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Paul G. Rothberg, Ph.D.

Paul G. Rothberg, Ph.D.

About Me

Dr. Rothberg is Director of the Molecular Diagnostics Section of the Strong Health clinical laboratories. The Molecular Diagnostics Section uses the techniques of molecular biology to aid in the diagnosis of human disease. Dr. Rothberg is responsible for the planning and development of laboratory te...
Dr. Rothberg is Director of the Molecular Diagnostics Section of the Strong Health clinical laboratories. The Molecular Diagnostics Section uses the techniques of molecular biology to aid in the diagnosis of human disease. Dr. Rothberg is responsible for the planning and development of laboratory tests that support the care of patients with inherited disease, cancer and infectious disease. His research interests include the development of new testing strategies for the measurement of minimal residual disease in cancer patients, and the development of methods to predict response to therapy.

Faculty Appointments

Professor Emeritus - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Post-doctoral Training & Residency

National Institutes of Health Postdoctoral Trainee, Special Fellow of the Leukemia Society of America, Institute for Cancer Research, Fox Chase Cancer Center. Advisor: S. M. Astrin 1982 - 1985

Education

PhD | St Univ at Stony Brook. Molecular Biology. 1981

BA | Cuny Queens College. Chemistry. 1976

Research

Dr. Rothberg's research focuses on deciphering the role of human genetic variation in the development of disease. Particular areas of focus include cancer and neurodegeneration. Current areas of investigation include studies on the molecular genetics of neuronal ceroid lipofuscinosis (Batten disease...
Dr. Rothberg's research focuses on deciphering the role of human genetic variation in the development of disease. Particular areas of focus include cancer and neurodegeneration. Current areas of investigation include studies on the molecular genetics of neuronal ceroid lipofuscinosis (Batten disease) in collaboration with the Batten Disease Clinical and Research Center, the early prediction of drug resistance in chronic myeloid leukemia, and the role of germline variation in the prognosis of prostate cancer.

Publications

Journal Articles

Next-Generation Sequencing-Based Antigen-Receptor Gene Clonality Assays: Will They Become the Clinical Standard?

Ho C, Rothberg PG

The Journal of molecular diagnostics : JMD.. 2021 September 23 (9):1043-1046. Epub 07/20/2021.

A Case of Acute Eosinophilic Leukemia with a Novel 6 Mutation.

Lipof JJ, Huselton EJ, Zent CS, Evans A, Zhang B, Rothberg PG, Bennett JM

Case reports in hematology.. 2021 2021 :5574766. Epub 07/03/2021.

Incidental splenic findings in pancreatosplenectomy specimens resected for primary pancreatic lesions.

Patel N, Evans AG, Rothberg PG, Gonzalez RS

Histopathology.. 2019 November 75 (5):746-754. Epub 09/05/2019.

Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the , , and Genes: A Study of the College of American Pathologists Molecular Oncology Committee.

Moncur JT, Bartley AN, Bridge JA, Kamel-Reid S, Lazar AJ, Lindeman NI, Long TA, Merker JD, Rai AJ, Rimm DL, Rothberg PG, Vasalos P, Kim AS

Archives of pathology & laboratory medicine.. 2019 October 143 (10):1203-1211. Epub 04/10/2019.

Comparison of Laboratory-Developed Tests and FDA-Approved Assays for BRAF, EGFR, and KRAS Testing.

Kim AS, Bartley AN, Bridge JA, Kamel-Reid S, Lazar AJ, Lindeman NI, Long TA, Merker JD, Rai AJ, Rimm DL, Rothberg PG, Vasalos P, Moncur JT

JAMA oncology.. 2018 June 14 (6):838-841. Epub 1900 01 01.

Is Tubulocystic Renal Cell Carcinoma Real?: Genomic Analysis Confirms the World Health Organization Classification.

Ding Y, Miyamoto H, Rothberg PG

The Journal of molecular diagnostics : JMD.. 2018 January 20 (1):28-30. Epub 11/16/2017.

p53 alteration in morphologically normal/benign breast luminal cells in BRCA carriers with or without history of breast cancer.

Wang X, El-Halaby AA, Zhang H, Yang Q, Laughlin TS, Rothberg PG, Skinner K, Hicks DG

Human pathology.. 2017 October 68 :22-25. Epub 04/21/2017.

Ibrutinib therapy for lymphoplasmacytic lymphoma.

Helber MJ, Moore JE, Williams AM, Meacham PJ, Rothberg PG, Zent CS

American journal of hematology.. 2017 September 92 (9):E542-E544. Epub 06/09/2017.

Pigmented epithelioid melanocytoma (animal-type melanoma): An institutional experience.

Bax MJ, Brown MD, Rothberg PG, Laughlin TS, Scott GA

Journal of the American Academy of Dermatology.. 2017 August 77 (2):328-332. Epub 04/14/2017.

Index case of acute myeloid leukemia in a family harboring a novel germ line mutation.

Ram J, Flamm G, Balys M, Sivagnanalingam U, Rothberg PG, Iqbal A, Myers JR, Corbett A, Ashton JM, Mendler JH

Blood advances.. 2017 March 141 (8):500-503. Epub 03/14/2017.

Next-Generation Sequencing for Minimal Residual Disease Surveillance in Acute Lymphoblastic Leukemia: An Update.

Reyes-Barron C, Burack WR, Rothberg PG, Ding Y

Critical reviews in oncogenesis.. 2017 22 (5-6):559-567. Epub 1900 01 01.

p53 alteration in morphologically normal/benign breast tissue in patients with triple-negative high-grade breast carcinomas: breast p53 signature?

Wang X, Stolla M, Ring BZ, Yang Q, Laughlin TS, Rothberg PG, Skinner K, G Hicks D

Human pathology.. 2016 September 55 :196-201. Epub 05/28/2016.

The Spectrum of Clinical Utilities in Molecular Pathology Testing Procedures for Inherited Conditions and Cancer: A Report of the Association for Molecular Pathology.

Joseph L, Cankovic M, Caughron S, Chandra P, Emmadi R, Hagenkord J, Hallam S, Jewell KE, Klein RD, Pratt VM, Rothberg PG, Temple-Smolkin RL, Lyon E

The Journal of molecular diagnostics : JMD.. 2016 September 18 (5):605-619. Epub 08/16/2016.

Evolution to plasmablastic lymphoma evades CD19-directed chimeric antigen receptor T cells.

Evans AG, Rothberg PG, Burack WR, Huntington SF, Porter DL, Friedberg JW, Liesveld JL

British journal of haematology.. 2015 October 171 (2):205-209. Epub 06/18/2015.

Standardized assessment of seizures in patients with juvenile neuronal ceroid lipofuscinosis.

Augustine EF, Adams HR, Beck CA, Vierhile A, Kwon J, Rothberg PG, Marshall F, Block R, Dolan J, Mink JW,

Developmental medicine and child neurology.. 2015 April 57 (4):366-71. Epub 11/11/2014.

Reporting incidental findings in genomic scale clinical sequencing--a clinical laboratory perspective: a report of the Association for Molecular Pathology.

Hegde M, Bale S, Bayrak-Toydemir P, Gibson J, Bone Jeng LJ, Joseph L, Laser J, Lubin IM, Miller CE, Ross LF, Rothberg PG, Tanner AK, Vitazka P, Mao R

The Journal of molecular diagnostics : JMD.. 2015 March 17 (2):107-17. Epub 02/12/2015.

ERBB3 is required for metastasis formation of melanoma cells.

Tiwary S, Preziosi M, Rothberg PG, Zeitouni N, Corson N, Xu L

Oncogenesis.. 2014 July 73 (7):e110. Epub 07/07/2014.

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma.

Scott GA, Laughlin TS, Rothberg PG

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.. 2014 April 27 (4):516-23. Epub 09/13/2013.

Methodology of clinical research in rare diseases: development of a research program in juvenile neuronal ceroid lipofuscinosis (JNCL) via creation of a patient registry and collaboration with patient advocates.

de Blieck EA, Augustine EF, Marshall FJ, Adams H, Cialone J, Dure L, Kwon JM, Newhouse N, Rose K, Rothberg PG, Vierhile A, Mink JW,

Contemporary clinical trials.. 2013 July 35 (2):48-54. Epub 04/26/2013.

Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies.

Xiong Y, Bai Y, Leong N, Laughlin TS, Rothberg PG, Xu H, Nong L, Zhao J, Dong Y, Li T

Diagnostic pathology.. 2013 February 188 :27. Epub 02/18/2013.

Quantifying physical decline in juvenile neuronal ceroid lipofuscinosis (Batten disease).

Kwon JM, Adams H, Rothberg PG, Augustine EF, Marshall FJ, Deblieck EA, Vierhile A, Beck CA, Newhouse NJ, Cialone J, Levy E, Ramirez-Montealegre D, Dure LS, Rose KR, Mink JW

Neurology.. 2011 November 1577 (20):1801-7. Epub 10/19/2011.

Parent-reported benefits of flupirtine in juvenile neuronal ceroid lipofuscinosis (Batten disease; CLN3) are not supported by quantitative data.

Cialone J, Augustine EF, Newhouse N, Adams H, Vierhile A, Marshall FJ, de Blieck EA, Kwon J, Rothberg PG, Mink JW

Journal of inherited metabolic disease.. 2011 October 34 (5):1075-81. Epub 05/10/2011.

Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens.

Spence JM, Rothberg PG, Wang N, Burack WR

The Journal of molecular diagnostics : JMD.. 2011 May 13 (3):252-62. Epub 1900 01 01.

Is the association of "cup-like" nuclei with mutation of the NPM1 gene in acute myeloid leukemia clinically useful?

Bennett JM, Pryor J, Laughlin TS, Rothberg PG, Burack WR

American journal of clinical pathology.. 2010 October 134 (4):648-52. Epub 1900 01 01.

PCR assays detect B-lymphocyte clonality in formalin-fixed, paraffin-embedded specimens of classical hodgkin lymphoma without microdissection.

Burack WR, Laughlin TS, Friedberg JW, Spence JM, Rothberg PG

American journal of clinical pathology.. 2010 July 134 (1):104-11. Epub 1900 01 01.

Detection of exon 12 Mutations in the JAK2 gene: enhanced analytical sensitivity using clamped PCR and nucleotide sequencing.

Laughlin TS, Moliterno AR, Stein BL, Rothberg PG

The Journal of molecular diagnostics : JMD.. 2010 May 12 (3):278-82. Epub 03/04/2010.

Genotyping of hepatitis C virus by sequence analysis of the amplicon from the Roche Cobas AmpliPrep/Cobas TaqMan viral load assay.

Laughlin TS, Nuccie B, Rothberg PG

Journal of clinical microbiology.. 2010 February 48 (2):671-2. Epub 12/02/2009.

Exploratory study of a KLK2 polymorphism as a prognostic marker in prostate cancer.

Kohli M, Rothberg PG, Feng C, Messing E, Joseph J, Rao SS, Hendershot A, Sahsrabudhe D

Cancer biomarkers : section A of Disease markers.. 2010 7 (2):101-8. Epub 1900 01 01.

Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma.

Friedberg JW, Kelly JL, Neuberg D, Peterson DR, Kutok JL, Salloum R, Brenn T, Fisher DC, Ronan E, Dalton V, Rich L, Marquis D, Sims P, Rothberg PG, Liesveld J, Fisher RI, Coffman R, Mosmann T, Freedman AS

British journal of haematology.. 2009 August 146 (3):282-91. Epub 06/10/2009.

Laboratory practice guidelines for detecting and reporting BCR-ABL drug resistance mutations in chronic myelogenous leukemia and acute lymphoblastic leukemia: a report of the Association for Molecular Pathology.

Jones D, Kamel-Reid S, Bahler D, Dong H, Elenitoba-Johnson K, Press R, Quigley N, Rothberg P, Sabath D, Viswanatha D, Weck K, Zehnder J

The Journal of molecular diagnostics : JMD.. 2009 January 11 (1):4-11. Epub 12/18/2008.

Mixed chimerism in SCT: conflict or peaceful coexistence?

Liesveld JL, Rothberg PG

Bone marrow transplantation.. 2008 September 42 (5):297-310. Epub 07/28/2008.

Rapid method for detection of mutations in the nucleophosmin gene in acute myeloid leukemia.

Laughlin TS, Becker MW, Liesveld JL, Mulford DA, Abboud CN, Brown P, Rothberg PG

The Journal of molecular diagnostics : JMD.. 2008 July 10 (4):338-45. Epub 06/13/2008.

A 46 XY phenotypic female adolescent with bilateral gonadal tumors consisting of five different components.

Simon RA, Laughlin TS, Nuccie B, Wang N, Rothberg PG, Wang X

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists.. 2008 July 27 (3):407-11. Epub 1900 01 01.

Detection of clonality in lymphoproliferations using PCR of the antigen receptor genes: does size matter?

Vargas RL, Felgar RE, Rothberg PG

Leukemia research.. 2008 February 32 (2):335-8. Epub 06/22/2007.

Diagnosis of neuronal ceroid lipofuscinosis: mutation detection strategies.

Getty AL, Rothberg PG, Pearce DA

Expert opinion on medical diagnostics.. 2007 November 1 (3):351-62. Epub 1900 01 01.

A case of JAK2 positive essential thrombocythemia 16.5 years after autologous marrow transplantation for AML.

Walker AR, Rothberg PG, Liesveld JL

Bone marrow transplantation.. 2007 June 39 (11):725-6. Epub 04/02/2007.

Homogeneous PCR nucleobase quenching assays to detect four mutations that cause neuronal ceroid lipofuscinosis: T75P and R151X in CLN1, and IVS5-1G>C and R208X in CLN2.

Leman AR, Polochock S, Mole SE, Pearce DA, Rothberg PG

Journal of neuroscience methods.. 2006 October 15157 (1):124-31. Epub 05/23/2006.

Another disorder finds its gene.

Ramirez-Montealegre D, Rothberg PG, Pearce DA

Brain : a journal of neurology.. 2006 June 129 (Pt 6):1353-6. Epub 1900 01 01.

Is there an association between ocular adnexal lymphoma and infection with Chlamydia psittaci? The University of Rochester experience.

Vargas RL, Fallone E, Felgar RE, Friedberg JW, Arbini AA, Andersen AA, Rothberg PG

Leukemia research.. 2006 May 30 (5):547-51. Epub 10/24/2005.

Standardized assessment of behavior and adaptive living skills in juvenile neuronal ceroid lipofuscinosis.

Adams H, de Blieck EA, Mink JW, Marshall FJ, Kwon J, Dure L, Rothberg PG, Ramirez-Montealegre D, Pearce DA

Developmental medicine and child neurology.. 2006 April 48 (4):259-64. Epub 1900 01 01.

Novel CLN3 mutation predicted to cause complete loss of protein function does not modify the classical JNCL phenotype.

Kwon JM, Rothberg PG, Leman AR, Weimer JM, Mink JW, Pearce DA

Neuroscience letters.. 2005 October 21387 (2):111-4. Epub 1900 01 01.

Sequence diversity in the glycoprotein B gene complicates real-time PCR assays for detection and quantification of cytomegalovirus.

Nye MB, Leman AR, Meyer ME, Menegus MA, Rothberg PG

Journal of clinical microbiology.. 2005 October 43 (10):4968-71. Epub 1900 01 01.

A clinical rating scale for Batten disease: reliable and relevant for clinical trials.

Marshall FJ, de Blieck EA, Mink JW, Dure L, Adams H, Messing S, Rothberg PG, Levy E, McDonough T, DeYoung J, Wang M, Ramirez-Montealegre D, Kwon JM, Pearce DA

Neurology.. 2005 July 2665 (2):275-9. Epub 1900 01 01.

Re: Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia.

Vargas RL, Felgar RE, Rothberg PG

Journal of the National Cancer Institute.. 2005 July 2097 (14):1089-90; author reply 1093-5. Epub 1900 01 01.

Gene symbol: CLN3. Disease: Juvenile neuronal ceroid lipofuscinosis (Batten disease).

Leman AR, Pearce DA, Rothberg PG

Human genetics.. 2005 May 116 (6):544. Epub 1900 01 01.

Autoimmunity to glutamic acid decarboxylase in the neurodegenerative disorder Batten disease.

Ramirez-Montealegre D, Chattopadhyay S, Curran TM, Wasserfall C, Pritchard L, Schatz D, Petitto J, Hopkins D, She JX, Rothberg PG, Atkinson M, Pearce DA

Neurology.. 2005 February 2264 (4):743-5. Epub 1900 01 01.

Gene symbol: CLN3. Disease: juvenile neuronal ceroid lipofuscinosis (Batten disease).

Leman AR, Pearce DA, Rothberg PG

Human genetics.. 2005 February 116 (3):236. Epub 1900 01 01.

Homogeneous amplification nucleobase quenching assay to detect the E474Q LCHAD deficiency mutation.

McClaskey JH, Leman AR, Rothberg PG

Genetic testing.. 2005 9 (1):1-5. Epub 1900 01 01.

Liver transplantation for type 1 primary hyperoxaluria as a cure for combined thrombophilia.

Jeong W, Rothberg PG, Delaney V, Facciuto ME, Yalamanchili K, Nelson JC

Thrombosis and haemostasis.. 2004 November 92 (5):1157-8. Epub 1900 01 01.

Homogeneous polymerase chain reaction nucleobase quenching assay to detect the 1-kbp deletion in CLN3 that causes Batten disease.

Rothberg PG, Ramirez-Montealegre D, Frazier SD, Pearce DA

The Journal of molecular diagnostics : JMD.. 2004 August 6 (3):260-3. Epub 1900 01 01.

Imatinib: resisting the resistance.

Rothberg PG

Leukemia research.. 2003 November 27 (11):977-8. Epub 1900 01 01.

Von Hippel-Lindau disease masquerading as autosomal dominant polycystic kidney disease.

Chatha RK, Johnson AM, Rothberg PG, Townsend RR, Neumann HP, Gabow PA

American journal of kidney diseases : the official journal of the National Kidney Foundation.. 2001 April 37 (4):852-8. Epub 1900 01 01.

Is the P25L a "real" VHL mutation?

Rothberg PG, Bradley JF, Baker DW, Huelsman KM

Molecular diagnosis : a journal devoted to the understanding of human

Metabolic pathway for leucovorin.

Rothberg PG

Molecular diagnosis : a journal devoted to the understanding of human

Diagnostic dilemma caused by overlapping features of Prader-Willi syndrome and trisomy 18 during infancy.

Ishmael HA, Pasztor LM, Rothberg PG, Butler MG, Pfotenhauer J, Hannig V, Summar M

The Journal of pediatrics.. 2000 January 136 (1):135-6. Epub 1900 01 01.

Human Gene Mutation. Gene symbol: VHL. Disease: pancreatic cancer.

Bradley, J.F., Lin, E.C., Rothberg, P.G.

Human Genetics. 2000; 106: 671.

Human Gene Mutation. Gene symbol: VHL. Disease: von Hippel-Lindau syndrome. .

Baker, D.W.; Cherches, I.M.; Rothberg, P.G.

Human Genetics. 2000; 106: 671.

Human Gene Mutation. Gene symbol: VHL. Disease: Von Hippel-Lindau syndrome.

Rothberg, P.G.; Baker, D.W.; Wallerstein, R.

Human Genetics. 2000; 107: 533.

Human Gene Mutation. Gene symbol: CYP21A2. Disease: Adrenal Hyperplasia.

Rothberg, P.G.; Schwartz, I.D.; Khalili, D.S.; Bradley, J.F.

Human Genetics. 2000; 107: 536.

Two distinct phenotypes caused by two different missense mutations in the same codon of the VHL gene.

Bradley JF, Collins DL, Schimke RN, Parrott HN, Rothberg PG

American journal of medical genetics.. 1999 November 1987 (2):163-7. Epub 1900 01 01.

Posttransplant lymphoproliferative disorder in pediatric renal transplantation.

Srivastava T, Zwick DL, Rothberg PG, Warady BA

Pediatric nephrology : journal of the International Pediatric Nephrology Association.. 1999 November 13 (9):748-54. Epub 1900 01 01.

Diminished energy metabolism and enhanced apoptosis in livers of B6C3F1 mice treated with the antihepatocarcinogen rotenone.

Wang C, Youssef J, Saran B, Rothberg PG, Cunningham ML, Molteni A, Badr M

Molecular and cellular biochemistry.. 1999 November 201 (1-2):25-32. Epub 1900 01 01.

Cytokine-mediated stimulation of laminin expression and cell-growth arrest in a human submandibular gland duct-cell line (HSG).

Daniels PJ, McArthur CP, Heruth DP, Rothberg PG, Pasztor L, Wang Y

Archives of oral biology.. 1999 July 44 (7):603-15. Epub 1900 01 01.

Processed pseudogene from the von Hippel-Lindau disease gene is located on human chromosome 1

Bradley, J.F.; Rothberg, P.G.;.

DIAGNOSTIC MOLECULAR PATHOLOGY. 1999; 8: 100-106.

Mutation Report for 4 mutations in the VHL gene.

Rothberg, P.G.; Bradley, J.F.

Human Genetics. 1999; 105: 373.

Functioning carotid paraganglioma in the von Hippel-Lindau syndrome.

Schimke RN, Collins DL, Rothberg PG

American journal of medical genetics.. 1998 December 2880 (5):533-4. Epub 1900 01 01.

An Unexpected Product From Polymerase Chain Reaction-Mediated Site-Directed Mutagenesis Due to Misalignment of the Mismatched Primer.

Baker DW, Rothberg PG

Molecular diagnosis : a journal devoted to the understanding of human

The Importance of Heteroduplexes in Interpreting the Results of PCR-RED Diagnostic Assays: Application to the Analysis of Mutations in the Steroid 21-Hydroxylase Gene in a Case of Congenital Adrenal Hyperplasia.

Bradley JF, Baker D, Schwartz ID, Rothberg PG

Molecular diagnosis : a journal devoted to the understanding of human

Simultaneous detection of five mutations in the steroid 21-hydroxylase gene using nested allele-specific amplification.

Rothberg PG, Baker DW, Bradley JF

Genetic testing.. 1998 2 (4):343-6. Epub 1900 01 01.

A deletion polymorphism due to Alu-Alu recombination in intron 2 of the retinoblastoma gene: association with human gliomas.

Rothberg PG, Ponnuru S, Baker D, Bradley JF, Freeman AI, Cibis GW, Harris DJ, Heruth DP

Molecular carcinogenesis.. 1997 June 19 (2):69-73. Epub 1900 01 01.

Use of DNA polymorphisms to monitor engraftment after allogeneic bone marrow transplantation.

Rothberg PG, Gamis AS, Baker D

Clinics in laboratory medicine.. 1997 March 17 (1):109-18. Epub 1900 01 01.

Influence of protein tyrosine phosphorylation on the expression of the c-myc oncogene in cancer of the large bowel.

Heruth DP, Wetmore LA, Leyva A, Rothberg PG

Journal of cellular biochemistry.. 1995 May 58 (1):83-94. Epub 1900 01 01.

A polymorphic variant of human c-Myc: Asn11-->Ser.

Rothberg PG, Otto YM

Mammalian genome : official journal of the International Mammalian Genome Society.. 1995 March 6 (3):209-11. Epub 1900 01 01.

Clonal, nonconstitutional rearrangements of the MLL gene in infant twins with acute lymphoblastic leukemia: in utero chromosome rearrangement of 11q23.

Gill Super HJ, Rothberg PG, Kobayashi H, Freeman AI, Diaz MO, Rowley JD

Blood.. 1994 February 183 (3):641-4. Epub 1900 01 01.

The effects of dystrophin gene mutations on the ERG in mice and humans.

Cibis GW, Fitzgerald KM, Harris DJ, Rothberg PG, Rupani M

Investigative ophthalmology & visual science.. 1993 December 34 (13):3646-52. Epub 1900 01 01.

Sodium butyrate causes an increase in the block to transcriptional elongation in the c-myc gene in SW837 rectal carcinoma cells.

Heruth DP, Zirnstein GW, Bradley JF, Rothberg PG

The Journal of biological chemistry.. 1993 September 25268 (27):20466-72. Epub 1900 01 01.

Hypermutation of the MYC gene in diffuse large cell lymphomas with translocations involving band 8q24.

Bradley JF, Rothberg PG, Ladanyi M, Chaganti RS

Genes, chromosomes & cancer.. 1993 July 7 (3):128-30. Epub 1900 01 01.

Extended electrophoresis resolves the dystrophin gene 5.2-kbp cDMD4-5a/HindIII fragment into two bands.

Otto YM, Rothberg PG

American journal of human genetics.. 1992 December 51 (6):1452-3. Epub 1900 01 01.

Bilateral choroidal neonatal neuroblastoma.

Cibis GW, Freeman AI, Pang V, Roloson GJ, Case WF, Ost M, Huntrakoon M, Rothberg PG

American journal of ophthalmology.. 1990 April 15109 (4):445-9. Epub 1900 01 01.

Altered levels of endogenous retrovirus-like sequence (VL30) RNA during mouse epidermal cell carcinogenesis

Han, K.A.; Rothberg, P.; Kulesz-Martin, M.

Mol. Carcinogenesis. 1990; 3: 75-82.

Somatic mutation and transcriptional deregulation of myc in endemic Burkitt's lymphoma disease: heptamer-nonamer recognition mistakes?

Morse B, South VJ, Rothberg PG, Astrin SM

Molecular and cellular biology.. 1989 January 9 (1):74-82. Epub 1900 01 01.

Evidence for a labile intermediate in the butyrate induced reduction of the level of c-myc RNA in SW837 rectal carcinoma cells.

Herold KM, Rothberg PG

Oncogene.. 1988 October 3 (4):423-8. Epub 1900 01 01.

Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma.

Morse B, Rotherg PG, South VJ, Spandorfer JM, Astrin SM

Nature.. 1988 May 5333 (6168):87-90. Epub 1900 01 01.

The role of the oncogene c-myc in sporadic large bowel cancer and familial polyposis coli.

Rothberg PG

Seminars in surgical oncology.. 1987 3 (3):152-8. Epub 1900 01 01.

Enhanced expression of the c-myc gene in bovine leukemia virus-induced bovine tumors.

Gupta P, Kashmiri SV, Erisman MD, Rothberg PG, Astrin SM, Ferrer JF

Cancer research.. 1986 December 46 (12 Pt 1):6295-8. Epub 1900 01 01.

Evidence that c-myc expression defines two genetically distinct forms of colorectal adenocarcinoma.

Rothberg PG, Spandorfer JM, Erisman MD, Staroscik RN, Sears HF, Petersen RO, Astrin SM

British journal of cancer.. 1985 October 52 (4):629-32. Epub 1900 01 01.

Deregulation of c-myc gene expression in human colon carcinoma is not accompanied by amplification or rearrangement of the gene.

Erisman MD, Rothberg PG, Diehl RE, Morse CC, Spandorfer JM, Astrin SM

Molecular and cellular biology.. 1985 August 5 (8):1969-76. Epub 1900 01 01.

Cellular transformation by avian viruses.

Makowski DR, Rothberg PG, Astrin SM

Pharmacology & therapeutics.. 1985 27 (1):63-97. Epub 1900 01 01.

Structure and expression of the oncogene c-myc in fresh tumor material from patients with hematopoietic malignancies.

Rothberg PG, Erisman MD, Diehl RE, Rovigatti UG, Astrin SM

Molecular and cellular biology.. 1984 June 4 (6):1096-103. Epub 1900 01 01.

The role of promoter insertion in the induction of neoplasia.

Makowski DR, Rothberg PG, Astrin SM

Survey and synthesis of pathology research. 1984 3 (4):342-9. Epub 1900 01 01.

Oncogenes and cancer.

Astrin SM, Rothberg PG

Cancer investigation.. 1983 1 (4):355-64. Epub 1900 01 01.

Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite.

Reitsma PH, Rothberg PG, Astrin SM, Trial J, Bar-Shavit Z, Hall A, Teitelbaum SL, Kahn AJ

Nature.. 1983 306 (5942):492-4. Epub 1900 01 01.

Restriction map of poliovirus type 1 cDNA

Kopecka, H.; van der Werf, S.; Bregegere, F.; Kitamura, N.; Dreano, M.; Rothberg, P.G.; Wimmer, E.; Kourilsky, P.; Girard, M.;.

DEVELOP. BIOL. STANDARDS. 1982; 50: 301-309.

Mononucleotide and dinucleotide frequencies, and codon usage in poliovirion RNA.

Rothberg PG, Wimmer E

Nucleic acids research.. 1981 December 119 (23):6221-9. Epub 1900 01 01.

Molecular cloning of the genome of poliovirus type 1.

van der Werf S, Bregegere F, Kopecka H, Kitamura N, Rothberg PG, Kourilsky P, Wimmer E, Girard M

Proceedings of the National Academy of Sciences of the United States of America.. 1981 October 78 (10):5983-7. Epub 1900 01 01.

The fate of VPg during in vitro translation of poliovirus RNA.

Dorner AJ, Rothberg PG, Wimmer E

FEBS letters.. 1981 September 28132 (2):219-23. Epub 1900 01 01.

Identification of point mutations in the genome of the poliovirus Sabin vaccine LSc 2ab, and catalogue of RNase T1- and RNase A-resistant oligonucleotides of poliovirus type 1 (Mahoney) RNA.

Nomoto A, Kitamura N, Lee JJ, Rothberg PG, Imura N, Wimmer E

Virology.. 1981 July 15112 (1):217-27. Epub 1900 01 01.

Primary structure, gene organization and polypeptide expression of poliovirus RNA.

Kitamura N, Semler BL, Rothberg PG, Larsen GR, Adler CJ, Dorner AJ, Emini EA, Hanecak R, Lee JJ, van der Werf S, Anderson CW, Wimmer E

Nature.. 1981 June 18291 (5816):547-53. Epub 1900 01 01.

Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing.

Semler BL, Anderson CW, Kitamura N, Rothberg PG, Wishart WL, Wimmer E

Proceedings of the National Academy of Sciences of the United States of America.. 1981 June 78 (6):3464-8. Epub 1900 01 01.

Restriction map of poliovirus type 2 cDNA.

Kopecka H, van der Werf S, Bregegere F, Kitamura N, Dreano M, Rothberg PG, Wimmer E, Kourilsky P, Girard M

Developments in biological standardization. 1981 50 :301-9. Epub 1900 01 01.

The genome-linked protein of picornaviruses. VII. Genetic mapping of poliovirus VPg by protein and RNA sequence studies.

Kitamura N, Adler CJ, Rothberg PG, Martinko J, Nathenson SG, Wimmer E

Cell.. 1980 August 21 (1):295-302. Epub 1900 01 01.

O4-(5'-uridylyl)tyrosine is the bond between the genome-linked protein and the RNA of poliovirus.

Rothberg PG, Harris TJ, Nomoto A, Wimmer E

Proceedings of the National Academy of Sciences of the United States of America.. 1978 October 75 (10):4868-72. Epub 1900 01 01.

Books

Clinics in Laboratory Medicine 17 (1997)

Chapter: Use of DNA plymorphisms to monitor engraftment after allogeneic bone marrow transplantation

Advances in Genome Biology (1995)

Chapter: Adventures in MYC-ology

Familial Adenomatous Polyposis (1989)

Chapter: Amplification and activation of the c-myc oncogene in adenocarcinoma of the large bowel.

Mechanisms of Cellular Transformation by Carcinogenic Agents (1985)

Chapter: Cellular transformation by avian viruses

Mechanism of the formation of malignant cells (1983)

Chapter: Involvement of the oncogene c-myc in human leukemia and lymphoma

Metabolic Interconversion of Enzymes (1981)

Chapter: Structure possible function, and biosynthesis of VPg, the genome-linked protein of poliovirus

Biosynthesis, modification, and processing of cellular and viral protein. (1980)

Chapter: VPg: The Genome-linked protein of picornaviruses