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Zheng-Gen Jin, Ph.D.

Zheng-Gen Jin, Ph.D.

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Office (585) 276-7691
Fax (585) 276-9829
Administrative (585) 276-7698

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About Me

Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate th...
Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis in the pathological condition. Normal laminar shear stress, a fractional force generated by blood flow, regulates the activity of endothelial nitric oxide synthase (eNOS) and promotes the expression of genes in endothelial cells that may protect against atherosclerosis. In contrast, oxidant stress caused by over-production of reactive oxygen species plays a major role in impairing vascular functions, by reducing the bioavailability of nitric oxide and stimulating proinflammatory pathways. By understanding the nature of molecular regulation of endothelial function and dysfunction by shear stress and oxidative stress as well as growth factors and cytokines, Dr. Jin's research will help to develop novel therapeutic strategies for preventing atherosclerotic vascular diseases.

The specific ongoing projects in the lab are: 1) to characterize the signaling pathways involved in flow-mediated eNOS activation and anti-inflammatory effect; 2) to identify specific intracellular signaling molecules essential for oxidative stress-induced endothelial dysfunction; 3) to define the molecular mechanisms of endothelial proinflammatory and angiogenetic responses to growth factors and cytokines.

Faculty Appointments

Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)

Credentials

Education

PhD | China - Non-Medical School. Physiology. 1991

BS | China - Non-Medical School. Physics. 1987

Research

Research

* Molecular regulation of vascular endothelial function.

Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only p...
Research

* Molecular regulation of vascular endothelial function.

Dr. Jin's research has been focused on molecular regulation of vascular endothelial function. Vascular endothelial cells in blood vessels produce a number of vasodilator and vasoconstrictor substances that not only physiologically regulate vasomotor tone and vascular homeostasis, but also mediate the recruitment and activity of inflammatory cells and the propensity towards atherosclerotic lesion formation and thrombosis in the pathological condition. Normal laminar shear stress, a fractional force generated by blood flow, regulates the activity of endothelial nitric oxide synthase (eNOS) and promotes the expression of genes in endothelial cells that may protect against atherosclerosis. In contrast, oxidant stress caused by over-production of reactive oxygen species plays a major role in impairing vascular functions, by reducing the bioavailability of nitric oxide and stimulating proinflammatory pathways. By understanding the nature of molecular regulation of endothelial function and dysfunction by shear stress and oxidative stress as well as growth factors and cytokines, Dr. Jin's research will help to develop novel therapeutic strategies for preventing atherosclerotic vascular diseases.

The specific ongoing projects in the lab are: 1) to characterize the signaling pathways involved in flow-mediated eNOS activation and anti-inflammatory effect; 2) to identify specific intracellular signaling molecules essential for oxidative stress-induced endothelial dysfunction; 3) to define the molecular mechanisms of endothelial proinflammatory and angiogenetic responses to growth factors and cytokines.

Publications

Journal Articles

SIRT6 Protects Against Lipopolysaccharide-Induced Inflammation in Human Pulmonary Lung Microvascular Endothelial Cells.

Wang J, Luo J, Rotili D, Mai A, Steegborn C, Xu S, Jin ZG

Inflammation.. 2024 February 47 (1):323-332. Epub 10/11/2023.

Endothelial-specific YY1 governs sprouting angiogenesis through directly interacting with RBPJ.

Zhang S, Kim JY, Xu S, Liu H, Yin M, Koroleva M, Guo J, Pei X, Jin ZG

Proceedings of the National Academy of Sciences of the United States of America.. 2020 March 3117 (9):4792-4801. Epub 02/19/2020.

Regulation of SRF protein stability by an autophagy-dependent pathway.

Luo J, Jin FQ, Yin M, Jin ZG

Biochemical and biophysical research communications.. 2020 January 8521 (2):279-284. Epub 10/23/2019.

The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis.

Xu S, Xu Y, Liu P, Zhang S, Liu H, Slavin S, Kumar S, Koroleva M, Luo J, Wu X, Rahman A, Pelisek J, Jo H, Si S, Miller CL, Jin ZG

European heart journal.. 2019 August 140 (29):2398-2408. Epub 1900 01 01.

Hutchinson-Gilford Progeria Syndrome: Cardiovascular Pathologies and Potential Therapies.

Xu S, Jin ZG

Trends in biochemical sciences.. 2019 July 44 (7):561-564. Epub 04/26/2019.

Myofibroblast-specific YY1 promotes liver fibrosis.

Liu H, Zhang S, Xu S, Koroleva M, Small EM, Jin ZG

Biochemical and biophysical research communications.. 2019 June 30514 (3):913-918. Epub 05/10/2019.

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics.

Xu S, Kamato D, Little PJ, Nakagawa S, Pelisek J, Jin ZG

Pharmacology & therapeutics.. 2019 April 196 :15-43. Epub 11/13/2018.

Targeting Mechanosensitive Transcription Factors in Atherosclerosis.

Niu N, Xu S, Xu Y, Little PJ, Jin ZG

Trends in pharmacological sciences.. 2019 April 40 (4):253-266. Epub 02/28/2019.

stabilizes vascular endothelial cell adherens junctions through interaction with CKAP4.

Lyu Q, Xu S, Lyu Y, Choi M, Christie CK, Slivano OJ, Rahman A, Jin ZG, Long X, Xu Y, Miano JM

Proceedings of the National Academy of Sciences of the United States of America.. 2019 January 8116 (2):546-555. Epub 12/24/2018.

Atherosclerosis Is an Epigenetic Disease.

Xu S, Pelisek J, Jin ZG

Trends in endocrinology and metabolism : TEM.. 2018 November 29 (11):739-742. Epub 05/10/2018.

Expression, regulation and function of miR-126 in the mouse choroid vasculature.

Zhao F, Anderson C, Karnes S, Zhou Q, Ma J, Jin ZG, Bhattacharjee PS, Wang S

Experimental eye research.. 2018 May 170 :169-176. Epub 03/01/2018.

Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects.

Xu S, Xu Y, Yin M, Zhang S, Liu P, Koroleva M, Si S, Little PJ, Pelisek J, Jin ZG

Theranostics.. 2018 8 (11):3007-3021. Epub 04/30/2018.

Suberanilohydroxamic Acid as a Pharmacological Kruppel-Like Factor 2 Activator That Represses Vascular Inflammation and Atherosclerosis.

Xu Y, Xu S, Liu P, Koroleva M, Zhang S, Si S, Jin ZG

Journal of the American Heart Association.. 2017 November 306 (12)Epub 11/30/2017.

Tannic acid as a plant-derived polyphenol exerts vasoprotection via enhancing KLF2 expression in endothelial cells.

Xu Y, Liu P, Xu S, Koroleva M, Zhang S, Si S, Jin ZG

Scientific reports.. 2017 July 277 (1):6686. Epub 07/27/2017.

Loss of LMOD1 impairs smooth muscle cytocontractility and causes megacystis microcolon intestinal hypoperistalsis syndrome in humans and mice.

Halim D, Wilson MP, Oliver D, Brosens E, Verheij JB, Han Y, Nanda V, Lyu Q, Doukas M, Stoop H, Brouwer RW, van IJcken WF, Slivano OJ, Burns AJ, Christie CK, de Mesy Bentley KL, Brooks AS, Tibboel D, Xu S, Jin ZG, Djuwantono T, Yan W, Alves MM, Hofstra RM, Miano JM

Proceedings of the National Academy of Sciences of the United States of America.. 2017 March 28114 (13):E2739-E2747. Epub 03/14/2017.

Cleavage of Grb2-Associated Binding Protein 2 by Viral Proteinase 2A during Infection.

Deng H, Fung G, Qiu Y, Wang C, Zhang J, Jin ZG, Luo H

Frontiers in cellular and infection microbiology.. 2017 7 :85. Epub 03/16/2017.

Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells.

Xu S, Koroleva M, Yin M, Jin ZG

Translational research : the journal of laboratory and clinical medicine.. 2016 October 176 :18-28.e2. Epub 05/26/2016.

Sirtuins in Cardiovascular Health and Diseases.

Xu S, Bai P, Jin ZG

Trends in endocrinology and metabolism : TEM.. 2016 October 27 (10):677-678. Epub 07/22/2016.

A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.

Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, Morrell CN, Zhang DX, Fisher EA, Jin ZG

Oncotarget.. 2016 June 217 (25):37622-37635. Epub 1900 01 01.

SIRT6 protects against endothelial dysfunction and atherosclerosis in mice.

Xu S, Yin M, Koroleva M, Mastrangelo MA, Zhang W, Bai P, Little PJ, Jin ZG

Aging.. 2016 May 8 (5):1064-82. Epub 1900 01 01.

PECAM1 regulates flow-mediated Gab1 tyrosine phosphorylation and signaling.

Xu S, Ha CH, Wang W, Xu X, Yin M, Jin FQ, Mastrangelo M, Koroleva M, Fujiwara K, Jin ZG

Cellular signalling.. 2016 March 28 (3):117-124. Epub 12/17/2015.

Cryptotanshinone, an orally bioactive herbal compound from Danshen, attenuates atherosclerosis in apolipoprotein E-deficient mice: role of lectin-like oxidized LDL receptor-1 (LOX-1).

Liu Z, Xu S, Huang X, Wang J, Gao S, Li H, Zhou C, Ye J, Chen S, Jin ZG, Liu P

British journal of pharmacology.. 2015 December 172 (23):5661-75. Epub 02/27/2015.

Enhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1.

Deng H, Fung G, Shi J, Xu S, Wang C, Yin M, Hou J, Zhang J, Jin ZG, Luo H

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2015 November 29 (11):4523-31. Epub 07/16/2015.

Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis.

Wang W, Xu S, Yin M, Jin ZG

International journal of cardiology.. 2015 February 15181 :180-4. Epub 10/24/2014.

Histone deacetylase 5 interacts with Krüppel-like factor 2 and inhibits its transcriptional activity in endothelium.

Kwon IS, Wang W, Xu S, Jin ZG

Cardiovascular research.. 2014 October 1104 (1):127-37. Epub 08/05/2014.

Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG

Circulation research.. 2012 January 6110 (1):59-70. Epub 11/10/2011.

Endothelial Grb2-associated binder 1 is crucial for postnatal angiogenesis.

Zhao J, Wang W, Ha CH, Kim JY, Wong C, Redmond EM, Hamik A, Jain MK, Feng GS, Jin ZG

Arteriosclerosis, thrombosis, and vascular biology.. 2011 May 31 (5):1016-23. Epub 03/03/2011.

PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.

Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG

Proceedings of the National Academy of Sciences of the United States of America.. 2010 August 31107 (35):15467-72. Epub 08/17/2010.

Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells.

Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I

Antioxidants & redox signaling.. 2010 June 1512 (12):1355-69. Epub 1900 01 01.

Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS.

Wang W, Ha CH, Jhun BS, Wong C, Jain MK, Jin ZG

Blood.. 2010 April 8115 (14):2971-9. Epub 12/30/2009.

Protein kinase D1, a new molecular player in VEGF signaling and angiogenesis.

Ha CH, Jin ZG

Molecules and cells.. 2009 July 3128 (1):1-5. Epub 07/20/2009.

VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis.

Ha CH, Jhun BS, Kao HY, Jin ZG

Arteriosclerosis, thrombosis, and vascular biology.. 2008 October 28 (10):1782-8. Epub 07/10/2008.

Molecular mechanisms of ghrelin-mediated endothelial nitric oxide synthase activation.

Xu X, Jhun BS, Ha CH, Jin ZG

Endocrinology.. 2008 August 149 (8):4183-92. Epub 05/01/2008.

VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction.

Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2008 July 22 (7):2297-310. Epub 02/08/2008.

Cyclophilin A mediates vascular remodeling by promoting inflammation and vascular smooth muscle cell proliferation.

Satoh K, Matoba T, Suzuki J, O'Dell MR, Nigro P, Cui Z, Mohan A, Pan S, Li L, Jin ZG, Yan C, Abe J, Berk BC

Circulation.. 2008 June 17117 (24):3088-98. Epub 06/09/2008.

Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis.

Ha CH, Wang W, Jhun BS, Wong C, Hausser A, Pfizenmaier K, McKinsey TA, Olson EN, Jin ZG

The Journal of biological chemistry.. 2008 May 23283 (21):14590-9. Epub 03/10/2008.

VEGF-C, a lymphatic growth factor, is a RANKL target gene in osteoclasts that enhances osteoclastic bone resorption through an autocrine mechanism.

Zhang Q, Guo R, Lu Y, Zhao L, Zhou Q, Schwarz EM, Huang J, Chen D, Jin ZG, Boyce BF, Xing L

The Journal of biological chemistry.. 2008 May 9283 (19):13491-9. Epub 03/20/2008.

A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor.

Ha CH, Bennett AM, Jin ZG

The Journal of biological chemistry.. 2008 March 14283 (11):7261-70. Epub 01/07/2008.

"VEGF Stimulates HDAC7 Phosphorylation and Cytoplasmic Accumulation Modulating Matrix Metalloproteinase Expression and Angiongenesis."

Ha, C.H., Jhun, B.S., Kao, H.Y., Jin, Z.G.

Arterioscler Thromb Vasc Biol. 2008; .

Angiotensin II stimulates protein kinase D-dependent histone deacetylase 5 phosphorylation and nuclear export leading to vascular smooth muscle cell hypertrophy.

Xu X, Ha CH, Wong C, Wang W, Hausser A, Pfizenmaier K, Olson EN, McKinsey TA, Jin ZG

Arteriosclerosis, thrombosis, and vascular biology.. 2007 November 27 (11):2355-62. Epub 09/06/2007.

Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.

Suzuki J, Jin ZG, Meoli DF, Matoba T, Berk BC

Circulation research.. 2006 March 3198 (6):811-7. Epub 03/09/2006.