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Roman A. Eliseev, M.D., Ph.D.

Roman A. Eliseev, M.D., Ph.D.

Contact

Office (585) 276-3396
Fax (585) 275-1121
Administrative (585) 273-5635

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About Me

Faculty Appointments

Associate Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Associate Professor - Department of Pathology and Laboratory Medicine (SMD) - Joint

Associate Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Center for Musculoskeletal Research 2003 - 2005

Education

PhD | Univ Rochester Sch Med/Dent. Biochemistry. 2002

MS | University of Rochester School of Medicine. 1999

MD | Russia-Russian State Medical Univ. Medicine. 1995

Undergraduate/Medical | Russian State Medical University (RSMU). 0

Graduate | University of Rochester School of Medicine. 0

Awards

CTSI KL2 Career Award. 2009 - 2011

Wilmot Cancer Research Fellowship. 2004 - 2007

NIH Travel Scholarship. 2002

Graduate Student Society Research Award. 2001

Young Investigator Award. 2000

Young Investigator Award. 1998

Moscow Mayor's Honorary Scholarship. 1993 - 1995

Freshman Competitive Scholarship. 1987 - 1988

Research

The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitoc...
The main goal of our research efforts is to understand how cell metabolism determines cell fate and how it can be manipulated for the purposes of prevention and therapies. Mitochondria are "powerhouses" of the cell and also important components of cell signaling. In undifferentiated stem cells mitochondria are inactive but become activated during the process of differentiation. We focus on the mechanism of this metabolic switch in mesenchymal stem cells (MSC), common precursors of osteoblasts, chondrocytes, and adipocytes, and how this mechanism is disrupted in aging and in various diseases.

Similarly to undifferentiated stem cells, many cancer cells show preference for glycolytic over mitochondrial metabolism even in the presence of adequate oxygen, a phenomenon known as the Warburg effect. We study how cell metabolism regulates sensitivity of osteosarcoma to treatments. Our data indicate that the Warburg effect is especially pronounced in osteosarcoma cancer stem cells (CSC), and reversal of this effect makes CSCs less viable and more sensitive to radiation.

Patents

Use of Cyclophilin D Inhibitors to Treat or Prevent Bone Disorders

Issue date: December 05, 2017

Publications

Journal Articles

Energy metabolism in osteoprogenitors and osteoblasts: Role of the pentose phosphate pathway.

Catheline SE, Smith CO, McArthur M, Yu C, Brookes PS, Eliseev RA

The Journal of biological chemistry.. 2025 January 301 (1):108016. Epub 11/26/2024.

Cyclophilin D, regulator of the mitochondrial permeability transition, impacts bone development and fracture repair.

Sautchuk R, Martinez J, Catheline SE, Eliseev RA

Bone.. 2024 December 189 :117258. Epub 09/18/2024.

Mitochondrial permeability transition regulator, cyclophilin D, is transcriptionally activated by C/EBP during adipogenesis.

Yu C, Sautchuk R, Martinez J, Eliseev RA

The Journal of biological chemistry.. 2023 December 299 (12):105458. Epub 11/08/2023.

Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging.

Catheline SE, Kaiser E, Eliseev RA

Current osteoporosis reports.. 2023 October 21 (5):540-551. Epub 08/05/2023.

Efferocytosis by bone marrow mesenchymal stromal cells disrupts osteoblastic differentiation via mitochondrial remodeling.

Quarato ER, Salama NA, Li AJ, Smith CO, Zhang J, Kawano Y, McArthur M, Liesveld JL, Becker MW, Elliott MR, Eliseev RA, Calvi LM

Cell death & disease.. 2023 July 1414 (7):428. Epub 07/14/2023.

Mitochondrial Transfer to Host Cells from Ex Vivo Expanded Donor Hematopoietic Stem Cells.

Kawano H, Kawano Y, Yu C, LaMere MW, McArthur MJ, Becker MW, Ballinger SW, Gojo S, Eliseev RA, Calvi LM

Cells.. 2023 May 2512 (11)Epub 05/25/2023.

Role of the Mitochondrial Permeability Transition in Bone Metabolism and Aging.

Sautchuk R, Yu C, McArthur M, Massie C, Brookes PS, Porter GA, Awad H, Eliseev RA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2023 April 38 (4):522-540. Epub 03/09/2023.

SR-Mitochondria Crosstalk Shapes Ca Signalling to Impact Pathophenotype in Disease Models Marked by Dysregulated Intracellular Ca Release.

Tow BD, Deb A, Neupane S, Patel S, Reed M, Loper AB, Eliseev RA, Knollmann BC, Györke S, Liu B

Cardiovascular research.. 2022 October 21118 (13):2819-2832. Epub 1900 01 01.

Cell energy metabolism and bone formation.

Sautchuk R, Eliseev RA

Bone reports.. 2022 June 16 :101594. Epub 05/27/2022.

Transcriptional regulation of cyclophilin D by BMP/Smad signaling and its role in osteogenic differentiation.

Sautchuk R, Kalicharan BH, Escalera-Rivera K, Jonason JH, Porter GA, Awad HA, Eliseev RA

eLife.. 2022 May 3011 Epub 05/30/2022.

Electromagnetic stimulation increases mitochondrial function in osteogenic cells and promotes bone fracture repair.

Hollenberg AM, Huber A, Smith CO, Eliseev RA

Scientific reports.. 2021 September 2711 (1):19114. Epub 09/27/2021.

Bone morphogenic protein-2 signaling in human disc degeneration and correlation to the Pfirrmann MRI grading system.

Hollenberg AM, Maqsoodi N, Phan A, Huber A, Jubril A, Baldwin AL, Yokogawa N, Eliseev RA, Mesfin A

The spine journal : official journal of the North American Spine Society.. 2021 July 21 (7):1205-1216. Epub 03/05/2021.

Energy Metabolism During Osteogenic Differentiation: The Role of Akt.

Smith CO, Eliseev RA

Stem cells and development.. 2021 February 30 (3):149-162. Epub 01/11/2021.

Lactate Dehydrogenase Inhibition With Oxamate Exerts Bone Anabolic Effect.

Hollenberg AM, Smith CO, Shum LC, Awad H, Eliseev RA

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2020 December 35 (12):2432-2443. Epub 09/19/2020.

Inhibition of the mitochondrial permeability transition improves bone fracture repair.

Shares BH, Smith CO, Sheu TJ, Sautchuk R, Schilling K, Shum LC, Paine A, Huber A, Gira E, Brown E, Awad H, Eliseev RA

Bone.. 2020 August 137 :115391. Epub 04/28/2020.

Role of oxidative metabolism in osseointegration during spinal fusion.

Shum LC, Hollenberg AM, Baldwin AL, Kalicharan BH, Maqsoodi N, Rubery PT, Mesfin A, Eliseev RA

PloS one.. 2020 15 (11):e0241998. Epub 11/09/2020.

Active mitochondria support osteogenic differentiation by stimulating ?-catenin acetylation.

Shares BH, Busch M, White N, Shum L, Eliseev RA

The Journal of biological chemistry.. 2018 October 12293 (41):16019-16027. Epub 08/27/2018.

PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.

Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ

Journal of cellular biochemistry.. 2017 December 118 (12):4383-4393. Epub 05/31/2017.

Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation.

Shum LC, White NS, Mills BN, de Mesy Bentley KL, Eliseev RA

Stem cells and development.. 2016 January 1525 (2):114-22. Epub 12/10/2015.

Cyclophilin D Knock-Out Mice Show Enhanced Resistance to Osteoporosis and to Metabolic Changes Observed in Aging Bone.

Shum LC, White NS, Nadtochiy SM, Bentley KL, Brookes PS, Jonason JH, Eliseev RA

PloS one.. 2016 11 (5):e0155709. Epub 05/16/2016.

Initiation of electron transport chain activity in the embryonic heart coincides with the activation of mitochondrial complex 1 and the formation of supercomplexes.

Beutner G, Eliseev RA, Porter GA

PloS one.. 2014 9 (11):e113330. Epub 11/26/2014.

Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect.

Giang AH, Raymond T, Brookes P, Demesy-Bentley K, Schwarz E, O'Keefe R, Eliseev R

The Journal of biological chemistry.. 2013 November 15288 (46):33303-11. Epub 10/07/2013.

Targeting radioresistant osteosarcoma cells with parthenolide.

Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA

Journal of cellular biochemistry.. 2012 April 113 (4):1282-91. Epub 1900 01 01.

Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication.

Shapovalov Y, Hoffman D, Zuch D, de Mesy Bentley KL, Eliseev RA

The Journal of biological chemistry.. 2011 June 24286 (25):22331-8. Epub 05/02/2011.

Proteasome inhibition with bortezomib suppresses growth and induces apoptosis in osteosarcoma.

Shapovalov Y, Benavidez D, Zuch D, Eliseev RA

International journal of cancer.. 2010 July 1127 (1):67-76. Epub 1900 01 01.

Cyclophilin D interacts with Bcl2 and exerts an anti-apoptotic effect.

Eliseev RA, Malecki J, Lester T, Zhang Y, Humphrey J, Gunter TE

The Journal of biological chemistry.. 2009 April 10284 (15):9692-9. Epub 02/19/2009.

Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.

Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH

Oncogene.. 2008 June 527 (25):3605-14. Epub 01/28/2008.

Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition.

Eliseev RA, Filippov G, Velos J, VanWinkle B, Goldman A, Rosier RN, Gunter TE

Neurobiology of aging.. 2007 October 28 (10):1532-42. Epub 07/31/2006.

Determining the oxidation states of manganese in NT2 cells and cultured astrocytes.

Gunter KK, Aschner M, Miller LM, Eliseev R, Salter J, Anderson K, Gunter TE

Neurobiology of aging.. 2006 December 27 (12):1816-26. Epub 11/14/2005.

Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.

Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN

Experimental cell research.. 2006 January 1312 (1):40-50. Epub 11/02/2005.

Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.

Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN

Journal of cellular biochemistry.. 2005 December 1596 (6):1262-73. Epub 1900 01 01.

Determining the oxidation states of manganese in PC12 and nerve growth factor-induced PC12 cells.

Gunter KK, Aschner M, Miller LM, Eliseev R, Salter J, Anderson K, Hammond S, Gunter TE

Free radical biology & medicine.. 2005 July 1539 (2):164-81. Epub 03/31/2005.

Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB.

Eliseev RA, Vanwinkle B, Rosier RN, Gunter TE

The Journal of biological chemistry.. 2004 November 5279 (45):46748-54. Epub 08/23/2004.

Calcium and mitochondria.

Gunter TE, Yule DI, Gunter KK, Eliseev RA, Salter JD

FEBS letters.. 2004 June 1567 (1):96-102. Epub 1900 01 01.

Determination of the oxidation states of manganese in brain, liver, and heart mitochondria.

Gunter TE, Miller LM, Gavin CE, Eliseev R, Salter J, Buntinas L, Alexandrov A, Hammond S, Gunter KK

Journal of neurochemistry.. 2004 January 88 (2):266-80. Epub 1900 01 01.

High-Yield Expression and Purification of p18 Form of Bax as an MBP-Fusion Protein.

Eliseev, RA, Alexandrov, AA, and TE Gunter.

Prot Expr Purif. 2004; : 206-209.

Bcl-2 prevents abnormal mitochondrial proliferation during etoposide-induced apoptosis.

Eliseev RA, Gunter KK, Gunter TE

Experimental cell research.. 2003 October 1289 (2):275-81. Epub 1900 01 01.

Bcl-2 and tBid proteins counter-regulate mitochondrial potassium transport.

Eliseev RA, Salter JD, Gunter KK, Gunter TE

Biochimica et biophysica acta.. 2003 April 181604 (1):1-5. Epub 1900 01 01.

XANES spectroscopy: a promising tool for toxicology: a tutorial.

Gunter KK, Miller LM, Aschner M, Eliseev R, Depuis D, Gavin CE, Gunte TE

Neurotoxicology.. 2002 July 23 (2):127-46. Epub 1900 01 01.

Bcl-2 sensitive mitochondrial potassium accumulation and swelling in apoptosis.

Eliseev RA, Gunter KK, Gunter TE

Mitochondrion.. 2002 February 1 (4):361-70. Epub 1900 01 01.

The role of autocrine growth factors in radiation damage to the epiphyseal growth plate.

Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN

Radiation research.. 2001 June 155 (6):847-57. Epub 1900 01 01.

Radiation injury to growth plate/epiphyseal chondrocytes: molecular mechanisms

Constine, LS, Pateder, D, O'Keefe, R, Hicks, D, Eliseev, R, Williams, J, Puzas, E, and R Rosier.

Intl J Rad Onc Biol Phys. 2000; : 284.

Mitochondrial calcium transport: mechanisms and functions.

Gunter TE, Buntinas L, Sparagna G, Eliseev R, Gunter K

Cell calcium.. 2000 28 (5-6):285-96. Epub 1900 01 01.

The Rapid Mode (RaM) of Mitochondrial Calcium Transport

Buntinas, L, Eliseev, R, Gunter, KK, and TE Gunter,.

Biophys J,. 1998; : A382.

Influence of Some Steroid Hormones on Calcium Transport and Oxidative Metabolism in Isolated Mitochondria

Lukianova, LD, Eliseev, RA, Makarenko, T, and AI Matiushin.

Bull Exp Biol Med. 1994; : 1307-1310.