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Lianping Xing, B.Med., Ph.D.

Lianping Xing, B.Med., Ph.D.

Contact

Office (585) 273-4090
Fax (585) 756-4468
Administrative (585) 275-5892

About Me

Faculty Appointments

Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Education

PhD | Penn State University. Cell and Molecular Biology. 1994

MS | China-Fourth Military Medical Univ, Xian. Internal Medicine. 1985

MD | China-Fourth Military Medical Univ, Xian. Medicine. 1977

Awards

Travel Award, ASBMR (50 selected from a pool of 2000 abstracts) 2000

Young Investigator Award, ORS (20 selected from a pool of 1000 abstracts) 2000

Most Outstanding Abstract Award, ASBMR (one selected from a pool of 2000 abstracts) 1997

Young Investigator Award, ASBMR (50 selected from a pool of 2000 abstracts) 1996

Research

The major focus of my research is to study the regulation of bone cell function in inflammatory bone loss using combinations of genetically modified animals, in vivo imaging technologies, histology and in vitro cellular and molecular approaches. I have two established research programs which are fun...
The major focus of my research is to study the regulation of bone cell function in inflammatory bone loss using combinations of genetically modified animals, in vivo imaging technologies, histology and in vitro cellular and molecular approaches. I have two established research programs which are funded by NIH to investigate the molecular mechanisms mediating increased osteoclastic bone resorption and reduced osteoblastic bone formation in animal models of rheumatoid arthritis (RA). Patients with RA suffer from joint inflammation and bone erosion as well as systemic osteoporosis. In one program, we are investigating the mechanism by which pro-inflammatory cytokine TNF affects joint tissue injury in RA through the regulation of function of osteoclasts and precursors. In another program, we are investigating the role of ubiquitin-mediated proteasomal degradation in osteoblast function in RA. Currently, we are testing the hypothesis that an inflammatory bone marrow environment increases proteasome-mediated protein degradation in mesenchymal stem cells and inhibits their differentiation to osteoblast precursors, accounting for inflammation-mediated bone loss. The ultimate goal of our research is to provide pre-clinical information that is useful for developing agents that improve bone health in patients with chronic inflammatory disorders.

Patents

Methods and Compositions for Treating Inflammatory Conditions

Issue date: November 12, 2013

Patent #: 8,580,755

Country: United States

Inventors: Brendan Boyce, Edward Michael Schwarz, Lianping Xing

Bortezomib Conjugates and Methods Using Same

Issue date: February 26, 2020

Patent #: 3371203

Country: Europe

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Bortezomib Conjugates and Methods Using Same

Issue date: February 26, 2020

Patent #: FR3371203

Country: France

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Bortezomib Conjugates and Methods Using Same

Issue date: February 26, 2020

Patent #: DE3371203

Country: Germany

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Bortezomib Conjugates and Methods Using Same

Issue date: February 26, 2020

Patent #: GB3371203

Country: United Kingdom

Inventors: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Lianping Xing

Publications

Journal Articles

Reduced expression of semaphorin 3A in osteoclasts causes lymphatic expansion in a Gorham-Stout disease (GSD) mouse model.

Zhang D, Xu H, Qin C, Cai K, Zhang J, Xia X, Bi J, Zhang L, Xing L, Liang Q, Wang W

Journal of Zhejiang University. Science. B.. 2024 January 1525 (1):38-50. Epub 1900 01 01.

Lymphatic platelet thrombosis limits bone repair by precluding lymphatic transporting DAMPs.

Wang YJ, Zheng Y, Cong L, Wang P, Zhao L, Xing L, Liu J, Xu H, Li N, Zhao Y, Shi Q, Liang Q

Research square.. 2023 November 14 Epub 11/14/2023.

Distinct mast cell subpopulations within and around lymphatic vessels regulate lymph flow and progression of inflammatory-erosive arthritis in TNF-transgenic mice.

Peng Y, Kenney HM, de Mesy Bentley KL, Xing L, Ritchlin CT, Schwarz EM

Frontiers in immunology.. 2023 14 :1275871. Epub 12/14/2023.

Aged Callus Skeletal Stem/Progenitor Cells Contain an Inflammatory Osteogenic Population With Increased IRF and NF-?B Pathways and Reduced Osteogenic Potential.

Lin X, Zhang H, Liu J, Wu CL, McDavid A, Boyce BF, Xing L

Frontiers in molecular biosciences.. 2022 9 :806528. Epub 06/09/2022.

Bisphosphonates for delivering drugs to bone.

Sun S, Tao J, Sedghizadeh PP, Cherian P, Junka AF, Sodagar E, Xing L, Boeckman RK, Srinivasan V, Yao Z, Boyce BF, Lipe B, Neighbors JD, Russell G, McKenna CE, Ebetino FH

British journal of pharmacology.. 2021 May 178 (9):2008-2025. Epub 04/10/2021.

Targeting anti-cancer agents to bone using bisphosphonates.

Xing L, Ebetino FH, Boeckman RK, Srinivasan V, Tao J, Sawyer TK, Li J, Yao Z, Boyce BF

Bone.. 2020 September 138 :115492. Epub 06/23/2020.

Ubiquitination of interleukin-1? is associated with increased pro-inflammatory polarization of murine macrophages deficient in the E3 ligase ITCH.

Lin X, Zhang H, Boyce BF, Xing L

The Journal of biological chemistry.. 2020 August 14295 (33):11764-11775. Epub 06/25/2020.

TNF Receptor-Associated Factor 6 Mediates TNF?-Induced Skeletal Muscle Atrophy in Mice During Aging.

Li J, Yi X, Yao Z, Chakkalakal JV, Xing L, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 August 35 (8):1535-1548. Epub 04/27/2020.

Effect of VEGFC on lymph flow and inflammation-induced alveolar bone loss.

Wang H, Chen Y, Li W, Sun L, Chen H, Yang Q, Zhang H, Zhang W, Yuan H, Zhang H, Xing L, Sun W

The Journal of pathology.. 2020 July 251 (3):323-335. Epub 06/10/2020.

RGS12 Is a Novel Critical NF-?B Activator in Inflammatory Arthritis.

Yuan G, Yang S, Ng A, Fu C, Oursler MJ, Xing L, Yang S

iScience.. 2020 June 2623 (6):101172. Epub 05/19/2020.

Meningeal lymphatics clear erythrocytes that arise from subarachnoid hemorrhage.

Chen J, Wang L, Xu H, Xing L, Zhuang Z, Zheng Y, Li X, Wang C, Chen S, Guo Z, Liang Q, Wang Y

Nature communications.. 2020 June 2211 (1):3159. Epub 06/22/2020.

Targeting Bortezomib to Bone Increases Its Bone Anabolic Activity and Reduces Systemic Adverse Effects in Mice.

Wang H, Zhang H, Srinivasan V, Tao J, Sun W, Lin X, Wu T, Boyce BF, Ebetino FH, Boeckman RK, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 February 35 (2):343-356. Epub 11/19/2019.

Avian Reticuloendotheliosis Viral Oncogene Related B Regulates Lymphatic Endothelial Cells during Vessel Maturation and Is Required for Lymphatic Vessel Function in Adult Mice.

Liang Q, Zhang L, Wood RW, Ji RC, Boyce BF, Schwarz EM, Wang Y, Xing L

The American journal of pathology.. 2019 December 189 (12):2516-2530. Epub 09/17/2019.

iNOS dependent and independent phases of lymph node expansion in mice with TNF-induced inflammatory-erosive arthritis.

Bell RD, Slattery PN, Wu EK, Xing L, Ritchlin CT, Schwarz EM

Arthritis research & therapy.. 2019 November 1421 (1):240. Epub 11/14/2019.

TGF?-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.

Li J, Ayoub A, Xiu Y, Yin X, Sanders JO, Mesfin A, Xing L, Yao Z, Boyce BF

Nature communications.. 2019 June 2610 (1):2795. Epub 06/26/2019.

Attenuated Joint Tissue Damage Associated With Improved Synovial Lymphatic Function Following Treatment With Bortezomib in a Mouse Model of Experimental Posttraumatic Osteoarthritis.

Wang W, Lin X, Xu H, Sun W, Bouta EM, Zuscik MJ, Chen D, Schwarz EM, Xing L

Arthritis & rheumatology.. 2019 February 71 (2):244-257. Epub 01/05/2019.

B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.

Sun W, Meednu N, Rosenberg A, Rangel-Moreno J, Wang V, Glanzman J, Owen T, Zhou X, Zhang H, Boyce BF, Anolik JH, Xing L

Nature communications.. 2018 December 39 (1):5127. Epub 12/03/2018.

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.

Ye H, Adane B, Khan N, Alexeev E, Nusbacher N, Minhajuddin M, Stevens BM, Winters AC, Lin X, Ashton JM, Purev E, Xing L, Pollyea DA, Lozupone CA, Serkova NJ, Colgan SP, Jordan CT

Cancer cell.. 2018 October 834 (4):659-673.e6. Epub 09/27/2018.

Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice.

Wang H, Xiao L, Tao J, Srinivasan V, Boyce BF, Ebetino FH, Oyajobi BO, Boeckman RK, Xing L

Pharmaceutics.. 2018 September 1010 (3)Epub 09/10/2018.

Thy1 is a positive regulator of osteoblast differentiation and modulates bone homeostasis in obese mice.

Paine A, Woeller CF, Zhang H, de la Luz Garcia-Hernandez M, Huertas N, Xing L, Phipps RP, Ritchlin CT

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2018 June 32 (6):3174-3183. Epub 01/17/2018.

Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis.

Bouta EM, Bell RD, Rahimi H, Xing L, Wood RW, Bingham CO, Ritchlin CT, Schwarz EM

Nature reviews. Rheumatology.. 2018 February 14 (2):94-106. Epub 01/11/2018.

Fabrication of a triptolide-loaded and poly-?-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis.

Zhang L, Chang J, Zhao Y, Xu H, Wang T, Li Q, Xing L, Huang J, Wang Y, Liang Q

International journal of nanomedicine.. 2018 13 :2051-2064. Epub 04/04/2018.

Bone Remodeling and the Role of TRAF3 in Osteoclastic Bone Resorption.

Boyce BF, Li J, Xing L, Yao Z

Frontiers in immunology.. 2018 9 :2263. Epub 09/28/2018.

Association of Increased F4/80 Macrophages With Suppression of Serum-Transfer Arthritis in Mice With Reduced FLIP in Myeloid Cells.

Huang QQ, Birket R, Doyle RE, Haines GK, Perlman H, Shi B, Homan P, Xing L, Pope RM

Arthritis & rheumatology.. 2017 September 69 (9):1762-1771. Epub 08/01/2017.

Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis.

Sun W, Zhang H, Wang H, Chiu YG, Ritchlin CT, Kiernan A, Boyce BF, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 July 32 (7):1469-1480. Epub 04/10/2017.

Brief Report: Treatment of Tumor Necrosis Factor-Transgenic Mice With Anti-Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress.

Bouta EM, Kuzin I, de Mesy Bentley K, Wood RW, Rahimi H, Ji RC, Ritchlin CT, Bottaro A, Xing L, Schwarz EM

Arthritis & rheumatology.. 2017 June 69 (6):1187-1193. Epub 04/04/2017.

The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool.

Lawal RA, Zhou X, Batey K, Hoffman CM, Georger MA, Radtke F, Hilton MJ, Xing L, Frisch BJ, Calvi LM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 June 32 (6):1320-1331. Epub 03/09/2017.

Clinical Significance of Lipid-Rich Plaque Detected by Optical Coherence Tomography: A 4-Year Follow-Up Study.

Xing L, Higuma T, Wang Z, Aguirre AD, Mizuno K, Takano M, Dauerman HL, Park SJ, Jang Y, Kim CJ, Kim SJ, Choi SY, Itoh T, Uemura S, Lowe H, Walters DL, Barlis P, Lee S, Lerman A, Toma C, Tan JWC, Yamamoto E, Bryniarski K, Dai J, Zanchin T, Zhang S, Yu B, Lee H, Fujimoto J, Fuster V, Jang IK

Journal of the American College of Cardiology.. 2017 May 2369 (20):2502-2513. Epub 1900 01 01.

Lymphatic Endothelial Cells Produce M-CSF, Causing Massive Bone Loss in Mice.

Wang W, Wang H, Zhou X, Li X, Sun W, Dellinger M, Boyce BF, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 May 32 (5):939-950. Epub 01/31/2017.

Ubiquitin E3 ligase Itch negatively regulates osteoblast function by promoting proteasome degradation of osteogenic proteins.

Liu J, Li X, Zhang H, Gu R, Wang Z, Gao Z, Xing L

Bone & joint research.. 2017 March 6 (3):154-161. Epub 1900 01 01.

Clomipramine causes osteoporosis by promoting osteoclastogenesis via E3 ligase Itch, which is prevented by Zoledronic acid.

Li X, Sun W, Li J, Wang M, Zhang H, Pei L, Boyce BF, Wang Z, Xing L

Scientific reports.. 2017 February 17 :41358. Epub 02/01/2017.

Utilization of longitudinal ultrasound to quantify joint soft-tissue changes in a mouse model of posttraumatic osteoarthritis.

Xu H, Bouta EM, Wood RW, Schwarz EM, Wang Y, Xing L

Bone research.. 2017 5 :17012. Epub 06/13/2017.

Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.

Li J, Chen Y, Zhang L, Xing L, Xu H, Wang Y, Shi Q, Liang Q

Journal of ethnopharmacology.. 2016 December 4193 :293-302. Epub 08/21/2016.

Deletion of calponin 2 in macrophages attenuates the severity of inflammatory arthritis in mice.

Huang QQ, Hossain MM, Sun W, Xing L, Pope RM, Jin JP

American journal of physiology. Cell physiology.. 2016 October 1311 (4):C673-C685. Epub 08/03/2016.

Lymphatic imaging to assess rheumatoid flare: mechanistic insights and biomarker potential.

Rahimi H, Bell R, Bouta EM, Wood RW, Xing L, Ritchlin CT, Schwarz EM

Arthritis research & therapy.. 2016 September 118 :194. Epub 09/01/2016.

Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.

Zhang H, Sun W, Li X, Wang M, Boyce BF, Hilton MJ, Xing L

Bone.. 2016 September 90 :80-9. Epub 06/04/2016.

Production of RANKL by Memory B Cells: A Link Between B Cells and Bone Erosion in Rheumatoid Arthritis.

Meednu N, Zhang H, Owen T, Sun W, Wang V, Cistrone C, Rangel-Moreno J, Xing L, Med B, Anolik JH

Arthritis & rheumatology.. 2016 April 68 (4):805-16. Epub 1900 01 01.

Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice.

Liang Q, Ju Y, Chen Y, Wang W, Li J, Zhang L, Xu H, Wood RW, Schwarz EM, Boyce BF, Wang Y, Xing L

Arthritis research & therapy.. 2016 March 1218 :62. Epub 03/12/2016.

Du-Huo-Ji-Sheng-Tang Attenuates Inflammation of TNF-Tg Mice Related to Promoting Lymphatic Drainage Function.

Chen Y, Li J, Li Q, Wang T, Xing L, Xu H, Wang Y, Shi Q, Zhou Q, Liang Q

Evidence-based complementary and alternative medicine : eCAM.. 2016 2016 :7067691. Epub 04/27/2016.

Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis.

Liang QQ, Shi Q, Wood RW, Xing LP, Wang YJ

Chinese journal of integrative medicine.. 2015 September 21 (9):648-55. Epub 10/03/2015.

High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment.

Shu L, Beier E, Sheu T, Zhang H, Zuscik MJ, Puzas EJ, Boyce BF, Mooney RA, Xing L

Calcified tissue international.. 2015 April 96 (4):313-23. Epub 02/13/2015.

NF-?B-Mediated Regulation of Osteoclastogenesis.

Boyce BF, Xiu Y, Li J, Xing L, Yao Z

Endocrinology and metabolism.. 2015 March 2730 (1):35-44. Epub 1900 01 01.

The role of the lymphatic system in inflammatory-erosive arthritis.

Bouta EM, Li J, Ju Y, Brown EB, Ritchlin CT, Xing L, Schwarz EM

Seminars in cell & developmental biology.. 2015 February 38 :90-7. Epub 01/15/2015.

Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2.

Wang Z, Wang J, Li X, Xing L, Ding Y, Shi P, Zhang Y, Guo S, Shu X, Shan B

International journal of oncology.. 2014 October 45 (4):1469-78. Epub 07/17/2014.

Effect of neoadjuvant chemotherapy combined with hyperthermic intraperitoneal perfusion chemotherapy on advanced gastric cancer.

Cui HB, Ge HE, Bai XY, Zhang W, Zhang YY, Wang J, Li X, Xing LP, Guo SH, Wang ZY

Experimental and therapeutic medicine.. 2014 May 7 (5):1083-1088. Epub 03/04/2014.

NF-?B RelB negatively regulates osteoblast differentiation and bone formation.

Yao Z, Li Y, Yin X, Dong Y, Xing L, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2014 April 29 (4):866-77. Epub 1900 01 01.

Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.

Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS

Bone.. 2014 March 60 :148-61. Epub 12/04/2013.

Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.

Shi J, Liang Q, Zuscik M, Shen J, Chen D, Xu H, Wang YJ, Chen Y, Wood RW, Li J, Boyce BF, Xing L

Arthritis & rheumatology.. 2014 March 66 (3):657-66. Epub 1900 01 01.

Chondrocyte ?-catenin signaling regulates postnatal bone remodeling through modulation of osteoclast formation in a murine model.

Wang B, Jin H, Zhu M, Li J, Zhao L, Zhang Y, Tang D, Xiao G, Xing L, Boyce BF, Chen D

Arthritis & rheumatology.. 2014 January 66 (1):107-20. Epub 1900 01 01.

RANKL-based osteoclastogenic assays from murine bone marrow cells.

Xing L, Boyce BF

Methods in molecular biology.. 2014 1130 :307-313. Epub 1900 01 01.

Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus.

Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ

PloS one.. 2014 9 (6):e99656. Epub 06/09/2014.

Mice Deficient in NF-?B p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism.

Xing L, Chen D, Boyce BF

Bone research.. 2013 December 1 (4):336-45. Epub 12/31/2013.

Alteration of lymphatic vessel and function in osteoarthritic joints.

Shi J, Liang Q, Zuscik M, Shen J, Chen D, Xu H, Wang Y, Chen Y, Wood RW, Li J, Boyce BF, Xing L

Arthritis and rheumatism.. 2013 November 18 Epub 11/18/2013.

Immature mice are more susceptible to the detrimental effects of high fat diet on cancellous bone in the distal femur.

Inzana JA, Kung M, Shu L, Hamada D, Xing LP, Zuscik MJ, Awad HA, Mooney RA

Bone.. 2013 November 57 (1):174-83. Epub 08/14/2013.

Ubiquitin E3 ligase Wwp1 negatively regulates osteoblast function by inhibiting osteoblast differentiation and migration.

Shu L, Zhang H, Boyce B, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2013 September 28 (9):1925-35. Epub 1900 01 01.

Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice.

Ju Y, Li J, Xie C, Ritchlin CT, Xing L, Hilton MJ, Schwarz EM

Genesis : the journal of genetics and development.. 2013 September 51 (9):667-75. Epub 07/09/2013.

Ubiquitin E3 ligase Itch negatively regulates osteoclast formation by promoting deubiquitination of tumor necrosis factor (TNF) receptor-associated factor 6.

Zhang H, Wu C, Matesic LE, Li X, Wang Z, Boyce BF, Xing L

The Journal of biological chemistry.. 2013 August 2288 (31):22359-68. Epub 06/19/2013.

Ubiquitin e3 ligase itch negatively regulates osteoblast differentiation from mesenchymal progenitor cells.

Zhang H, Xing L

Stem cells.. 2013 August 31 (8):1574-83. Epub 1900 01 01.

Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow.

Li J, Ju Y, Bouta EM, Xing L, Wood RW, Kuzin I, Bottaro A, Ritchlin CT, Schwarz EM

Arthritis and rheumatism.. 2013 January 65 (1):130-8. Epub 1900 01 01.

Power Doppler ultrasound phenotyping of expanding versus collapsed popliteal lymph nodes in murine inflammatory arthritis.

Bouta EM, Ju Y, Rahimi H, de Mesy-Bentley KL, Wood RW, Xing L, Schwarz EM

PloS one.. 2013 8 (9):e73766. Epub 09/09/2013.

Mice Deficient in NF-?B p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism.

Xing L, Chen D, Boyce BF

Bone research.. 2013 4 :336-345. Epub 1900 01 01.

Osteoclast fusion and regulation by RANKL-dependent and independent factors.

Xing L, Xiu Y, Boyce BF

World journal of orthopedics.. 2012 December 183 (12):212-22. Epub 1900 01 01.

Mechanisms of bone fragility in a mouse model of glucocorticoid-treated rheumatoid arthritis: implications for insufficiency fracture risk.

Takahata M, Maher JR, Juneja SC, Inzana J, Xing L, Schwarz EM, Berger AJ, Awad HA

Arthritis and rheumatism.. 2012 November 64 (11):3649-59. Epub 1900 01 01.

Validation of 3-dimensional ultrasound versus magnetic resonance imaging quantification of popliteal lymph node volume as a biomarker of erosive inflammatory arthritis in mice.

Ju Y, Rahimi H, Li J, Wood RW, Xing L, Schwarz EM

Arthritis and rheumatism.. 2012 June 64 (6):2048-50. Epub 02/21/2012.

The ubiquitin E3 ligase WWP1 decreases CXCL12-mediated MDA231 breast cancer cell migration and bone metastasis.

Subik K, Shu L, Wu C, Liang Q, Hicks D, Boyce B, Schiffhauer L, Chen D, Chen C, Tang P, Xing L

Bone.. 2012 April 50 (4):813-23. Epub 01/11/2012.

Noncanonical NF-?B signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions.

Zhao C, Xiu Y, Ashton J, Xing L, Morita Y, Jordan CT, Boyce BF

Stem cells.. 2012 April 30 (4):709-18. Epub 1900 01 01.

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia.

Frisch BJ, Ashton JM, Xing L, Becker MW, Jordan CT, Calvi LM

Blood.. 2012 January 12119 (2):540-50. Epub 09/28/2011.

Src inhibitors in the treatment of metastatic bone disease: rationale and clinical data.

Boyce B, Xing L

Clinical investigation.. 2011 December 11 (12):1695-1706. Epub 1900 01 01.

Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes.

Bouta EM, Wood RW, Perry SW, Brown EB, Ritchlin CT, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2011 December 1240 :47-52. Epub 1900 01 01.

Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1.

Zhao L, Huang J, Zhang H, Wang Y, Matesic LE, Takahata M, Awad H, Chen D, Xing L

Stem cells.. 2011 October 29 (10):1601-10. Epub 1900 01 01.

CD23(+)/CD21(hi) B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice.

Li J, Zhou Q, Wood R, Kuzin I, Bottaro A, Ritchlin C, Xing L, Schwarz E

Arthritis research & therapy.. 2011 August 3113 (4):R138. Epub 08/31/2011.

Vascular endothelial growth factor C attenuates joint damage in chronic inflammatory arthritis by accelerating local lymphatic drainage in mice.

Zhou Q, Guo R, Wood R, Boyce BF, Liang Q, Wang YJ, Schwarz EM, Xing L

Arthritis and rheumatism.. 2011 August 63 (8):2318-28. Epub 1900 01 01.

Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy.

Li J, Kuzin I, Moshkani S, Proulx ST, Xing L, Skrombolas D, Dunn R, Sanz I, Schwarz EM, Bottaro A

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 June 1184 (11):6142-50. Epub 04/30/2010.

Smurf control in bone cells.

Xing L, Zhang M, Chen D

Journal of cellular biochemistry.. 2010 June 1110 (3):554-63. Epub 1900 01 01.

Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation.

Zhao L, Huang J, Guo R, Wang Y, Chen D, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2010 June 25 (6):1246-56. Epub 1900 01 01.

The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines.

Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG, Tang P

Breast cancer : basic and clinical research.. 2010 May 204 :35-41. Epub 05/20/2010.

Mediation of nonerosive arthritis in a mouse model of lupus by interferon-alpha-stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis.

Mensah KA, Mathian A, Ma L, Xing L, Ritchlin CT, Schwarz EM

Arthritis and rheumatism.. 2010 April 62 (4):1127-37. Epub 1900 01 01.

Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw.

Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Søballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2010 March 1192 (1):84-94. Epub 1900 01 01.

Functions of nuclear factor kappaB in bone.

Boyce BF, Yao Z, Xing L

Annals of the New York Academy of Sciences.. 2010 March 1192 :367-75. Epub 1900 01 01.

MicroRNA-204 regulates Runx2 protein expression and mesenchymal progenitor cell differentiation.

Huang J, Zhao L, Xing L, Chen D

Stem cells.. 2010 February 28 (2):357-64. Epub 1900 01 01.

The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis.

Schwarz EM, Proulx ST, Ritchlin CT, Boyce BF, Xing L

Advances in experimental medicine and biology.. 2010 658 :1-10. Epub 1900 01 01.

BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts.

Zhang M, Yan Y, Lim YB, Tang D, Xie R, Chen A, Tai P, Harris SE, Xing L, Qin YX, Chen D

Journal of cellular biochemistry.. 2009 November 1108 (4):896-905. Epub 1900 01 01.

Regulation of osteoclast precursors in inflammatory bone loss.

Xing L

Current opinion in investigational drugs.. 2009 November 10 (11):1195-203. Epub 1900 01 01.

NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism.

Yao Z, Xing L, Boyce BF

The Journal of clinical investigation.. 2009 October 119 (10):3024-34. Epub 09/21/2009.

Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis.

Guo R, Zhou Q, Proulx ST, Wood R, Ji RC, Ritchlin CT, Pytowski B, Zhu Z, Wang YJ, Schwarz EM, Xing L

Arthritis and rheumatism.. 2009 September 60 (9):2666-76. Epub 1900 01 01.

Post-translational Regulation of Runx2 in Bone and Cartilage.

Jonason JH, Xiao G, Zhang M, Xing L, Chen D

Journal of dental research.. 2009 August 88 (8):693-703. Epub 1900 01 01.

Osteoclasts have multiple roles in bone in addition to bone resorption.

Boyce BF, Yao Z, Xing L

Critical reviews in eukaryotic gene expression.. 2009 19 (3):171-80. Epub 1900 01 01.

Lymphangiogenesis, myeloid cells and inflammation.

Xing L, Ji RC

Expert review of clinical immunology.. 2008 September 4 (5):599-613. Epub 1900 01 01.

Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.

Guo R, Yamashita M, Zhang Q, Zhou Q, Chen D, Reynolds DG, Awad HA, Yanoso L, Zhao L, Schwarz EM, Zhang YE, Boyce BF, Xing L

The Journal of biological chemistry.. 2008 August 22283 (34):23084-92. Epub 06/19/2008.

Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Calvi LM, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2008 July 58 (7):2019-29. Epub 1900 01 01.

Functions of RANKL/RANK/OPG in bone modeling and remodeling.

Boyce BF, Xing L

Archives of biochemistry and biophysics.. 2008 May 15473 (2):139-46. Epub 03/25/2008.

VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.

Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L

The Journal of biological chemistry.. 2008 May 9283 (19):13491-9. Epub 03/20/2008.

Osteoclast precursor interaction with bone matrix induces osteoclast formation directly by an interleukin-1-mediated autocrine mechanism.

Yao Z, Xing L, Qin C, Schwarz EM, Boyce BF

The Journal of biological chemistry.. 2008 April 11283 (15):9917-24. Epub 02/04/2008.

Bruton and Tec: new links in osteoimmunology.

Boyce BF, Xing L

Cell metabolism.. 2008 April 7 (4):283-5. Epub 1900 01 01.

Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2.

Usui M, Xing L, Drissi H, Zuscik M, O'Keefe R, Chen D, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2008 March 23 (3):314-25. Epub 1900 01 01.

TNF inhibits production of stromal cell-derived factor 1 by bone stromal cells and increases osteoclast precursor mobilization from bone marrow to peripheral blood.

Zhang Q, Guo R, Schwarz EM, Boyce BF, Xing L

Arthritis research & therapy.. 2008 10 (2):R37. Epub 03/27/2008.

Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography.

Proulx ST, Kwok E, You Z, Papuga MO, Beck CA, Shealy DJ, Ritchlin CT, Awad HA, Boyce BF, Xing L, Schwarz EM

Arthritis and rheumatism.. 2007 December 56 (12):4024-37. Epub 1900 01 01.

MRI and quantification of draining lymph node function in inflammatory arthritis.

Proulx ST, Kwok E, You Z, Beck CA, Shealy DJ, Ritchlin CT, Boyce BF, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2007 November 1117 :106-23. Epub 07/23/2007.

New roles for osteoclasts in bone.

Boyce BF, Yao Z, Zhang Q, Guo R, Lu Y, Schwarz EM, Xing L

Annals of the New York Academy of Sciences.. 2007 November 1116 :245-54. Epub 1900 01 01.

The RANKL/RANK/OPG pathway.

Boyce BF, Xing L

Current osteoporosis reports.. 2007 September 5 (3):98-104. Epub 1900 01 01.

NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1.

Yamashita T, Yao Z, Li F, Zhang Q, Badell IR, Schwarz EM, Takeshita S, Wagner EF, Noda M, Matsuo K, Xing L, Boyce BF

The Journal of biological chemistry.. 2007 June 22282 (25):18245-18253. Epub 05/07/2007.

MRI and Quantification of Draining Lymph Node Function in Inflammatory Arthritis.

Ann N Y Acad Sci. 2007; [Epub ahead of print].

Biology of RANK, RANKL, and osteoprotegerin.

Boyce, B.F.; Xing, L.

Arthritis Res Ther. 2007; 9(Suppl 1): S1.

Biology of RANK, RANKL, and osteoprotegerin.

Boyce BF, Xing L

Arthritis research & therapy.. 2007 9 Suppl 1 (Suppl 1):S1. Epub 1900 01 01.

Increased lymphangiogenesis in joints of mice with inflammatory arthritis.

Zhang Q, Lu Y, Proulx ST, Guo R, Yao Z, Schwarz EM, Boyce BF, Xing L

Arthritis research & therapy.. 2007 9 (6):R118. Epub 1900 01 01.

Osteoclasts, no longer osteoblast slaves.

Boyce BF, Xing L

Nature medicine.. 2006 December 12 (12):1356-8. Epub 1900 01 01.

SRC inhibitors in metastatic bone disease.

Boyce BF, Xing L, Yao Z, Yamashita T, Shakespeare WC, Wang Y, Metcalf CA, Sundaramoorthi R, Dalgarno DC, Iuliucci JD, Sawyer TK

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2006 October 1512 (20 Pt 2):6291s-6295s. Epub 1900 01 01.

Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease.

Boyce BF, Schwarz EM, Xing L

Current opinion in rheumatology.. 2006 July 18 (4):427-32. Epub 1900 01 01.

Tumor necrosis factor-alpha increases circulating osteoclast precursor numbers by promoting their proliferation and differentiation in the bone marrow through up-regulation of c-Fms expression.

Yao Z, Li P, Zhang Q, Schwarz EM, Keng P, Arbini A, Boyce BF, Xing L

The Journal of biological chemistry.. 2006 April 28281 (17):11846-55. Epub 02/06/2006.

Autoimmunity and bone.

Schwarz EM, Looney RJ, Drissi MH, O'Keefe RJ, Boyce BF, Xing L, Ritchlin CT

Annals of the New York Academy of Sciences.. 2006 April 1068 :275-83. Epub 1900 01 01.

Future anti-catabolic therapeutic targets in bone disease.

Boyce BF, Xing L, Yao Z, Shakespeare WC, Wang Y, Metcalf CA, Sundaramoorthi R, Dalgarno DC, Iuliucci JD, Sawyer TK

Annals of the New York Academy of Sciences.. 2006 April 1068 :447-57. Epub 1900 01 01.

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

Kaneki H, Guo R, Chen D, Yao Z, Schwarz EM, Zhang YE, Boyce BF, Xing L

The Journal of biological chemistry.. 2006 February 17281 (7):4326-33. Epub 12/22/2005.

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation.

Shen R, Chen M, Wang YJ, Kaneki H, Xing L, O'keefe RJ, Chen D

The Journal of biological chemistry.. 2006 February 10281 (6):3569-76. Epub 11/18/2005.

Osteoclast precursors, RANKL/RANK, and immunology.

Xing L, Schwarz EM, Boyce BF

Immunological reviews.. 2005 December 208 :19-29. Epub 1900 01 01.

Osteoprotegerin, the bone protector, is a surprising target for beta-catenin signaling.

Boyce BF, Xing L, Chen D

Cell metabolism.. 2005 December 2 (6):344-5. Epub 1900 01 01.

Tumor necrosis factor prevents alendronate-induced osteoclast apoptosis in vivo by stimulating Bcl-xL expression through Ets-2.

Zhang Q, Badell IR, Schwarz EM, Boulukos KE, Yao Z, Boyce BF, Xing L

Arthritis and rheumatism.. 2005 September 52 (9):2708-18. Epub 1900 01 01.

TNF-alpha and pathologic bone resorption.

Boyce BF, Li P, Yao Z, Zhang Q, Badell IR, Schwarz EM, O'Keefe RJ, Xing L

The Keio journal of medicine.. 2005 September 54 (3):127-31. Epub 1900 01 01.

Regulation of apoptosis in osteoclasts and osteoblastic cells.

Xing L, Boyce BF

Biochemical and biophysical research communications.. 2005 March 18328 (3):709-20. Epub 1900 01 01.

Receptor activator of nuclear kB ligand and osteoprotegerin: where are we now and what about future treatment uses?

Schwarz, E.M.; O'Keefe, R.J.; Xing, L.; Looney, J.; and Ritchlin, C.T.

Curr Opin Orthop. 2005; 16: 370-375.

Regulation of apoptosis in osteoclasts and osteoblastic cells.

Xing, L.; and Boyce, B.F.

Biochem Biophys Res Commun 709-20. 2005; 328(3): 709-20.

Circulating osteoclast precursors: A mechanism and a marker of erosive arthritis.

Xing, L.; and Schwarz, E.M.

Curr Rheu Rev. 2005; 1: 21-28.

Roles for NF-?B and c-Fos in osteoclasts.

Boyce, B.F.; Yamashita, T.; Yao, Z.; Zhang, Q.; Li, F.; and Xing, L.

J Bone Miner Metab 11-5. 2005; 23 Suppl: 11-25.

Roles for NF-kappaB and c-Fos in osteoclasts.

Boyce BF, Yamashita T, Yao Z, Zhang Q, Li F, Xing L

Journal of bone and mineral metabolism.. 2005 23 Suppl :11-5. Epub 1900 01 01.

Malignant autosomal recessive osteopetrosis caused by spontaneous mutation of murine Rank.

Kapur RP, Yao Z, Iida MH, Clarke CM, Doggett B, Xing L, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 October 19 (10):1689-97. Epub 07/21/2004.

RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Boyce BF, Xing L

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2004 February 19 (2):207-13. Epub 1900 01 01.

Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice.

Li P, Schwarz EM, O'Keefe RJ, Ma L, Looney RJ, Ritchlin CT, Boyce BF, Xing L

Arthritis and rheumatism.. 2004 January 50 (1):265-76. Epub 1900 01 01.

Systemic TNFa mediates an increase in peripheral CD11bhi osteoclast precursors in TNFa transgenic mice.

Li, P.; Schwarz, E.M.; O'Keefe, R.J.; Ma, L.; Looney, J.; Ritchlin, C.T.; Boyce, B.F.; and Xing, L.

Arthritis & Rheum. 2004; 50: 256-76.

NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro.

Feng JQ, Xing L, Zhang JH, Zhao M, Horn D, Chan J, Boyce BF, Harris SE, Mundy GR, Chen D

The Journal of biological chemistry.. 2003 August 1278 (31):29130-5. Epub 05/20/2003.

Regulation of bone remodeling and emerging breakthrough drugs for osteoporosis and osteolytic bone metastases.

Boyce BF, Xing L, Shakespeare W, Wang Y, Dalgarno D, Iuliucci J, Sawyer T

Kidney international. Supplement.. 2003 June (85):S2-5. Epub 1900 01 01.

Expression of either NF-kappaB p50 or p52 in osteoclast precursors is required for IL-1-induced bone resorption.

Xing L, Carlson L, Story B, Tai Z, Keng P, Siebenlist U, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 February 18 (2):260-9. Epub 1900 01 01.

Regulation of bone remodeling and emerging breakthrough drugs for osteoporosis and osteolytic bone metastases.

Boyce, B.F.; Xing, L.; Shakespeare, W.; Wang, Y.; Dalgarno, D.; Iuliucci, J.; and Sawyer, T.

Kidney Int. 2003; Suppl 85: S2-5.

Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues.

Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C, Hung MC

Proceedings of the National Academy of Sciences of the United States of America.. 2002 October 1599 (21):13498-503. Epub 10/07/2002.

NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis.

Xing L, Bushnell TP, Carlson L, Tai Z, Tondravi M, Siebenlist U, Young F, Boyce BF

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 July 17 (7):1200-10. Epub 1900 01 01.

In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis.

Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 February 17 (2):192-9. Epub 1900 01 01.

Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis.

Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 April 16 (4):660-70. Epub 1900 01 01.

Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.

Xing L, Venegas AM, Chen A, Garrett-Beal L, Boyce BF, Varmus HE, Schwartzberg PL

Genes & development.. 2001 January 1515 (2):241-53. Epub 1900 01 01.

Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival.

Xing, L.; Venegas, A.M.; Chen, A.; Garrett-Beal, L.; Boyce, B.F.; Varmus, H.E.; Schwartzberg, P.L.

Genes Dev. 2001; 15: 5241-5321.

The C terminal subnuclear targeting signal and regulatory functions of the Runx2/Cbfa1/AML3 transcription factor are required for skeletal development.

Choi, J.Y.; Pratap, J.; Javed, A.; Zaidi, S.K.; Balint, E.; Xing, L.; Boyce, B.; Wilnen, A.; Lian, J.B.; Stain, J.L.; Jones, S.N.; Stain, G.S.

PANS. 2001; 98: 8650-55.

Required and nonessential functions of nuclear factor-kappa B in bone cells.

Boyce BF, Xing L, Franzoso G, Siebenlist U

Bone.. 1999 July 25 (1):137-9. Epub 1900 01 01.

Recent advances in bone biology provide insight into the pathogenesis of bone diseases.

Boyce BF, Hughes DE, Wright KR, Xing L, Dai A

Laboratory investigation; a journal of technical methods and pathology.. 1999 February 79 (2):83-94. Epub 1900 01 01.

Dental abnormalities associated with failure of tooth eruption in src knockout and op/op mice.

Tiffee, J.; Xing, L.; Nilsson, S.; Boyce, B.F.

Cal Tissue Int. 1999; 65: 53-8.

Mesolimbic expression of neurotensin and neurotensin receptor during stress-induced gastric mucosal injury.

Xing L, Karinch AM, Kauffman GL

The American journal of physiology.. 1998 January 274 (1):R38-45. Epub 1900 01 01.

Requirement for NF-kappaB in osteoclast and B-cell development.

Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U

Genes & development.. 1997 December 1511 (24):3482-96. Epub 1900 01 01.

Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice.

Schwartzberg PL, Xing L, Hoffmann O, Lowell CA, Garrett L, Boyce BF, Varmus HE

Genes & development.. 1997 November 111 (21):2835-44. Epub 1900 01 01.

cAMP response element-binding protein (CREB) interacts with transcription factors IIB and IID.

Xing L, Gopal VK, Quinn PG

The Journal of biological chemistry.. 1995 July 21270 (29):17488-93. Epub 1900 01 01.

Three distinct regions within the constitutive activation domain of cAMP regulatory element-binding protein (CREB) are required for transcription activation.

Xing L, Quinn PG

The Journal of biological chemistry.. 1994 November 18269 (46):28732-6. Epub 1900 01 01.

Involvement of 3',5'-cyclic adenosine monophosphate regulatory element binding protein (CREB) in both basal and hormone-mediated expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene.

Xing L, Quinn PG

Molecular endocrinology.. 1993 November 7 (11):1484-94. Epub 1900 01 01.

Mesolimbic dopamine mediates gastric mucosal protection by central neurotensin.

Xing LP, Balaban C, Seaton J, Washington J, Kauffman G

The American journal of physiology.. 1991 January 260 (1 Pt 1):G34-8. Epub 1900 01 01.

Mesolimbic oxidase B inhibition reduces gastric mucosal blood flow, basal acid secretion, and cold water restraint-induced gastric mucosal injury in rats.

Xing, L.; Washington, J.; Seaton, J.; Kauffman, G.

Digestive Diseases & Sciences. 1991; 35: 61-65.

Effect of neurotensin on regional cerebral glucose utilization in cold water-restrained rats.

Xing LP, King JC, Bryan RM, Kauffman GL

The American journal of physiology.. 1990 April 258 (4 Pt 1):G591-5. Epub 1900 01 01.

Central neurotensin protects the mucosa by a prostaglandin-mediated mechanism and inhibits gastric acid secretion in the rat.

Kauffman GL, Zhang L, Xing LP, Seaton J, Colony P, Demers L

Annals of the New York Academy of Sciences.. 1990 597 :175-90. Epub 1900 01 01.

Central neurotensin inhibits gastric acid secretion: an adrenergic mechanism in rats.

Zhang L, Xing LP, Demers L, Washington J, Kauffman GL

Gastroenterology.. 1989 November 97 (5):1130-4. Epub 1900 01 01.

Effect of furazolidone on gut catecholamine levels in cysteamine-induced duodenal ulcer in rats.

Zheng, Z.; Xing, L.

Scand J Gastroenterology. 1988; 23: 1020-1024.

Books

Yearbook of Science and Technology (2001)

Chapter: Bone

Authors: Boyce BF and Xing L.

Publisher: McGraw-Hill, New York 2001

Principles of Bone Biology (2001)

Chapter: Bone Cell Apoptosis

Authors: Boyce, B. F., Xing, L., Jilka, R. L., Bellido, T., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C.

Publisher: Academic Press, San Diego 2001

Novel Approaches to Treatment of Osteoporosis (1998)

Chapter: Apoptosis in Bone Cells.

Authors: Boyce, B.F.; Hughes, D.E.; Wright, K.R.; Xing, L.; Dai, A.

Publisher: Kollenkirchen U. 1998