Home Home Stephen D. Dertinger, Ph.D.

Stephen D. Dertinger, Ph.D.

Contact

Call Center (585) 276-3000

About Me
Credentials
Publications

About Me

Faculty Appointments

Adjunct Assistant Professor - Department of Environmental Medicine (SMD)

Credentials

Education

PhD | Univ Rochester Sch Med/Dent. Toxicology. 2001

BS | Rochester Inst Technology. Biotechnology. 1988

Awards

NIEHS Toxicology Training Grant (T32 ES07026), predoctoral fellowship 1996 - 2000

Keynote Speaker, Meeting of the Japanese Environmental Mutagen Society, Japan, 1998

Finalist, Society of Toxicology Graduate Student Fellowship, 1999

Infurma Award for Best Publication, University of Rochester Toxicology Training Program, 1999 and 2001

Invited Expert, 1999 International Workshop on Genotoxicity Test Procedures (IWGT), Washington, DC

SOT Continuing Education Speaker, National Meeting in San Francisco, 2001

Invited Expert, 2005 International Workshop on Genotoxicity Test Procedures (IWGT), San Francisco, CA

Invited Speaker, HUMN Automated Micronucleus Workshop, Prague, Czech Republic, 2006

Tibbett's Award Recipient, 2006. An honor that is given to SBIR awardees whose work has had tremendous societal and/or economic impact.

Invited Speaker, 8th International Symposium on Chromosomal Aberrations, Hyojo, Japan, 2007

Publications

Journal Articles

In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

Hayashi M, MacGregor JT, Gatehouse DG, Blakey DH, Dertinger SD, Abramsson-Zetterberg L, Krishna G, Morita T, Russo A, Asano N, Suzuki H, Ohyama W, Gibson D,

Mutation research.. 2007 February 3627 (1):10-30. Epub 12/06/2006.

Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage.

Dertinger SD, Miller RK, Brewer K, Smudzin T, Torous DK, Roberts DJ, Avlasevich SL, Bryce SM, Sugunan S, Chen Y

Mutation research.. 2007 January 10626 (1-2):111-9. Epub 10/23/2006.

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring.

Dertinger SD, Bishop ME, McNamee JP, Hayashi M, Suzuki T, Asano N, Nakajima M, Saito J, Moore M, Torous DK, Macgregor JT

Toxicological sciences : an official journal of the Society of Toxicology.. 2006 November 94 (1):83-91. Epub 08/03/2006.

Performance of flow cytometric analysis for the micronucleus assay--a reconstruction model using serial dilutions of malaria-infected cells with normal mouse peripheral blood.

Torous D, Asano N, Tometsko C, Sugunan S, Dertinger S, Morita T, Hayashi M

Mutagenesis.. 2006 January 21 (1):11-3. Epub 09/27/2005.

Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine.

Asano N, Torous DK, Tometsko CR, Dertinger SD, Morita T, Hayashi M

Mutagenesis.. 2006 January 21 (1):15-20. Epub 12/19/2005.

In vitro micronucleus scoring by flow cytometry: differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

Avlasevich, SL; Bryce, SM; Cairns, SE; Dertinger, SD.

Environ. Molec. Mutagen. 2006; 47: 56-66.

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat

MacGregor, JT; Bishop, ME; McNamee, JP; Hayashi, M; Asano, N; Nakajima, M; Aidoo, A; Moore, MM; Dertinger, SD.

Tox. Sci. 2006; 94: 92-107.

Quantitative analysis of Howell-Jolly bodies in children with sickle cell disease

Harrod, V; Howard, T; Zimmerman, S; Dertinger, SD; Ware, R.

Experimental Hematology. 2006; .

Three-color labeling method for flow cytometric measurement of cytogenic damage in roden and human blood

Dertinger, SD; Camphausen, K; MacGregor, JT, et al.

Environ. Mol. Mutagen. 2005; 44: 427-435.

Interlaboratory validation of a CD71-based flow cytometric method (MicroFlow) for the scoring of micronucleated reticulocytes in mouse peripheral blood

Torous, DK; Hall, N; Illi-Love, A, et al.

Environ. Molec. Mutagen. 2005; 45: 44-55.

Quantitative analysis of Howell-Jolly bodies measures both splenic filtration and possible genotoxicity in children with sickle cell anemia

Ware, RE; Howard, TA; Torous, DK; Dertinger, SD.

Pediatric Res. 2004; 55(1666 Part 2 Suppl.): 293A-293A.

Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans.

Dertinger SD, Chen Y, Miller RK, Brewer KJ, Smudzin T, Torous DK, Hall NE, Olvany KA, Murante FG, Tometsko CR

Mutation research.. 2003 December 9542 (1-2):77-87. Epub 1900 01 01.

Identification of potential aryl hydrocarbon receptor antagonists in green tea.

Palermo CM, Hernando JI, Dertinger SD, Kende AS, Gasiewicz TA

Chemical research in toxicology.. 2003 July 16 (7):865-72. Epub 1900 01 01.

Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements

Zhou, J-G; Henry, EC; Palermo, CM; Dertinger, SD; Gasiewicz, TA.

Molec. Pharmacol. 2003; 63: 915-924.

Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy

Torous, DK; Hall, NE; Murante, FG; Gleason, SE; Tometsko, CR; Dertinger, SD.

Tox. Sci. 2003; 74: 309-314.

Enumeration of micronucleated CD71-positive human reticulocytes with a single-laser flow cytometer.

Dertinger SD, Torous DK, Hall NE, Murante FG, Gleason SE, Miller RK, Tometsko CR

Mutation research.. 2002 March 25515 (1-2):3-14. Epub 1900 01 01.

Enhanced detection of beta-galactosidase reporter activation is achieved by a reduction of hemoglobin content in tissue lysates.

Nazarenko DA, Dertinger SD, Gasiewicz TA

BioTechniques.. 2001 April 30 (4):776-7, 780-1. Epub 1900 01 01.

Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.

Dertinger SD, Nazarenko DA, Silverstone AE, Gasiewicz TA

Carcinogenesis.. 2001 January 22 (1):171-7. Epub 1900 01 01.

In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice

Nazarenko, DA; Dertinger, SD; Gasiewicz, TA.

Tox. Sci. 2001; 61: 256-264.

Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms.

Dertinger SD, Lantum HB, Silverstone AE, Gasiewicz TA

Biochemical pharmacology.. 2000 July 1560 (2):189-96. Epub 1900 01 01.

Enumeration of micronucleated reticulocytes in rat peripheral blood: a flow cytometric study.

Torous DK, Dertinger SD, Hall NE, Tometsko CR

Mutation research.. 2000 February 16465 (1-2):91-9. Epub 1900 01 01.

Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry.

Dertinger SD, Torous DK, Hall NE, Tometsko CR, Gasiewicz TA

Mutation research.. 2000 January 24464 (2):195-200. Epub 1900 01 01.

In vivo rodent erythrocyte micronucleus assay: Aspects of protocol desing including repeated treatments, integration with toxicity testing, and automated scoring. A report from the International Workshop on Genotoxicity Test Procedures (IWGTP)

Hayashi, M; MacGregor, JT; Gatehouse, DG; Adler, I-D; Blakey, DH; Dertinger, SD; Krishna, G; Morita, T; Russo, A; Sutou, S.

Environ. Molec. Mutagen. 2000; 35: 234-252.

Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation.

Henry EC, Kende AS, Rucci G, Totleben MJ, Willey JJ, Dertinger SD, Pollenz RS, Jones JP, Gasiewicz TA

Molecular pharmacology.. 1999 April 55 (4):716-25. Epub 1900 01 01.

Influence of aromatic hydrocarbon receptor-mediated events on the genotoxicity of cigarette smoke condensate.

Dertinger SD, Silverstone AE, Gasiewicz TA

Carcinogenesis.. 1998 November 19 (11):2037-42. Epub 1900 01 01.

An automated method for discriminating aneugen vs. clastogen-induced micronuclei

Torous, DK; Dertinger, SD; Hall, NE; Tometsko.

Environ. Molec. Mutagen. 1998; 31: 340-344.

Flow cytometric analysis of micronucleated reticulocytes in mouse bone marrow.