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Helene McMurray, Ph.D.

Helene McMurray, Ph.D.

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Office (585) 276-4368
Administrative (585) 275-1959

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About Me

Helene R. McMurray, Ph.D., is co-director of the Tissue Typing / Histocompatibility Laboratory, which provides state-of-the-art compatibility testing for the solid organ and stem cell transplantation services including HLA typing by molecular methods, antibody screening and identification, and cross...
Helene R. McMurray, Ph.D., is co-director of the Tissue Typing / Histocompatibility Laboratory, which provides state-of-the-art compatibility testing for the solid organ and stem cell transplantation services including HLA typing by molecular methods, antibody screening and identification, and cross-matching. Dr. McMurray is board certified by the American College of Histocompatibility and Immunogenetics (ACHI) and holds a NYS Certificate of Qualification in Histocompatibility. Over Helene’s career in biomedical science, she has gained expertise in histocompatibility, cancer biology, genetics, genomics, and bioinformatics with publications and presentations of her scientific work in all these areas. Moreover, Dr. McMurray is a highly experienced educator who has taught numerous graduate-level courses in a variety of biomedical subject areas, as well as currently serving as program director for the PhD in Pathology.

Faculty Appointments

Associate Professor - Department of Pathology and Laboratory Medicine (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellow, Laboratory of Dr. Hartmut Land, Department of Biomedical Genetics, University of Rochester, School of Medicine and Dentistry, Rochester, NY 2003 - 2009

Education

PhD | University of Rochester School of Medicine & Dentistry. Microbiology. 2003

BS | Cornell University. Biological Science. 1998

Awards

Award for Outstanding CP Didactics Presentation / Excellence in Resident Education. 2021

Career Development Award, Medical Informatics Section. 2017

MLA / CHLA / ICLC Joint Meeting Scholarship Award. 2016

NLM Biomedical Informatics Workshop Fellowship. 2015

The Graduate Student Society Faculty Award. 2014

Wilson A. Stone Memorial Award. 2008

Outstanding Poster by a Post-Doctoral Fellow, University Day in Genetics. 2008

Outstanding Research Contribution, Medical School Convocation. 2008

Postdoctoral Fellowship. 2003 - 2006

GSS Merit Award. 2002

Pre-Doctoral Fellowship. 2001 - 2003

Cornell Tradition Summer Research Fellowship. 1996 - 1997

Cornell Tradition Fellowship. 1994 - 1998

Research

Dr. McMurray conducts collaborative research projects using approaches in genomics, bioinformatics, biostatistics, genetics and cell and molecular biology. With Drs. Hartmut "Hucky" Land, Matthew McCall and Aslihan Ambeskovic, Dr. McMurray studies gene regulatory networks underlying malignant cell ...
Dr. McMurray conducts collaborative research projects using approaches in genomics, bioinformatics, biostatistics, genetics and cell and molecular biology. With Drs. Hartmut "Hucky" Land, Matthew McCall and Aslihan Ambeskovic, Dr. McMurray studies gene regulatory networks underlying malignant cell transformation to understand the molecular architecture of cancer cells and identify cancer cell vulnerabilities. Dr. McMurray also contributes her genomics and bioinformatics expertise to the work of Drs. Carol Fries on the pediatric cancer B-ALL. With Drs. Myra Coppage, Elizabeth Sunderhaus, Emily Smithers and Reut Hod Dvorai, Dr. McMurray has also conducted several projects to address questions related to clinical histocompatibility testing.

Publications

Journal Articles

Correction: Multiple imputation and direct estimation for qPCR data with non-detects.

Sherina V, McMurray HR, Powers W, Land H, Love TMT, McCall MN

BMC bioinformatics.. 2024 February 725 (1):63. Epub 02/07/2024.

Protocol to use TopNet for gene regulatory network modeling using gene expression data from perturbation experiments.

McMurray HR, Stern HA, Ambeskovic A, Land H, McCall MN

STAR protocols.. 2022 December 163 (4):101737. Epub 09/30/2022.

Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes.

McMurray HR, Ambeskovic A, Newman LA, Aldersley J, Balakrishnan V, Smith B, Stern HA, Land H, McCall MN

Cell reports.. 2021 December 2137 (12):110136. Epub 1900 01 01.

Multiple imputation and direct estimation for qPCR data with non-detects.

Sherina V, McMurray HR, Powers W, Land H, Love TMT, McCall MN

BMC bioinformatics.. 2020 November 2621 (1):545. Epub 11/26/2020.

Bone marrow mesenchymal stromal cells from acute myelogenous leukemia patients demonstrate adipogenic differentiation propensity with implications for leukemia cell support.

Azadniv M, Myers JR, McMurray HR, Guo N, Rock P, Coppage ML, Ashton J, Becker MW, Calvi LM, Liesveld JL

Leukemia.. 2020 February 34 (2):391-403. Epub 09/06/2019.

P136 Pre- and Post-Transplant Assessment of Autoantibody in a Series of Cardiac Transplant Recipients.

Coppage, M.; H.R. McMurray; J. Hoffmann; J. Martens; A. Sorensen; and B. Goldman.

Human Immunology. 2019; 80(supplement): 158.

Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex.

Wong EL, Lutz NM, Hogan VA, Lamantia CE, McMurray HR, Myers JR, Ashton JM, Majewska AK

Brain, behavior, and immunity.. 2018 January 67 :257-278. Epub 09/14/2017.

On non-detects in qPCR data.

McCall MN, McMurray H, Land H, Almudevar A

Bioinformatics.. 2014 August 1530 (16):2310-6. Epub 04/23/2014.

Gene signature critical to cancer phenotype as a paradigm for anticancer drug discovery.

Sampson ER, McMurray HR, Hassane DC, Newman L, Salzman P, Jordan CT, Land H

Oncogene.. 2013 August 1532 (33):3809-18. Epub 09/10/2012.

On the underlying assumptions of threshold Boolean networks as a model for genetic regulatory network behavior.

Tran V, McCall MN, McMurray HR, Almudevar A

Frontiers in genetics.. 2013 4 :263. Epub 12/11/2013.

Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells.

Ashton JM, Balys M, Neering SJ, Hassane DC, Cowley G, Root DE, Miller PG, Ebert BL, McMurray HR, Land H, Jordan CT

Cell stem cell.. 2012 September 711 (3):359-72. Epub 08/02/2012.

Fitting Boolean networks from steady state perturbation data

Almudevar, A.; McCall, M.N.; McMurray, H.R.; Land, H.

Statistical Applications in Genetics and Molecular Biology. 2011; 10(1): Article 47.

Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype.

McMurray HR, Sampson ER, Compitello G, Kinsey C, Newman L, Smith B, Chen SR, Klebanov L, Salzman P, Yakovlev A, Land H

Nature.. 2008 June 19453 (7198):1112-6. Epub 05/25/2008.

Degradation of p53, not telomerase activation, by E6 is required for bypass of crisis and immortalization by human papillomavirus type 16 E6/E7.

McMurray HR, McCance DJ

Journal of virology.. 2004 June 78 (11):5698-706. Epub 1900 01 01.

Human papillomavirus type 16 E6 activates TERT gene transcription through induction of c-Myc and release of USF-mediated repression.

McMurray HR, McCance DJ

Journal of virology.. 2003 September 77 (18):9852-61. Epub 1900 01 01.

Biology of human papillomaviruses.

McMurray HR, Nguyen D, Westbrook TF, McAnce DJ

International journal of experimental pathology.. 2001 February 82 (1):15-33. Epub 1900 01 01.

Rapid communication: Partial clone and sequence of an ovine glyceraldehyde-3-phosphate dehydrogenase cDNA

Lee GH, Richards HM, Thonney ML.

Journal of Animal Science. 1998; 76(3): 917.