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Abdellatif Benraiss, Ph.D.

Abdellatif Benraiss, Ph.D.

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Office (585) 275-6313
Fax (585) 276-2298
Administrative (585) 275-9588

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About Me

Faculty Appointments

Research Associate Professor - Department of Neurology, Center for Translational Neuromedicine (SMD)

Credentials

Post-doctoral Training & Residency

Junior faculty at St Vincent de Paul Hospital/Paris. Dr. Patrick Aubourg Laboratory. INSERM U561-France 2002 - 2005

Instructor in Neurology and Neuroscience. Dr. Steven. Goldman Laboratory. Weill
Medical School of Cornell University. Department of Neurology and Neuroscience 2000 - 2001

Postdoctoral Associate. Dr. Steven. Goldman Laboratory. Weill Medical School of Cornell University. Department of Neurology and Neuroscience. 1997 - 2000

Post-doctoral position: Dr. Genevieve Rougon Laboratory. Institute of Developmental Biology of Marseille, Laboratory of Genetic and Physiology of Development. 1996 - 1996

Education

French National Postdoctoral Degree | University Paris V.. "Habilitation à diriger des recherches". 2004

PhD | France-Fac Med U Aix-Marseille. Cell Biology, Neurobiology. 1996

MS | France-Fac Med U Aix-Marseille. Cell Biology, Neurobiology. 1992

BS | France-Fac Med U Aix-Marseille. Genetics. 1991

BS | Morocco-University of Caddi Ayyad. Animal Biology. 1990

Awards

European Leukodystrophy Association (ELA) Research grant. 2004 - 2004

European Leukodystrophy Association (ELA) Research grant. 2003 - 2003

Cornell Medical School Aging Foundation Award.. 2001

Research

Publications

Journal Articles

Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells.

Mariani JN, Mansky B, Madsen PM, Salinas D, Kesmen D, Huynh NPT, Kuypers NJ, Kesel ER, Bates J, Payne C, Chandler-Militello D, Benraiss A, Goldman SA

Nature communications.. 2024 May 815 (1):3873. Epub 05/08/2024.

Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain.

Vieira R, Mariani JN, Huynh NPT, Stephensen HJT, Solly R, Tate A, Schanz S, Cotrupi N, Mousaei M, Sporring J, Benraiss A, Goldman SA

Nature biotechnology.. 2024 May 42 (5):719-730. Epub 07/17/2023.

Astrocytic engagement of the corticostriatal synaptic cleft is disrupted in a mouse model of Huntington's disease.

Villanueva CB, Stephensen HJT, Mokso R, Benraiss A, Sporring J, Goldman SA

Proceedings of the National Academy of Sciences of the United States of America.. 2023 June 13120 (24):e2210719120. Epub 06/06/2023.

A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.

Benraiss A, Mariani JN, Tate A, Madsen PM, Clark KM, Welle KA, Solly R, Capellano L, Bentley K, Chandler-Militello D, Goldman SA

Cell reports.. 2022 August 3040 (9):111291. Epub 1900 01 01.

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.

Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA

Cell reports.. 2021 July 636 (1):109308. Epub 1900 01 01.

Circadian control of brain glymphatic and lymphatic fluid flow.

Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications.. 2020 September 211 (1):4411. Epub 09/02/2020.

Impacts of the MHC class I-like XNC10 and innate-like T cells on tumor tolerance and rejection in the amphibian Xenopus.

Banach M, Edholm ES, Gonzalez X, Benraiss A, Robert J

Carcinogenesis.. 2019 July 2040 (7):924-935. Epub 1900 01 01.

Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.

Liu Z, Osipovitch M, Benraiss A, Huynh NPT, Foti R, Bates J, Chandler-Militello D, Findling RL, Tesar PJ, Nedergaard M, Windrem MS, Goldman SA

Cell reports.. 2019 June 2527 (13):3832-3843.e6. Epub 1900 01 01.

PDGF-B Is Required for Development of the Glymphatic System.

Munk AS, Wang W, Bèchet NB, Eltanahy AM, Cheng AX, Sigurdsson B, Benraiss A, Mäe MA, Kress BT, Kelley DH, Betsholtz C, Møllgård K, Meissner A, Nedergaard M, Lundgaard I

Cell reports.. 2019 March 1226 (11):2955-2969.e3. Epub 1900 01 01.

Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.

Osipovitch M, Asenjo Martinez A, Mariani JN, Cornwell A, Dhaliwal S, Zou L, Chandler-Militello D, Wang S, Li X, Benraiss SJ, Agate R, Lampp A, Benraiss A, Windrem MS, Goldman SA

Cell stem cell.. 2019 January 324 (1):107-122.e7. Epub 12/13/2018.

Fluorescent Ca indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.

Smith NA, Kress BT, Lu Y, Chandler-Militello D, Benraiss A, Nedergaard M

Science signaling.. 2018 January 3011 (515)Epub 01/30/2018.

SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions.

Sun W, Cornwell A, Li J, Peng S, Osorio MJ, Su Wanga NA, Benraiss A, Lou N, Goldman SA, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2017 April 2637 (17):4493-4507. Epub 03/23/2017.

Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation.

Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R

Molecular neurodegeneration.. 2017 January 1212 (1):3. Epub 01/12/2017.

PAR1 inhibition suppresses the self-renewal and growth of A2B5-defined glioma progenitor cells and their derived gliomas in vivo.

Auvergne R, Wu C, Connell A, Au S, Cornwell A, Osipovitch M, Benraiss A, Dangelmajer S, Guerrero-Cazares H, Quinones-Hinojosa A, Goldman SA

Oncogene.. 2016 July 2135 (29):3817-28. Epub 11/30/2015.

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.

Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA

Nature communications.. 2016 June 77 :11758. Epub 06/07/2016.

Task-dependent modulation of word processing mechanisms during modified visual search tasks.

Dampure J, Benraiss A, Vibert N

The quarterly journal of experimental psychology : QJEP.. 2016 69 (6):1145-63. Epub 08/18/2015.

Neuronal transgene expression in dominant-negative SNARE mice.

Fujita T, Chen MJ, Li B, Smith NA, Peng W, Sun W, Toner MJ, Kress BT, Wang L, Benraiss A, Takano T, Wang S, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 December 1034 (50):16594-604. Epub 1900 01 01.

Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes.

Auvergne RM, Sim FJ, Wang S, Chandler-Militello D, Burch J, Al Fanek Y, Davis D, Benraiss A, Walter K, Achanta P, Johnson M, Quinones-Hinojosa A, Natesan S, Ford HL, Goldman SA

Cell reports.. 2013 June 273 (6):2127-41. Epub 05/30/2013.

Sustained mobilization of endogenous neural progenitors delays disease progression in a transgenic model of Huntington's disease.

Benraiss A, Toner MJ, Xu Q, Bruel-Jungerman E, Rogers EH, Wang F, Economides AN, Davidson BL, Kageyama R, Nedergaard M, Goldman SA

Cell stem cell.. 2013 June 612 (6):787-99. Epub 1900 01 01.

Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF.

Benraiss A, Bruel-Jungerman E, Lu G, Economides AN, Davidson B, Goldman SA

Gene therapy.. 2012 May 19 (5):483-93. Epub 09/15/2011.

Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF.

Benraiss A, Bruel-Jungerman E, Lu G, Economides AN, Davidson B, Goldman SA

Gene therapy.. 2012 May 19 (5):582. Epub 11/10/2011.

Cellular therapy and induced neuronal replacement for Huntington's disease.

Benraiss A, Goldman SA

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2011 October 8 (4):577-90. Epub 1900 01 01.

Adeno-associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease.

Hudry E, Van Dam D, Kulik W, De Deyn PP, Stet FS, Ahouansou O, Benraiss A, Delacourte A, Bougnères P, Aubourg P, Cartier N

Molecular therapy : the journal of the American Society of Gene Therapy.. 2010 January 18 (1):44-53. Epub 08/04/2009.

The paradoxical effect of warning on reaction time: demonstrating proactive response inhibition with event-related potentials.

Boulinguez P, Ballanger B, Granjon L, Benraiss A

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology.. 2009 April 120 (4):730-7. Epub 03/28/2009.

Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease.

Cho SR, Benraiss A, Chmielnicki E, Samdani A, Economides A, Goldman SA

The Journal of clinical investigation.. 2007 October 117 (10):2889-902. Epub 1900 01 01.

Partial cure of established disease in an animal model of metachromatic leukodystrophy after intracerebral adeno-associated virus-mediated gene transfer.

Sevin C, Verot L, Benraiss A, Van Dam D, Bonnin D, Nagels G, Fouquet F, Gieselmann V, Vanier MT, De Deyn PP, Aubourg P, Cartier N

Gene therapy.. 2007 March 14 (5):405-14. Epub 11/09/2006.

An 8-bp deletion in mNOTCH4 intron 10 leads to its retention in mRNA and to synthesis of a truncated protein.

Auffray C, Gayon R, Benraiss A, Martin N, Laurendeau I, Garaud J, Lucas B, Boitard C, Krief P

Experimental cell research.. 2006 February 1312 (3):233-44. Epub 11/21/2005.

Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy.

Sevin C, Benraiss A, Van Dam D, Bonnin D, Nagels G, Verot L, Laurendeau I, Vidaud M, Gieselmann V, Vanier M, De Deyn PP, Aubourg P, Cartier N

Human molecular genetics.. 2006 January 115 (1):53-64. Epub 11/25/2005.

Identification of a replication-defective herpes simplex virus for recombinant adeno-associated virus type 2 (rAAV2) particle assembly using stable producer cell lines.

Toublanc E, Benraiss A, Bonnin D, Blouin V, Brument N, Cartier N, Epstein AL, Moullier P, Salvetti A

The journal of gene medicine.. 2004 May 6 (5):555-64. Epub 1900 01 01.

Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone.

Chmielnicki E, Benraiss A, Economides AN, Goldman SA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2004 March 324 (9):2133-42. Epub 1900 01 01.

Nitric oxide negatively regulates mammalian adult neurogenesis.

Packer MA, Stasiv Y, Benraiss A, Chmielnicki E, Grinberg A, Westphal H, Goldman SA, Enikolopov G

Proceedings of the National Academy of Sciences of the United States of America.. 2003 August 5100 (16):9566-71. Epub 07/28/2003.

Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain.

Windrem MS, Roy NS, Wang J, Nunes M, Benraiss A, Goodman R, McKhann GM, Goldman SA

Journal of neuroscience research.. 2002 September 1569 (6):966-75. Epub 1900 01 01.

Selective mutagenesis of lysyl residues leads to a stable and active form of delta 9 stearoyl-CoA desaturase.

Mziaut H, Korza G, Benraiss A, Ozols J

Biochimica et biophysica acta.. 2002 June 131583 (1):45-52. Epub 1900 01 01.

Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain.

Benraiss A, Chmielnicki E, Lerner K, Roh D, Goldman SA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2001 September 121 (17):6718-31. Epub 1900 01 01.

High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain.

Keyoung HM, Roy NS, Benraiss A, Louissaint A, Suzuki A, Hashimoto M, Rashbaum WK, Okano H, Goldman SA

Nature biotechnology.. 2001 September 19 (9):843-50. Epub 1900 01 01.

In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus.

Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA

Nature medicine.. 2000 March 6 (3):271-7. Epub 1900 01 01.

Promoter-targeted selection and isolation of neural progenitor cells from the adult human ventricular zone.

Roy NS, Benraiss A, Wang S, Fraser RA, Goodman R, Couldwell WT, Nedergaard M, Kawaguchi A, Okano H, Goldman SA

Journal of neuroscience research.. 2000 February 159 (3):321-31. Epub 1900 01 01.

Promoter-based isolation and fluorescence-activated sorting of mitotic neuronal progenitor cells from the adult mammalian ependymal/subependymal zone.

Wang S, Roy NS, Benraiss A, Goldman SA

Developmental neuroscience.. 2000 22 (1-2):167-76. Epub 1900 01 01.

Identification, isolation, and promoter-defined separation of mitotic oligodendrocyte progenitor cells from the adult human subcortical white matter.

Roy NS, Wang S, Harrison-Restelli C, Benraiss A, Fraser RA, Gravel M, Braun PE, Goldman SA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 1999 November 1519 (22):9986-95. Epub 1900 01 01.

Neurogenesis during caudal spinal cord regeneration in adult newts.

Benraiss A, Arsanto JP, Coulon J, Thouveny Y

Development genes and evolution.. 1999 June 209 (6):363-9. Epub 1900 01 01.

Neural crest-like cells originate from the spinal cord during tail regeneration in adult amphibian urodeles.

Benraiss A, Arsanto JP, Coulon J, Thouveny Y

Developmental dynamics : an official publication of the American Association of Anatomists.. 1997 May 209 (1):15-28. Epub 1900 01 01.

Clonal cell cultures from adult spinal cord of the amphibian urodele Pleurodeles waltl to study the identity and potentialities of cells during tail regeneration.

Benraiss A, Caubit X, Arsanto JP, Coulon J, Nicolas S, Le Parco Y, Thouveny Y

Developmental dynamics : an official publication of the American Association of Anatomists.. 1996 February 205 (2):135-49. Epub 1900 01 01.

Tenascin expression in developing, adult and regenerating caudal spinal cord in the urodele amphibians.

Caubit X, Riou JF, Coulon J, Arsanto JP, Benraiss A, Boucaut JC, Thouveny Y

The International journal of developmental biology.. 1994 December 38 (4):661-72. Epub 1900 01 01.