Associate Professor
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Department of Environmental Medicine (SMD)
Credentials
Post-doctoral Training & Residency
Post-doctoral Fellow, Department of Environmental Medicine, University of Rochester 1997 - 2000
Education
PhD | Univ of Cal Irvine.Environmental Toxicology.1997
BS | Chatham College.Chemistry.1992
Awards
Young Investigator Award, Inhalation and Respiratory Specialty Section, Society of Toxicology.2009
Cornerstone Alumna Award in Environmental Medicine, Chatham University.2007
Graduate Student Fellowship, U.S. Environmental Protection Agency.1995 - 1996
College Chemistry Award, Society for Analytical Chemists of Pittsburgh.1992
Research
Toxicology of Inhaled Ultrafine Particles and Engineered Nanomaterials
Our laboratory has focused for several years on the toxicology of inhaled ultrafine particles (UFPs), the most numerous size fraction of particulate air pollution. Interests include the impacts of age, gaseous co-pollutant...
Toxicology of Inhaled Ultrafine Particles and Engineered Nanomaterials
Our laboratory has focused for several years on the toxicology of inhaled ultrafine particles (UFPs), the most numerous size fraction of particulate air pollution. Interests include the impacts of age, gaseous co-pollutant exposure, and health status on the response(s) to inhaled UFPs. We are also interested in determining the basis for potential adverse effects of inhaled particles in the cardiovascular and central nervous systems.
This research focus has naturally led to our work with engineered nanomaterials. The research commonalities between UFP and nanomaterials are numerous, including the kinetics of tissue distribution following exposure, mechanisms of response related to oxidative stress, particle-protein interactions, and the physicochemical characteristics of the particles that determine response. Our research aims are met by using a combination of animal and cell culture models as well as detailed particle characterization.
In addition to looking for nanosized particles in tissues via chemical and microscopic means, responses are determined by measuring markers of inflammation and oxidative stress in the lung lining fluid, lung tissue, blood, circulating inflammatory cells, and extrapulmonary tissues (e.g. heart, liver, spleen, kidney, brain regions). We also have specific projects focused on cardiovascular stability and neurodegeneration following exposures to UFPs and nanomaterials.
Riediker M, Zink D, Kreyling W, Oberdörster G, Elder A, Graham U, Lynch I, Duschl A, Ichihara G, Ichihara S, Kobayashi T, Hisanaga N, Umezawa M, Cheng TJ, Handy R, Gulumian M, Tinkle S, Cassee F
Particle and fibre toxicology.. 2019 June 2716 (1):26. Epub 06/27/2019.
Riediker M, Zink D, Kreyling W, Oberdörster G, Elder A, Graham U, Lynch I, Duschl A, Ichihara G, Ichihara S, Kobayashi T, Hisanaga N, Umezawa M, Cheng TJ, Handy R, Gulumian M, Tinkle S, Cassee F
Particle and fibre toxicology.. 2019 April 2316 (1):19. Epub 04/23/2019.
Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Alstrup Jensen K, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Teixeira JP, Tran CL, Cassee FR
Environmental health perspectives.. 2017 October 10125 (10):106002. Epub 10/10/2017.
Stone V, Miller MR, Clift MJ, Elder A, Mills NL, Møller P, Schins RP, Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TA, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR
Environmental health perspectives.. 2016 November 4 Epub 11/04/2016.
Baer DR, Engelhard MH, Johnson GE, Laskin J, Lai J, Mueller K, Munusamy P, Thevuthasan S, Wang H, Washton N, Elder A, Baisch BL, Karakoti A, Kuchibhatla SV, Moon D
Journal of vacuum science & technology. A, Vacuum, surfaces, and films : an official journal of the American Vacuum Society.. 2013 September 31 (5):50820. Epub 08/27/2013.
Bonner JC, Silva RM, Taylor AJ, Brown JM, Hilderbrand SC, Castranova V, Porter D, Elder A, Oberdörster G, Harkema JR, Bramble LA, Kavanagh TJ, Botta D, Nel A, Pinkerton KE
Environmental health perspectives.. 2013 June 121 (6):676-82. Epub 05/06/2013.
Xia T, Hamilton RF, Bonner JC, Crandall ED, Elder A, Fazlollahi F, Girtsman TA, Kim K, Mitra S, Ntim SA, Orr G, Tagmount M, Taylor AJ, Telesca D, Tolic A, Vulpe CD, Walker AJ, Wang X, Witzmann FA, Wu N, Xie Y, Zink JI, Nel A, Holian A
Environmental health perspectives.. 2013 June 121 (6):683-90. Epub 05/06/2013.
Linkov I, Steevens J, Adlakha-Hutcheon G, Bennett E, Chappell M, Colvin V, Davis JM, Davis T, Elder A, Foss Hansen S, Hakkinen PB, Hussain SM, Karkan D, Korenstein R, Lynch I, Metcalfe C, Ramadan AB, Satterstrom FK
Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology.. 2009 April 11 (3):513-527. Epub 10/08/2008.
Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G
Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C
Journal of toxicology and environmental health. Part A.. 2002 October 2565 (20):1531-43. Epub 1900 01 01.
Systemic Interactions Between Inhaled Ultrafine Particles and Endotoxin
Elder, A.C.P.; Gelein, R.; Azadniv, M.; Frampton, M.; Oberdörster, G.
Ann. Occup. Hyg. 2002; 46(Suppl. 1): 231-234.
Limitations of Power Spectrum Analysis and Time-Domain Analysis of Heart Rate Variability in Short-Term ECGs Recorded using Telemetry in Unrestrained Rats
Couderc, J-P.; Elder, A.; Cox, C.; Zareba, W.; Oberdörster, G.
