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B Paige Lawrence, Ph.D.

B Paige Lawrence, Ph.D.

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About Me

Dr. B. Paige Lawrence is a Professor at the University of Rochester School of Medicine, where she holds appointments in the Departments of Environmental Medicine and Microbiology & Immunology. She earned a B.A. from Skidmore College (1986), where she concentrated in biology and chemistry, and a Ph.D...
Dr. B. Paige Lawrence is a Professor at the University of Rochester School of Medicine, where she holds appointments in the Departments of Environmental Medicine and Microbiology & Immunology. She earned a B.A. from Skidmore College (1986), where she concentrated in biology and chemistry, and a Ph.D. from the Department of Biochemistry, Molecular and Cell Biology at Cornell University (1993). She received specialized training in immunology and toxicology during a post-doctoral fellowship at Oregon State University. Her research addresses problems of human health and how our environment influences our health. Much of her work focuses on the impact of pollutants on our ability to fight infections, such as influenza viruses. Other work centers on understanding how signals from the environment affect proper development in early life, and how these developmental changes adversely impact health later in life. She is a member of the Society of Toxicology, American Association of Immunologists, and American Association for the Advancement of Scientists, and currently serves on the Editorial Boards for Toxicological Sciences, Toxicology, The American Journal of Physiology - Lung Cellular and Molecular Physiology, The Journal of Toxicology and Environmental Health, and The American Journal of Reproductive Immunology. She provides peer review service to the National Institutes of Health and to other research organizations and agencies.

Dr. Lawrence's expertise is in the disciplines of immunology and toxicology. Studying whether chemicals (e.g., pollutants, pharmaceuticals) affect the way the immune system works is the primary area of her expertise. The immune system is the part of our body that helps us fight infections and detect and destroy tumor cells before cancer gets a chance to take hold. There is growing evidence that many chemicals that are found in the environment adversely impact the development and function of the immune system. In contrast to pollutants, which we generally perceive as 'bad' chemicals, some pharmaceuticals are used to deliberately modulate the immune system in order to treat a disease. Studying how these drugs carry out their function gives us a lot of insight into how chemicals (good ones and bad ones) affect the development and function of the immune system.

She has had a long-standing interest in public outreach and science education. She has served on the Society of Toxicology's Education Committee, sponsored high school biology teachers through the John H. Wallace High School Teachers Summer Research Program of the American Association of Immunologists, and participated in other science education projects. Outside of work, she enjoys spending time with her family, cooking, hiking, camping and losing herself a really good book.

Faculty Appointments

Professor - Department of Environmental Medicine (SMD)

Chair - Department of Environmental Medicine (SMD)

Wright Family Research Professorship - Dean's Office M&D - Administration (SMD)

Professor - Department of Microbiology and Immunology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Toxicology Program and Dept. Environmental and Molecular Toxicology, Oregon State University 1993 - 1997

Education

PhD | Cornell University. Biochemistry, Molecular and Cell Biology. 1993

BA | Skidmore College. Biology, Chemistry. 1986

Awards

Faculty Mentoring Award. 2012

Service Recognition Award for Excellence in Mentoring. 2007

Outstanding Young Investigator Award. 2006

Independent Scientist Award (K02). 2004

Advisor Excellence Award. 2003

National Research Service Award (NRSA) Postdoctoral Fellowship. 1995

Phi Beta Kappa, Skidmore College Chapter. 1986

Periclean Honor Society. 1986

Charlotte W. Fahey Prize for academic achievement in the field of Chemistry. 1986

Research

Environmental signaling, immune function, and cellular development
Environmental signals influence the behavior of cells throughout the body. In some cases this is part of normal physiology, but in other instances environmental signals cue cells to work aberrantly. When this occurs, pathology ge...
Environmental signaling, immune function, and cellular development
Environmental signals influence the behavior of cells throughout the body. In some cases this is part of normal physiology, but in other instances environmental signals cue cells to work aberrantly. When this occurs, pathology generally ensues, leading to poorer health. For many chemicals from our environment the mechanisms by which they perturb physiology are largely unknown, and determining these mechanisms forms the basis of most of our research. We have several interrelated projects currently underway.

The aryl hydrocarbon receptor (AhR)
The AhR is a ligand-activated transcription factor that mediates many environmental signals. Its normal function in the body is unknown, but numerous exogenous chemicals bind to AhR, affecting gene expression and cell function. A major focus of our research is to delineate the mechanisms by which the AhR regulates the development and function of the immune system. To accomplish this, we often use influenza viruses, as they are common human pathogens, and because humans exposed to pollutants that bind AhR often have more respiratory illness. We often use the pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) because it binds the AhR with very high affinity and causes sustained activation. This makes it a powerful research tool, as we can probe AhR-regulated pathways by exploiting the knowledge gained when they are perturbed. Also, TCDD represents a large group of highly toxic chemicals found throughout the world, and daily low-level exposure to them has been linked to impairment of the immune, reproductive, and endocrine systems. Current projects seek to understand AhR's normal role in, and how pollutants impact, the immune system and developing organs, and include the following projects:
• The role of AhR in immune response to respiratory viral infection
• The role of AhR in programming the developing immune system
• The role of the AhR in mammary gland differentiation and lactogenesis
There is now compelling evidence that developmental exposures to chemicals from our environment lead to disease later in life, and our interest in how environmental signals alter the developing immune system extends beyond AhR and dioxin. We have two additional funded projects in this area.

Neonatal oxygen supplementation and respiratory viral infection
In collaboration with Dr. Michael O'Reilly, we are studying the effects of neonatal oxygen supplementation on pulmonary immune function. Premature infants are often given high oxygen supplementation, which has substantially reduced premature infant mortality. However, even as adolescents, these infants exhibit reduced lung function and are more likely to be re-hospitalized due to respiratory viral infection. Using a mouse model, we are currently determining how neonatal high oxygen treatment disrupts the response to respiratory viral infection. Moreover, we are integrating our research findings with studies of immune responses in infected children who were born prematurely, which we hope will help us identify novel therapeutic opportunities for improving the health of children born prematurely.

Developmental immunotoxicity of bisphenol A (BPA)
BPA is used in the manufacture of polycarbonate plastics and epoxy resins, and is one of the highest volume chemicals produced worldwide. Existing but very limited data indicate that maternal exposure adversely impacts the developing immune system, and this is a cause for concern. Yet, our current inadequate understanding of BPA's developmental immunotoxicity fetters progress toward comprehensive assessment of the human health effects of BPA. To address this we have started a new project in which we will conduct the most detailed analysis to-date of the impact of the BPA on immune system development and function in the context of animal models of human diseases, such as asthma, influenza, and inflammatory bowel disease.

Publications

Journal Articles

Binary and quaternary mixtures of perfluoroalkyl substances (PFAS) differentially affect the immune response to influenza A virus infection.

Post CM, McDonough C, Lawrence BP

Journal of immunotoxicology.. 2024 December 21 (1):2340495. Epub 07/01/2024.

DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid ? proteotoxicity.

Peng W, Chung KB, Lawrence BP, O'Banion MK, Dirksen RT, Wojtovich AP, Onukwufor JO

Free radical biology & medicine.. 2024 September 22 Epub 09/22/2024.

DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in amyloid ? proteotoxicity.

Peng W, Chung KB, Lawrence BP, O'Banion MK, Dirksen RT, Wojtovich AP, Onukwufor JO

bioRxiv : the preprint server for biology.. 2024 August 9 Epub 08/09/2024.

Timing influences the impact of aryl hydrocarbon receptor activation on the humoral immune response to respiratory viral infection.

Houser CL, Fenner KN, Lawrence BP

Toxicology and applied pharmacology.. 2024 August 489 :117010. Epub 06/18/2024.

Aryl hydrocarbon receptor activation alters immune cell populations in the lung and bone marrow during coronavirus infection.

Healey AM, Fenner KN, O'Dell CT, Lawrence BP

American journal of physiology. Lung cellular and molecular physiology.. 2024 March 1326 (3):L313-L329. Epub 01/30/2024.

Dry-Cleaning Chemicals and a Cluster of Parkinson's Disease and Cancer: A Retrospective Investigation.

Dorsey ER, Kinel D, Pawlik ME, Zafar M, Lettenberger SE, Coffey M, Auinger P, Hylton KL, Shaw CW, Adams JL, Barbano R, Braun MK, Schwarz HB, Lawrence BP, Kieburtz K, Tanner CM, de Miranda BR, Goldman SM

Movement disorders : official journal of the Movement Disorder Society.. 2024 March 39 (3):606-613. Epub 02/23/2024.

Invited Perspective: Environmental Chemical-Sensing AHR Remains an Enigmatic Key Player in Toxicology.

Kaplan BLF, Lawrence BP

Environmental health perspectives.. 2023 March 131 (3):31307. Epub 03/28/2023.

Postnatal administration of S-adenosylmethionine restores developmental AHR activation-induced deficits in CD8+ T cell function during influenza A virus infection.

Post CM, Myers JR, Winans B, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2023 February 27192 (2):233-46. Epub 02/27/2023.

Trends and Non-Clinical Predictors of Respiratory Syncytial Virus (RSV) and Influenza Diagnosis in an Urban Pediatric Population.

Feiler MO, Yucel R, Liu Z, Caserta M, Lawrence BP, Pason CH, Hardy DJ, Thevenet-Morrison K, Dozier A, Jusko TA

International journal of pediatric research.. 2023 9 (1)Epub 03/06/2023.

Diacetyl inhalation impairs airway epithelial repair in mice infected with influenza A virus.

McGraw MD, Yee M, Kim SY, Dylag AM, Lawrence BP, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2022 November 1323 (5):L578-L592. Epub 09/06/2022.

Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification.

Germolec DR, Lebrec H, Anderson SE, Burleson GR, Cardenas A, Corsini E, Elmore SE, Kaplan BLF, Lawrence BP, Lehmann GM, Maier CC, McHale CM, Myers LP, Pallardy M, Rooney AA, Zeise L, Zhang L, Smith MT

Environmental health perspectives.. 2022 October 130 (10):105001. Epub 10/06/2022.

Dung biomass smoke exposure impairs resolution of inflammatory responses to influenza infection.

McCarthy CE, Duffney PF, Nogales A, Post CM, Lawrence BP, Martinez-Sobrido L, Thatcher TH, Phipps RP, Sime PJ

Toxicology and applied pharmacology.. 2022 September 1450 :116160. Epub 07/09/2022.

The Aryl Hydrocarbon Receptor Modulates T Follicular Helper Cell Responses to Influenza Virus Infection in Mice.

Houser CL, Lawrence BP

The Journal of immunology : official journal of the American Association of Immunologists.. 2022 May 15208 (10):2319-2330. Epub 04/20/2022.

Exposure to a mixture of 23 chemicals associated with unconventional oil and gas operations alters immune response to challenge in adult mice.

O'Dell CT, Boule LA, Robert J, Georas SN, Eliseeva S, Lawrence BP

Journal of immunotoxicology.. 2021 December 18 (1):105-117. Epub 1900 01 01.

The Aryl Hydrocarbon Receptor Modulates Murine Hematopoietic Stem Cell Homeostasis and Influences Lineage-Biased Stem and Progenitor Cells.

Vaughan KL, Franchini AM, Kern HG, Lawrence BP

Stem cells and development.. 2021 October 130 (19):970-980. Epub 09/20/2021.

Thyroid Disrupting Chemicals in Mixture Perturb Thymocyte Differentiation in Xenopus laevis Tadpoles.

McGuire CC, Lawrence BP, Robert J

Toxicological sciences : an official journal of the Society of Toxicology.. 2021 May 27181 (2):262-272. Epub 1900 01 01.

Refinement of coding SNPs in the human aryl hydrocarbon receptor gene using ISNPranker: An integrative-SNP ranking web-tool.

Aftabi Y, Rafei S, Zarredar H, Amiri-Sadeghan A, Akbari-Shahpar M, Khoshkam Z, Seyedrezazadeh E, Khalili M, Mehrnejad F, Fereidouni S, Lawrence BP

Computational biology and chemistry.. 2021 February 90 :107416. Epub 11/17/2020.

DNA Methylation Patterns in T Cells of Naïve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand.

Burke CG, Myers JR, Post CM, Boulé LA, Lawrence BP

Environmental health perspectives.. 2021 January 129 (1):17007. Epub 01/15/2021.

Environmental Lead Exposure and Influenza and Respiratory Syncytial Virus Diagnoses in Young Children: A Test-Negative Case-Control Study.

Feiler MO, Caserta MT, van Wijngaarden E, Thevenet-Morrison K, Hardy DJ, Zhang YV, Dozier AM, Lawrence BP, Jusko TA

International journal of environmental research and public health.. 2020 October 1917 (20)Epub 10/19/2020.

Developmental exposure to a mixture of unconventional oil and gas chemicals: A review of experimental effects on adult health, behavior, and disease.

Nagel SC, Kassotis CD, Vandenberg LN, Lawrence BP, Robert J, Balise VD

Molecular and cellular endocrinology.. 2020 August 1513 :110722. Epub 03/05/2020.

The Ancestral Environment Shapes Antiviral CD8 T cell Responses across Generations.

Post CM, Boule LA, Burke CG, O'Dell CT, Winans B, Lawrence BP

iScience.. 2019 October 2520 :168-183. Epub 09/14/2019.

Blood Lead Concentrations and Antibody Levels to Measles, Mumps, and Rubella among U.S. Children.

Jusko TA, Singh K, Greener EA, Oktapodas Feiler M, Thevenet-Morrison K, Lawrence BP, Wright RO, Thurston SW

International journal of environmental research and public health.. 2019 August 2216 (17)Epub 08/22/2019.

Early life exposures shape the CD4 T cell transcriptome, influencing proliferation, differentiation, and mitochondrial dynamics later in life.

Burke CG, Myers JR, Boule LA, Post CM, Brookes PS, Lawrence BP

Scientific reports.. 2019 August 79 (1):11489. Epub 08/07/2019.

Developmental exposure to chemicals associated with unconventional oil and gas extraction alters immune homeostasis and viral immunity of the amphibian Xenopus.

Robert J, McGuire CC, Nagel S, Lawrence BP, Andino FJ

The Science of the total environment.. 2019 June 25671 :644-654. Epub 03/26/2019.

Genome-Wide Transcriptional Analysis Reveals Novel AhR Targets That Regulate Dendritic Cell Function during Influenza A Virus Infection.

Franchini AM, Myers JR, Jin GB, Shepherd DM, Lawrence BP

ImmunoHorizons.. 2019 June 173 (6):219-235. Epub 06/17/2019.

Old Receptor, New Tricks-The Ever-Expanding Universe of Aryl Hydrocarbon Receptor Functions. Report from the 4th AHR Meeting, 29?31 August 2018 in Paris, France.

Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X

International journal of molecular sciences.. 2018 November 1519 (11)Epub 11/15/2018.

Water Contaminants Associated With Unconventional Oil and Gas Extraction Cause Immunotoxicity to Amphibian Tadpoles.

Robert J, McGuire CC, Kim F, Nagel SC, Price SJ, Lawrence BP, De Jesús Andino F

Toxicological sciences : an official journal of the Society of Toxicology.. 2018 November 1166 (1):39-50. Epub 1900 01 01.

Environmental exposures are hidden modifiers of anti-viral immunity.

Franchini AM, Lawrence BP

Current opinion in toxicology.. 2018 August 10 :54-59. Epub 01/31/2018.

Developmental Exposure to a Mixture of 23 Chemicals Associated With Unconventional Oil and Gas Operations Alters the Immune System of Mice.

Boulé LA, Chapman TJ, Hillman SE, Kassotis CD, O'Dell C, Robert J, Georas SN, Nagel SC, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2018 June 1163 (2):639-654. Epub 1900 01 01.

Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome.

Boule LA, Burke CG, Jin GB, Lawrence BP

Scientific reports.. 2018 January 298 (1):1826. Epub 01/29/2018.

Conditional deletion of Ahr alters gene expression profiles in hematopoietic stem cells.

Bennett JA, Singh KP, Welle SL, Boule LA, Lawrence BP, Gasiewicz TA

PloS one.. 2018 13 (11):e0206407. Epub 11/02/2018.

Environmental cues received during development shape dendritic cell responses later in life.

Meyers JL, Winans B, Kelsaw E, Murthy A, Gerber S, Lawrence BP

PloS one.. 2018 13 (11):e0207007. Epub 11/09/2018.

Alternative Progenitor Lineages Regenerate the Adult Lung Depleted of Alveolar Epithelial Type 2 Cells.

Yee M, Domm W, Gelein R, Bentley KL, Kottmann RM, Sime PJ, Lawrence BP, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2017 April 56 (4):453-464. Epub 1900 01 01.

Long term effects of carbaryl exposure on antiviral immune responses in Xenopus laevis.

De Jesús Andino F, Lawrence BP, Robert J

Chemosphere.. 2017 March 170 :169-175. Epub 12/08/2016.

Assessment of recent developmental immunotoxicity studies with bisphenol A in the context of the 2015 EFSA t-TDI.

Hessel EV, Ezendam J, Broekhuizen FA, Hakkert B, DeWitt J, Granum B, Guzylack L, Lawrence BP, Penninks A, Rooney AA, Piersma AH, Loveren HV

Reproductive toxicology.. 2016 October 65 :448-456. Epub 06/25/2016.

Demographic, Reproductive, and Dietary Determinants of Perfluorooctane Sulfonic (PFOS) and Perfluorooctanoic Acid (PFOA) Concentrations in Human Colostrum.

Jusko T, Oktapodas M, Palkovi?ová Murinová ?, Babinska K, Babjakova J, Verner MA, DeWitt J, Thevenet-Morrison K, Conka K, Drobná B, Chovancova J, Thurston S, Lawrence BP, Dozier A, Jarvinen K, Patayova H, Trnovec T, Legler J, Hertz-Picciotto I, Lamoree MH

Environmental science & technology.. 2016 July 550 (13):7152-62. Epub 06/14/2016.

A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination.

Jusko TA, De Roos AJ, Lee SY, Thevenet-Morrison K, Schwartz SM, Verner MA, Palkovicova Murinova L, Drobná B, Ko?an A, Fabišiková A, ?onka K, Trnovec T, Hertz-Picciotto I, Lawrence BP

Environmental health perspectives.. 2016 June 124 (6):813-21. Epub 12/09/2015.

The Oxygen Environment at Birth Specifies the Population of Alveolar Epithelial Stem Cells in the Adult Lung.

Yee M, Gelein R, Mariani TJ, Lawrence BP, O'Reilly MA

Stem cells.. 2016 May 34 (5):1396-406. Epub 03/07/2016.

Developmental Activation of the AHR Increases Effector CD4+ T Cells and Exacerbates Symptoms in Autoimmune Disease-Prone Gnaq+/- Mice.

Boule LA, Burke CG, Fenton BM, Thevenet-Morrison K, Jusko TA, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2015 December 148 (2):555-66. Epub 09/11/2015.

Activation of the aryl hydrocarbon receptor during development enhances the pulmonary CD4+ T-cell response to viral infection.

Boule LA, Winans B, Lambert K, Vorderstrasse BA, Topham DJ, Pavelka MS, Lawrence BP

American journal of physiology. Lung cellular and molecular physiology.. 2015 August 1309 (3):L305-13. Epub 06/12/2015.

Linking the aryl hydrocarbon receptor with altered DNA methylation patterns and developmentally induced aberrant antiviral CD8+ T cell responses.

Winans B, Nagari A, Chae M, Post CM, Ko CI, Puga A, Kraus WL, Lawrence BP

The Journal of immunology : official journal of the American Association of Immunologists.. 2015 May 1194 (9):4446-57. Epub 03/25/2015.

Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD.

Sundar IK, Ahmad T, Yao H, Hwang JW, Gerloff J, Lawrence BP, Sellix MT, Rahman I

Scientific reports.. 2015 April 294 :9927. Epub 04/29/2015.

Cumulative neonatal oxygen exposure predicts response of adult mice infected with influenza A virus.

Maduekwe ET, Buczynski BW, Yee M, Rangasamy T, Stevens TP, Lawrence BP, O'Reilly MA

Pediatric pulmonology.. 2015 March 50 (3):222-230. Epub 05/22/2014.

Neonatal hyperoxia leads to persistent alterations in NK responses to influenza A virus infection.

Reilly EC, Martin KC, Jin GB, Yee M, O'Reilly MA, Lawrence BP

American journal of physiology. Lung cellular and molecular physiology.. 2015 January 1308 (1):L76-85. Epub 11/07/2014.

Sex-specific enhanced behavioral toxicity induced by maternal exposure to a mixture of low dose endocrine-disrupting chemicals.

Sobolewski M, Conrad K, Allen JL, Weston H, Martin K, Lawrence BP, Cory-Slechta DA

Neurotoxicology.. 2014 December 45 :121-30. Epub 10/22/2014.

Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis.

Sifkarovski J, Grayfer L, De Jesús Andino F, Paige Lawrence B, Robert J

Developmental and comparative immunology.. 2014 November 47 (1):52-8. Epub 06/28/2014.

Effects of developmental activation of the AhR on CD4+ T-cell responses to influenza virus infection in adult mice.

Boule LA, Winans B, Lawrence BP

Environmental health perspectives.. 2014 November 122 (11):1201-8. Epub 07/22/2014.

New insights into the role of the aryl hydrocarbon receptor in the function of CD11c? cells during respiratory viral infection.

Jin GB, Winans B, Martin KC, Lawrence BP

European journal of immunology.. 2014 June 44 (6):1685-1698. Epub 03/19/2014.

Neonatal oxygen exposure alters airway hyper-responsiveness but not the response to allergen challenge in adult mice.

Regal JF, Lawrence BP, Johnson AC, Lojovich SJ, O'Reilly MA

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.. 2014 March 25 (2):180-6. Epub 02/13/2014.

Differential consequences of two distinct AhR ligands on innate and adaptive immune responses to influenza A virus.

Wheeler JL, Martin KC, Resseguie E, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2014 February 137 (2):324-34. Epub 11/05/2013.

New insights into the aryl hydrocarbon receptor as a modulator of host responses to infection.

Lawrence BP, Vorderstrasse BA

Seminars in immunopathology.. 2013 November 35 (6):615-26. Epub 08/21/2013.

Neonatal hyperoxia alters the host response to influenza A virus infection in adult mice through multiple pathways.

Buczynski BW, Yee M, Martin KC, Lawrence BP, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2013 August 15305 (4):L282-90. Epub 06/07/2013.

Exacerbation of lung radiation injury by viral infection: the role of Clara cells and Clara cell secretory protein.

Manning CM, Johnston CJ, Hernady E, Miller JN, Reed CK, Lawrence BP, Williams JP, Finkelstein JN

Radiation research.. 2013 June 179 (6):617-29. Epub 04/26/2013.

Lung irradiation increases mortality after influenza A virus challenge occurring late after exposure.

Manning CM, Johnston CJ, Reed CK, Lawrence BP, Williams JP, Finkelstein JN

International journal of radiation oncology, biology, physics.. 2013 May 186 (1):128-35. Epub 11/27/2012.

Neonatal hyperoxia increases sensitivity of adult mice to bleomycin-induced lung fibrosis.

Yee M, Buczynski BW, Lawrence BP, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2013 February 48 (2):258-66. Epub 12/20/2012.

Novel cellular targets of AhR underlie alterations in neutrophilic inflammation and inducible nitric oxide synthase expression during influenza virus infection.

Wheeler JL, Martin KC, Lawrence BP

The Journal of immunology : official journal of the American Association of Immunologists.. 2013 January 15190 (2):659-68. Epub 12/10/2012.

Neither direct nor developmental exposure to bisphenol A alters the severity of experimental inflammatory colitis in mice.

Roy A, Gaylo A, Cao W, Saubermann LJ, Lawrence BP

Journal of immunotoxicology.. 2013 10 (4):334-40. Epub 01/03/2013.

The effects of maternal exposure to bisphenol A on allergic lung inflammation into adulthood.

Bauer SM, Roy A, Emo J, Chapman TJ, Georas SN, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2012 November 130 (1):82-93. Epub 07/21/2012.

Memory CD8+ T cells are sufficient to alleviate impaired host resistance to influenza A virus infection caused by neonatal oxygen supplementation.

Giannandrea M, Yee M, O'Reilly MA, Lawrence BP

Clinical and vaccine immunology : CVI.. 2012 September 19 (9):1432-41. Epub 07/11/2012.

Neonatal oxygen increases sensitivity to influenza A virus infection in adult mice by suppressing epithelial expression of Ear1.

O'Reilly MA, Yee M, Buczynski BW, Vitiello PF, Keng PC, Welle SL, Finkelstein N, Dean DA, Lawrence BP

The American journal of pathology.. 2012 August 181 (2):441-51. Epub 06/05/2012.

Lung development and the host response to influenza A virus are altered by different doses of neonatal oxygen in mice.

Buczynski BW, Yee M, Lawrence BP, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2012 May 15302 (10):L1078-87. Epub 03/09/2012.

You AhR what you eat?

Lawrence BP, Sherr DH

Nature immunology.. 2012 January 1913 (2):117-9. Epub 01/19/2012.

Developmental exposure to bisphenol A modulates innate but not adaptive immune responses to influenza A virus infection.

Roy A, Bauer SM, Lawrence BP

PloS one.. 2012 7 (6):e38448. Epub 06/04/2012.

Immunotoxicology: fifty years of global scientific progress.

McKarns SC, Kerkvliet NI, Dean JH, Bonn MB, Cohen MD, Franko J, Laiosa MD, Lawrence BP, Luebke RW, Luster MI, Miller PG, Palmer RK, Pfau JC, Raman P, Regal JF, Rodgers KE, Schondelmeyer RS, Zhang X, Burns-Naas LA

Journal of immunotoxicology.. 2012 9 (4):339-40. Epub 10/19/2012.

Activation of the aryl hydrocarbon receptor during pregnancy in the mouse alters mammary development through direct effects on stromal and epithelial tissues.

Lew BJ, Manickam R, Lawrence BP

Biology of reproduction.. 2011 June 84 (6):1094-102. Epub 01/26/2011.

Aryl hydrocarbon receptor activation during pregnancy, and in adult nulliparous mice, delays the subsequent development of DMBA-induced mammary tumors.

Wang T, Gavin HM, Arlt VM, Lawrence BP, Fenton SE, Medina D, Vorderstrasse BA

International journal of cancer.. 2011 April 1128 (7):1509-23. Epub 06/02/2010.

Environmental toxicants and the developing immune system: a missing link in the global battle against infectious disease?

Winans B, Humble MC, Lawrence BP

Reproductive toxicology.. 2011 April 31 (3):327-36. Epub 09/22/2010.

Maternal and early postnatal polychlorinated biphenyl exposure in relation to total serum immunoglobulin concentrations in 6-month-old infants.

Jusko TA, De Roos AJ, Schwartz SM, Lawrence BP, Palkovicova L, Nemessanyi T, Drobna B, Fabisikova A, Kocan A, Jahnova E, Kavanagh TJ, Trnovec T, Hertz-Picciotto I

Journal of immunotoxicology.. 2011 8 (1):95-100. Epub 1900 01 01.

Aryl hydrocarbon receptor activation reduces dendritic cell function during influenza virus infection.

Jin GB, Moore AJ, Head JL, Neumiller JJ, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2010 August 116 (2):514-22. Epub 05/23/2010.

A cohort study of developmental polychlorinated biphenyl (PCB) exposure in relation to post-vaccination antibody response at 6-months of age.

Jusko TA, De Roos AJ, Schwartz SM, Lawrence BP, Palkovicova L, Nemessanyi T, Drobna B, Fabisikova A, Kocan A, Sonneborn D, Jahnova E, Kavanagh TJ, Trnovec T, Hertz-Picciotto I

Environmental research.. 2010 May 110 (4):388-95. Epub 04/07/2010.

Activation of the aryl hydrocarbon receptor during different critical windows in pregnancy alters mammary epithelial cell proliferation and differentiation.

Lew BJ, Collins LL, O'Reilly MA, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2009 September 111 (1):151-62. Epub 06/05/2009.

TCDD exposure disrupts mammary epithelial cell differentiation and function.

Collins LL, Lew BJ, Lawrence BP

Reproductive toxicology.. 2009 July 28 (1):11-7. Epub 03/13/2009.

The aryl hydrocarbon receptor is a modulator of anti-viral immunity.

Head JL, Lawrence BP

Biochemical pharmacology.. 2009 February 1577 (4):642-53. Epub 11/05/2008.

Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound.

Lawrence BP, Denison MS, Novak H, Vorderstrasse BA, Harrer N, Neruda W, Reichel C, Woisetschläger M

Blood.. 2008 August 15112 (4):1158-65. Epub 02/12/2008.

Neonatal hyperoxia enhances the inflammatory response in adult mice infected with influenza A virus.

O'Reilly MA, Marr SH, Yee M, McGrath-Morrow SA, Lawrence BP

American journal of respiratory and critical care medicine.. 2008 May 15177 (10):1103-10. Epub 02/21/2008.

Aryl hydrocarbon receptor targets pathways extrinsic to bone marrow cells to enhance neutrophil recruitment during influenza virus infection.

Teske S, Bohn AA, Hogaboam JP, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2008 March 102 (1):89-99. Epub 11/15/2007.

The aryl hydrocarbon receptor affects distinct tissue compartments during ontogeny of the immune system.

Hogaboam JP, Moore AJ, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2008 March 102 (1):160-70. Epub 11/17/2007.

Aryl hydrocarbon receptor activation during influenza virus infection unveils a novel pathway of IFN-gamma production by phagocytic cells.

Neff-LaFord H, Teske S, Bushnell TP, Lawrence BP

The Journal of immunology : official journal of the American Association of Immunologists.. 2007 July 1179 (1):247-55. Epub 1900 01 01.

Environmental toxins as modulators of antiviral immune responses.

Lawrence BP

Viral immunology.. 2007 20 (2):231-42. Epub 1900 01 01.

Aryl hydrocarbon receptor activation impairs the priming but not the recall of influenza virus-specific CD8+ T cells in the lung.

Lawrence BP, Roberts AD, Neumiller JJ, Cundiff JA, Woodland DL

The Journal of immunology : official journal of the American Association of Immunologists.. 2006 November 1177 (9):5819-28. Epub 1900 01 01.

Protection against lethal challenge with Streptococcus pneumoniae is conferred by aryl hydrocarbon receptor activation but is not associated with an enhanced inflammatory response.

Vorderstrasse BA, Lawrence BP

Infection and immunity.. 2006 October 74 (10):5679-86. Epub 1900 01 01.

A dose-response study of the effects of prenatal and lactational exposure to TCDD on the immune response to influenza a virus.

Vorderstrasse BA, Cundiff JA, Lawrence BP

Journal of toxicology and environmental health. Part A.. 2006 March 69 (6):445-63. Epub 1900 01 01.

Increased mortality associated with TCDD exposure in mice infected with influenza A virus is not due to severity of lung injury or alterations in Clara cell protein content.

Bohn AA, Harrod KS, Teske S, Lawrence BP

Chemico-biological interactions.. 2005 August 15155 (3):181-90. Epub 1900 01 01.

Diverse gene expression pattern during 5-fluorouridine-induced apoptosis.

Schmittgen TD, Gissel KA, Zakrajsek BA, Lawrence BP, Liu Q, Jupe ER, Lerner MR, Do SV, Brackett DJ

International journal of oncology.. 2005 August 27 (2):297-306. Epub 1900 01 01.

Activation of the aryl hydrocarbon receptor increases pulmonary neutrophilia and diminishes host resistance to influenza A virus.

Teske S, Bohn AA, Regal JF, Neumiller JJ, Lawrence BP

American journal of physiology. Lung cellular and molecular physiology.. 2005 July 289 (1):L111-24. Epub 03/25/2005.

Measuring the activity of cytolytic lymphocytes.

Lawrence BP

Current protocols in toxicology. 2005 Chapter 18 :Unit18.6. Epub 1900 01 01.

Activation of the aryl hydrocarbon receptor diminishes the memory response to homotypic influenza virus infection but does not impair host resistance.

Lawrence BP, Vorderstrasse BA

Toxicological sciences : an official journal of the Society of Toxicology.. 2004 June 79 (2):304-14. Epub 02/19/2004.

A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation.

Vorderstrasse BA, Fenton SE, Bohn AA, Cundiff JA, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2004 April 78 (2):248-57. Epub 01/12/2004.

Developmental exposure to the potent aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin Impairs the cell-mediated immune response to infection with influenza a virus, but enhances elements of innate immunity.

Vorderstrasse BA, Cundiff JA, Lawrence BP

Journal of immunotoxicology.. 2004 April 1 (2):103-12. Epub 1900 01 01.

T cell receptor transgenic mice provide novel insights into understanding cellular targets of TCDD: suppression of antibody production, but not the response of CD8(+) T cells, during infection with influenza virus.

Mitchell KA, Lawrence BP

Toxicology and applied pharmacology.. 2003 November 1192 (3):275-86. Epub 1900 01 01.

Fewer CTL, not enhanced NK cells, are sufficient for viral clearance from the lungs of immunocompromised mice.

Neff-LaFord HD, Vorderstrasse BA, Lawrence BP

Cellular immunology.. 2003 November 226 (1):54-64. Epub 1900 01 01.

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) renders influenza virus-specific CD8+ T cells hyporesponsive to antigen.

Mitchell KA, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2003 July 74 (1):74-84. Epub 05/02/2003.

Examining the relationship between impaired host resistance and altered immune function in mice treated with TCDD.

Vorderstrasse BA, Bohn AA, Lawrence BP

Toxicology.. 2003 June 3188 (1):15-28. Epub 1900 01 01.

Fewer T lymphocytes and decreased pulmonary influenza virus burden in mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Lawrence BP, Warren TK, Luong H

Journal of toxicology and environmental health. Part A.. 2000 September 1561 (1):39-53. Epub 1900 01 01.

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppresses the humoral and cell-mediated immune responses to influenza A virus without affecting cytolytic activity in the lung.

Warren TK, Mitchell KA, Lawrence BP

Toxicological sciences : an official journal of the Society of Toxicology.. 2000 July 56 (1):114-23. Epub 1900 01 01.

Gamma-glutamyltranspeptidase knockout mice as a model for understanding the consequences of diminished glutathione on T cell-dependent immune responses.

Lawrence BP, Will Y, Reed DJ, Kerkvliet NI

European journal of immunology.. 2000 July 30 (7):1902-10. Epub 1900 01 01.

The role of polycyclic aromatic hydrocarbon metabolism in dimethylbenz[a]anthracene-induced pre-B lymphocyte apoptosis.

Mann KK, Matulka RA, Hahn ME, Trombino AF, Lawrence BP, Kerkvliet NI, Sherr DH

Toxicology and applied pharmacology.. 1999 November 15161 (1):10-22. Epub 1900 01 01.

Role of glutathione and reactive oxygen intermediates in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression in C57Bl/6 mice.

Lawrence BP, Meyer M, Reed DJ, Kerkvliet NI

Toxicological sciences : an official journal of the Society of Toxicology.. 1999 November 52 (1):50-60. Epub 1900 01 01.

2,3,7,8-Tetrachlorodibenzo-p-dioxin induction of cytochrome P450-dependent arachidonic acid metabolism in mouse liver microsomes: evidence for species-specific differences in responses.

Lee CA, Lawrence BP, Kerkvliet NI, Rifkind AB

Toxicology and applied pharmacology.. 1998 November 153 (1):1-11. Epub 1900 01 01.

Role of altered arachidonic acid metabolism in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-induced immune suppression in C57Bl/6 mice.

Lawrence BP, Kerkvliet NI

Toxicological sciences : an official journal of the Society of Toxicology.. 1998 March 42 (1):13-22. Epub 1900 01 01.

Distribution and behavior of the Ah receptor in murine T lymphocytes.

Lawrence BP, Leid M, Kerkvliet NI

Toxicology and applied pharmacology.. 1996 June 138 (2):275-84. Epub 1900 01 01.

Inhibition of protein synthesis separates autophagic sequestration from the delivery of lysosomal enzymes.

Lawrence BP, Brown WJ

Journal of cell science.. 1993 June 105 ( Pt 2) :473-80. Epub 1900 01 01.

Autophagic vacuoles rapidly fuse with pre-existing lysosomes in cultured hepatocytes.

Lawrence BP, Brown WJ

Journal of cell science.. 1992 July 102 ( Pt 3) :515-26. Epub 1900 01 01.

Books

Comprehensive Toxicology (2010)

Chapter: Cytotoxic T Cells

Authors: N. I. Kerkvliet and B. P. Lawrence

Publisher: Elsevier Ltd, Kidlington, UK 2010

Immunotoxicology and Immunopharmacology (2006)

Chapter: Immune modulation by TCDD and related polyhalogenated aromatic hydrocarbons

Authors: B.P. LAWRENCE and N.I. Kerkvliet

Publisher: CRC Press, Boca Raton 2006

Cytotoxic T Lymphocytes (2005)

Chapter: Encyclopedic Reference of Immunotoxicology

Authors: B.P. LAWRENCE

Publisher: Springer-Verlag, Germany 2005

Encyclopedic Reference of Immunotoxicology (2005)

Chapter: Cell-mediated lysis

Authors: B.P. LAWRENCE

Publisher: Springer-Verlag, Germany 2005

Current Protocols in Toxicology (2004)

Chapter: Examining the response of cytolytic lymphocytes

Authors: B.P. LAWRENCE

Publisher: John Wiley & Sons, New York 2004

T Lymphocyte Subpopulations in Immunotoxicology (1998)

Chapter: T helper cell clones and in vitro assessment of immunotoxicity

Authors: B.P. LAWRENCE and N.I. Kerkvliet

Publisher: John Wiley & Sons, New York 1998