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Gisela Beutner, Ph.D.

Gisela Beutner, Ph.D.

Contact

Office (585) 275-3210

About Me

Faculty Appointments

Research Associate Professor - Department of Pediatrics, Cardiology (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral fellow at University of Rochester Department of Pharmacology and Physiology 1998 - 2002

Education

PhD | Germany-University of Konstanz. Biology. 1997

Diploma | Germany - University of Osnabrück. Biology. 1993

Awards

Young Investigator Award. 2001

Travel Award. 1996

Research

My primary research interest is energy generation in the heart, both physiologically and pathologically. Energy in form of ATP is made by mitochondria and necessary to keep the heart working and even apoptotic cell death requires energy. My special research interest is the mitochondrial permeability...
My primary research interest is energy generation in the heart, both physiologically and pathologically. Energy in form of ATP is made by mitochondria and necessary to keep the heart working and even apoptotic cell death requires energy. My special research interest is the mitochondrial permeability transition pore. Although a variety of mitochondrial proteins have been hypothesized to constitute the pore, the structural components are still not identified. It is well established that opening of the permeability transition pore will lead to apoptotic cell death. However, the physiological role of this pore is much less understood. My research will focus on the identification of the components of the permeability transition pore and how this pore is regulated during cardiac development. Experimental models of my research will include isolate mitochondria from the heart, primary cultured cardiac myocytes and in vivo models like transgenic mice.

Patents

Low Intensity Magnetic Field Devices For Treatment of Cardiac and Neurological Disorders

Issue date: January 23, 2018

Publications

Journal Articles

Physiological roles of the mitochondrial permeability transition pore.

Mnatsakanyan N, Beutner G, Porter GA, Alavian KN, Jonas EA

Journal of bioenergetics and biomembranes.. 2017 February 49 (1):13-25. Epub 02/11/2016.

The Mitochondrial Permeability Transition Pore and ATP Synthase.

Beutner G, Kambiz AN, Jonas EA, Porter GA

Handbook of experimental pharmacology.. 2017 240 :21-46. Epub 1900 01 01.

Induction of Expression of p75 Neurotrophin Receptor Intracellular Domain Does Not Induce Expression or Enhance Activity of Mitochondrial Complex II.

Yang YP, Lotta L, Beutner G, Li X, Schor NF

Oxidative medicine and cellular longevity.. 2016 2016 :8752821. Epub 11/10/2015.

Cell death disguised: The mitochondrial permeability transition pore as the c-subunit of the F(1)F(O) ATP synthase.

Jonas EA, Porter GA, Beutner G, Mnatsakanyan N, Alavian KN

Pharmacological research.. 2015 September 99 :382-92. Epub 05/05/2015.

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore.

Alavian KN, Beutner G, Lazrove E, Sacchetti S, Park HA, Licznerski P, Li H, Nabili P, Hockensmith K, Graham M, Porter GA, Jonas EA

Proceedings of the National Academy of Sciences of the United States of America.. 2014 July 22111 (29):10580-5. Epub 06/16/2014.

Molecular and functional identification of a mitochondrial ryanodine receptor in neurons.

Jakob R, Beutner G, Sharma VK, Duan Y, Gross RA, Hurst S, Jhun BS, O-Uchi J, Sheu SS

Neuroscience letters.. 2014 July 11575 :7-12. Epub 05/23/2014.

Initiation of electron transport chain activity in the embryonic heart coincides with the activation of mitochondrial complex 1 and the formation of supercomplexes.

Beutner G, Eliseev RA, Porter GA

PloS one.. 2014 9 (11):e113330. Epub 11/26/2014.

ADP protects cardiac mitochondria under severe oxidative stress.

Sokolova N, Pan S, Provazza S, Beutner G, Vendelin M, Birkedal R, Sheu SS

PloS one.. 2013 8 (12):e83214. Epub 12/13/2013.

Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts.

Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS

The Journal of biological chemistry.. 2011 June 17286 (24):21324-9. Epub 04/27/2011.

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels.

Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS

FEBS letters.. 2010 May 17584 (10):1948-55. Epub 01/21/2010.

Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity.

Kalifa L, Beutner G, Phadnis N, Sheu SS, Sia EA

DNA repair.. 2009 October 28 (10):1242-9. Epub 08/21/2009.

The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile.

Altschafl BA, Beutner G, Sharma VK, Sheu SS, Valdivia HH

Biochimica et biophysica acta.. 2007 July 1768 (7):1784-95. Epub 04/19/2007.

Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling.

Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, Sheu SS

Biochimica et biophysica acta.. 2005 November 101717 (1):1-10. Epub 10/11/2005.

Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation.

Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS

Journal of neurochemistry.. 2002 February 80 (3):531-8. Epub 1900 01 01.

Identification of a ryanodine receptor in rat heart mitochondria.

Beutner G, Sharma VK, Giovannucci DR, Yule DI, Sheu SS

The Journal of biological chemistry.. 2001 June 15276 (24):21482-8. Epub 04/10/2001.

The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins.

Marzo I, Brenner C, Zamzami N, Susin SA, Beutner G, Brdiczka D, Rémy R, Xie ZH, Reed JC, Kroemer G

The Journal of experimental medicine.. 1998 April 20187 (8):1261-71. Epub 1900 01 01.

Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases.

Beutner G, Rück A, Riede B, Brdiczka D

Biochimica et biophysica acta.. 1998 January 51368 (1):7-18. Epub 1900 01 01.

The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition.

Brdiczka D, Beutner G, Rück A, Dolder M, Wallimann T

BioFactors.. 1998 8 (3-4):235-42. Epub 1900 01 01.

The role of creatine kinase in inhibition of mitochondrial permeability transition.

O'Gorman E, Beutner G, Dolder M, Koretsky AP, Brdiczka D, Wallimann T

FEBS letters.. 1997 September 8414 (2):253-7. Epub 1900 01 01.

Complexes between hexokinase, mitochondrial porin and adenylate translocator in brain: regulation of hexokinase, oxidative phosphorylation and permeability transition pore.

Beutner G, Rück A, Riede B, Brdiczka D

Biochemical Society transactions.. 1997 February 25 (1):151-7. Epub 1900 01 01.

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore.

Beutner G, Ruck A, Riede B, Welte W, Brdiczka D

FEBS letters.. 1996 November 4396 (2-3):189-95. Epub 1900 01 01.

Differential effects of creatine depletion on the regulation of enzyme activities and on creatine-stimulated mitochondrial respiration in skeletal muscle, heart, and brain.

O'Gorman E, Beutner G, Wallimann T, Brdiczka D

Biochimica et biophysica acta.. 1996 September 121276 (2):161-70. Epub 1900 01 01.