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Coeli M. Lopes, Ph.D.

Coeli M. Lopes, Ph.D.

Contact

Office (585) 276-7692

About Me

EDUCATION

BS: PUC-Rio, Brazil; Physics (1989)
MS: PUC-Rio, Brazil; Biophysics (1992)
PhD: Imperial College, UK; Biophysics (1997)
Postdoctoral Fellow - Yale University - Department of Physiology (1997-2000)
Postdoctoral Fellow - Mount Sinai School of Medicine - Department of Physi...
EDUCATION

BS: PUC-Rio, Brazil; Physics (1989)
MS: PUC-Rio, Brazil; Biophysics (1992)
PhD: Imperial College, UK; Biophysics (1997)
Postdoctoral Fellow - Yale University - Department of Physiology (1997-2000)
Postdoctoral Fellow - Mount Sinai School of Medicine - Department of Physiology and Biophysics (2000-2003)

APPOINTMENTS
2003-2004: Instructor - Mount Sinai School of Medicine - Department of Physiology and Biophysics
2004-2012: Assistant Professor - University of Rochester - Department of medicine - Cardiovascular Research Institute
2013-now: Associate Professor (Research) - University of Rochester - Department of medicine - Cardiovascular Research Institute

Faculty Appointments

Adjunct Associate Professor - Department of Medicine, Aab Cardiovascular Research Institute (SMD)

Credentials

Education

PhD | Imperial College. Biophysics. 1997

MS | Brazil-Pontificia Universidade Catolica. Physics. 1992

BS | Brazil-Pontificia Universidade Catolica. Physics. 1989

Awards

NIH reviewer ESTA Study Section. 2013

AHA reviewer - Cardiac Electrophysiology Study Section. 2012

Scientist Development Grant. 2004

Postdoctoral Fellowship American Heart Association. 2002 - 2004

New York City Board Fellow Award American Heart Association. 2002

PhD Scholarship Federal Agency for Post-Graduate Education (CAPES- Brazil). 1992 - 1996

Graduate Student Scholarship National Research Council (CNPq Brazil). 1990 - 1992

Outstanding Basic Science Student Award PUC-Rio. 1987

Full Merit University Scholarship PUC-Rio. 1986 - 1989

Outstanding Basic Science Student Award PUC-Rio. 1986

Research

We are interested in understanding the regulation of ion channels by diverse G-protein signaling pathways in normal and pathological states.

One major focus of our current work involves the changes in function and regulation of cardiac ion channels that lead to the pathogenesis of the Long Q...
We are interested in understanding the regulation of ion channels by diverse G-protein signaling pathways in normal and pathological states.

One major focus of our current work involves the changes in function and regulation of cardiac ion channels that lead to the pathogenesis of the Long QT syndrome. Our work attempts to translate channel function and dysregulation at the cellular level to patient clinical phenotype and response to treatment.

A second focus of our current research is the study of the pathological remodeling of the slow delayed rectifier-like current (IKs) in heart failure. KCNQ1 is co-assembled with the KCNE1 gene product in the heart to produce IKs, which is one of the main currents responsible for myocyte repolarization. The most commonly inherited cardiac arrhythmia, long-QT1 (LQT1), is due to mutations in the KCNQ1 potassium channel. Heart disease is also known to decrease IKs currents. Our current research focus on stress signals caused by chronic stimulation of kinase signaling pathways, and their consequence for ion channel function and membrane trafficking. We explore possible novel antiarrhythmic treatments to reverse IKs pathological remodeling during heart failure.

Publications

Journal Articles

PKC?II specifically regulates KCNQ1/KCNE1 channel membrane localization.

Braun C, Parks XX, Qudsi H, Lopes CM

Journal of molecular and cellular cardiology.. 2020 January 138 :283-290. Epub 11/27/2019.

Statin-specific inhibition of Rab-GTPase regulates cPKC-mediated IKs internalization.

Ronzier E, Parks XX, Qudsi H, Lopes CM

Scientific reports.. 2019 November 289 (1):17747. Epub 11/28/2019.

Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic Ca-dependent PKC activation.

Lopes CM, O-Uchi J, Ronzier E, Parks XX

Journal of molecular and cellular cardiology.. 2019 April 129 :314-325. Epub 03/18/2019.

Impact of Outpatient vs Inpatient ABSSSI Treatment on Outcomes: A Retrospective Observational Analysis of Medical Charts Across US Emergency Departments.

Bookstaver PB, Jenkins TC, Stenehjem E, Doron S, Brown J, Goldwater SH, Lopes C, Haynes A, Udeze C, Mo Y, Gillard P, Liu Y, Keyloun K

Open forum infectious diseases.. 2018 July 5 (7):ofy109. Epub 05/15/2018.

Clinical aspects of the three major genetic forms of long QT syndrome (LQT1, LQT2, LQT3).

Kutyifa V, Daimee U, McNitt S, Polonsky B, Lowenstein C, Cutter K, Lopes C, Zareba W, Moss AJ

Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.. 2018 May 23 (3):e12537. Epub 03/05/2018.

Loss-of-Function Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?

Roberts JD, Krahn AD, Ackerman MJ, Rohatgi RK, Moss AJ, Nazer B, Tadros R, Gerull B, Sanatani S, Wijeyeratne YD, Baruteau AE, Muir AR, Pang B, Cadrin-Tourigny J, Talajic M, Rivard L, Tester DJ, Liu T, Whitman IR, Wojciak J, Conacher S, Gula LJ, Leong-Sit P, Manlucu J, Green MS, Hamilton R, Healey JS, Lopes CM, Behr ER, Wilde AA, Gollob MH, Scheinman MM

Circulation. Arrhythmia and electrophysiology.. 2017 August 10 (8)Epub 1900 01 01.

Clinical Aspects of Type 3 Long-QT Syndrome: An International Multicenter Study.

Wilde AA, Moss AJ, Kaufman ES, Shimizu W, Peterson DR, Benhorin J, Lopes C, Towbin JA, Spazzolini C, Crotti L, Zareba W, Goldenberg I, Kanters JK, Robinson JL, Qi M, Hofman N, Tester DJ, Bezzina C, Alders M, Aiba T, Kamakura S, Miyamoto Y, Andrews ML, McNitt S, Polonsky B, Schwartz PJ, Ackerman MJ

Circulation.. 2016 September 20134 (12):872-82. Epub 08/26/2016.

Stop-codon and C-terminal nonsense mutations are associated with a lower risk of cardiac events in patients with long QT syndrome type 1.

Ruwald MH, Parks XX, Moss AJ, Zareba W, Baman J, McNitt S, Kanters JK, Shimizu W, Wilde AA, Jons C, Lopes CM

Heart rhythm.. 2016 January 13 (1):122-31. Epub 08/28/2015.

Isoform-specific dynamic translocation of PKC by ?1-adrenoceptor stimulation in live cells.

O-Uchi J, Sorenson J, Jhun BS, Mishra J, Hurst S, Williams K, Sheu SS, Lopes CM

Biochemical and biophysical research communications.. 2015 September 25465 (3):464-70. Epub 08/12/2015.

Impaired IKs channel activation by Ca(2+)-dependent PKC shows correlation with emotion/arousal-triggered events in LQT1.

O-Uchi J, Rice JJ, Ruwald MH, Parks XX, Ronzier E, Moss AJ, Zareba W, Lopes CM

Journal of molecular and cellular cardiology.. 2015 February 79 :203-11. Epub 12/02/2014.

Prognostic implications of mutation-specific QTc standard deviation in congenital long QT syndrome.

Mathias A, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Qi M, Shimizu W, Towbin JA, Michael Vincent G, Wilde AA, Zhang L, Goldenberg I

Heart rhythm.. 2013 May 10 (5):720-5. Epub 01/29/2013.

Risk of life-threatening cardiac events among patients with long QT syndrome and multiple mutations.

Mullally J, Goldenberg I, Moss AJ, Lopes CM, Ackerman MJ, Zareba W, McNitt S, Robinson JL, Benhorin J, Kaufman ES, Towbin JA, Barsheshet A

Heart rhythm.. 2013 March 10 (3):378-82. Epub 11/19/2012.

In silico cardiac risk assessment in patients with long QT syndrome: type 1: clinical predictability of cardiac models.

Hoefen R, Reumann M, Goldenberg I, Moss AJ, O-Uchi J, Gu Y, McNitt S, Zareba W, Jons C, Kanters JK, Platonov PG, Shimizu W, Wilde AA, Rice JJ, Lopes CM

Journal of the American College of Cardiology.. 2012 November 2060 (21):2182-91. Epub 1900 01 01.

Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome.

Costa J, Lopes CM, Barsheshet A, Moss AJ, Migdalovich D, Ouellet G, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I

Heart rhythm.. 2012 June 9 (6):892-8. Epub 01/28/2012.

Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: implications for mutation-specific response to ?-blocker therapy in type 1 long-QT syndrome.

Barsheshet A, Goldenberg I, O-Uchi J, Moss AJ, Jons C, Shimizu W, Wilde AA, McNitt S, Peterson DR, Zareba W, Robinson JL, Ackerman MJ, Cypress M, Gray DA, Hofman N, Kanters JK, Kaufman ES, Platonov PG, Qi M, Towbin JA, Vincent GM, Lopes CM

Circulation.. 2012 April 24125 (16):1988-96. Epub 03/28/2012.

Genotype- and Sex-Specific QT-RR Relationship in the Type-1 Long-QT Syndrome.

Couderc JP, Xia X, Denjoy I, Extramiana F, Maison-Blanche P, Moss AJ, Zareba W, Lopes CM

Journal of the American Heart Association.. 2012 April 1 (2):e000570. Epub 04/24/2012.

Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1.

Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG

Circulation research.. 2012 January 6110 (1):59-70. Epub 11/10/2011.

Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome.

Goldenberg I, Thottathil P, Lopes CM, Moss AJ, McNitt S, O-Uchi J, Robinson JL, Zareba W, Ackerman MJ, Kaufman ES, Towbin JA, Vincent M, Barsheshet A

Heart rhythm.. 2012 January 9 (1):49-56. Epub 08/24/2011.

Mutation and gender-specific risk in type 2 long QT syndrome: implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome.

Migdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I

Heart rhythm.. 2011 October 8 (10):1537-43. Epub 03/25/2011.

Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation.

Barsheshet A, Moss AJ, McNitt S, Polonsky S, Lopes CM, Zareba W, Robinson JL, Ackerman MJ, Benhorin J, Kaufman ES, Towbin JA, Vincent GM, Qi M, Goldenberg I

Circulation. Cardiovascular genetics.. 2011 October 4 (5):491-9. Epub 08/10/2011.

Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients.

Jons C, O-Uchi J, Moss AJ, Reumann M, Rice JJ, Goldenberg I, Zareba W, Wilde AA, Shimizu W, Kanters JK, McNitt S, Hofman N, Robinson JL, Lopes CM

Science translational medicine.. 2011 March 303 (76):76ra28. Epub 1900 01 01.

Ion channel mechanisms related to sudden cardiac death in phenotype-negative long-QT syndrome genotype-phenotype correlations of the KCNQ1(S349W) mutation.

Horr S, Goldenberg I, Moss AJ, O-Uchi J, Barsheshet A, Connelly H, Gray DA, Zareba W, Lopes CM

Journal of cardiovascular electrophysiology.. 2011 February 22 (2):193-200. Epub 1900 01 01.

Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals.

Goldenberg I, Horr S, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Platonov PG, Priori SG, Qi M, Schwartz PJ, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Zhang L

Journal of the American College of Cardiology.. 2011 January 457 (1):51-9. Epub 1900 01 01.

Trigger-specific risk factors and response to therapy in long QT syndrome type 2.

Kim JA, Lopes CM, Moss AJ, McNitt S, Barsheshet A, Robinson JL, Zareba W, Ackerman MJ, Kaufman ES, Towbin JA, Vincent M, Goldenberg I

Heart rhythm.. 2010 December 7 (12):1797-805. Epub 09/17/2010.

Molecular basis of decreased Kir4.1 function in SeSAME/EAST syndrome.

Williams DM, Lopes CM, Rosenhouse-Dantsker A, Connelly HL, Matavel A, O-Uchi J, McBeath E, Gray DA

Journal of the American Society of Nephrology : JASN.. 2010 December 21 (12):2117-29. Epub 11/18/2010.

Combined blockade of ?- and ??-adrenoceptors in left ventricular remodeling induced by hypertension: beneficial or not?

O-Uchi J, Lopes CM

Hypertension research : official journal of the Japanese Society of Hypertension.. 2010 October 33 (10):984-5. Epub 08/19/2010.

Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure.

Casey LM, Pistner AR, Belmonte SL, Migdalovich D, Stolpnik O, Nwakanma FE, Vorobiof G, Dunaevsky O, Matavel A, Lopes CM, Smrcka AV, Blaxall BC

Circulation research.. 2010 August 20107 (4):532-9. Epub 06/24/2010.

A novel mitochondrial K(ATP) channel assay.

Wojtovich AP, Williams DM, Karcz MK, Lopes CM, Gray DA, Nehrke KW, Brookes PS

Circulation research.. 2010 April 16106 (7):1190-6. Epub 02/25/2010.

PKA and PKC partially rescue long QT type 1 phenotype by restoring channel-PIP2 interactions.

Matavel A, Medei E, Lopes CM

Channels.. 2010 4 (1):3-11. Epub 01/05/2010.

Short and long QT syndromes: does QT length really matter?

Couderc JP, Lopes CM

Journal of electrocardiology.. 2010 43 (5):396-9. Epub 1900 01 01.

Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome.

Jons C, Moss AJ, Lopes CM, McNitt S, Zareba W, Goldenberg I, Qi M, Wilde AA, Shimizu W, Kanters JK, Towbin JA, Ackerman MJ, Robinson JL

Journal of cardiovascular electrophysiology.. 2009 August 20 (8):859-65. Epub 03/13/2009.

PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.

Matavel A, Lopes CM

Journal of molecular and cellular cardiology.. 2009 May 46 (5):704-12. Epub 02/20/2009.

Protein kinase A modulates PLC-dependent regulation and PIP2-sensitivity of K+ channels.

Lopes CM, Remon JI, Matavel A, Sui JL, Keselman I, Medei E, Shen Y, Rosenhouse-Dantsker A, Rohacs T, Logothetis DE

Channels.. 2007 1 (2):124-34. Epub 04/23/2007.

PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain.

Rohács T, Lopes CM, Michailidis I, Logothetis DE

Nature neuroscience.. 2005 May 8 (5):626-34. Epub 04/24/2005.

PIP2 hydrolysis underlies agonist-induced inhibition and regulates voltage gating of two-pore domain K+ channels.

Lopes CM, Rohács T, Czirják G, Balla T, Enyedi P, Logothetis DE

The Journal of physiology.. 2005 April 1564 (Pt 1):117-29. Epub 01/27/2005.

Characteristic interactions with phosphatidylinositol 4,5-bisphosphate determine regulation of kir channels by diverse modulators.

Du X, Zhang H, Lopes C, Mirshahi T, Rohacs T, Logothetis DE

The Journal of biological chemistry.. 2004 September 3279 (36):37271-81. Epub 05/20/2004.

Sorcin regulates excitation-contraction coupling in the heart.

Meyers MB, Fischer A, Sun YJ, Lopes CM, Rohacs T, Nakamura TY, Zhou YY, Lee PC, Altschuld RA, McCune SA, Coetzee WA, Fishman GI

The Journal of biological chemistry.. 2003 August 1278 (31):28865-71. Epub 05/16/2003.

PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.

Zhang H, Craciun LC, Mirshahi T, Rohács T, Lopes CM, Jin T, Logothetis DE

Neuron.. 2003 March 2737 (6):963-75. Epub 1900 01 01.

Specificity of activation by phosphoinositides determines lipid regulation of Kir channels.

Rohács T, Lopes CM, Jin T, Ramdya PP, Molnár Z, Logothetis DE

Proceedings of the National Academy of Sciences of the United States of America.. 2003 January 21100 (2):745-50. Epub 01/13/2003.

Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies.

Lopes CM, Zhang H, Rohacs T, Jin T, Yang J, Logothetis DE

Neuron.. 2002 June 1334 (6):933-44. Epub 1900 01 01.

Assaying phosphatidylinositol bisphosphate regulation of potassium channels.

Rohács T, Lopes C, Mirshahi T, Jin T, Zhang H, Logothetis DE

Methods in enzymology.. 2002 345 :71-92. Epub 1900 01 01.

Block of Kcnk3 by protons. Evidence that 2-P-domain potassium channel subunits function as homodimers.

Lopes CM, Zilberberg N, Goldstein SA

The Journal of biological chemistry.. 2001 July 6276 (27):24449-52. Epub 05/17/2001.

Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3.

Lopes CM, Gallagher PG, Buck ME, Butler MH, Goldstein SA

The Journal of biological chemistry.. 2000 June 2275 (22):16969-78. Epub 1900 01 01.

Actions of general anaesthetics and arachidonic pathway inhibitors on K+ currents activated by volatile anaesthetics and FMRFamide in molluscan neurones.

Lopes CM, Franks NP, Lieb WR

British journal of pharmacology.. 1998 September 125 (2):309-18. Epub 1900 01 01.

The effects of n-alkanols on the lipid/protein interface of Ca(2+)-ATPase of sarcoplasmic reticulum vesicles.

Lopes CM, Louro SR

Biochimica et biophysica acta.. 1991 December 91070 (2):467-73. Epub 1900 01 01.

pH-dependent phase transition of chlorpromazine micellar solutions in the physiological range.

Wajnberg E, Tabak M, Nussenzveig PA, Lopes CM, Louro SR

Biochimica et biophysica acta.. 1988 October 6944 (2):185-90. Epub 1900 01 01.

Books

The molecular genetics of cardiac electrophysiology (2000)

Chapter: Single cell electrophysiology and ion channelopathies

Authors: C.M. Lopes, Goldstein S.A., Apkon M.

Publisher: Kluwer Academic Publishers 2000