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Christoph Proschel, Ph.D.

Christoph Proschel, Ph.D.

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Appointment (585) 273-5368
Fax (585) 273-1450
Administrative (585) 273-1440

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About Me

Faculty Appointments

Professor - Department of Biomedical Genetics (SMD)

Credentials

Post-doctoral Training & Residency

Max-Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology Göttingen/Germany, Professor P. Gruss 1998 - 1998

Postdoctoral Research Fellow,
Department of Oncological Sciences,
Huntsman Cancer Institute,
University of Utah, Salt Lake City

Research Project:
Identification of Molecular Determinants of the Glial Cell Fate in Vertebrates: a potential role of GCM2 in CNS Gliogenesis 1995 - 2000

Education

PhD | LICR Univ. College. Molecular & Cellular Biology. 1995

M.Sc. | Julius-Maximillian Univ.. Immunology. 1990

BS | Julius-Maximillian Univ.. Biology. 1986

Awards

European Molecular Biology Organization, Practical Course:
"Mouse Developmental Genetics"
Course supervisor: Prof. P. Gruss
Max-Planck Institute, Göttingen 1995

Scholarship of the University Würzburg:
Postgraduate Studies
Departments of Molecular Genetics and Neurobiology
State University of New York, Albany, U.S.A. 1986 - 1987

Research

Within the context of our work on glial progenitor cells, we are now focusing on the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our discovery that the generation of mature astrocytes may be impaired in Vani...
Within the context of our work on glial progenitor cells, we are now focusing on the role of astrocytes as critical modulators in response to injury or stress. The importance of understanding this process is emphasized by our discovery that the generation of mature astrocytes may be impaired in Vanishing White Matter leukodystrophy (Nat Med. 2005 Mar;11(3):277-83.).

The ability to study astrocyte development in normal and pathological conditions, provides a unique opportunity to test the utility of glial precursor cells and their astrocytic progeny for cell transplantation therapy in diseases of the central nervous system (CNS), such as traumatic injury (spinal cord and traumatic brain injury) and neurodegenerative diseases (Parkinsons Disease, Multiple sclerosis).

We have identified distinct astrocyte populations that demonstrate different functional properties with respect to their ability to promote injury repair upon transplantation into the injured nervous system. While one type shows little benefit and may even cause neuropathic pain syndrome, the other remodels the injured host tissue, enables axon outgrowth and extensive functional recovery (J Biol 2006 Apr 27, 5(3):7; J Biol 2008 Sep 19;7(7):245). As a prerequisite for the transition to the clinic we are analyzing the factors secreted by these astrocytes and have now derived homologous astrocyte populations from human precursor cells. (PLoS One. 2011 Mar 2;6(3)).

Patents

Transplantation of Glial Restricted Precursor - Derived Astrocytes For Promotion of Axon Growth

Issue date: June 12, 2013

Publications

Journal Articles

Expression of the human herpesvirus 6A latency-associated transcript U94A impairs cytoskeletal functions in human neural cells.

Hogestyn JM, Salois G, Xie L, Apa C, Youngyunpipatkul J, Pröschel C, Mayer-Pröschel M

Molecular and cellular neurosciences.. 2022 December 123 :103770. Epub 08/30/2022.

AKT constitutes a signal-promoted alternative exon-junction complex that regulates nonsense-mediated mRNA decay.

Cho H, Abshire ET, Popp MW, Pröschel C, Schwartz JL, Yeo GW, Maquat LE

Molecular cell.. 2022 August 482 (15):2779-2796.e10. Epub 06/07/2022.

NMD abnormalities during brain development in the Fmr1-knockout mouse model of fragile X syndrome.

Kurosaki T, Sakano H, Pröschel C, Wheeler J, Hewko A, Maquat LE

Genome biology.. 2021 November 1622 (1):317. Epub 11/16/2021.

Deletion or Inhibition of Astrocytic Transglutaminase 2 Promotes Functional Recovery after Spinal Cord Injury.

Elahi A, Emerson J, Rudlong J, Keillor JW, Salois G, Visca A, Girardi P, Johnson GVW, Pröschel C

Cells.. 2021 October 2910 (11)Epub 10/29/2021.

Loss of the fragile X syndrome protein FMRP results in misregulation of nonsense-mediated mRNA decay.

Kurosaki T, Imamachi N, Pröschel C, Mitsutomi S, Nagao R, Akimitsu N, Maquat LE

Nature cell biology.. 2021 January 23 (1):40-48. Epub 01/08/2021.

The many roles of C1q.

Noble M, Pröschel C

eLife.. 2020 September 149 Epub 09/14/2020.

Depletion of astrocytic transglutaminase 2 improves injury outcomes.

Monteagudo A, Feola J, Natola H, Ji C, Pröschel C, Johnson GVW

Molecular and cellular neurosciences.. 2018 October 92 :128-136. Epub 06/30/2018.

Erythropoietin Signaling Regulates Key Epigenetic and Transcription Networks in Fetal Neural Progenitor Cells.

Sollinger C, Lillis J, Malik J, Getman M, Proschel C, Steiner L

Scientific reports.. 2017 October 307 (1):14381. Epub 10/30/2017.

Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration.

Campbell A, Hogestyn JM, Folts CJ, Lopez B, Pröschel C, Mock D, Mayer-Pröschel M

Scientific reports.. 2017 June 217 (1):3978. Epub 06/21/2017.

Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology.

Pröschel C, Hansen JN, Ali A, Tuttle E, Lacagnina M, Buscaglia G, Halterman MW, Paciorkowski AR

European journal of human genetics : EJHG.. 2017 February 25 (2):216-221. Epub 12/14/2016.

Lysosomal Re-acidification Prevents Lysosphingolipid-Induced Lysosomal Impairment and Cellular Toxicity.

Folts CJ, Scott-Hewitt N, Pröschel C, Mayer-Pröschel M, Noble M

PLoS biology.. 2016 December 14 (12):e1002583. Epub 12/15/2016.

Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.

Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M

Glia.. 2016 February 64 (2):227-39. Epub 10/15/2015.

A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioral defect and a low incidence of lymphoma but no increased oxidative burden.

Campbell A, Krupp B, Bushman J, Noble M, Pröschel C, Mayer-Pröschel M

Human molecular genetics.. 2015 November 1524 (22):6331-49. Epub 08/26/2015.

Redox biology in normal cells and cancer: restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.

Noble M, Mayer-Pröschel M, Li Z, Dong T, Cui W, Pröschel C, Ambeskovic I, Dietrich J, Han R, Miranda Yang Y, Folts C, Stripay J, Chen HY, Stevens BM

Free radical biology & medicine.. 2015 February 79 :300-23. Epub 12/04/2014.

Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons.

Proschel C, Stripay JL, Shih CH, Munger JC, Noble MD

EMBO molecular medicine.. 2014 April 6 (4):504-18. Epub 01/29/2014.

Astroglial-derived periostin promotes axonal regeneration after spinal cord injury.

Shih CH, Lacagnina M, Leuer-Bisciotti K, Pröschel C

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 February 1234 (7):2438-43. Epub 1900 01 01.

iOPs: a new tool for studying myelin pathologies?

Noble M, Mayer-Pröschel M, Pröschel C

Cell stem cell.. 2013 May 212 (5):503-4. Epub 1900 01 01.

Cell therapies for the central nervous system: how do we identify the best candidates?

Noble M, Mayer-Pröschel M, Davies JE, Davies SJ, Pröschel C

Current opinion in neurology.. 2011 December 24 (6):570-6. Epub 1900 01 01.

Precursor cell biology and the development of astrocyte transplantation therapies: lessons from spinal cord injury.

Noble M, Davies JE, Mayer-Pröschel M, Pröschel C, Davies SJ

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2011 October 8 (4):677-93. Epub 1900 01 01.

Transplantation of specific human astrocytes promotes functional recovery after spinal cord injury.

Davies SJ, Shih CH, Noble M, Mayer-Proschel M, Davies JE, Proschel C

PloS one.. 2011 March 26 (3):e17328. Epub 03/02/2011.

Oxidative-reductionist approaches to stem and progenitor cell function.

Noble M, Pröschel C, Mayer-Pröschel M

Cell stem cell.. 2011 January 78 (1):1-2. Epub 1900 01 01.

Glial restricted precursor cell transplant with cyclic adenosine monophosphate improved some autonomic functions but resulted in a reduced graft size after spinal cord contusion injury in rats.

Nout YS, Culp E, Schmidt MH, Tovar CA, Pröschel C, Mayer-Pröschel M, Noble MD, Beattie MS, Bresnahan JC

Experimental neurology.. 2011 January 227 (1):159-71. Epub 10/30/2010.

Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury.

Davies JE, Pröschel C, Zhang N, Noble M, Mayer-Pröschel M, Davies SJ

Journal of biology.. 2008 September 197 (7):24. Epub 09/19/2008.

Transplanted astrocytes derived from BMP or CNTF treated glial restricted precursors have opposite effects on recovery and allodynia after spinal cord injury

Davies JE; Proschel C; Zhang N; Noble M; Mayer-Proschel M; Davies SA.

J Biol. 2008; 19(7): 24.

Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function.

Li Z, Dong T, Pröschel C, Noble M

PLoS biology.. 2007 February 5 (2):e35. Epub 1900 01 01.

Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function

Li, Z.; Dong, T., Pröschel, C.; Noble, M.

PLoS Biology. 2007; 5(2): 35.

Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data (PDF)

Hyrien O.; Ambeskovic I.; Mayer-Pröschel M.; Noble M.; Yakovlev, A.

Theoretical Biology and Medical Modelling. 2006; 3.

Astrocytes derived from glial-restricted precursors promote spinal cord repair.

Davies JE, Huang C, Proschel C, Noble M, Mayer-Proschel M, Davies SJ

Journal of biology.. 2006 5 (3):7. Epub 04/27/2006.

EIF2B5 mutations compromise GFAP+ astrocyte generation in vanishing white matter leukodystrophy.

Dietrich J, Lacagnina M, Gass D, Richfield E, Mayer-Pröschel M, Noble M, Torres C, Pröschel C

Nature medicine.. 2005 March 11 (3):277-83. Epub 02/20/2005.

Redox regulation of precursor cell function: insights and paradoxes

Noble,M.; Mayer-Proschel,M.; Proschel,C.;.

Antioxidants & Redox Signalling. 2005; 7(11-12): 1456-1467.

Redox regulation of precursor cell function: insights and paradoxes.

Noble M, Mayer-Pröschel M, Pröschel C

Antioxidants & redox signaling.. 2005 7 (11-12):1456-67. Epub 1900 01 01.

Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration.

Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC

Experimental neurology.. 2004 December 190 (2):289-310. Epub 1900 01 01.

Getting a GR(i)P on oligodendrocyte development.

Noble M, Pröschel C, Mayer-Pröschel M

Developmental biology.. 2004 January 1265 (1):33-52. Epub 1900 01 01.

The tripotential glial-restricted precursor (GRP) cell and glial development in the spinal cord: generation of bipotential oligodendrocyte-type-2 astrocyte progenitor cells and dorsal-ventral differences in GRP cell function.

Gregori N, Pröschel C, Noble M, Mayer-Pröschel M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 January 122 (1):248-56. Epub 1900 01 01.

Embryonic-derived glial-restricted precursor cells (GRP cells) can differentiate into astrocytes and oligodendrocytes in vivo.

Herrera J, Yang H, Zhang SC, Proschel C, Tresco P, Duncan ID, Luskin M, Mayer-Proschel M

Experimental neurology.. 2001 September 171 (1):11-21. Epub 1900 01 01.

LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition.

Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, Keating MT

Cell.. 1996 July 1286 (1):59-69. Epub 1900 01 01.

LIM-kinase deleted in Williams syndrome.

Tassabehji M, Metcalfe K, Fergusson WD, Carette MJ, Dore JK, Donnai D, Read AP, Pröschel C, Gutowski NJ, Mao X, Sheer D

Nature genetics.. 1996 July 13 (3):272-3. Epub 1900 01 01.

Assignment of the human and mouse LIM-kinase genes (LIMK1; Limk1) to chromosome bands 7q11.23 and 5G1, respectively, by in situ hybridization.

Mao X, Jones TA, Williamson J, Gutowski NJ, Pröschel C, Noble M, Sheer D

Cytogenetics and cell genetics.. 1996 74 (3):190-1. Epub 1900 01 01.

Limk1 is predominantly expressed in neural tissues and phosphorylates serine, threonine and tyrosine residues in vitro.

Pröschel C, Blouin MJ, Gutowski NJ, Ludwig R, Noble M

Oncogene.. 1995 October 511 (7):1271-81. Epub 1900 01 01.