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Thomas J. Mariani, Ph.D.

Thomas J. Mariani, Ph.D.

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About Me

Faculty Appointments

Professor - Department of Pediatrics, Neonatology (SMD)

David H. Smith Professor in Pediatrics - Department of Pediatrics (SMD)

Professor - Department of Biomedical Genetics (SMD) - Joint

Professor - Department of Environmental Medicine (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Research Associate, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 1997 - 1998

Postdoctoral Fellow, Dermatology Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 1994 - 1997

Education

PhD | Rutgers University. Microbiology and Molecular Genetics. 1993

B.S. | Rutgers University, Cook College. Biology. 1989

Awards

Andy Tager Award for Excellence in Mentoring. 2020

Mentored 2nd place winner - Respiratory Disease Young Investigators' Forum. 2006

Mentored 1st place winner - Respiratory Disease Young Investigators' Forum. 2005

Parker B. Francis Fellowship in Pulmonary Research. 2000 - 2003

Novartis (Ciba) Foundation Bursar. 1994 - 1994

Individual National Research Service Award. 1994 - 1997

Research

Premature infant morbidity and mortality often results from pulmonary complications, primarily insufficient lung maturation or alveolar formation. Likewise, many adult lung diseases involve obliteration of the distal respiratory structure. With the advent of clinical means to dramatically improve pr...
Premature infant morbidity and mortality often results from pulmonary complications, primarily insufficient lung maturation or alveolar formation. Likewise, many adult lung diseases involve obliteration of the distal respiratory structure. With the advent of clinical means to dramatically improve pre-term infant survival, there has been a growing appreciation of a relationship between developmental complications and susceptibility to chronic lung disease. The broad objectives of Dr. Mariani's laboratory are to identify the genetic mechanisms of susceptibility to chronic lung diseases, particularly focusing upon their developmental antecedents and the influence of environmental factors. Recent efforts have also investigated biomarkers and disease mechanisms involved in infant respiratory infection. Dr. Mariani's research program focuses upon defining regulatory networks involved in lung development and maturation, and which may be perturbed in diseased states. His laboratory uses a combination of animal modeling research and studies of human subjects. He is a leader in the application of genomics methods to pulmonary biology and lung disease. Current research projects in the Mariani lab include:

1. Studying immune cell dysregulation associated with chronic respiratory morbidity following preterm birth.

2. Identifying diagnostic biomarkers and therapeutic targets defining severity of clinical responses to respiratory syncytial virus infection in infants.

3. Determining the contribution of resident cells and the extracellular matrix to normal lung development, lung homeostasis and susceptibility to respiratory disease.

4. Characterizing the cellular and pathological effects of exposure to non-traditional tobacco-related products, particularly during childhood.

This work is currently supported by the NIH.

Publications

Journal Articles

Cell Population-resolved Multi-Omics Atlas of the Developing Lung.

Ushakumary MG, Feng S, Bandyopadhyay G, Olson H, Weitz KK, Huyck HL, Poole C, Purkerson JM, Bhattacharya S, Ljungberg MC, Mariani TJ, Deutsch GH, Misra RS, Carson JP, Adkins JN, Pryhuber GS, Clair G

American journal of respiratory cell and molecular biology.. 2024 October 24 Epub 10/24/2024.

Association of disease severity and genetic variation during primary Respiratory Syncytial Virus infections.

Bender W, Zhang Y, Corbett A, Chu C, Grier A, Wang L, Qiu X, McCall MN, Topham DJ, Walsh EE, Mariani TJ, Scheuermann R, Caserta MT, Anderson CS

BMC medical genomics.. 2024 June 1917 (1):165. Epub 06/19/2024.

Bulk RNA sequencing of human pediatric lung cell populations reveals unique transcriptomic signature associated with postnatal pulmonary development.

Bandyopadhyay G, Jehrio MG, Baker C, Bhattacharya S, Misra RS, Huyck HL, Chu CY, Myers JR, Ashton J, Polter S, Cochran M, Bushnell T, Dutra J, Katzman PJ, Deutsch GH, Mariani TJ, Pryhuber GS

American journal of physiology. Lung cellular and molecular physiology.. 2024 May 1326 (5):L604-L617. Epub 03/05/2024.

Single-Cell Transcriptomic Profiling Identifies Molecular Phenotypes of Newborn Human Lung Cells.

Bhattacharya S, Myers JA, Baker C, Guo M, Danopoulos S, Myers JR, Bandyopadhyay G, Romas ST, Huyck HL, Misra RS, Dutra J, Holden-Wiltse J, McDavid AN, Ashton JM, Al Alam D, Potter SS, Whitsett JA, Xu Y, Pryhuber GS, Mariani TJ

Genes.. 2024 February 2615 (3)Epub 02/26/2024.

Single-cell resolution of human airway epithelial cells exposed to bronchiolitis obliterans-associated chemicals.

Chu CY, Kim SY, Pryhuber GS, Mariani TJ, McGraw MD

American journal of physiology. Lung cellular and molecular physiology.. 2024 February 1326 (2):L135-L148. Epub 12/12/2023.

New insights into the natural history of bronchopulmonary dysplasia from proteomics and multiplexed immunohistochemistry.

Dylag AM, Misra RS, Bandyopadhyay G, Poole C, Huyck HL, Jehrio MG, Haak J, Deutsch GH, Dvorak C, Olson HM, Paurus V, Katzman P, Woo J, Purkerson JM, Adkins JN, Mariani TJ, Clair GC, Pryhuber GS

American journal of physiology. Lung cellular and molecular physiology.. 2023 October 1325 (4):L419-L433. Epub 07/25/2023.

Building Career Paths for Ph.D., Basic and Translational Scientists in Clinical Departments in the United States: An Official American Thoracic Society Workshop Report.

Moore BB, Ballinger MN, Bauer NN, Blackwell TS, Borok Z, Budinger GRS, Camoretti-Mercado B, Erzurum SC, Himes BE, Keshamouni VG, Kulkarni HS, Mallampalli RK, Mariani TJ, Martinez FJ, McCombs JE, Newcomb DC, Johnston RA, O'Reilly MA, Prakash YS, Ridge KM, Sime PJ, Sperling AI, Violette S, Wilkes DS, Königshoff M

Annals of the American Thoracic Society.. 2023 August 20 (8):1077-1087. Epub 1900 01 01.

Generation and Functional Analysis of Defective Viral Genomes during SARS-CoV-2 Infection.

Zhou T, Gilliam NJ, Li S, Spandau S, Osborn RM, Connor S, Anderson CS, Mariani TJ, Thakar J, Dewhurst S, Mathews DH, Huang L, Sun Y

mBio.. 2023 June 2714 (3):e0025023. Epub 04/19/2023.

A Trisomy 21 Lung Cell Atlas.

Bhattacharya S, Cherry C, Deutsch G, , Glass IA, Mariani TJ, Alam DA, Danopoulos S

bioRxiv : the preprint server for biology.. 2023 April 3 Epub 04/03/2023.

Gene Expression Risk Scores for COVID-19 Illness Severity.

Peterson DR, Baran AM, Bhattacharya S, Branche AR, Croft DP, Corbett AM, Walsh EE, Falsey AR, Mariani TJ

The Journal of infectious diseases.. 2023 February 1227 (3):322-331. Epub 1900 01 01.

Preparation of noninfectious scRNAseq samples from SARS-CoV-2-infected epithelial cells.

Osborn RM, Leach J, Zanche M, Ashton JM, Chu C, Thakar J, Dewhurst S, Rosenberger S, Pavelka M, Pryhuber GS, Mariani TJ, Anderson CS

PloS one.. 2023 18 (2):e0281898. Epub 02/24/2023.

Use of Host Response to Refine the Diagnosis of Group A Streptococcal Pharyngitis.

Yu J, Tycksen E, Yang W, Mariani TJ, Bhattacharya S, Falsey AR, Topham DJ, Storch GA

Journal of the Pediatric Infectious Diseases Society.. 2022 December 511 (11):482-491. Epub 1900 01 01.

Generation and functional analysis of defective viral genomes during SARS-CoV-2 infection.

Zhou T, Gilliam NJ, Li S, Spaudau S, Osborn RM, Anderson CS, Mariani TJ, Thakar J, Dewhurst S, Mathews DH, Huang L, Sun Y

bioRxiv : the preprint server for biology.. 2022 September 23 Epub 09/23/2022.

Proteomic Analysis of Human Lung Development.

Clair G, Bramer LM, Misra R, McGraw MD, Bhattacharya S, Kitzmiller JA, Feng S, Danna VG, Bandyopadhyay G, Bhotika H, Huyck HL, Deutsch GH, Mariani TJ, Carson J, Whitsett JA, Pryhuber GS, Adkins JN, Ansong C

American journal of respiratory and critical care medicine.. 2022 January 15205 (2):208-218. Epub 1900 01 01.

Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension.

Wang S, Zhu G, Jiang D, Rhen J, Li X, Liu H, Lyu Y, Tsai P, Rose Y, Nguyen T, White RJ, Pryhuber GS, Mariani TJ, Li C, Mohan A, Xu Y, Pang J

Hypertension.. 2022 January 79 (1):79-92. Epub 11/05/2021.

A systems genomics approach uncovers molecular associates of RSV severity.

McCall MN, Chu CY, Wang L, Benoodt L, Thakar J, Corbett A, Holden-Wiltse J, Slaunwhite C, Grier A, Gill SR, Falsey AR, Topham DJ, Caserta MT, Walsh EE, Qiu X, Mariani TJ

PLoS computational biology.. 2021 December 17 (12):e1009617. Epub 12/28/2021.

Lung disease manifestations in Down syndrome.

Danopoulos S, Deutsch GH, Dumortier C, Mariani TJ, Al Alam D

American journal of physiology. Lung cellular and molecular physiology.. 2021 November 1321 (5):L892-L899. Epub 09/01/2021.

The effect of air pollution on the transcriptomics of the immune response to respiratory infection.

Croft DP, Burton DS, Nagel DJ, Bhattacharya S, Falsey AR, Georas SN, Hopke PK, Johnston CJ, Kottmann RM, Litonjua AA, Mariani TJ, Rich DQ, Thevenet-Morrison K, Thurston SW, Utell MJ, McCall MN

Scientific reports.. 2021 September 3011 (1):19436. Epub 09/30/2021.

Prenatal histological, cellular, and molecular anomalies in trisomy 21 lung.

Danopoulos S, Bhattacharya S, Deutsch G, Nih LR, Slaunwhite C, Mariani TJ, Al Alam D

The Journal of pathology.. 2021 September 255 (1):41-51. Epub 06/23/2021.

Gene Expression Risk Scores for COVID-19 Illness Severity.

Peterson DR, Baran AM, Bhattacharya S, Branche AR, Croft DP, Corbett AM, Walsh EE, Falsey AR, Mariani TJ

bioRxiv : the preprint server for biology.. 2021 August 24 Epub 08/24/2021.

Serotonin system genes contribute to the susceptibility to obesity in Black adolescents.

Meng Y, Groth SW, Hodgkinson CA, Mariani TJ

Obesity science & practice.. 2021 August 7 (4):441-449. Epub 03/27/2021.

Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology.

Wang J, Kim SY, House E, Olson HM, Johnston CJ, Chalupa D, Hernady E, Mariani TJ, Clair G, Ansong C, Qian WJ, Finkelstein JN, McGraw MD

Archives of toxicology.. 2021 July 95 (7):2469-2483. Epub 05/24/2021.

The critical role of collagen VI in lung development and chronic lung disease.

Mereness JA, Mariani TJ

Matrix biology plus.. 2021 June 10 :100058. Epub 02/20/2021.

Temporal Dysbiosis of Infant Nasal Microbiota Relative to Respiratory Syncytial Virus Infection.

Grier A, Gill AL, Kessler HA, Corbett A, Bandyopadhyay S, Java J, Holden-Wiltse J, Falsey AR, Topham DJ, Mariani TJ, Caserta MT, Walsh EE, Gill SR

The Journal of infectious diseases.. 2021 May 20223 (9):1650-1658. Epub 1900 01 01.

Airway Gene Expression Correlates of Respiratory Syncytial Virus Disease Severity and Microbiome Composition in Infants.

Chu CY, Qiu X, McCall MN, Wang L, Corbett A, Holden-Wiltse J, Slaunwhite C, Grier A, Gill SR, Pryhuber GS, Falsey AR, Topham DJ, Caserta MT, Walsh EE, Mariani TJ

The Journal of infectious diseases.. 2021 May 20223 (9):1639-1649. Epub 1900 01 01.

CX3CR1 Engagement by Respiratory Syncytial Virus Leads to Induction of Nucleolin and Dysregulation of Cilia-related Genes.

Anderson CS, Chirkova T, Slaunwhite CG, Qiu X, Walsh EE, Anderson LJ, Mariani TJ

Journal of virology.. 2021 May 1095 (11)Epub 03/17/2021.

Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.

Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subramanian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber AL, Chung H, Montoro DT, Adams T, Aliee H, Allon SJ, Andrusivova Z, Angelidis I, Ashenberg O, Bassler K, Bécavin C, Benhar I, Bergenstråhle J, Bergenstråhle L, Bolt L, Braun E, Bui LT, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Conlon TM, Cuoco MS, Cuomo ASE, Deprez M, Duclos G, Fine D, Fischer DS, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez AJ, Habermann AC, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos TS, Kuo CS, Larsson L, Leney-Greene MA, Lim K, Litvi?uková M, Ludwig LS, Lukassen S, Luo W, Maatz H, Madissoon E, Mamanova L, Manakongtreecheep K, Leroy S, Mayr CH, Mbano IM, McAdams AM, Nabhan AN, Nyquist SK, Penland L, Poirion OB, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp JC, Shea CV, Shi X, Sinha R, Sit RV, Slowikowski K, Slyper M, Smith NP, Sountoulidis A, Strunz M, Sullivan TB, Sun D, Talavera-López C, Tan P, Tantivit J, Travaglini KJ, Tucker NR, Vernon KA, Wadsworth MH, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler CGK, ,

Nature medicine.. 2021 March 27 (3):546-559. Epub 03/02/2021.

Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants.

Wang L, Chu CY, McCall MN, Slaunwhite C, Holden-Wiltse J, Corbett A, Falsey AR, Topham DJ, Caserta MT, Mariani TJ, Walsh EE, Qiu X

BMC medical genomics.. 2021 February 2514 (1):57. Epub 02/25/2021.

Human Fetal Tissue Regulation. Impact on Pediatric and Adult Respiratory-related Research.

Al Alam D, Ballard PL, Jourdan Le Saux C, Ingram JL, Mariani TJ, Moore NS, Weiss DJ, Yu M

Annals of the American Thoracic Society.. 2021 February 18 (2):204-208. Epub 1900 01 01.

Unbiased analysis of peripheral blood mononuclear cells reveals CD4 T cell response to RSV matrix protein.

Thakar J, Qian Y, Benoodt L, Roumanes D, Qiu X, Laniewski N, Chu C, Slaunwhite C, Wang L, Mandava A, Chang I, Falsey AR, Caserta MT, Mariani TJ, Scheuermann RH, Walsh EE, Topham DJ

Vaccine: X.. 2020 August 75 :100065. Epub 04/21/2020.

Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis.

Ren Y, Lyu Y, Mereness JA, Wang S, Pang J, Mariani TJ

The American journal of pathology.. 2020 August 190 (8):1763-1773. Epub 05/22/2020.

Implementing sequence-based antigenic distance calculation into immunological shape space model.

Anderson CS, Sangster MY, Yang H, Mariani TJ, Chaudhury S, Topham DJ

BMC bioinformatics.. 2020 June 1921 (1):256. Epub 06/19/2020.

Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure.

McGraw MD, Kim SY, Reed C, Hernady E, Rahman I, Mariani TJ, Finkelstein JN

Toxicology letters.. 2020 June 1325 :25-33. Epub 02/26/2020.

CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung.

Anderson CS, Chu CY, Wang Q, Mereness JA, Ren Y, Donlon K, Bhattacharya S, Misra RS, Walsh EE, Pryhuber GS, Mariani TJ

Pediatric research.. 2020 April 87 (5):862-867. Epub 11/14/2019.

A novel in vitro model of primary human pediatric lung epithelial cells.

Wang Q, Bhattacharya S, Mereness JA, Anderson C, Lillis JA, Misra RS, Romas S, Huyck H, Howell A, Bandyopadhyay G, Donlon K, Myers JR, Ashton J, Pryhuber GS, Mariani TJ

Pediatric research.. 2020 February 87 (3):511-517. Epub 02/18/2019.

Collagen VI Deficiency Results in Structural Abnormalities in the Mouse Lung.

Mereness JA, Bhattacharya S, Ren Y, Wang Q, Anderson CS, Donlon K, Dylag AM, Haak J, Angelin A, Bonaldo P, Mariani TJ

The American journal of pathology.. 2020 February 190 (2):426-441. Epub 12/13/2019.

Transcriptional characterisation of human lung cells identifies novel mesenchymal lineage markers.

Danopoulos S, Bhattacharya S, Mariani TJ, Al Alam D

The European respiratory journal.. 2020 January 55 (1)Epub 01/23/2020.

Lymphocyte-Specific Biomarkers Associated With Preterm Birth and Bronchopulmonary Dysplasia.

Bhattacharya S, Mereness JA, Baran AM, Misra RS, Peterson DR, Ryan RM, Reynolds AM, Pryhuber GS, Mariani TJ

Frontiers in immunology.. 2020 11 :563473. Epub 01/21/2021.

Comprehensive anatomic ontologies for lung development: A comparison of alveolar formation and maturation within mouse and human lung.

Pan H, Deutsch GH, Wert SE, ,

Journal of biomedical semantics. 2019 October 2410 (1):18. Epub 10/24/2019.

Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection.

Sonawane AR, Tian L, Chu CY, Qiu X, Wang L, Holden-Wiltse J, Grier A, Gill SR, Caserta MT, Falsey AR, Topham DJ, Walsh EE, Mariani TJ, Weiss ST, Silverman EK, Glass K, Liu YY

Scientific reports.. 2019 September 259 (1):13824. Epub 09/25/2019.

Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung.

Du Y, Clair GC, Al Alam, Danopoulos S, Schnell D, Kitzmiller JA, Misra RS, Bhattacharya S, Warburton D, Mariani TJ, Pryhuber GS, Whitsett JA, Ansong C, Xu Y

American journal of physiology. Lung cellular and molecular physiology.. 2019 September 1317 (3):L347-L360. Epub 07/03/2019.

Mutation of Respiratory Syncytial Virus G Protein's CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells.

Ha B, Chirkova T, Boukhvalova MS, Sun HY, Walsh EE, Anderson CS, Mariani TJ, Anderson LJ

Vaccines.. 2019 July 197 (3)Epub 07/19/2019.

Aims, Study Design, and Enrollment Results From the Assessing Predictors of Infant Respiratory Syncytial Virus Effects and Severity Study.

Walsh EE, Mariani TJ, Chu C, Grier A, Gill SR, Qiu X, Wang L, Holden-Wiltse J, Corbett A, Thakar J, Benoodt L, McCall MN, Topham DJ, Falsey AR, Caserta MT

JMIR research protocols.. 2019 June 68 (6):e12907. Epub 06/06/2019.

Host Gene Expression in Nose and Blood for the Diagnosis of Viral Respiratory Infection.

Yu J, Peterson DR, Baran AM, Bhattacharya S, Wylie TN, Falsey AR, Mariani TJ, Storch GA

The Journal of infectious diseases.. 2019 April 1219 (7):1151-1161. Epub 1900 01 01.

Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia.

Ryan RM, Feng R, Bazacliu C, Ferkol TW, Ren CL, Mariani TJ, Poindexter BB, Wang F, Moore PE,

The Journal of pediatrics.. 2019 April 207 :130-135.e2. Epub 01/04/2019.

Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth.

Hamvas A, Feng R, Bi Y, Wang F, Bhattacharya S, Mereness J, Kaushal M, Cotten CM, Ballard PL, Mariani TJ,

BMC genetics.. 2018 October 2019 (1):94. Epub 10/20/2018.

Dissociation, cellular isolation, and initial molecular characterization of neonatal and pediatric human lung tissues.

Bandyopadhyay G, Huyck HL, Misra RS, Bhattacharya S, Wang Q, Mereness J, Lillis JA, Myers JR, Ashton J, Bushnell T, Cochran M, Holden-Wiltse J, Katzman P, Deutsch GH, Whitsett JA, Xu Y, Mariani TJ, Pryhuber GS

American journal of physiology. Lung cellular and molecular physiology.. 2018 October 1315 (4):L576-L583. Epub 07/05/2018.

Cell type-resolved human lung lipidome reveals cellular cooperation in lung function.

Kyle JE, Clair G, Bandyopadhyay G, Misra RS, Zink EM, Bloodsworth KJ, Shukla AK, Du Y, Lillis J, Myers JR, Ashton J, Bushnell T, Cochran M, Deutsch G, Baker ES, Carson JP, Mariani TJ, Xu Y, Whitsett JA, Pryhuber G, Ansong C

Scientific reports.. 2018 September 78 (1):13455. Epub 09/07/2018.

Virus-Specific Antibody, Viral Load, and Disease Severity in Respiratory Syncytial Virus Infection.

Walsh EE, Wang L, Falsey AR, Qiu X, Corbett A, Holden-Wiltse J, Mariani TJ, Topham DJ, Caserta MT

The Journal of infectious diseases.. 2018 June 20218 (2):208-217. Epub 1900 01 01.

T cell developmental arrest in former premature infants increases risk of respiratory morbidity later in infancy.

Scheible KM, Emo J, Laniewski N, Baran AM, Peterson DR, Holden-Wiltse J, Bandyopadhyay S, Straw AG, Huyck H, Ashton JM, Tripi KS, Arul K, Werner E, Scalise T, Maffett D, Caserta M, Ryan RM, Reynolds AM, Ren CL, Topham DJ, Mariani TJ, Pryhuber GS

JCI insight.. 2018 February 223 (4)Epub 02/22/2018.

PPAR?-mediated peroxisome induction compensates PPAR?-deficiency in bronchiolar club cells.

Karnati S, Oruqaj G, Janga H, Tumpara S, Colasante C, Van Veldhoven PP, Braverman N, Pilatz A, Mariani TJ, Baumgart-Vogt E

PloS one.. 2018 13 (9):e0203466. Epub 09/13/2018.

Type VI collagen promotes lung epithelial cell spreading and wound-closure.

Mereness JA, Bhattacharya S, Wang Q, Ren Y, Pryhuber GS, Mariani TJ

PloS one.. 2018 13 (12):e0209095. Epub 12/14/2018.

Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth.

Grier A, Qiu X, Bandyopadhyay S, Holden-Wiltse J, Kessler HA, Gill AL, Hamilton B, Huyck H, Misra S, Mariani TJ, Ryan RM, Scholer L, Scheible KM, Lee YH, Caserta MT, Pryhuber GS, Gill SR

Microbiome.. 2017 December 115 (1):158. Epub 12/11/2017.

Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants.

Mariani TJ, Qiu X, Chu CY, Wang L, Thakar J, Holden-Wiltse J, Corbett A, Topham DJ, Falsey AR, Caserta MT, Walsh EE

The Journal of infectious diseases.. 2017 November 15216 (8):1027-1037. Epub 1900 01 01.

LungMAP: The Molecular Atlas of Lung Development Program.

Ardini-Poleske ME, Clark RF, Ansong C, Carson JP, Corley RA, Deutsch GH, Hagood JS, Kaminski N, Mariani TJ, Potter SS, Pryhuber GS, Warburton D, Whitsett JA, Palmer SM, Ambalavanan N, LungMAP Consortium T

American journal of physiology. Lung cellular and molecular physiology.. 2017 November 1313 (5):L733-L740. Epub 08/10/2017.

Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness.

Bhattacharya S, Rosenberg AF, Peterson DR, Grzesik K, Baran AM, Ashton JM, Gill SR, Corbett AM, Holden-Wiltse J, Topham DJ, Walsh EE, Mariani TJ, Falsey AR

Scientific reports.. 2017 July 267 (1):6548. Epub 07/26/2017.

Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development.

Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y

Thorax.. 2017 May 72 (5):481-484. Epub 01/09/2017.

MicroRNA expression profiling defines the impact of electronic cigarettes on human airway epithelial cells.

Solleti SK, Bhattacharya S, Ahmad A, Wang Q, Mereness J, Rangasamy T, Mariani TJ

Scientific reports.. 2017 April 247 (1):1081. Epub 04/24/2017.

Flow-based sorting of neonatal lymphocyte populations for transcriptomics analysis.

Misra RS, Bhattacharya S, Huyck HL, Wang JE, Slaunwhite CG, Slaunwhite SL, Wightman TR, Secor-Socha S, Misra SK, Bushnell TP, Reynolds AM, Ryan RM, Quataert SA, Pryhuber GS, Mariani TJ

Journal of immunological methods.. 2016 October 437 :13-20. Epub 07/18/2016.

The Healthy Infant Nasal Transcriptome: A Benchmark Study.

Chu CY, Qiu X, Wang L, Bhattacharya S, Lofthus G, Corbett A, Holden-Wiltse J, Grier A, Tesini B, Gill SR, Falsey AR, Caserta MT, Walsh EE, Mariani TJ

Scientific reports.. 2016 September 236 :33994. Epub 09/23/2016.

Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation.

Solleti SK, Srisuma S, Bhattacharya S, Rangel-Moreno J, Bijli KM, Randall TD, Rahman A, Mariani TJ

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 July 30 (7):2615-26. Epub 04/08/2016.

Postnatal development of the bronchiolar club cells of distal airways in the mouse lung: stereological and molecular biological studies.

Karnati S, Graulich T, Oruqaj G, Pfreimer S, Seimetz M, Stamme C, Mariani TJ, Weissmann N, Mühlfeld C, Baumgart-Vogt E

Cell and tissue research.. 2016 June 364 (3):543-557. Epub 01/21/2016.

Recurrent copy number variants associated with bronchopulmonary dysplasia.

Ahmad A, Bhattacharya S, Sridhar A, Iqbal AM, Mariani TJ

Pediatric research.. 2016 June 79 (6):940-5. Epub 03/14/2016.

The Oxygen Environment at Birth Specifies the Population of Alveolar Epithelial Stem Cells in the Adult Lung.

Yee M, Gelein R, Mariani TJ, Lawrence BP, O'Reilly MA

Stem cells.. 2016 May 34 (5):1396-406. Epub 03/07/2016.

Respiratory disorders: Ironing out smoking-related airway disease.

Mariani TJ

Nature.. 2016 March 31531 (7596):586-7. Epub 03/09/2016.

Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants.

Scheible KM, Emo J, Yang H, Holden-Wiltse J, Straw A, Huyck H, Misra S, Topham DJ, Ryan RM, Reynolds AM, Mariani TJ, Pryhuber GS

Clinical immunology : the official journal of the Clinical Immunology Society.. 2015 December 161 (2):65-74. Epub 07/29/2015.

Update on Molecular Biology of Lung Development--Transcriptomics.

Mariani TJ

Clinics in perinatology.. 2015 December 42 (4):685-95. Epub 1900 01 01.

CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion.

Legoux FP, Lim JB, Cauley AW, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way SS, Moon JJ

Immunity.. 2015 November 1743 (5):896-908. Epub 11/10/2015.

Airway epithelial cell PPAR? modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice.

Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ

American journal of physiology. Lung cellular and molecular physiology.. 2015 August 1309 (3):L293-304. Epub 05/29/2015.

Alterations in gene expression and DNA methylation during murine and human lung alveolar septation.

Cuna A, Halloran B, Faye-Petersen O, Kelly D, Crossman DK, Cui X, Pandit K, Kaminski N, Bhattacharya S, Ahmad A, Mariani TJ, Ambalavanan N

American journal of respiratory cell and molecular biology.. 2015 July 53 (1):60-73. Epub 1900 01 01.

Preterm cord blood CD4? T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4? T cells in bronchopulmonary dysplasia.

Misra R, Shah S, Fowell D, Wang H, Scheible K, Misra S, Huyck H, Wyman C, Ryan RM, Reynolds AM, Mariani T, Katzman PJ, Pryhuber GS

Human immunology.. 2015 May 76 (5):329-338. Epub 03/20/2015.

Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study of respiratory outcomes of preterm infants in the United States.

Pryhuber GS, Maitre NL, Ballard RA, Cifelli D, Davis SD, Ellenberg JH, Greenberg JM, Kemp J, Mariani TJ, Panitch H, Ren C, Shaw P, Taussig LM, Hamvas A,

BMC pediatrics.. 2015 April 1015 :37. Epub 04/10/2015.

Integrated genomic analyses in bronchopulmonary dysplasia.

Ambalavanan N, Cotten CM, Page GP, Carlo WA, Murray JC, Bhattacharya S, Mariani TJ, Cuna AC, Faye-Petersen OM, Kelly D, Higgins RD,

The Journal of pediatrics.. 2015 March 166 (3):531-7.e13. Epub 11/06/2014.

The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator.

Bhattacharya S, Zhou Z, Yee M, Chu CY, Lopez AM, Lunger VA, Solleti SK, Resseguie E, Buczynski BW, Mariani TJ, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2014 October 1307 (7):L516-23. Epub 08/22/2014.

Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis.

Qiu W, Rogers AJ, Damask A, Raby BA, Klanderman BJ, Duan QL, Tyagi S, Niu S, Anderson C, Cahir-McFarland E, Mariani TJ, Carey V, Tantisira KG

Human molecular genetics.. 2014 September 1523 (18):5017-24. Epub 04/25/2014.

HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.

Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK

PLoS biology.. 2013 September 11 (9):e1001665. Epub 09/24/2013.

Chronic obstructive pulmonary disease genomics: yesterday, discovering population biomarkers; tomorrow, defining disease clusters.

Mariani TJ, Martinez F

American journal of respiratory and critical care medicine.. 2013 May 1187 (9):900-2. Epub 1900 01 01.

Systems biology approaches to identify developmental bases for lung diseases.

Bhattacharya S, Mariani TJ

Pediatric research.. 2013 April 73 (4 Pt 2):514-22. Epub 01/11/2013.

Molecular determinants of lung development.

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS

Annals of the American Thoracic Society.. 2013 April 10 (2):S12-6. Epub 1900 01 01.

Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection.

Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S

Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2012 November 81 (11):937-49. Epub 10/01/2012.

Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia.

Bhattacharya S, Go D, Krenitsky DL, Huyck HL, Solleti SK, Lunger VA, Metlay L, Srisuma S, Wert SE, Mariani TJ, Pryhuber GS

American journal of respiratory and critical care medicine.. 2012 August 15186 (4):349-58. Epub 06/21/2012.

Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation.

Reddy NM, Potteti HR, Mariani TJ, Biswal S, Reddy SP

American journal of respiratory cell and molecular biology.. 2011 December 45 (6):1161-8. Epub 06/09/2011.

Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease.

Brehm JM, Hagiwara K, Tesfaigzi Y, Bruse S, Mariani TJ, Bhattacharya S, Boutaoui N, Ziniti JP, Soto-Quiros ME, Avila L, Cho MH, Himes B, Litonjua AA, Jacobson F, Bakke P, Gulsvik A, Anderson WH, Lomas DA, Forno E, Datta S, Silverman EK, Celedón JC

Thorax.. 2011 December 66 (12):1085-90. Epub 09/15/2011.

Association of SERPINE2 with asthma.

Himes BE, Klanderman B, Ziniti J, Senter-Sylvia J, Soto-Quiros ME, Avila L, Celedón JC, Lange C, Mariani TJ, Lasky-Su J, Hersh CP, Raby BA, Silverman EK, Weiss ST, Demeo DL

Chest.. 2011 September 140 (3):667-674. Epub 03/24/2011.

Expression analysis of asthma candidate genes during human and murine lung development.

Melen E, Kho AT, Sharma S, Gaedigk R, Leeder JS, Mariani TJ, Carey VJ, Weiss ST, Tantisira KG

Respiratory research.. 2011 June 2312 (1):86. Epub 06/23/2011.

SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development.

Hersh CP, Silverman EK, Gascon J, Bhattacharya S, Klanderman BJ, Litonjua AA, Lefebvre V, Sparrow D, Reilly JJ, Anderson WH, Lomas DA, Mariani TJ,

American journal of respiratory and critical care medicine.. 2011 June 1183 (11):1482-9. Epub 02/17/2011.

Peripheral blood gene expression profiles in COPD subjects.

Bhattacharya S, Tyagi S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ

Journal of clinical bioinformatics. 2011 April 241 (1):12. Epub 04/24/2011.

PPARgamma deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution.

Simon DM, Tsai LW, Ingenito EP, Starcher BC, Mariani TJ

Respiratory research.. 2010 June 211 (1):69. Epub 06/02/2010.

Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation.

Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S

American journal of respiratory cell and molecular biology.. 2010 May 42 (5):524-36. Epub 06/11/2009.

Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis.

Srisuma S, Bhattacharya S, Simon DM, Solleti SK, Tyagi S, Starcher B, Mariani TJ

American journal of respiratory and critical care medicine.. 2010 April 15181 (8):838-50. Epub 01/21/2010.

A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma.

Sharma S, Tantisira K, Carey V, Murphy AJ, Lasky-Su J, Celedón JC, Lazarus R, Klanderman B, Rogers A, Soto-Quirós M, Avila L, Mariani T, Gaedigk R, Leeder S, Torday J, Warburton D, Raby B, Weiss ST

American journal of respiratory and critical care medicine.. 2010 February 15181 (4):328-36. Epub 11/19/2009.

Transcriptomic analysis of human lung development.

Kho AT, Bhattacharya S, Tantisira KG, Carey VJ, Gaedigk R, Leeder JS, Kohane IS, Weiss ST, Mariani TJ

American journal of respiratory and critical care medicine.. 2010 January 1181 (1):54-63. Epub 10/08/2009.

Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.

DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK

American journal of human genetics.. 2009 October 85 (4):493-502. Epub 1900 01 01.

Array of hope: expression profiling identifies disease biomarkers and mechanism.

Bhattacharya S, Mariani TJ

Biochemical Society transactions.. 2009 August 37 (Pt 4):855-62. Epub 1900 01 01.

Platform dependence of inference on gene-wise and gene-set involvement in human lung development.

Du R, Tantisira K, Carey V, Bhattacharya S, Metje S, Kho AT, Klanderman BJ, Gaedigk R, Lazarus R, Mariani TJ, Leeder JS, Weiss ST

BMC bioinformatics.. 2009 June 1910 :189. Epub 06/19/2009.

Molecular biomarkers for quantitative and discrete COPD phenotypes.

Bhattacharya S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ

American journal of respiratory cell and molecular biology.. 2009 March 40 (3):359-67. Epub 10/10/2008.

Expression profiles of the mouse lung identify a molecular signature of time-to-birth.

Kho AT, Bhattacharya S, Mecham BH, Hong J, Kohane IS, Mariani TJ

American journal of respiratory cell and molecular biology.. 2009 January 40 (1):47-57. Epub 07/29/2008.

Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma.

Planagumà A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD

American journal of respiratory and critical care medicine.. 2008 September 15178 (6):574-82. Epub 06/26/2008.

Conditional stabilization of beta-catenin expands the pool of lung stem cells.

Reynolds SD, Zemke AC, Giangreco A, Brockway BL, Teisanu RM, Drake JA, Mariani T, Di PY, Taketo MM, Stripp BR

Stem cells.. 2008 May 26 (5):1337-46. Epub 03/20/2008.

Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility.

Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L

American journal of respiratory cell and molecular biology.. 2008 January 38 (1):57-67. Epub 07/26/2007.

FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma.

Tantisira KG, Silverman ES, Mariani TJ, Xu J, Richter BG, Klanderman BJ, Litonjua AA, Lazarus R, Rosenwasser LJ, Fuhlbrigge AL, Weiss ST

The Journal of allergy and clinical immunology.. 2007 December 120 (6):1285-91. Epub 11/05/2007.

Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury.

Hirakawa H, Pierce RA, Bingol-Karakoc G, Karaaslan C, Weng M, Shi GP, Saad A, Weber E, Mariani TJ, Starcher B, Shapiro SD, Cataltepe S

American journal of respiratory and critical care medicine.. 2007 October 15176 (8):778-85. Epub 08/02/2007.

Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma.

Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR

The Journal of immunology : official journal of the American Association of Immunologists.. 2007 May 15178 (10):6191-9. Epub 1900 01 01.

Role of PPARs and Retinoid X Receptors in the Regulation of Lung Maturation and Development.

Simon DM, Mariani TJ

PPAR research. 2007 2007 :91240. Epub 1900 01 01.

Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells.

Chu EK, Cheng J, Foley JS, Mecham BH, Owen CA, Haley KJ, Mariani TJ, Kohane IS, Tschumperlin DJ, Drazen JM

American journal of respiratory cell and molecular biology.. 2006 December 35 (6):628-38. Epub 06/22/2006.

Microarray data-based prioritization of chronic obstructive pulmonary disease susceptibility genes.

Bhattacharya S, Srisuma S, Demeo DL, Reilly JJ, Bueno R, Silverman EK, Mariani TJ

Proceedings of the American Thoracic Society.. 2006 August 3 (6):472. Epub 1900 01 01.

Epithelial cell PPARgamma is an endogenous regulator of normal lung maturation and maintenance.

Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Andalcio T, Shapiro SD, Mariani TJ

Proceedings of the American Thoracic Society.. 2006 August 3 (6):510-1. Epub 1900 01 01.

Epithelial cell PPAR[gamma] contributes to normal lung maturation.

Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Tsai LW, Ingenito EP, Gonzalez F, Shapiro SD, Mariani TJ

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2006 July 20 (9):1507-9. Epub 05/23/2006.

K-ras activation generates an inflammatory response in lung tumors.

Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK

Oncogene.. 2006 March 3025 (14):2105-12. Epub 1900 01 01.

The SERPINE2 gene is associated with chronic obstructive pulmonary disease.

Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK

American journal of human genetics.. 2006 February 78 (2):253-64. Epub 12/15/2005.

Transformation of expression intensities across generations of Affymetrix microarrays using sequence matching and regression modeling.

Bhattacharya S, Mariani TJ

Nucleic acids research.. 2005 October 1333 (18):e157. Epub 10/13/2005.

Induction of macrophage elastase (MMP-12) gene expression by statins.

Arikan MC, Shapiro SD, Mariani TJ

Journal of cellular physiology.. 2005 July 204 (1):139-45. Epub 1900 01 01.

Increased measurement accuracy for sequence-verified microarray probes.

Mecham BH, Wetmore DZ, Szallasi Z, Sadovsky Y, Kohane I, Mariani TJ

Physiological genomics.. 2004 August 1118 (3):308-15. Epub 08/11/2004.

Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements.

Mecham BH, Klus GT, Strovel J, Augustus M, Byrne D, Bozso P, Wetmore DZ, Mariani TJ, Kohane IS, Szallasi Z

Nucleic acids research.. 2004 May 2532 (9):e74. Epub 05/25/2004.

Regulation of alveogenesis by reciprocal proximo-distal fibroblast growth factor and retinoic acid signaling.

Mariani, T.J.

Am J Resp Cell Mol Biol. 2004; 31(2 Suppl): S1-S81.

Gene expression studies in lung development and lung stem cell biology.

Mariani TJ, Kaminski N

Current topics in developmental biology.. 2004 64 :57-71. Epub 1900 01 01.

A variable fold change threshold determines significance for expression microarrays.

Mariani TJ, Budhraja V, Mecham BH, Gu CC, Watson MA, Sadovsky Y

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2003 February 17 (2):321-3. Epub 12/03/2002.

Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression.

Zelko IN, Mariani TJ, Folz RJ

Free radical biology & medicine.. 2002 August 133 (3):337-49. Epub 1900 01 01.

Expression profiling of the developing mouse lung: insights into the establishment of the extracellular matrix.

Mariani TJ, Reed JJ, Shapiro SD

American journal of respiratory cell and molecular biology.. 2002 May 26 (5):541-8. Epub 1900 01 01.

Fibroblast tropoelastin and alpha-smooth-muscle actin expression are repressed by particulate-activated macrophage-derived tumor necrosis factor-alpha in experimental silicosis.

Mariani TJ, Arikan MC, Pierce RA

American journal of respiratory cell and molecular biology.. 1999 August 21 (2):185-92. Epub 1900 01 01.

Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells.

Mariani TJ, Dunsmore SE, Li Q, Ye X, Pierce RA

American journal of physiology. Lung cellular and molecular physiology.. 1998 January 1274 (1):L47-L57. Epub 1900 01 01.

Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells.

Mariani TJ, Dunsmore SE, Li Q, Ye X, Pierce RA

The American journal of physiology.. 1998 January 274 (1):L47-57. Epub 1900 01 01.

Elastin in lung development.

Mariani TJ, Sandefur S, Pierce RA

Experimental lung research.. 1997 23 (2):131-45. Epub 1900 01 01.

Localization of type I procollagen gene expression in silica-induced granulomatous lung disease and implication of transforming growth factor-beta as a mediator of fibrosis.

Mariani TJ, Roby JD, Mecham RP, Parks WC, Crouch E, Pierce RA

The American journal of pathology.. 1996 January 148 (1):151-64. Epub 1900 01 01.

Increased elastin production in experimental granulomatous lung disease.

Mariani TJ, Crouch E, Roby JD, Starcher B, Pierce RA

The American journal of pathology.. 1995 October 147 (4):988-1000. Epub 1900 01 01.

Ultraviolet radiation increases tropoelastin accumulation by a post-transcriptional mechanism in dermal fibroblasts.

Schwartz E, Feinberg E, Lebwohl M, Mariani TJ, Boyd CD

The Journal of investigative dermatology.. 1995 July 105 (1):65-9. Epub 1900 01 01.

The size heterogeneity of human lysyl oxidase mRNA is due to alternate polyadenylation site and not alternate exon usage.

Boyd CD, Mariani TJ, Kim Y, Csiszar K

Molecular biology reports.. 1995 21 (2):95-103. Epub 1900 01 01.

Elastin in lung development and disease.

Pierce RA, Mariani TJ, Senior RM

Ciba Foundation symposium.. 1995 192 :199-212; discussion 212-4. Epub 1900 01 01.

The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene).

Mariani TJ, Trackman PC, Kagan HM, Eddy RL, Shows TB, Boyd CD, Deak SB

Matrix (Stuttgart, Germany). 1992 June 12 (3):242-8. Epub 1900 01 01.

The role of abnormal type III collagen in the development of common aneurysms.

Deak SB, Ricotta JJ, Mariani TJ, Deak ST, Zatina MA, Mackenzie JW, Boyd CD

Journal of vascular surgery.. 1992 May 15 (5):926-7. Epub 1900 01 01.

Abnormalities in the biosynthesis of type III procollagen in cultured skin fibroblasts from two patients with multiple aneurysms.

Deak SB, Ricotta JJ, Mariani TJ, Deak ST, Zatina MA, Mackenzie JW, Boyd CD

Matrix (Stuttgart, Germany). 1992 April 12 (2):92-100. Epub 1900 01 01.

Books

Principles of Developmental Genetics (2006)

Chapter: Developmental genetics of the pulmonary system

Authors: Mariani, T.J

Publisher: Elsevier, San Diego, CA 2006

Lung Biology in Health and Disease (2006)

Chapter: Microarray techniques and data in asthma and COPD

Authors: Mariani, T.J.; Ramoni, M.F

Publisher: Informa Health Care, New York, NY 2006

Extracellular Matrices and Development (2005)

Chapter: Extracellular matrix gene expression in developing mouse aorta

Authors: McLean, S.E.; Mecham, B.H.; Kelleher, C.M.; Mariani, T.J.; Mecham, R.P

Publisher: Elsevier 2005

Lung Development (1999)

Chapter: Development of lung elastic matrix

Authors: Mariani, T.J.; Pierce, R.A

Publisher: Oxford University Press, New York, NY 1999