RF, Tallents RH, Kalmar JR, Macher DJ, Katzberg RW, Kyrkanides S.

Int Med Image Reg. 1997; 2: 133-34.

Generalized joint laxity and temporomandibular disorders.

Perrini F, Tallents RH, Katzberg RW, Ribeiro RF, Kyrkanides S, Moss ME

Journal of orofacial pain.. 1997 11 (3):215-21. Epub 1900 01 01.

Effect of a surgically created disk displacement on mandibular symmetry in the growing rabbit.

Hatala MP, Macher DJ, Tallents RH, Spoon M, Subtelny JD, Kyrkanides S

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.. 1996 December 82 (6):625-33. Epub 1900 01 01.

Asymmetries of the upper lip and nose in noncleft and postsurgical unilateral cleft lip and palate individuals.

Kyrkanides S, Bellohusen R, Subtelny JD

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 1996 July 33 (4):306-11. Epub 1900 01 01.

Melnick-Needles syndrome in a mother and her son.

Neou P, Kyrkanides S, Gioureli E, Bartsocas CS

Genetic counseling (Geneva, Switzerland). 1996 7 (2):123-9. Epub 1900 01 01.

Skeletal asymmetries of the nasomaxillary complex in noncleft and postsurgical unilateral cleft lip and palate individuals.

Kyrkanides S, Bellohusen R, Subtelny JD

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association.. 1995 September 32 (5):428-33. Epub 1900 01 01.

Temporomandibular joint disorders ad mandibular development in children and adolescence.

Kyrkanides S; Tallents RH (1995).

Paidodontia. 1995; 9(1): 1-5.

Familial bilateral blepharoptosis and subvalvular aortic stenosis.

Bazopoulou E, Neou P, Bartsocas CS, Kyrkanides S, Fanourakis I.

Genetic Counceling. 1995; 6: 227-232.

Cephalometric analysis of Rapp-Hodgkin syndrome.

Hart TC, Kyrkanides S

Journal of medical genetics.. 1994 October 31 (10):758-60. Epub 1900 01 01.

Hyperbrachycephaly, short face, midface hypoplasia, fusion of cervical vertebrae, radiolucent bone defects and severe destruction of the periodontium - A new syndrome: craniofaciocervial osteoglyphic dysplasia.

Bazopoulou E, Vrotsos I, Kyrkanides S, Tsichlakis K, Tosios K, Mandelakaki-Lambrou K, Kondyli A, Nassi H, Sarri C, Grigoriadou M, Michelakakis H.

Genetic Counceling. 1994; 7: 257-267.

The basilar part of the occipital bone in normal and pathological fetuses.

Kyrkanides S, Kjaer I, Fisher-Hansen B.

Journal Craniofacial Genetics Developmental Biology. 1993; 13: 184-192.

Microdontia, hypodontia, short bulbous roots and root canals with strabismus, short stature, and borderline mentality.

Bazopoulou-Kyrkanidou E, Dacou-Voutetakis C, Nassi H, Tosios K, Kyrkanides S, Damoli M

Oral surgery, oral medicine, and oral pathology.. 1992 July 74 (1):93-5. Epub 1900 01 01.

A proposal of an Orthodontic Treatment Priority Index.

Kyrkanides S; Spyropoulou MN; Papapanagiotou K; Adamides I; Soteriadou A.

Journal of Odontostomatologic Progress. 1992; 46: 305-311.

Books

Dysmorphology and Genetics of Cardiovascular Disorsers (1994)

Chapter: Solitary Maxillary incisor and short stature