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Patricia Janet Sime, M.D.

Patricia Janet Sime, M.D.

About Me

Modulation of Pulmonary Inflammation using Gene Transfer Techniques
Modulation of Pulmonary Inflammation using Gene Transfer Techniques

Faculty Appointments

Adjunct Professor - Department of Medicine, Pulmonary Diseases and Critical Care (SMD)

Credentials

Education

MD | UK-U Edinburgh Fac Med. Medicine. 1988

BS | UK-U Edinburgh Fac Med. Pathology. 1984

Research

The Sime lab is focused on studying pulmonary disease and pathologic processes in the lung. Our 2 primary areas of focus include lung scarring, and smoking related diseases such as chronic obstructive pulmonary disease (COPD).

Lung scarring, or pulmonary fibrosis, can be caused by environment...
The Sime lab is focused on studying pulmonary disease and pathologic processes in the lung. Our 2 primary areas of focus include lung scarring, and smoking related diseases such as chronic obstructive pulmonary disease (COPD).

Lung scarring, or pulmonary fibrosis, can be caused by environmental exposures such as silica, asbestos, and radiation, or develop of unknown reasons (Idiopathic pulmonary fibrosis). We are interested in studying the cellular mechanisms involved in the pathogenesis of pulmonary fibrosis to identify novel therapeutic targets.

We are also interested in studying the effects of cigarette and biomass smoke exposure in the lung. Our lab is investigating the mechanisms by which cigarette smoke leads to lung pathologies such as COPD, and dampened anti-viral responses in the lung. Biomass smoke exposure is another common environmental exposure, especially in the developing world, that is associated with lung infection and disease. For our smoking-related projects, we utilize a state-of-the-art smoking facility in the MRBX to expose cells and mice to biomass or cigarette smoke.

Publications

Journal Articles

Work readiness of student nurses voluntarily supporting NHS during COVID-19 pandemic: a mixed methods investigation into students' experiences.

Shapiro E, Piotrowska B, Sime PJ

Contemporary nurse.. 2024 September 20 :1-14. Epub 09/20/2024.

Ablation of LRP6 in alpha-smooth muscle actin-expressing cells abrogates lung inflammation and fibrosis upon bleomycin-induced lung injury.

Sung EA, Dozmorov MG, Song S, Aung T, Park MH, Sime PJ, Chae WJ

bioRxiv : the preprint server for biology.. 2024 September 10 Epub 09/10/2024.

Pioneering Research Driving Progress toward a Cure for Interstitial Lung Disease (ILD): Introduction to the Special Issue on ILD (Part 2).

Podolanczuk AJ, Maher TM, Drake WP, Sime PJ, Eickelberg O, DeMeo DL, Richeldi L

American journal of respiratory and critical care medicine.. 2024 August 15210 (4):373-374. Epub 1900 01 01.

Rape Myths and Verdict Systems: What Is Influencing Conviction Rates in Rape Trials in Scotland?

Curley LJ, Lages M, Sime PJ, Munro J

Behavioral sciences.. 2024 July 2114 (7)Epub 07/21/2024.

Transglutaminase 2 knockout mice are protected from bleomycin-induced lung fibrosis with preserved lung function and reduced metabolic derangements.

Freeberg MAT, Thatcher TH, Camus SV, Huang L, Atkinson J, Narrow W, Haak J, Dylag AM, Cowart LA, Johnson TS, Sime PJ

Physiological reports.. 2024 June 12 (12):e16012. Epub 1900 01 01.

Watching an Evolution in Progress, Cutting-Edge Research Transforming Outcomes in Interstitial Lung Disease: Introduction to an Special Issue.

Maher TM, Podolanczuk AJ, Drake WP, Sime PJ, Eickelberg O, DeMeo DL, Richeldi L

American journal of respiratory and critical care medicine.. 2024 May 1209 (9):1049-1050. Epub 1900 01 01.

Decline in forced vital capacity as a surrogate for mortality in patients with pulmonary fibrosis.

Maher TM, Stowasser S, Voss F, Bendstrup E, Kreuter M, Martinez FJ, Sime PJ, Stock C

Respirology : official journal of the Asian Pacific Society of Respirology.. 2023 December 28 (12):1147-1153. Epub 08/30/2023.

Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury.

Sung EA, Park MH, Henegariu O, Sime PJ, Chae WJ

The American journal of pathology.. 2023 September 193 (9):1130-1142. Epub 05/30/2023.

Building Career Paths for Ph.D., Basic and Translational Scientists in Clinical Departments in the United States: An Official American Thoracic Society Workshop Report.

Moore BB, Ballinger MN, Bauer NN, Blackwell TS, Borok Z, Budinger GRS, Camoretti-Mercado B, Erzurum SC, Himes BE, Keshamouni VG, Kulkarni HS, Mallampalli RK, Mariani TJ, Martinez FJ, McCombs JE, Newcomb DC, Johnston RA, O'Reilly MA, Prakash YS, Ridge KM, Sime PJ, Sperling AI, Violette S, Wilkes DS, Königshoff M

Annals of the American Thoracic Society.. 2023 August 20 (8):1077-1087. Epub 1900 01 01.

Is there a role for specialized pro-resolving mediators in pulmonary fibrosis?

Thatcher TH, Freeberg MAT, Myo YPA, Sime PJ

Pharmacology & therapeutics.. 2023 July 247 :108460. Epub 05/26/2023.

Exhaled breath condensate identifies metabolic dysregulation in patients with radiation-induced lung injury.

Odoom JP, Freeberg MAT, Camus SV, Toft R, Szomju BB, Sanchez Rosado RM, Jackson PD, Allegood JC, Silvey S, Liu J, Cowart LA, Weiss E, Thatcher TH, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2023 June 1324 (6):L863-L869. Epub 04/11/2023.

Thrombocyte-derived Dickkopf1 promotes macrophage polarization in the Bleomycin-induced lung injury model.

Sung EA, Park MH, Song S, Alanya H, Henegariu O, Liu J, Erson-Omay EZ, Sime PJ, Chae WJ

Frontiers in immunology.. 2023 14 :1247330. Epub 12/15/2023.

The Future of Endowed Chairs in Academic Medicine.

Buckley PF, Sime PJ, Collins L, Eggleston N, Davenport JE

Academic medicine : journal of the Association of American Medical Colleges.. 2022 November 197 (11):1583-1586. Epub 08/30/2022.

The Novel Small Molecule BTB Inhibits Pro-Fibrotic Fibroblast Behavior though Inhibition of RhoA Activity.

Rackow AR, Nagel DJ, Zapas G, Clough RS, Sime PJ, Kottmann RM

International journal of molecular sciences.. 2022 October 823 (19)Epub 10/08/2022.

Dung biomass smoke exposure impairs resolution of inflammatory responses to influenza infection.

McCarthy CE, Duffney PF, Nogales A, Post CM, Lawrence BP, Martinez-Sobrido L, Thatcher TH, Phipps RP, Sime PJ

Toxicology and applied pharmacology.. 2022 September 1450 :116160. Epub 07/09/2022.

Cell-Type-Specific Effects of the Ovarian Cancer G-Protein Coupled Receptor (OGR1) on Inflammation and Fibrosis; Potential Implications for Idiopathic Pulmonary Fibrosis.

Nagel DJ, Rackow AR, Ku WY, Bell TJ, Sime PJ, Kottmann RM

Cells.. 2022 August 1611 (16)Epub 08/16/2022.

miR-338-3p blocks TGF?-induced myofibroblast differentiation through the induction of PTEN.

Rackow AR, Judge JL, Woller CF, Sime PJ, Kottmann RM

American journal of physiology. Lung cellular and molecular physiology.. 2022 March 1322 (3):L385-L400. Epub 01/05/2022.

Epithelial Wntless regulates postnatal alveologenesis.

Fang Y, Shao H, Wu Q, Wong NC, Tsong N, Sime P, Que J

Development.. 2022 January 1149 (1)Epub 01/10/2022.

Specialized pro-resolving mediators as modulators of immune responses.

Julliard WA, Myo YPA, Perelas A, Jackson PD, Thatcher TH, Sime PJ

Seminars in immunology.. 2022 January 59 :101605. Epub 06/02/2022.

AT-RvD1 Mitigates Secondhand Smoke-Exacerbated Pulmonary Inflammation and Restores Secondhand Smoke-Suppressed Antibacterial Immunity.

Bhat TA, Kalathil SG, Bogner PN, Lehmann PV, Thatcher TH, Sime PJ, Thanavala Y

The Journal of immunology : official journal of the American Association of Immunologists.. 2021 March 15206 (6):1348-1360. Epub 02/08/2021.

Potential late effects of SARS-CoV-2 (COVID-19) infection: parallels to cancer late effects.

Phipps RP, Sime PJ, Phipps CR

Cancer metastasis reviews.. 2021 March 40 (1):1-2. Epub 02/04/2021.

Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms.

Guerrina N, Traboulsi H, Rico de Souza A, Bossé Y, Thatcher TH, Robichaud A, Ding J, Li PZ, Simon L, Pareek S, Bourbeau J, Tan WC, Benedetti A, Obeidat M, Sin DD, Brandsma CA, Nickle DC, Sime PJ, Phipps RP, Nair P, Zago M, Hamid Q, Smith BM, Eidelman DH, Baglole CJ

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2021 March 35 (3):e21376. Epub 1900 01 01.

Center for clinical and translational research COVID-19 clinical trial committee: The development of a review and prioritization matrix during a pandemic.

Bobb L, Ballance LR, Abbate A, Bain JC, Sime PJ, Moeller FG, Lessard MK, Montpetit AJ, Harmon MP, Stevens MP, DiazGranados D

Journal of clinical and translational science.. 2021 January 255 (1):e80. Epub 01/25/2021.

Mechanical Feed-Forward Loops Contribute to Idiopathic Pulmonary Fibrosis.

Freeberg MAT, Perelas A, Rebman JK, Phipps RP, Thatcher TH, Sime PJ

The American journal of pathology.. 2021 January 191 (1):18-25. Epub 10/05/2020.

Reproducible Single-Cell Genomic Research in Pulmonary and Critical Care Medicine.

Eickelberg O, Misharin AV, Sime PJ

American journal of respiratory and critical care medicine.. 2020 December 1202 (11):1495-1497. Epub 1900 01 01.

Specialized Proresolving Mediators Overcome Immune Suppression Induced by Exposure to Secondhand Smoke.

Bhat TA, Kalathil SG, Miller A, Thatcher TH, Sime PJ, Thanavala Y

The Journal of immunology : official journal of the American Association of Immunologists.. 2020 December 1205 (11):3205-3217. Epub 10/28/2020.

The self-fulfilling prophecy of pulmonary fibrosis: a selective inspection of pathological signalling loops.

Rackow AR, Nagel DJ, McCarthy C, Judge J, Lacy S, Freeberg MAT, Thatcher TH, Kottmann RM, Sime PJ

The European respiratory journal.. 2020 November 56 (5)Epub 11/26/2020.

Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?

Panigrahy D, Gilligan MM, Huang S, Gartung A, Cortés-Puch I, Sime PJ, Phipps RP, Serhan CN, Hammock BD

Cancer metastasis reviews.. 2020 June 39 (2):337-340. Epub 1900 01 01.

Cigarette smoke increases susceptibility to infection in lung epithelial cells by upregulating caveolin-dependent endocytosis.

Duffney PF, Embong AK, McGuire CC, Thatcher TH, Phipps RP, Sime PJ

PloS one.. 2020 15 (5):e0232102. Epub 05/21/2020.

Analysis of Postdeployment Serum Samples Identifies Potential Biomarkers of Exposure to Burn Pits and Other Environmental Hazards.

Thatcher TH, Woeller CF, Thakar J, Khan A, Hopke PK, Smith MR, Uppal K, Walker DI, Go YM, Jones DP, Krahl PL, Mallon TM, Sime PJ, Phipps RP, Utell MJ

Journal of occupational and environmental medicine. 2019 December 61 Suppl 12 (Suppl 12):S45-S54. Epub 1900 01 01.

Machine Learning Approach for Predicting Past Environmental Exposures From Molecular Profiling of Post-Exposure Human Serum Samples.

Khan A, Thatcher TH, Woeller CF, Sime PJ, Phipps RP, Hopke PK, Utell MJ, Krahl PL, Mallon TM, Thakar J

Journal of occupational and environmental medicine. 2019 December 61 Suppl 12 (Suppl 12):S55-S64. Epub 1900 01 01.

Exposure to Heptachlorodibenzo-p-dioxin (HpCDD) Regulates microRNA Expression in Human Lung Fibroblasts.

Woeller CF, Thatcher TH, Thakar J, Cornwell A, Smith MR, Jones DP, Hopke PK, Sime PJ, Krahl P, Mallon TM, Phipps RP, Utell MJ

Journal of occupational and environmental medicine. 2019 December 61 Suppl 12 (Suppl 12):S82-S89. Epub 1900 01 01.

Quenching the fires: Pro-resolving mediators, air pollution, and smoking.

Thatcher TH, Woeller CF, McCarthy CE, Sime PJ

Pharmacology & therapeutics.. 2019 May 197 :212-224. Epub 02/10/2019.

Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Antifibrotic Prostaglandins.

Lacy SH, Woeller CF, Thatcher TH, Pollock SJ, Small EM, Sime PJ, Phipps RP

American journal of respiratory cell and molecular biology.. 2019 March 60 (3):269-278. Epub 1900 01 01.

The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology.

Heffer AM, Proaño J, Roztocil E, Phipps RP, Feldon SE, Huxlin KR, Sime PJ, Libby RT, Woeller CF, Kuriyan AE

PloS one.. 2019 14 (9):e0222596. Epub 09/17/2019.

Key roles for lipid mediators in the adaptive immune response.

Duffney PF, Falsetta ML, Rackow AR, Thatcher TH, Phipps RP, Sime PJ

The Journal of clinical investigation.. 2018 July 2128 (7):2724-2731. Epub 07/02/2018.

Secondhand Smoke Induces Inflammation and Impairs Immunity to Respiratory Infections.

Bhat TA, Kalathil SG, Bogner PN, Miller A, Lehmann PV, Thatcher TH, Phipps RP, Sime PJ, Thanavala Y

The Journal of immunology : official journal of the American Association of Immunologists.. 2018 April 15200 (8):2927-2940. Epub 03/19/2018.

Activated human T lymphocytes inhibit TGF?-induced fibroblast to myofibroblast differentiation via prostaglandins D and E.

Lacy SH, Epa AP, Pollock SJ, Woeller CF, Thatcher TH, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2018 April 1314 (4):L569-L582. Epub 12/20/2017.

Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage.

Duffney PF, McCarthy CE, Nogales A, Thatcher TH, Martinez-Sobrido L, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2018 March 1314 (3):L505-L513. Epub 12/14/2017.

Prevention and treatment of bleomycin-induced pulmonary fibrosis with the lactate dehydrogenase inhibitor gossypol.

Judge JL, Nagel DJ, Owens KM, Rackow A, Phipps RP, Sime PJ, Kottmann RM

PloS one.. 2018 13 (5):e0197936. Epub 05/24/2018.

Management of Platelet Disorders and Platelet Transfusions in ICU Patients.

Blumberg N, Cholette JM, Schmidt AE, Phipps RP, Spinelli SL, Heal JM, Pietropaoli AP, Refaai MA, Sime PJ

Transfusion medicine reviews.. 2017 October 31 (4):252-257. Epub 05/04/2017.

Development of an accurate and sensitive method for lactate analysis in exhaled breath condensate by LC MS/MS.

Jackson TC, Zhang YV, Sime PJ, Phipps RP, Kottmann RM

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.. 2017 September 11061-1062 :468-473. Epub 07/24/2017.

Comparison of in vitro toxicological effects of biomass smoke from different sources of animal dung.

McCarthy CE, Duffney PF, Wyatt JD, Thatcher TH, Phipps RP, Sime PJ

Toxicology in vitro : an international journal published in association with BIBRA.. 2017 September 43 :76-86. Epub 05/30/2017.

Antifibrotic Actions of Peroxisome Proliferator-Activated Receptor ? Ligands in Corneal Fibroblasts Are Mediated by ?-Catenin-Regulated Pathways.

Jeon KI, Phipps RP, Sime PJ, Huxlin KR

The American journal of pathology.. 2017 August 187 (8):1660-1669. Epub 06/10/2017.

The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis.

Conforti F, Davies ER, Calderwood CJ, Thatcher TH, Jones MG, Smart DE, Mahajan S, Alzetani A, Havelock T, Maher TM, Molyneaux PL, Thorley AJ, Tetley TD, Warner JA, Packham G, Ganesan A, Skipp PJ, Marshall BJ, Richeldi L, Sime PJ, O'Reilly KMA, Davies DE

Oncotarget.. 2017 July 258 (30):48737-48754. Epub 1900 01 01.

The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis.

Judge JL, Lacy SH, Ku WY, Owens KM, Hernady E, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM

Radiation research.. 2017 July 188 (1):35-43. Epub 05/02/2017.

An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis.

Jenkins RG, Moore BB, Chambers RC, Eickelberg O, Königshoff M, Kolb M, Laurent GJ, Nanthakumar CB, Olman MA, Pardo A, Selman M, Sheppard D, Sime PJ, Tager AM, Tatler AL, Thannickal VJ, White ES,

American journal of respiratory cell and molecular biology.. 2017 May 56 (5):667-679. Epub 1900 01 01.

Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells.

Yee M, Domm W, Gelein R, Bentley KL, Kottmann RM, Sime PJ, Lawrence BP, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2017 April 56 (4):453-464. Epub 1900 01 01.

Corticosteroids inhibit anti-IgE activities of specialized proresolving mediators on B cells from asthma patients.

Kim N, Thatcher TH, Sime PJ, Phipps RP

JCI insight.. 2017 February 92 (3):e88588. Epub 02/09/2017.

Dung biomass smoke activates inflammatory signaling pathways in human small airway epithelial cells.

McCarthy CE, Duffney PF, Gelein R, Thatcher TH, Elder A, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2016 December 1311 (6):L1222-L1233. Epub 11/11/2016.

Human lung fibroblasts produce proresolving peroxisome proliferator-activated receptor-? ligands in a cyclooxygenase-2-dependent manner.

Lacy SH, Woeller CF, Thatcher TH, Maddipati KR, Honn KV, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2016 November 1311 (5):L855-L867. Epub 09/09/2016.

Resolvin D2 decreases TLR4 expression to mediate resolution in human monocytes.

Croasdell A, Sime PJ, Phipps RP

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 September 30 (9):3181-93. Epub 06/02/2016.

Pilot Metabolome-Wide Association Study of Benzo(a)pyrene in Serum From Military Personnel.

Walker DI, Pennell KD, Uppal K, Xia X, Hopke PK, Utell MJ, Phipps RP, Sime PJ, Rohrbeck P, Mallon CT, Jones DP

Journal of occupational and environmental medicine. 2016 August 58 (8 Suppl 1):S44-52. Epub 1900 01 01.

MicroRNAs as Novel Biomarkers of Deployment Status and Exposure to Polychlorinated Dibenzo-p-Dioxins/Dibenzofurans.

Woeller CF, Thatcher TH, Van Twisk D, Pollock SJ, Croasdell A, Hopke PK, Xia X, Thakar J, Sime PJ, Mallon TM, Utell MJ, Phipps RP

Journal of occupational and environmental medicine. 2016 August 58 (8 Suppl 1):S89-96. Epub 1900 01 01.

Resolvin D1 Dampens Pulmonary Inflammation and Promotes Clearance of Nontypeable Haemophilus influenzae.

Croasdell A, Lacy SH, Thatcher TH, Sime PJ, Phipps RP

The Journal of immunology : official journal of the American Association of Immunologists.. 2016 March 15196 (6):2742-52. Epub 02/03/2016.

Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production.

Kim N, Ramon S, Thatcher TH, Woeller CF, Sime PJ, Phipps RP

European journal of immunology.. 2016 January 46 (1):81-91. Epub 11/02/2015.

Endogenous ligands of the aryl hydrocarbon receptor regulate lung dendritic cell function.

Thatcher TH, Williams MA, Pollock SJ, McCarthy CE, Lacy SH, Phipps RP, Sime PJ

Immunology.. 2016 January 147 (1):41-54. Epub 11/10/2015.

Pharmacologic inhibition of lactate production prevents myofibroblast differentiation.

Kottmann RM, Trawick E, Judge JL, Wahl LA, Epa A, Owens KM, Thatcher TH, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2015 December 1309 (11):L1305-12. Epub 09/25/2015.

Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease.

Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I

American journal of respiratory cell and molecular biology.. 2015 December 53 (6):782-92. Epub 1900 01 01.

Resolvin D1 Reduces Emphysema and Chronic Inflammation.

Hsiao HM, Thatcher TH, Colas RA, Serhan CN, Phipps RP, Sime PJ

The American journal of pathology.. 2015 December 185 (12):3189-201. Epub 10/24/2015.

Ionizing radiation induces myofibroblast differentiation via lactate dehydrogenase.

Judge JL, Owens KM, Pollock SJ, Woeller CF, Thatcher TH, Williams JP, Phipps RP, Sime PJ, Kottmann RM

American journal of physiology. Lung cellular and molecular physiology.. 2015 October 15309 (8):L879-87. Epub 08/07/2015.

Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages.

Croasdell A, Thatcher TH, Kottmann RM, Colas RA, Dalli J, Serhan CN, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2015 October 15309 (8):L888-901. Epub 08/21/2015.

Inhibitory effects of PPAR? ligands on TGF-?1-induced CTGF expression in cat corneal fibroblasts.

Jeon KI, Phipps RP, Sime PJ, Huxlin KR

Experimental eye research.. 2015 September 138 :52-8. Epub 07/02/2015.

Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung.

Kottmann RM, Sharp J, Owens K, Salzman P, Xiao GQ, Phipps RP, Sime PJ, Brown EB, Perry SW

Respiratory research.. 2015 May 2716 (1):61. Epub 05/27/2015.

Measuring extracellular pH in a lung fibrosis model with acidoCEST MRI.

Jones KM, Randtke EA, Howison CM, Cárdenas-Rodríguez J, Sime PJ, Kottmann MR, Pagel MD

Molecular imaging and biology.. 2015 April 17 (2):177-84. Epub 1900 01 01.

Normal Human Lung Epithelial Cells Inhibit Transforming Growth Factor-? Induced Myofibroblast Differentiation via Prostaglandin E2.

Epa AP, Thatcher TH, Pollock SJ, Wahl LA, Lyda E, Kottmann RM, Phipps RP, Sime PJ

PloS one.. 2015 10 (8):e0135266. Epub 08/06/2015.

PPAR? and the Innate Immune System Mediate the Resolution of Inflammation.

Croasdell A, Duffney PF, Kim N, Lacy SH, Sime PJ, Phipps RP

PPAR research. 2015 2015 :549691. Epub 12/02/2015.

Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1.

Hsiao HM, Thatcher TH, Levy EP, Fulton RA, Owens KM, Phipps RP, Sime PJ

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 November 15193 (10):4980-7. Epub 10/15/2014.

Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection.

Lugade AA, Bogner PN, Thatcher TH, Sime PJ, Phipps RP, Thanavala Y

The Journal of immunology : official journal of the American Association of Immunologists.. 2014 June 1192 (11):5226-35. Epub 04/21/2014.

Matrix biology of idiopathic pulmonary fibrosis: a workshop report of the national heart, lung, and blood institute.

Thannickal VJ, Henke CA, Horowitz JC, Noble PW, Roman J, Sime PJ, Zhou Y, Wells RG, White ES, Tschumperlin DJ

The American journal of pathology.. 2014 June 184 (6):1643-51. Epub 04/13/2014.

SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism.

Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente LP, Rahman I

American journal of physiology. Lung cellular and molecular physiology.. 2014 May 1306 (9):L816-28. Epub 03/14/2014.

Inhibitory effects of PPAR? ligands on TGF-?1-induced corneal myofibroblast transformation.

Jeon KI, Kulkarni A, Woeller CF, Phipps RP, Sime PJ, Hindman HB, Huxlin KR

The American journal of pathology.. 2014 May 184 (5):1429-45. Epub 03/17/2014.

Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules.

Olsen KC, Epa AP, Kulkarni AA, Kottmann RM, McCarthy CE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ

American journal of respiratory cell and molecular biology.. 2014 April 50 (4):737-47. Epub 1900 01 01.

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP

American journal of respiratory and critical care medicine.. 2014 January 15189 (2):214-22. Epub 1900 01 01.

Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis.

Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I

PloS one.. 2014 9 (2):e87999. Epub 02/10/2014.

New light is shed on the enigmatic origin of the lung myofibroblast.

Rosas IO, Kottman RM, Sime PJ

American journal of respiratory and critical care medicine.. 2013 October 1188 (7):765-6. Epub 1900 01 01.

Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation.

Thatcher TH, Hsiao HM, Pinner E, Laudon M, Pollock SJ, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2013 July 15305 (2):L165-74. Epub 05/17/2013.

Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts.

McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2013 June 1304 (11):L774-81. Epub 04/05/2013.

A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation.

Hsiao HM, Sapinoro RE, Thatcher TH, Croasdell A, Levy EP, Fulton RA, Olsen KC, Pollock SJ, Serhan CN, Phipps RP, Sime PJ

PloS one.. 2013 8 (3):e58258. Epub 03/06/2013.

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.

Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ

PloS one.. 2013 8 (5):e63798. Epub 05/31/2013.

Topical rosiglitazone is an effective anti-scarring agent in the cornea.

Huxlin KR, Hindman HB, Jeon KI, Bühren J, Macrae S, Demagistris M, Ciufo D, Sime PJ, Phipps RP

PloS one.. 2013 8 (8):e70785. Epub 08/05/2013.

Peroxisome proliferator-activated receptor ? B cell-specific-deficient mice have an impaired antibody response.

Ramon S, Bancos S, Thatcher TH, Murant TI, Moshkani S, Sahler JM, Bottaro A, Sime PJ, Phipps RP

The Journal of immunology : official journal of the American Association of Immunologists.. 2012 November 15189 (10):4740-7. Epub 10/05/2012.

Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-?.

Kottmann RM, Kulkarni AA, Smolnycki KA, Lyda E, Dahanayake T, Salibi R, Honnons S, Jones C, Isern NG, Hu JZ, Nathan SD, Grant G, Phipps RP, Sime PJ

American journal of respiratory and critical care medicine.. 2012 October 15186 (8):740-51. Epub 08/23/2012.

Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis.

Davies ER, Haitchi HM, Thatcher TH, Sime PJ, Kottmann RM, Ganesan A, Packham G, O'Reilly KM, Davies DE

American journal of respiratory cell and molecular biology.. 2012 May 46 (5):687-94. Epub 01/12/2012.

Electrophilic PPAR? ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: a potentially novel therapy for corneal scarring.

Kuriyan AE, Lehmann GM, Kulkarni AA, Woeller CF, Feldon SE, Hindman HB, Sime P, Huxlin KR, Phipps RP

Experimental eye research.. 2012 January 94 (1):136-45. Epub 12/08/2011.

Emerging PPAR?-Independent Role of PPAR? Ligands in Lung Diseases.

Kulkarni AA, Woeller CF, Thatcher TH, Ramon S, Phipps RP, Sime PJ

PPAR research. 2012 2012 :705352. Epub 06/18/2012.

PPARs: Regulators and Translational Targets in the Lung.

Reddy RC, Rehan VK, Roman J, Sime PJ

PPAR research. 2012 2012 :342924. Epub 11/04/2012.

Genetic ablation of the aryl hydrocarbon receptor causes cigarette smoke-induced mitochondrial dysfunction and apoptosis.

Rico de Souza A, Zago M, Pollock SJ, Sime PJ, Phipps RP, Baglole CJ

The Journal of biological chemistry.. 2011 December 16286 (50):43214-28. Epub 10/07/2011.

The mystery of transfusion-related acute lung injury.

Blumberg N, Sime PJ, Phipps RP

Transfusion.. 2011 October 51 (10):2054-7. Epub 1900 01 01.

Transglutaminase 2 and its role in pulmonary fibrosis.

Olsen KC, Sapinoro RE, Kottman RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ

American journal of respiratory and critical care medicine.. 2011 September 15184 (6):699-707. Epub 06/23/2011.

Bronchoscopy with bronchoalveolar lavage: determinants of yield and impact on management in immunosuppressed patients.

Kottmann RM, Kelly J, Lyda E, Gurell M, Stalica J, Ormsby W, Moon K, Trawick D, Sime PJ

Thorax.. 2011 September 66 (9):823. Epub 09/13/2010.

Ocular fibroblast diversity: implications for inflammation and ocular wound healing.

Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE, Phipps RP

Investigative ophthalmology & visual science.. 2011 July 152 (7):4859-65. Epub 07/01/2011.

Lung-targeted overexpression of the NF-?B member RelB inhibits cigarette smoke-induced inflammation.

McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP

The American journal of pathology.. 2011 July 179 (1):125-33. Epub 05/05/2011.

Yin yang 1 is a novel regulator of pulmonary fibrosis.

Lin X, Sime PJ, Xu H, Williams MA, Larussa L, Georas SN, Guo J

American journal of respiratory and critical care medicine.. 2011 June 15183 (12):1689-97. Epub 12/17/2010.

The aryl hydrocarbon receptor ligand ITE inhibits TGF?1-induced human myofibroblast differentiation.

Lehmann GM, Xi X, Kulkarni AA, Olsen KC, Pollock SJ, Baglole CJ, Gupta S, Casey AE, Huxlin KR, Sime PJ, Feldon SE, Phipps RP

The American journal of pathology.. 2011 April 178 (4):1556-67. Epub 03/03/2011.

PPAR-? ligands repress TGF?-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis.

Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ

PloS one.. 2011 January 66 (1):e15909. Epub 01/06/2011.

Electrophilic PPAR? Ligands Attenuate IL-1? and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPAR?-Independent Mechanism.

Hogan CM, Thatcher TH, Sapinoro RE, Gurell MN, Ferguson HE, Pollock SJ, Jones C, Phipps RP, Sime PJ

PPAR research. 2011 2011 :318134. Epub 06/16/2011.

A putative role for platelet-derived PPAR? in vascular homeostasis demonstrated by anti-PPAR? induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis.

Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP

Journal of biotechnology.. 2010 November 150 (3):417-27. Epub 10/01/2010.

Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells.

Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB

Virology.. 2010 May 10400 (2):224-32. Epub 02/25/2010.

Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro.

Hindman HB, Swanton JN, Phipps R, Sime PJ, Huxlin KR

Investigative ophthalmology & visual science.. 2010 April 51 (4):1935-42. Epub 11/11/2009.

Leukoreduction of blood transfusions--there is such a thing as a free lunch.

Blumberg N, Sime PJ, Phipps RP

Critical care medicine.. 2010 February 38 (2):720-1. Epub 1900 01 01.

Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts.

Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ

American journal of respiratory cell and molecular biology.. 2009 December 41 (6):722-30. Epub 03/13/2009.

Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism.

Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2009 November 297 (5):L912-9. Epub 09/04/2009.

Determinants of initiation and progression of idiopathic pulmonary fibrosis.

Kottmann RM, Hogan CM, Phipps RP, Sime PJ

Respirology : official journal of the Asian Pacific Society of Respirology.. 2009 September 14 (7):917-33. Epub 1900 01 01.

RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke.

Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I

American journal of respiratory cell and molecular biology.. 2009 February 40 (2):147-58. Epub 08/07/2008.

The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB.

Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ

The Journal of biological chemistry.. 2008 October 24283 (43):28944-57. Epub 08/12/2008.

Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione.

Baglole CJ, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2008 October 295 (4):L624-36. Epub 08/08/2008.

Exogenous lipoid pneumonia: an unexpected complication of substance abuse.

Gurell MN, Kottmann RM, Xu H, Sime PJ

Annals of internal medicine.. 2008 September 2149 (5):364-5. Epub 1900 01 01.

High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function.

Thatcher TH, Benson RP, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2008 September 295 (3):L412-21. Epub 06/20/2008.

PPARgamma: a novel molecular target in lung disease.

Hart CM, Roman J, Reddy R, Sime PJ

Journal of investigative medicine : the official publication of the American Federation for Clinical Research.. 2008 February 56 (2):515-7. Epub 1900 01 01.

The antifibrogenic potential of PPARgamma ligands in pulmonary fibrosis.

Sime PJ

Journal of investigative medicine : the official publication of the American Federation for Clinical Research.. 2008 February 56 (2):534-8. Epub 1900 01 01.

Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies.

Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP

PPAR research. 2008 2008 :834612. Epub 1900 01 01.

Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise.

Bernard MP, Bancos S, Sime PJ, Phipps RP

Current pharmaceutical design.. 2008 14 (21):2051-60. Epub 1900 01 01.

Metabolomics in lung inflammation:a high-resolution (1)h NMR study of mice exposedto silica dust.

Hu JZ, Rommereim DN, Minard KR, Woodstock A, Harrer BJ, Wind RA, Phipps RP, Sime PJ

Toxicology mechanisms and methods.. 2008 18 (5):385-98. Epub 1900 01 01.

Asbestos-related lung disease.

O'Reilly KM, Mclaughlin AM, Beckett WS, Sime PJ

American family physician.. 2007 March 175 (5):683-8. Epub 1900 01 01.

Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.

Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ

The American journal of pathology.. 2007 March 170 (3):855-64. Epub 1900 01 01.

The Role of PPARs in Lung Fibrosis.

Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ

PPAR research. 2007 2007 :71323. Epub 1900 01 01.

Severe airflow obstruction and eosinophilic lung disease after Stevens-Johnson syndrome.

Shah AP, Xu H, Sime PJ, Trawick DR

The European respiratory journal.. 2006 December 28 (6):1276-9. Epub 1900 01 01.

Antenatal Ureaplasma urealyticum respiratory tract infection stimulates proinflammatory, profibrotic responses in the preterm baboon lung.

Viscardi RM, Atamas SP, Luzina IG, Hasday JD, He JR, Sime PJ, Coalson JJ, Yoder BA

Pediatric research.. 2006 August 60 (2):141-6. Epub 1900 01 01.

Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema.

Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2006 July 291 (1):L19-29. Epub 01/27/2006.

Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation.

Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ

Experimental lung research.. 2006 May 32 (5):181-99. Epub 1900 01 01.

More than structural cells, fibroblasts create and orchestrate the tumor microenvironment.

Baglole CJ, Ray DM, Bernstein SH, Feldon SE, Smith TJ, Sime PJ, Phipps RP

Immunological investigations.. 2006 35 (3-4):297-325. Epub 1900 01 01.

The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.

Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2005 September 289 (3):L391-9. Epub 04/29/2005.

Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire.

Thatcher TH, Sime PJ, Barth RK

Experimental lung research.. 2005 September 31 (7):685-700. Epub 1900 01 01.

Role of CXCR2 in cigarette smoke-induced lung inflammation.

Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP

American journal of physiology. Lung cellular and molecular physiology.. 2005 August 289 (2):L322-8. Epub 04/15/2005.

TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis.

Vallance BA, Gunawan MI, Hewlett B, Bercik P, Van Kampen C, Galeazzi F, Sime PJ, Gauldie J, Collins SM

American journal of physiology. Gastrointestinal and liver physiology.. 2005 July 289 (1):G116-28. Epub 03/18/2005.

Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis.

O'Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2005 June 288 (6):L1010-6. Epub 01/21/2005.

PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis.

Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2005 June 288 (6):L1146-53. Epub 02/25/2005.

Isolation and phenotypic characterization of lung fibroblasts.

Baglole CJ, Reddy SY, Pollock SJ, Feldon SE, Sime PJ, Smith TJ, Phipps RP

Methods in molecular medicine.. 2005 117 :115-27. Epub 1900 01 01.

Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer.

Martey CA, Pollock SJ, Turner CK, O'Reilly KM, Baglole CJ, Phipps RP, Sime PJ

American journal of physiology. Lung cellular and molecular physiology.. 2004 November 287 (5):L981-91. Epub 07/02/2004.

Asbestos-derived reactive oxygen species activate TGF-beta1.

Pociask DA, Sime PJ, Brody AR

Laboratory investigation; a journal of technical methods and pathology.. 2004 August 84 (8):1013-23. Epub 1900 01 01.

A novel ELISpot method for adherent cells.

Turner CK, Blieden TM, Smith TJ, Feldon SE, Foster DC, Sime PJ, Phipps RP

Journal of immunological methods.. 2004 August 291 (1-2):63-70. Epub 1900 01 01.

A case of steroid responsive pulmonary hyalinising granuloma: complicated by deep venous thrombosis.

O'Reilly KM, Boscia JA, Kaplan KL, Sime PJ

The European respiratory journal.. 2004 June 23 (6):954-6. Epub 1900 01 01.

Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis.

Kaufman J, Sime PJ, Phipps RP

The Journal of immunology : official journal of the American Association of Immunologists.. 2004 February 1172 (3):1862-71. Epub 1900 01 01.

Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains.

Kolb M, Bonniaud P, Galt T, Sime PJ, Kelly MM, Margetts PJ, Gauldie J

American journal of respiratory cell and molecular biology.. 2002 August 27 (2):141-50. Epub 1900 01 01.

Titration of non-replicating adenovirus as a vector for transducing active TGF-beta1 gene expression causing inflammation and fibrogenesis in the lungs of C57BL/6 mice.

Warshamana GS, Pociask DA, Fisher KJ, Liu JY, Sime PJ, Brody AR

International journal of experimental pathology.. 2002 August 83 (4):183-201. Epub 1900 01 01.

A new direction in the pathogenesis of idiopathic pulmonary fibrosis?

Gauldie J, Kolb M, Sime PJ

Respiratory research.. 2002 3 (1):1. Epub 09/26/2001.

Transforming growth factor-beta(1) overexpression in tumor necrosis factor-alpha receptor knockout mice induces fibroproliferative lung disease.

Liu JY, Sime PJ, Wu T, Warshamana GS, Pociask D, Tsai SY, Brody AR

American journal of respiratory cell and molecular biology.. 2001 July 25 (1):3-7. Epub 1900 01 01.

Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung.

Kolb M, Margetts PJ, Sime PJ, Gauldie J

American journal of physiology. Lung cellular and molecular physiology.. 2001 June 280 (6):L1327-34. Epub 1900 01 01.

Fibrosis of the lung and other tissues: new concepts in pathogenesis and treatment.

Sime PJ, O'Reilly KM

Clinical immunology : the official journal of the Clinical Immunology Society.. 2001 June 99 (3):308-19. Epub 1900 01 01.

Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin.

Kolb M, Margetts PJ, Galt T, Sime PJ, Xing Z, Schmidt M, Gauldie J

American journal of respiratory and critical care medicine.. 2001 March 163 (3 Pt 1):770-7. Epub 1900 01 01.

Spatial-specific TGF-beta1 adenoviral expression determines morphogenetic phenotypes in embryonic mouse lung.

Zhao J, Sime PJ, Bringas P, Tefft JD, Buckley S, Bu D, Gauldie J, Warburton D

European journal of cell biology.. 1999 October 78 (10):715-25. Epub 1900 01 01.

Adenovirus-mediated decorin gene transfer prevents TGF-beta-induced inhibition of lung morphogenesis.

Zhao J, Sime PJ, Bringas P, Gauldie J, Warburton D

The American journal of physiology.. 1999 August 277 (2):L412-22. Epub 1900 01 01.

Enhancement of dendritic cell tolerogenicity by genetic modification using adenoviral vectors encoding cDNA for TGF beta 1.

Lee WC, Wan YH, Li W, Fu F, Sime PJ, Gauldie J, Thomson AW, Fung JJ, Lu L, Qian S

Transplantation proceedings.. 1999 31 (1-2):1195. Epub 1900 01 01.

Transforming growth factor-beta gene transfer to the lung induces myofibroblast presence and pulmonary fibrosis.

Gauldie J, Sime PJ, Xing Z, Marr B, Tremblay GM

Current topics in pathology. Ergebnisse der Pathologie. 1999 93 :35-45. Epub 1900 01 01.

Adenoviral infection inhibits allergic airways inflammation in mice.

Stämpfli MR, Ritz SA, Neigh GS, Sime PJ, Lei XF, Xing Z, Croitoru K, Jordana M

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 1998 December 28 (12):1581-90. Epub 1900 01 01.

Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts.

Sime PJ, Marr RA, Gauldie D, Xing Z, Hewlett BR, Graham FL, Gauldie J

The American journal of pathology.. 1998 September 153 (3):825-32. Epub 1900 01 01.

Epithelium-specific adenoviral transfer of a dominant-negative mutant TGF-beta type II receptor stimulates embryonic lung branching morphogenesis in culture and potentiates EGF and PDGF-AA.

Zhao J, Sime PJ, Bringas P, Gauldie J, Warburton D

Mechanisms of development.. 1998 March 72 (1-2):89-100. Epub 1900 01 01.

Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung.

Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J

The Journal of clinical investigation.. 1997 August 15100 (4):768-76. Epub 1900 01 01.

Transient gene transfer and expression in the lung.

Sime PJ, Xing Z, Foley R, Graham FL, Gauldie J

Chest.. 1997 June 111 (6 Suppl):89S-94S. Epub 1900 01 01.

Adenovirus-mediated gene transfer of the proteoglycan biglycan induces fibroblastic responses in the lung.

Sime PJ, Sarnstrand B, Xing Z, Graham F, Fisher L, Gauldie J

Chest.. 1997 June 111 (6 Suppl):137S. Epub 1900 01 01.

Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation.

Xing Z, Tremblay GM, Sime PJ, Gauldie J

The American journal of pathology.. 1997 January 150 (1):59-66. Epub 1900 01 01.

Adenovirus-vector-mediated cytokine gene transfer to lung tissue.

Gauldie J, Graham F, Xing Z, Braciak T, Foley R, Sime PJ

Annals of the New York Academy of Sciences.. 1996 October 31796 :235-44. Epub 1900 01 01.

Gene transfer for cytokine functional studies in the lung: the multifunctional role of GM-CSF in pulmonary inflammation.

Xing Z, Braciak T, Ohkawara Y, Sallenave JM, Foley R, Sime PJ, Jordana M, Graham FL, Gauldie J

Journal of leukocyte biology.. 1996 April 59 (4):481-8. Epub 1900 01 01.

Self assessment of daytime sleepiness: patient versus partner.

Kingshott RN, Sime PJ, Engleman HM, Douglas NJ

Thorax.. 1995 September 50 (9):994-5. Epub 1900 01 01.

Immune-inflammatory functions of fibroblasts.

Jordana M, Särnstrand B, Sime PJ, Ramis I

The European respiratory journal.. 1994 December 7 (12):2212-22. Epub 1900 01 01.

Miliary tuberculosis in Edinburgh--a comparison between 1984-1992 and 1954-1967.

Sime PJ, Chilvers ER, Leitch AG

Respiratory medicine.. 1994 September 88 (8):609-11. Epub 1900 01 01.

Time to extend 'the timetable of tuberculosis'?

Rubilar M, Sime PJ, Moudgil H, Chilvers ER, Leitch AG

Respiratory medicine.. 1994 August 88 (7):481-2. Epub 1900 01 01.

Skin fibroblast activity in pretibial myxoedema and the effect of octreotide (Sandostatin) in vitro.

Priestley GC, Aldridge RD, Sime PJ, Wilson D

The British journal of dermatology.. 1994 July 131 (1):52-6. Epub 1900 01 01.

Pulmonary Mycobacterium malmoense and aspergillus infection: a fatal combination?

Böllert FG, Sime PJ, MacNee W, Crompton GK

Thorax.. 1994 May 49 (5):521-2. Epub 1900 01 01.

Plasma lactate dehydrogenase: a marker of disease activity in cryptogenic fibrosing alveolitis and extrinsic allergic alveolitis?

Matusiewicz SP, Williamson IJ, Sime PJ, Brown PH, Wenham PR, Crompton GK, Greening AP

The European respiratory journal.. 1993 October 6 (9):1282-6. Epub 1900 01 01.

Differentiation in medulloblastomas and other primitive neuroectodermal tumours.

Sime PJ, Gordon A, Hooper ML, Bell JE

British journal of neurosurgery.. 1989 3 (1):89-100. Epub 1900 01 01.

Locations

Strong Memorial Hospital

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Rochester, NY 14642-0001

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