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Edward Brown, Ph.D.

Edward Brown, Ph.D.

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About Me

Faculty Appointments

Associate Professor - Department of Neuroscience (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Post-Doctoral Fellow, Department of Radiation Oncology, Harvard Medical School / Massachusetts General Hospital. Laboratory of Dr. Rakesh K. Jain. 1999 - 2001

Education

PhD | Cornell University. Physics. 1999

MS | Cornell University. Physics. 1995

BS | Wake Forest University. Physics. 1992

Awards

NIH Director's New Innovator Award. 2009 - 2014

Pew Scholar in the Biomedical Sciences Award. 2007 - 2011

Era of Hope Scholar Award. 2005 - 2010

AACR-Aflac Scholars in Cancer Research Award. 2000

Phi Beta Kappa. 1992

Speas Award for Excellence in Physics. 1992

Reynolds Scholarship (full room, full board, full tuition, stipend). 1984 - 1988

Research

Patents

Methods of Treating Cancer Using The Calcitonin-Gene Related Peptide ("CGRP") Receptor Antagonist CGRP8-37

Issue date: March 12, 2013

Patent #: 8,394,767

Country: United States

Inventors: Edward Brown III, Ian Dickerson

System and Method for Measuring the Ratio of Forward-Propagating to Back-Propagating Second Harmonic-Generation Signal, and Applications Thereof

Issue date: August 19, 2014

Patent #: 8,812,085

Country: United States

Inventors: Edward Brown III, Xiaoxing Han

Method and Apparatus to Diagnose the Metatstatic or Progressive Potential of Cancer, Fibrosis and other Diseases

Issue date: September 08, 2020

Patent #: 10,765,376

Country: United States

Inventors: Edward Brown III, Kathleen Burke, Robert Matthew Kottmann, Seth W Perry, Jesse W Sharpe, Patricia Janet Sime

Publications

Journal Articles

Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment.

Joshi IM, Mansouri M, Ahmed A, De Silva D, Simon RA, Esmaili P, Desa DE, Elias TM, Brown EB, Abhyankar VV

Advanced functional materials.. 2024 March 2534 (13)Epub 12/17/2023.

Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment.

Joshi IM, Mansouri M, Ahmed A, Simon RA, Bambizi PE, Desa DE, Elias TM, Brown EB, Abhyankar VV

bioRxiv : the preprint server for biology.. 2023 July 10 Epub 07/10/2023.

Expanding the applicability of multiphoton fluorescence recovery after photobleaching by incorporating shear stress in laminar flow.

Elias TM, Brown EB, Brown EB

Journal of biomedical optics.. 2023 July 28 (7):076502. Epub 07/21/2023.

High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy.

Schilling K, Zhai Y, Zhou Z, Zhou B, Brown E, Zhang X

eLife.. 2022 November 311 Epub 11/03/2022.

Matching an immersion medium's refractive index to a cell's cytosol isolates organelle scattering.

Dunn KJ, Elias TM, Brown EB, Berger AJ

Biomedical optics express.. 2022 August 113 (8):4236-4246. Epub 07/19/2022.

Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition.

Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2022 July 1528 (14):3076-3090. Epub 1900 01 01.

Second-Harmonic Generation Imaging Reveals Changes in Breast Tumor Collagen Induced by Neoadjuvant Chemotherapy.

Desa DE, Wu W, Brown RM, Brown EB, Hill RL, Turner BM, Brown EB

Cancers.. 2022 February 914 (4)Epub 02/09/2022.

NAD(P)H autofluorescence lifetime imaging enables single cell analyses of cellular metabolism of osteoblasts in vitro and in vivo via two-photon microscopy.

Schilling K, Brown E, Zhang X

Bone.. 2022 January 154 :116257. Epub 11/13/2021.

Spatiotemporal blood vessel specification at the osteogenesis and angiogenesis interface of biomimetic nanofiber-enabled bone tissue engineering.

Zhai Y, Schilling K, Wang T, El Khatib M, Vinogradov S, Brown EB, Zhang X

Biomaterials.. 2021 September 276 :121041. Epub 07/26/2021.

Intratumoral heterogeneity of second-harmonic generation scattering from tumor collagen and its effects on metastatic risk prediction.

Desa DE, Strawderman RL, Wu W, Hill RL, Smid M, Martens JWM, Turner BM, Brown EB

BMC cancer.. 2020 December 1020 (1):1217. Epub 12/10/2020.

Inhibition of the mitochondrial permeability transition improves bone fracture repair.

Shares BH, Smith CO, Sheu TJ, Sautchuk R, Schilling K, Shum LC, Paine A, Huber A, Gira E, Brown E, Awad H, Eliseev RA

Bone.. 2020 August 137 :115391. Epub 04/28/2020.

Author Correction: Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.

Stowell RD, Sipe GO, Dawes RP, Batchelor HN, Lordy KA, Whitelaw BS, Stoessel MB, Bidlack JM, Brown E, Sur M, Majewska AK

Nature neuroscience.. 2020 January 23 (1):152. Epub 1900 01 01.

Chronic Stress Exposure Suppresses Mammary Tumor Growth and Reduces Circulating Exosome TGF-? Content via ?-Adrenergic Receptor Signaling in MMTV-PyMT Mice.

Dawes RP, Burke KA, Byun DK, Xu Z, Stastka P, Chan L, Brown EB, Madden KS

Breast cancer : basic and clinical research.. 2020 14 :1178223420931511. Epub 06/17/2020.

Noradrenergic signaling in the wakeful state inhibits microglial surveillance and synaptic plasticity in the mouse visual cortex.

Stowell RD, Sipe GO, Dawes RP, Batchelor HN, Lordy KA, Whitelaw BS, Stoessel MB, Bidlack JM, Brown E, Sur M, Majewska AK

Nature neuroscience.. 2019 November 22 (11):1782-1792. Epub 10/21/2019.

Electrospun Fiber Mesh for High-Resolution Measurements of Oxygen Tension in Cranial Bone Defect Repair.

Schilling K, El Khatib M, Plunkett S, Xue J, Xia Y, Vinogradov SA, Brown E, Zhang X

ACS applied materials & interfaces.. 2019 September 1811 (37):33548-33558. Epub 09/04/2019.

Second-harmonic generation directionality is associated with neoadjuvant chemotherapy response in breast cancer core needle biopsies.

Desa DE, Bhanote M, Hill RL, Majeski JB, Buscaglia B, D'Aguiar M, Strawderman R, Hicks DG, Turner BM, Brown EB

Journal of biomedical optics.. 2019 August 24 (8):1-9. Epub 1900 01 01.

Tissue effects of intra-tissue refractive index shaping (IRIS): insights from two-photon autofluorescence and second harmonic generation microscopy.

Yu D, Brown EB, Huxlin KR, Knox WH

Biomedical optics express.. 2019 February 110 (2):855-867. Epub 01/24/2019.

Embryo movements regulate tendon mechanical property development.

Pan XS, Li J, Brown EB, Kuo CK

Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2018 September 24373 (1759)Epub 09/24/2018.

Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice.

Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM

Scientific reports.. 2018 April 108 (1):5746. Epub 04/10/2018.

Chemotherapeutic drug-specific alteration of microvascular blood flow in murine breast cancer as measured by diffuse correlation spectroscopy.

Ramirez G, Proctor AR, Jung KW, Wu TT, Han S, Adams RR, Ren J, Byun DK, Madden KS, Brown EB, Foster TH, Farzam P, Durduran T, Choe R

Biomedical optics express.. 2016 September 17 (9):3610-3630. Epub 08/24/2016.

Survival of Secondary Central Nervous System Lymphoma Patients in the Rituximab Era.

Herr MM, Mohile NA, Barr PM, van Wijngaarden E, Brown EB, Rich DQ

Clinical lymphoma, myeloma & leukemia.. 2016 September 16 (9):e123-e127. Epub 06/08/2016.

Antidepressant use and risk of central nervous system metastasis.

Herr MM, Mohile NA, van Wijngaarden E, Brown EB, Rich DQ

Journal of neuro-oncology.. 2016 August 129 (1):179-87. Epub 06/11/2016.

Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration.

Haynes-Gimore N, Banach M, Brown E, Dawes R, Edholm ES, Kim M, Robert J

Developmental biology.. 2015 December 15408 (2):205-12. Epub 01/17/2015.

Enzymatically-responsive pro-angiogenic peptide-releasing poly(ethylene glycol) hydrogels promote vascularization in vivo.

Van Hove AH, Burke K, Antonienko E, Brown E, Benoit DS

Journal of controlled release : official journal of the Controlled Release Society.. 2015 November 10217 :191-201. Epub 09/11/2015.

Temporally tunable, enzymatically responsive delivery of proangiogenic peptides from poly(ethylene glycol) hydrogels.

Van Hove AH, Antonienko E, Burke K, Brown E, Benoit DS

Advanced healthcare materials.. 2015 September 164 (13):2002-11. Epub 07/07/2015.

Spatiotemporal Analyses of Osteogenesis and Angiogenesis via Intravital Imaging in Cranial Bone Defect Repair.

Huang C, Ness VP, Yang X, Chen H, Luo J, Brown EB, Zhang X

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2015 July 30 (7):1217-30. Epub 1900 01 01.

Second harmonic generation microscopy reveals altered collagen microstructure in usual interstitial pneumonia versus healthy lung.

Kottmann RM, Sharp J, Owens K, Salzman P, Xiao GQ, Phipps RP, Sime PJ, Brown EB, Perry SW

Respiratory research.. 2015 May 2716 (1):61. Epub 05/27/2015.

Second-harmonic generation scattering directionality predicts tumor cell motility in collagen gels.

Burke KA, Dawes RP, Cheema MK, Van Hove A, Benoit DS, Perry SW, Brown E

Journal of biomedical optics.. 2015 May 20 (5):051024. Epub 1900 01 01.

The role of the lymphatic system in inflammatory-erosive arthritis.

Bouta EM, Li J, Ju Y, Brown EB, Ritchlin CT, Xing L, Schwarz EM

Seminars in cell & developmental biology.. 2015 February 38 :90-7. Epub 01/15/2015.

Single- and two-photon fluorescence recovery after photobleaching.

Sullivan KD, Majewska AK, Brown EB

Cold Spring Harbor protocols.. 2015 January 52015 (1):pdb.top083519. Epub 01/05/2015.

The Use of Second Harmonic Generation to Image the Extracellular Matrix During Tumor Progression.

Burke K, Brown E

Intravital.. 2014 December 3 (3):e984509. Epub 01/06/2015.

Fluoxetine modulates breast cancer metastasis to the brain in a murine model.

Shapovalov Y, Zettel M, Spielman SC, Amico-Ruvio SA, Kelly EA, Sipe GO, Dickerson IM, Majewska AK, Brown EB

BMC cancer.. 2014 August 1614 :598. Epub 08/16/2014.

In vivo quantification of lymph viscosity and pressure in lymphatic vessels and draining lymph nodes of arthritic joints in mice.

Bouta EM, Wood RW, Brown EB, Rahimi H, Ritchlin CT, Schwarz EM

The Journal of physiology.. 2014 March 15592 (6):1213-23. Epub 01/13/2014.

The antidepressant desipramine and ?2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure.

Szpunar MJ, Burke KA, Dawes RP, Brown EB, Madden KS

Cancer prevention research.. 2013 December 6 (12):1262-72. Epub 1900 01 01.

Stromal matrix metalloprotease-13 knockout alters Collagen I structure at the tumor-host interface and increases lung metastasis of C57BL/6 syngeneic E0771 mammary tumor cells.

Perry SW, Schueckler JM, Burke K, Arcuri GL, Brown EB

BMC cancer.. 2013 September 513 :411. Epub 09/05/2013.

Restricted diffusion of calretinin in cerebellar granule cell dendrites implies Ca²?-dependent interactions via its EF-hand 5 domain.

Arendt O, Schwaller B, Brown EB, Eilers J, Schmidt H

The Journal of physiology.. 2013 August 15591 (16):3887-99. Epub 06/03/2013.

Tumor-associated macrophages and stromal TNF-? regulate collagen structure in a breast tumor model as visualized by second harmonic generation.

Burke RM, Madden KS, Perry SW, Zettel ML, Brown EB

Journal of biomedical optics.. 2013 August 18 (8):86003. Epub 1900 01 01.

Engineering superficial zone features in tissue engineered cartilage.

Chen T, Hilton MJ, Brown EB, Zuscik MJ, Awad HA

Biotechnology and bioengineering.. 2013 May 110 (5):1476-86. Epub 12/27/2012.

Brain tumor imaging: live imaging of glioma by two-photon microscopy.

Madden KS, Zettel ML, Majewska AK, Brown EB

Cold Spring Harbor protocols.. 2013 March 12013 (3)Epub 03/01/2013.

Brain tumor imaging: imaging brain metastasis using a brain-metastasizing breast adenocarcinoma.

Madden KS, Zettel ML, Majewska AK, Brown EB

Cold Spring Harbor protocols.. 2013 March 12013 (3)Epub 03/01/2013.

Early impact of social isolation and breast tumor progression in mice.

Madden KS, Szpunar MJ, Brown EB

Brain, behavior, and immunity.. 2013 March 30 Suppl (Suppl):S135-41. Epub 05/17/2012.

Second harmonic generation reveals matrix alterations during breast tumor progression.

Burke K, Tang P, Brown E

Journal of biomedical optics.. 2013 March 18 (3):31106. Epub 1900 01 01.

Two-photon and second harmonic microscopy in clinical and translational cancer research.

Perry SW, Burke RM, Brown EB

Annals of biomedical engineering.. 2012 February 40 (2):277-91. Epub 01/19/2012.

?-Adrenergic receptors (?-AR) regulate VEGF and IL-6 production by divergent pathways in high ?-AR-expressing breast cancer cell lines.

Madden KS, Szpunar MJ, Brown EB

Breast cancer research and treatment.. 2011 December 130 (3):747-58. Epub 01/14/2011.

Measuring intranodal pressure and lymph viscosity to elucidate mechanisms of arthritic flare and therapeutic outcomes.

Bouta EM, Wood RW, Perry SW, Brown EB, Ritchlin CT, Xing L, Schwarz EM

Annals of the New York Academy of Sciences.. 2011 December 1240 :47-52. Epub 1900 01 01.

Multiphoton fluorescence recovery after photobleaching in bounded systems.

Sullivan KD, Brown EB

Physical review. E, Statistical, nonlinear, and soft matter physics.. 2011 May 83 (5 Pt 1):051916. Epub 05/16/2011.

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide.

Perry SW, Norman JP, Barbieri J, Brown EB, Gelbard HA

BioTechniques.. 2011 February 50 (2):98-115. Epub 1900 01 01.

Diffusion and multi-photon fluorescence recovery after photobleaching in bounded systems

Sullivan, K.;Brown, E.

Physical review E. In Press. 2011; .

Mitochondrial membrane potential probes and the proton gradient: a practical usage guide

Perry, S.; Norman, J.; Barbieri, J.; Brown, E.; Gelbard, H.

BioTechniques. In Press. 2011; .

Reduction of neurovascular damage resulting from microelectrode insertion into the cerebral cortex using in vivo two-photon mapping.

Kozai TD, Marzullo TC, Hooi F, Langhals NB, Majewska AK, Brown EB, Kipke DR

Journal of neural engineering.. 2010 August 7 (4):046011. Epub 07/19/2010.

Measurement of the ratio of forward-propagating to back-propagating second harmonic signal using a single objective.

Han X, Brown E

Optics express.. 2010 May 1018 (10):10538-50. Epub 1900 01 01.

Measuring diffusion coefficients via two-photon fluorescence recovery after photobleaching.

Sullivan KD, Brown EB

Journal of visualized experiments : JoVE.. 2010 February 26 (36)Epub 02/26/2010.

Thermally activated diffusion in reversibly associating polymers

Li, J.; Sullivan, K.; Brown, E.;Anthamatten, M.

Soft matter. 2010; 6: 235-238.

Measuring Diffusion Coefficients via Two-Photon Fluorescence Recovery After Photobleaching

Sullivan, K.;Brown, E.

Journal of visualized experiments. 2010; 36.

Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo.

Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK

Biophysical journal.. 2009 July 897 (1):330-6. Epub 1900 01 01.

Improved model of fluorescence recovery expands the application of multiphoton fluorescence recovery after photobleaching in vivo.

Sullivan KD, Sipprell WH, Brown EB, Brown EB

Biophysical journal.. 2009 June 1796 (12):5082-94. Epub 1900 01 01.

Second harmonic properties of tumor collagen: determining the structural relationship between reactive stroma and healthy stroma.

Han X, Burke RM, Zettel ML, Tang P, Brown EB

Optics express.. 2008 February 416 (3):1846-59. Epub 1900 01 01.

Parvalbumin is freely mobile in axons, somata and nuclei of cerebellar Purkinje neurones.

Schmidt H, Arendt O, Brown EB, Schwaller B, Eilers J

Journal of neurochemistry.. 2007 February 100 (3):727-35. Epub 1900 01 01.

A 2-D/3-D model-based method to quantify the complexity of microvasculature imaged by in vivo multiphoton microscopy.

Tyrrell JA, Mahadevan V, Tong RT, Brown EB, Jain RK, Roysam B

Microvascular research.. 2005 November 70 (3):165-78. Epub 10/18/2005.

Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo.

Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK

Nature medicine.. 2005 June 11 (6):678-82. Epub 05/08/2005.

Differential transplantability of tumor-associated stromal cells.

Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK

Cancer research.. 2004 September 164 (17):5920-4. Epub 1900 01 01.

Measurement of macromolecular diffusion coefficients in human tumors.

Brown EB, Boucher Y, Nasser S, Jain RK

Microvascular research.. 2004 May 67 (3):231-6. Epub 1900 01 01.

The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.

Garkavtsev I, Kozin SV, Chernova O, Xu L, Winkler F, Brown E, Barnett GH, Jain RK

Nature.. 2004 March 18428 (6980):328-32. Epub 1900 01 01.

Two-photon fluorescence correlation microscopy reveals the two-phase nature of transport in tumors.

Alexandrakis G, Brown EB, Tong RT, McKee TD, Campbell RB, Boucher Y, Jain RK

Nature medicine.. 2004 February 10 (2):203-7. Epub 01/11/2004.

Irradiation reduces interstitial fluid transport and increases the collagen content in tumors.

Znati CA, Rosenstein M, McKee TD, Brown E, Turner D, Bloomer WD, Watkins S, Jain RK, Boucher Y

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2003 November 159 (15):5508-13. Epub 1900 01 01.

Automated tracing and change analysis of angiogenic vasculature from in vivo multiphoton confocal image time series.

Abdul-Karim MA, Al-Kofahi K, Brown EB, Jain RK, Roysam B

Microvascular research.. 2003 September 66 (2):113-25. Epub 1900 01 01.

Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation.

Brown E, McKee T, diTomaso E, Pluen A, Seed B, Boucher Y, Jain RK

Nature medicine.. 2003 June 9 (6):796-800. Epub 05/18/2003.

Diffusional mobility of parvalbumin in spiny dendrites of cerebellar Purkinje neurons quantified by fluorescence recovery after photobleaching.

Schmidt H, Brown EB, Schwaller B, Eilers J

Biophysical journal.. 2003 April 84 (4):2599-608. Epub 1900 01 01.

Real-time imaging of nuclear permeation by EGFP in single intact cells.

Wei X, Henke VG, Strübing C, Brown EB, Clapham DE

Biophysical journal.. 2003 February 84 (2 Pt 1):1317-27. Epub 1900 01 01.

Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors.

Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL

Cancer research.. 2002 December 162 (23):6831-6. Epub 1900 01 01.

Red blood cells augment leukocyte rolling in a virtual blood vessel.

Migliorini C, Qian Y, Chen H, Brown EB, Jain RK, Munn LL

Biophysical journal.. 2002 October 83 (4):1834-41. Epub 1900 01 01.

Diffusion and convection in collagen gels: implications for transport in the tumor interstitium.

Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK

Biophysical journal.. 2002 September 83 (3):1650-60. Epub 1900 01 01.

Lymphatic metastasis in the absence of functional intratumor lymphatics.

Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK

Science.. 2002 June 7296 (5574):1883-6. Epub 04/25/2002.

In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy.

Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK

Nature medicine.. 2001 July 7 (7):864-8. Epub 1900 01 01.

Role of tumor-host interactions in interstitial diffusion of macromolecules: cranial vs. subcutaneous tumors.

Pluen A, Boucher Y, Ramanujan S, McKee TD, Gohongi T, di Tomaso E, Brown EB, Izumi Y, Campbell RB, Berk DA, Jain RK

Proceedings of the National Academy of Sciences of the United States of America.. 2001 April 1098 (8):4628-33. Epub 03/27/2001.

Mechanisms of calcium decay kinetics in hippocampal spines: role of spine calcium pumps and calcium diffusion through the spine neck in biochemical compartmentalization.

Majewska A, Brown E, Ross J, Yuste R

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2000 March 120 (5):1722-34. Epub 1900 01 01.

Measurement of molecular diffusion in solution by multiphoton fluorescence photobleaching recovery.

Brown EB, Wu ES, Zipfel W, Webb WW

Biophysical journal.. 1999 November 77 (5):2837-49. Epub 1900 01 01.

Photolysis of caged calcium in femtoliter volumes using two-photon excitation.

Brown EB, Shear JB, Adams SR, Tsien RY, Webb WW

Biophysical journal.. 1999 January 76 (1 Pt 1):489-99. Epub 1900 01 01.

Two-photon activation of caged calcium with submicron, submillisecond resolution.

Brown EB, Webb WW

Methods in enzymology.. 1998 291 :356-80. Epub 1900 01 01.

Multiphoton-excited fluorescence of fluorogen-labeled neurotransmitters.

Shear JB, Brown EB, Webb WW

Analytical chemistry.. 1996 May 1568 (10):1778-83. Epub 1900 01 01.

Books

Imaging: A Laboratory Manual (2011)

Chapter: Single and Multiphoton Fluorescence Recovery After Photobleaching

Authors: Sullivan K, Majewska A, Brown E

Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor 2011

Imaging in Neuroscience: A Laboratory Manual (2011)

Chapter: Imaging Tumors in the Brain

Authors: Madden K, Zettel M, Majewska A, Brown E

Publisher: Cold Spring Harbor Laboratory Press, In Press, Cold Spring Harbor 2011

Second Harmonic Generation Imaging (2011)

Chapter: Second Harmonic Imaging of Tumors

Authors: Han X, Perry S, Brown E

Publisher: Taylor and Francis Press, In Preparation 2011

Handbook of Biological Nonlinear Optical Microscopy (2008)

Chapter: Photobleaching and Recovery with Nonlinear Microscopy

Authors: Brown E, Majewska A, Jain RK

Publisher: Oxford University Press, Oxford 2008

Handbook of Biological Nonlinear Optical Microscopy (2008)

Chapter: Applications of Nonlinear Intravital Microscopy in Tumor Biology

Authors: Jain RK, Booth M, Padera T, Munn L, Fukumura D, Brown E

Publisher: Oxford University Press, Oxford 2008

Textbook of in vivo Imaging of Vertebrates (2007)

Chapter: Optical Microscopy in Small Animal Research

Authors: Jain RK, Fukumura D, Munn L, Brown E

Publisher: Wiley & Sons, London 2007

Textbook of in vivo Imaging of Vertebrates (2007)

Chapter: Tumor Angiogenesis and Blood Flow

Authors: Jain RK, Fukumura D, Munn L, Brown E

Publisher: Wiley & Sons, London 2007

Imaging in Neuroscience and Development: A Laboratory Manual (2005)

Chapter: FRAP and Multiphoton FRAP

Authors: Brown E, Majewska A, Jain RK

Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor 2005

Imaging in Neuroscience and Development: A Laboratory Manual (2005)

Chapter: A Practical Guide to in vivo Imaging of Tumors

Authors: Brown E, Munn L, Fukumura D, Jain RK

Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor 2005

Live Cell Imaging: A Laboratory Manual (2004)

Chapter: Intravital Microscopy of Normal and Diseased Tissue in the Mouse

Authors: Jain RK, Brown E, Munn L, Fukumura D

Publisher: Cold Spring Harbor Laboratory Press, Cold Spring Harbor 2004

Methods of Enzymology (1998)

Chapter: Two-Photon Activation of Caged Calcium with Submicron, Submillisecond Resolution

Authors: Brown E, Webb W

Publisher: Academic Press, San Diego 1998