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Margot Mayer-Proschel, Ph.D.

Margot Mayer-Proschel, Ph.D.

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Appointment (585) 273-1449
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Administrative (585) 273-1440

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About Me

Faculty Appointments

Professor - Department of Biomedical Genetics (SMD)

Martha M. Freeman, MD Professorship in Biomedical Genetics - Department of Biomedical Genetics (SMD)

Professor - Department of Neuroscience (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Dept of Developmental Biology, Ludwig Institute for Cancer Research, London, UK (Mentor: Mark Noble) 1990 - 1995

Education

PhD | Inst. Of Virology & Immunology, Univ of Wurzburg. Virology/Microbiology. 1990

MS | Julius Maximilian University. Immunology. 1986

Awards

Graduate Student Society Faculty Award. 2007

Excellence in Research incentive program Award. 2006

Excellence in Research incentive program Award. 2004

Trainee Academic Mentoring Award. 2004

Research

1. Identification of lineage restricted precursor cells for cell replacement
The concept of progressive lineage restriction is well accepted for hematopoeisis but has not been established in such detail in the developing CNS. We are pursuing how lineage restriction is regulated in various brain ...
1. Identification of lineage restricted precursor cells for cell replacement
The concept of progressive lineage restriction is well accepted for hematopoeisis but has not been established in such detail in the developing CNS. We are pursuing how lineage restriction is regulated in various brain regions of the CNS and have discovered that embryonic glial precursor cells do not directly generate terminally differentiated cell types, but give rise to other, more restricted precursor cell types before terminal differentiation. The identification of these different cell pools is critical for identifying ideal transplantable cells for therapeutic cell replacement approaches.
The therapeutic translation of our knowledge of precursor cells and their derivatives is demonstrated in our collaborative efforts on designing optimal repair strategies for spinal cord injuries. With our colleagues Drs. Chris Proschel, Mark Noble and Stephen and Jeanette Davies at the University of Colorado we showed that the transplantation of a defined embryonic astrocyte population into a dorsal transection models of SCI results in extensive regeneration associated with complete functional recovery. We are now in the process of extending these finding by devising a rational approach to identify the optimal cell source and cell population for SCI repair and by characterizing the graft cells and the injury site in respect to cell death, inflammation and cell division.
2. CNS precursor cells and their derivatives in human disease paradigms
The insights we have gained from studying CNS glial precursor cells has led to the idea that precursor cell populations are targets for a large number of developmental abnormalities associated with myelination defects in humans. Defects in myelination are associated with insults as diverse as genetic defects, exposure to toxicant or to nutritional deficiencies. Based on our precursor cell work, we hypothesize that adequate myelination of large areas of the mammalian brain will only be possible if precursor cells arise in adequate numbers and continue to develop normally throughout development. Any disruption of the precursor cell pool might hence be associated with myelination defects later in development.
Gestational Iron deficiency.
Our hypothesis of precursor cells being a major target during development is especially relevant for the pathology seen as a result of gestational nutritional iron deficiency. This world's most prevalent nutritional deficiency is associated with impaired myelination and results in cognitive defects in affected children. We have shown that embryonic CNS tissue is not protected from iron deficiency during pregnancy, as commonly thought, and that early glial precursor cell populations are highly sensitive to changes in tissue iron concentrations. We have established rat and mouse models of gestation iron deficiency with and without anemia to determine the impact of gestational iron deficiency on brain development with a focus on (i) early embryonic telencephalic development and (ii) myelination of the auditory nerve postnatally.
Ataxia Telangiectasia (AT)
A genetic disorder associated with widespread neurological defects is the devastating disease Ataxia telangiectasia (AT), caused by mutations in the ATM gene. The pathology is characterized by crippling ataxia beginning in late infancy followed by progressive CNS degeneration of the cerebellum. While the majority of research has been focused on the neuronal cell population affected in the cerebellum, we began to determine the extent of glial dysfunction on the progression of AT. Our result indicate that astrocytic function is severely impaired in AT CNS tissue and we show that AT mutant astrocytes are unable to maintain neuronal integrity and survival. This new discovery opens the possibility for generating new therapeutic strategies that target the dysfunction astrocytes in order to halt or abolish neuronal degeneration.

Patents

Transplantation of Glial Restricted Precursor - Derived Astrocytes For Promotion of Axon Growth

Issue date: June 12, 2013

Telencephalic Glial-Restricted Cell Populations and Related Compositions and Methods

Issue date: September 11, 2013

Publications

Journal Articles

Gestational iron deficiency affects the ratio between interneuron subtypes in the postnatal cerebral cortex in mice.

Rudy MJ, Salois G, Cubello J, Newell R, Mayer-Proschel M

Development.. 2023 October 15150 (20)Epub 03/03/2023.

Maternal Iron Deficiency and Environmental Lead (Pb) Exposure Alter the Predictive Value of Blood Pb Levels on Brain Pb Burden in the Offspring in a Dietary Mouse Model: An Important Consideration for Cumulative Risk in Development.

Cubello J, Peterson DR, Wang L, Mayer-Proschel M

Nutrients.. 2023 September 2215 (19)Epub 09/22/2023.

Expression of the human herpesvirus 6A latency-associated transcript U94A impairs cytoskeletal functions in human neural cells.

Hogestyn JM, Salois G, Xie L, Apa C, Youngyunpipatkul J, Pröschel C, Mayer-Pröschel M

Molecular and cellular neurosciences.. 2022 December 123 :103770. Epub 08/30/2022.

Ataxia telangiectasia mutated is required for efficient proximal airway epithelial cell regeneration following influenza A virus infection.

Warren R, Dylag AM, Behan M, Domm W, Yee M, Mayer-Proschel M, Martinez L, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2022 April 1322 (4):L581-L592. Epub 02/23/2022.

Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection.

Warren R, Domm W, Yee M, Campbell A, Malone J, Wright T, Mayer-Proschel M, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2019 November 1317 (5):L591-L601. Epub 09/11/2019.

Contributions of neurotropic human herpesviruses herpes simplex virus 1 and human herpesvirus 6 to neurodegenerative disease pathology.

Hogestyn JM, Mock DJ, Mayer-Proschel M

Neural regeneration research.. 2018 February 13 (2):211-221. Epub 1900 01 01.

Heterozygote galactocerebrosidase (GALC) mutants have reduced remyelination and impaired myelin debris clearance following demyelinating injury.

Scott-Hewitt NJ, Folts CJ, Hogestyn JM, Piester G, Mayer-Pröschel M, Noble MD

Human molecular genetics.. 2017 August 126 (15):2825-2837. Epub 1900 01 01.

Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration.

Campbell A, Hogestyn JM, Folts CJ, Lopez B, Pröschel C, Mock D, Mayer-Pröschel M

Scientific reports.. 2017 June 217 (1):3978. Epub 06/21/2017.

Neuropathological Consequences of Gestational Exposure to Concentrated Ambient Fine and Ultrafine Particles in the Mouse.

Klocke C, Allen JL, Sobolewski M, Mayer-Pröschel M, Blum JL, Lauterstein D, Zelikoff JT, Cory-Slechta DA

Toxicological sciences : an official journal of the Society of Toxicology.. 2017 April 1156 (2):492-508. Epub 1900 01 01.

Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: Parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders.

Allen JL, Oberdorster G, Morris-Schafer K, Wong C, Klocke C, Sobolewski M, Conrad K, M MP, Cory-Slechta DA

Neurotoxicology.. 2017 March 59 :140-154. Epub 12/22/2015.

Iron Deficiency Affects Seizure Susceptibility in a Time- and Sex-Specific Manner.

Rudy M, Mayer-Proschel M

ASN neuro.. 2017 9 (6):1759091417746521. Epub 1900 01 01.

Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity.

Folts CJ, Scott-Hewitt N, Pröschel C, Mayer-Pröschel M, Noble M

PLoS biology.. 2016 December 14 (12):e1002583. Epub 12/15/2016.

Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.

Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M

Glia.. 2016 February 64 (2):227-39. Epub 10/15/2015.

A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.

Campbell A, Krupp B, Bushman J, Noble M, Pröschel C, Mayer-Pröschel M

Human molecular genetics.. 2015 November 1524 (22):6331-49. Epub 08/26/2015.

cFLIP is critical for oligodendrocyte protection from inflammation.

Tanner DC, Campbell A, O'Banion KM, Noble M, Mayer-Pröschel M

Cell death and differentiation.. 2015 September 22 (9):1489-501. Epub 01/30/2015.

Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.

Noble M, Mayer-Pröschel M, Li Z, Dong T, Cui W, Pröschel C, Ambeskovic I, Dietrich J, Han R, Miranda Yang Y, Folts C, Stripay J, Chen HY, Stevens BM

Free radical biology & medicine.. 2015 February 79 :300-23. Epub 12/04/2014.

Identifying the threshold of iron deficiency in the central nervous system of the rat by the auditory brainstem response.

Greminger AR, Mayer-Pröschel M

ASN neuro.. 2015 7 (1)Epub 1900 01 01.

Early postnatal exposure to ultrafine particulate matter air pollution: persistent ventriculomegaly, neurochemical disruption, and glial activation preferentially in male mice.

Allen JL, Liu X, Pelkowski S, Palmer B, Conrad K, Oberdörster G, Weston D, Mayer-Pröschel M, Cory-Slechta DA

Environmental health perspectives.. 2014 September 122 (9):939-45. Epub 06/05/2014.

Gestational iron deficiency differentially alters the structure and function of white and gray matter brain regions of developing rats.

Greminger AR, Lee DL, Shrager P, Mayer-Pröschel M

The Journal of nutrition.. 2014 July 144 (7):1058-66. Epub 04/17/2014.

Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes.

Wang J, Bushman J, Wang X, Mayer-Proschel M, Johnson M, Noble M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 October 1633 (42):16805-17. Epub 1900 01 01.

iOPs: a new tool for studying myelin pathologies?

Noble M, Mayer-Pröschel M, Pröschel C

Cell stem cell.. 2013 May 212 (5):503-4. Epub 1900 01 01.

Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in Alzheimer disease (AD).

Wang G, Dinkins M, He Q, Zhu G, Poirier C, Campbell A, Mayer-Proschel M, Bieberich E

The Journal of biological chemistry.. 2012 June 15287 (25):21384-95. Epub 04/24/2012.

Iron deficiency disrupts axon maturation of the developing auditory nerve.

Lee DL, Strathmann FG, Gelein R, Walton J, Mayer-Pröschel M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2012 April 432 (14):5010-5. Epub 1900 01 01.

Cell therapies for the central nervous system: how do we identify the best candidates?

Noble M, Mayer-Pröschel M, Davies JE, Davies SJ, Pröschel C

Current opinion in neurology.. 2011 December 24 (6):570-6. Epub 1900 01 01.

Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury.

Noble M, Davies JE, Mayer-Pröschel M, Pröschel C, Davies SJ

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2011 October 8 (4):677-93. Epub 1900 01 01.

Oligodendrocyte progenitors reversibly exit the cell cycle and give rise to astrocytes in response to interferon-?.

Tanner DC, Cherry JD, Mayer-Pröschel M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2011 April 2031 (16):6235-46. Epub 1900 01 01.

Identifying a window of vulnerability during fetal development in a maternal iron restriction model.

Mihaila C, Schramm J, Strathmann FG, Lee DL, Gelein RM, Luebke AE, Mayer-Pröschel M

PloS one.. 2011 March 156 (3):e17483. Epub 03/15/2011.

Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury.

Davies SJ, Shih CH, Noble M, Mayer-Proschel M, Davies JE, Proschel C

PloS one.. 2011 March 26 (3):e17328. Epub 03/02/2011.

Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Latchney SE, Lioy DT, Henry EC, Gasiewicz TA, Strathmann FG, Mayer-Pröschel M, Opanashuk LA

Stem cells and development.. 2011 February 20 (2):313-26. Epub 08/31/2010.

Oxidative-reductionist approaches to stem and progenitor cell function.

Noble M, Pröschel C, Mayer-Pröschel M

Cell stem cell.. 2011 January 78 (1):1-2. Epub 1900 01 01.

A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process.

Chen R, Hyrien O, Noble M, Mayer-Pröschel M

Biostatistics.. 2011 January 12 (1):173-91. Epub 08/23/2010.

Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats.

Nout YS, Culp E, Schmidt MH, Tovar CA, Pröschel C, Mayer-Pröschel M, Noble MD, Beattie MS, Bresnahan JC

Experimental neurology.. 2011 January 227 (1):159-71. Epub 10/30/2010.

Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications.

Hyrien O, Chen R, Mayer-Pröschel M, Noble M

Biometrics.. 2010 June 66 (2):567-77. Epub 06/09/2009.

Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury.

Davies JE, Pröschel C, Zhang N, Noble M, Mayer-Pröschel M, Davies SJ

Journal of biology.. 2008 September 197 (7):24. Epub 09/19/2008.

Systemic 5-fluorouracil treatment causes a syndrome of delayed myelin destruction in the central nervous system.

Han R, Yang YM, Dietrich J, Luebke A, Mayer-Pröschel M, Noble M

Journal of biology.. 2008 7 (4):12. Epub 04/22/2008.

Identification of two novel glial-restricted cell populations in the embryonic telencephalon arising from unique origins.

Strathmann FG, Wang X, Mayer-Pröschel M

BMC developmental biology. 2007 April 177 :33. Epub 04/17/2007.

Infection of murine oligodendroglial precursor cells with Human Herpesvirus 6 (HHV-6)--establishment of a murine in vitro model.

Mock DJ, Strathmann F, Blumberg BM, Mayer-Proschel M

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.. 2006 December 37 Suppl 1 :S17-23. Epub 1900 01 01.

Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data.

Hyrien O, Ambeskovic I, Mayer-Proschel M, Noble M, Yakovlev A

Theoretical biology & medical modelling. 2006 May 173 :21. Epub 05/17/2006.

Characterization of specific HHV-6 and cell cycle genes implicated in virus-mediated G1/S cell-cycle arrest of glial precursors

Mock DJ; Chugh P; Kim B; Proschel C; Dietrich, J.; Strathmann F; Blumberg BM; Mayer-Proschel M.

Retrovirology. 2006; 21(3 Suppl 1): S65.

Astrocytes derived from glial-restricted precursors promote spinal cord repair.

Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ

Journal of biology.. 2006 5 (3):7. Epub 04/27/2006.

CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo.

Dietrich J, Han R, Yang Y, Mayer-Pröschel M, Noble M

Journal of biology.. 2006 5 (7):22. Epub 1900 01 01.

EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy.

Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Pröschel M, Noble M, Torres C, Pröschel C

Nature medicine.. 2005 March 11 (3):277-83. Epub 02/20/2005.

A stochastic model to analyze clonal data on multi-type cell populations.

Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A

Biometrics.. 2005 March 61 (1):199-207. Epub 1900 01 01.

Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture.

Hyrien O, Mayer-Pröschel M, Noble M, Yakovlev A

Mathematical biosciences.. 2005 February 193 (2):255-74. Epub 01/22/2005.

Redox regulation of precursor cell function: insights and paradoxes.

Noble M, Mayer-Pröschel M, Pröschel C

Antioxidants & redox signaling.. 2005 7 (11-12):1456-67. Epub 1900 01 01.

Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration.

Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC

Experimental neurology.. 2004 December 190 (2):289-310. Epub 1900 01 01.

Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties.

Dietrich J, Blumberg BM, Roshal M, Baker JV, Hurley SD, Mayer-Pröschel M, Mock DJ

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2004 May 1924 (20):4875-83. Epub 1900 01 01.

Glutamate transporter expression and function in human glial progenitors.

Maragakis NJ, Dietrich J, Wong V, Xue H, Mayer-Proschel M, Rao MS, Rothstein JD

Glia.. 2004 January 1545 (2):133-43. Epub 1900 01 01.

Getting a GR(i)P on oligodendrocyte development.

Noble M, Pröschel C, Mayer-Pröschel M

Developmental biology.. 2004 January 1265 (1):33-52. Epub 1900 01 01.

Redox state as a central modulator of precursor cell function.

Noble M, Smith J, Power J, Mayer-Pröschel M

Annals of the New York Academy of Sciences.. 2003 June 991 :251-71. Epub 1900 01 01.

The cortical ancestry of oligodendrocytes: common principles and novel features.

Noble M, Arhin A, Gass D, Mayer-Pröschel M

Developmental neuroscience.. 2003 25 (2-4):217-33. Epub 1900 01 01.

Characterization of A2B5+ glial precursor cells from cryopreserved human fetal brain progenitor cells.

Dietrich J, Noble M, Mayer-Proschel M

Glia.. 2002 October 40 (1):65-77. Epub 1900 01 01.

Oligodendrocyte precursor cells from different brain regions express divergent properties consistent with the differing time courses of myelination in these regions.

Power J, Mayer-Pröschel M, Smith J, Noble M

Developmental biology.. 2002 May 15245 (2):362-75. Epub 1900 01 01.

The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function.

Gregori N, Pröschel C, Noble M, Mayer-Pröschel M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 January 122 (1):248-56. Epub 1900 01 01.

Human neural precursor cells- an in vitro characterization

Mayer-Proschel, M.; Ying, Liu; Haipeng, Xue; Yuan Yuan, Wu; Carpenter, M.; Rao, M.

Clinical Neurosci. Res. 2002; 2: 58-69.

Iron deficiency during embryogenesis and consequences for oligodendrocyte generation in vivo.

Morath DJ, Mayer-Pröschel M

Developmental neuroscience.. 2002 24 (2-3):197-207. Epub 1900 01 01.

Iron modulates the differentiation of a distinct population of glial precursor cells into oligodendrocytes.

Morath DJ, Mayer-Pröschel M

Developmental biology.. 2001 September 1237 (1):232-43. Epub 1900 01 01.

Embryonic-derived glial-restricted precursor cells (GRP cells) can differentiate into astrocytes and oligodendrocytes in vivo.

Herrera J, Yang H, Zhang SC, Proschel C, Tresco P, Duncan ID, Luskin M, Mayer-Proschel M

Experimental neurology.. 2001 September 171 (1):11-21. Epub 1900 01 01.

An alternative stochastic model of generation of oligodendrocytes in cell culture.

Boucher K, Zorin A, Yakovlev AY, Mayer-Proschel M, Noble M

Journal of mathematical biology.. 2001 July 43 (1):22-36. Epub 1900 01 01.

Isolation and generation of oligodendrocytes by immunopanning.

Mayer-Pröschel M

Current protocols in neuroscience. 2001 May Chapter 3 :Unit 3.13. Epub 1900 01 01.

Are hypothyroidism and iron deficiency precursor cell diseases?

Mayer-Pröschel M, Morath D, Noble M

Developmental neuroscience.. 2001 23 (4-5):277-86. Epub 1900 01 01.

Estimation problems associated with stochastic modeling of proliferation and differentiation of O-2A progenitor cells in vitro.

Zorin A, Mayer-Proschel M, Noble M, Yakovlev AY

Mathematical biosciences.. 2000 October 167 (2):109-21. Epub 1900 01 01.

Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell.

Smith J, Ladi E, Mayer-Proschel M, Noble M

Proceedings of the National Academy of Sciences of the United States of America.. 2000 August 2997 (18):10032-7. Epub 1900 01 01.

Gliogenesis in the central nervous system.

Lee JC, Mayer-Proschel M, Rao MS

Glia.. 2000 April 30 (2):105-21. Epub 1900 01 01.

The reorganization of somatosensory and motor cortex after peripheral nerve or spinal cord injury in primates.

Kaas JH

Progress in brain research.. 2000 128 :173-9. Epub 1900 01 01.

Precursor cells for transplantation.

Rao MS, Mayer-Proschel M

Progress in brain research.. 2000 128 :273-92. Epub 1900 01 01.

Heparin is a unique marker of progenitors in the glial cell lineage.

Stringer SE, Mayer-Proschel M, Kalyani A, Rao M, Gallagher JT

The Journal of biological chemistry.. 1999 September 3274 (36):25455-60. Epub 1900 01 01.

A random walk model of oligodendrocyte generation in vitro and associated estimation problems.

von Collani E, Tsodikov A, Yakovlev A, Mayer-Proschel M, Noble M

Mathematical biosciences.. 1999 July 159 (2):189-204. Epub 1900 01 01.

A stochastic model of temporally regulated generation of oligodendrocytes in cell culture.

Boucher K, Yakovlev AY, Mayer-Proschel M, Noble M

Mathematical biosciences.. 1999 June 159 (1):47-78. Epub 1900 01 01.

Cell differentiation in the embryonic mammalian spinal cord.

Mayer-Pröschel M

Journal of neural transmission. Supplementum.. 1999 55 :1-8. Epub 1900 01 01.

Quantitative insight into proliferation and differentiation of oligodendrocyte type 2 astrocyte progenitor cells in vitro.

Yakovlev AY, Boucher K, Mayer-Proschel M, Noble M

Proceedings of the National Academy of Sciences of the United States of America.. 1998 November 2495 (24):14164-7. Epub 1900 01 01.

A common neural progenitor for the CNS and PNS.

Mujtaba T, Mayer-Proschel M, Rao MS

Developmental biology.. 1998 August 1200 (1):1-15. Epub 1900 01 01.

A stochastic model of brain cell differentiation in tissue culture.

Yakovlev AY, Mayer-Proschel M, Noble M

Journal of mathematical biology.. 1998 July 37 (1):49-60. Epub 1900 01 01.

A tripotential glial precursor cell is present in the developing spinal cord.

Rao MS, Noble M, Mayer-Pröschel M

Proceedings of the National Academy of Sciences of the United States of America.. 1998 March 3195 (7):3996-4001. Epub 1900 01 01.

Growth factors, glia and gliomas.

Noble M, Mayer-Pröschel M

Journal of neuro-oncology.. 1997 December 35 (3):193-209. Epub 1900 01 01.

Isolation of lineage-restricted neuronal precursors from multipotent neuroepithelial stem cells.

Mayer-Proschel M, Kalyani AJ, Mujtaba T, Rao MS

Neuron.. 1997 October 19 (4):773-85. Epub 1900 01 01.

Glial-restricted precursors are derived from multipotent neuroepithelial stem cells.

Rao MS, Mayer-Proschel M

Developmental biology.. 1997 August 1188 (1):48-63. Epub 1900 01 01.

Progenitor cells of the central nervous system: A boon for clinical neuroscience

Mayer-Pröschel M.; Rao, M.S.; Noble, M.

The Journal of NIH Research. 1997; 9: 31-36.

Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro.

Ibarrola N, Mayer-Pröschel M, Rodriguez-Peña A, Noble M

Developmental biology.. 1996 November 25180 (1):1-21. Epub 1900 01 01.

On the track of cell survival pharmaceuticals in the oligodendrocyte type-2 astrocyte lineage.

Noble M, Mayer-Próschel M

Perspectives on developmental neurobiology.. 1996 3 (2):121-31. Epub 1900 01 01.

N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro.

Mayer M, Noble M

Proceedings of the National Academy of Sciences of the United States of America.. 1994 August 291 (16):7496-500. Epub 1900 01 01.

Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro.

Mayer M, Bhakoo K, Noble M

Development.. 1994 January 120 (1):143-53. Epub 1900 01 01.

Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells.

Groves AK, Barnett SC, Franklin RJ, Crang AJ, Mayer M, Blakemore WF, Noble M

Nature.. 1993 April 1362 (6419):453-5. Epub 1900 01 01.

Books

Stem cells and CNS development (2001)

Chapter: PreGlial restricted Precursors

Isolation and purification of oligodendrocytes (1998)