Delayed concentration effect models for dabigatran anticoagulation
Eaton MP, Nadtochiy SM, Stefanos T, LeMoine D, Anderson BJ.
Paediatr Anaesth. 2022; 32(10): 1113-1120.
Distinct effects of intracellular vs. extracellular acidic pH on the cardiac metabolome during ischemia and reperfusion
Milliken AS, Ciesla JH, Nadtochiy SM, Brookes PS.
J Mol Cell Cardiol. 2022; 174: 101-114.
Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation
Alexander S Milliken, Sergiy M Nadtochiy, Paul S Brookes.
J Am Heart Assoc. 2022; e026135.
Rivaroxaban Reduces the Dabigatran Dose Required for Anticoagulation During Simulated Cardiopulmonary Bypass
Nadtochiy, Sergiy M.; Stefanos, Tatsiana; Angona, Ronald E.; Lebedko, Natalie; Baldzizhar, Aksana; Feng, Changyong; Eaton, Michael P.
Anesthesia & Analgesia. 2022; 135(1): 52-59.
High-Dose Dabigatran Is an Effective Anticoagulant for Simulated Cardiopulmonary Bypass Using Human Blood.
Nadtochiy, SM; Baldzizhar, A; Stefanos, T; et al.
Anesth Analg. 2021; 132(2): 566-574.
Nadtochiy, SM; Ngai, M; Brookes, PS.
Modified Blue Native Gel Approach for Analysis of Respiratory
ALKBH7 mediates necrosis via rewiring of glyoxal metabolism.
Kulkarni, CA; Nadtochiy, SM; Kennedy, L; Brookes, PS; et al.
Elife. 2020; 9.
Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation
Nadtochiy SM, Urciuoli W, Zhang J, Schafer X, Munger J, Brookes PS.
J Mol Cell Cardiol. 2015; 88: 64-72.
The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagy. Am J Physiol Heart Circ Physiol
Zhang J, Nadtochiy SM, Urciuoli WR, Brookes PS.
Am J Physiol Heart Circ Physiol. 2015; .
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Edward T. Chouchani, Victoria R. Pell, Edoardo Gaude, Dunja Aksentijevi?, Stephanie Y. Sundier, Ellen L. Robb, Angela Logan, Sergiy M. Nadtochiy, Emily N. J. Ord, Anthony C. Smith, Filmon Eyassu, Rachel Shirley, Chou-Hui Hu, Anna J. Dare, Andrew M. James, Sebastian Rogatti, Richard C. Hartley, Simon Eaton, Ana S. H. Costa, Paul S. Brookes, Sean M. Davidson, Michael R. Duchen, Kourosh Saeb-Parsy, Michael J. Shattock, Alan J. Robinson, Lorraine M. Work, Christian Frezza, Thomas Krieg & Michael P. Murphy.
Nature. 2014; 515: 431-435.
SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts
Porter GA, Urciuoli WR, Brookes PS, Nadtochiy SM. (.
Am J Physiol Heart Circ Physiol. 2014; 306: H1602-H1609.
Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotection
Nadtochiy SM, Madukwe J, Hagen F, Brookes PS.
Br J Pharmacol. 2014; 171: 2091-2098.
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I
Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, Krieg T, Brookes PS, Murphy MP.
Nat Med. 2013; 19: 753-759.
A non-cardiomyocyte autonomous mechanism of cardioprotection involving the SLO1 BK channel
Wojtovich AP, Nadtochiy SM, Urciuoli WR, Smith CO, Grunnet M, Nehrke K, Brookes PS.
PeerJ. 2013; 1(e48.).
A cell-based phenotypic assay to identify cardioprotective agents
Guo S, Olm-Shipman A, Walters A, Urciuoli WR, Devito S, Nadtochiy SM, Wojtovich AP, Brookes PS.
Circ Res. 2012; 110: 948-57.
Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1
Nadtochiy SM, Qiuyu Zhu, William Urciuoli, Ruslan Rafikov, Stephen M. Black, Paul S. Brookes.
J Biol Chem. 2012; 287: 3573-80.
SLO-2 Is Cytoprotective and Contributes to Mitochondrial Potassium Transport
Wojtovich AP, Sherman TA, Nadtochiy SM, Urciuoli WR, Brookes PS, Nehrke K.
PLoS One. 2011; 6: e28287.
SIRT1-mediated acute cardioprotection.
Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente L, Rahman I, Brookes PS.
Am J Physiol Heart Circ Physiol. 2011; 301: H1506-12.
p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: A pathogenic mechanism for ischemia-reperfusion injury
Shi X, Yan C, Nadtochiy SM, Abe JI, Brookes PS, Berk BC.
J Mol Cell Cardiol. 2011; 51: 272-5.
Redox Regulation of the Mitochondrial K(ATP) Channel in Cardioprotection
Queliconi BB, Wojtovich AP, Nadtochiy SM, Kowaltowski AJ, Brookes PS.
Biochim Biophys Acta. 2011; 1813: 1309-15.
Lysine Deacetylation in Ischemic Preconditioning: The Role of SIRT1
Nadtochiy SM, Redman E, Rahman I, Brookes PS.
Cardiovasc Res. 2011; 89: 643-9.
Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol Difference In Gel Electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation
Chouchani E, Hurd T, Nadtochiy SM, Brookes PS, Fearnley IM, Lilley KS, Smith RA, Murphy MP.
Biochem J. 2010; 430: 49-59.
Modulation of Cell Surface Protein Free Thiols; A Potential Novel Mechanism of Action of the Sesquiterpene Lactone Parthenolide.
Skalska J, Brookes PS, Nadtochiy SM, Hilchey S, Jordan C, Guzman G, Briehl M, Bernstein S.
PLoS One. 2009; 4: e8115.
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury
Prime TA, Blaikie FH, Nadtochiy SM, James AM, Dahm CC, Vitturi D, Patel RP, Hiley CA, Abakumova I, Requejo R, Chouchani E, Hurd TR, Garvey J, Taylor TC, Brookes PS, Smith RAJ & Murphy MP.
Proc. Natl. Acad. Sci. USA. 2009; 106: 10764-10769.
In-vivo cardioprotection by S-nitroso-2-mercaptopropionyl glycine
Nadtochiy SM, Burwell LS, Ingraham CA, Pinkert CA, Brookes PS.
J Mol Cell Cardiol. 2009; 46: 960-968.
Detection and Quantification of Protein Adduction by Electrophilic Fatty Acids: Mitochondrial Generation of Fatty Acid Nitroalkene Derivatives.
Schopfer FJ, Batthyany C, Baker PR, Bonacci G, Cole MP, Rudolph V, Groeger AL, Rudolph TK, Nadtochiy SM, Brookes PS, Freeman BA.
Free Rad. Biol. Med. 2009; 46: 1250-9.
Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection.
Nadtochiy SM, Baker PR, Freeman BA, Brookes PS.
Cardiovascular Research. 2009; 82: 333-40.
Purine release: A protective signaling mechanism of the mitochondrial permeability transition pore in ischemia
Nadtochiy SM, Nauduri D, Shymanskaya TV, Sagach VF, Brookes PS.
Fiziol Zh. 2008; 54(5-14.).
Sustained Weight Loss After Roux-en-Y Gastric Bypass Is Characterized by Down Regulation of Endocannabinoids and Mitochondrial Function.
Guijarro A, Osei-Hyiaman D, Harvey-White J, Kunos G, Suzuki S, Nadtochiy SM, Brookes PS, Meguid MM.
Ann Surg. 2008; 247: 779-790.
Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats.
Guijarro A, Suzuki S, Chen C, Kirchner H, Middleton FA, Nadtochiy SM, Brookes PS, Niijima A, Inui A, Meguid MM.
Am J Physiol Regul Integr Comp Physiol. 2007; 293: R1474-89.
Cardioprotection & mitochondrial S-nitrosation: effect of the mitochondrial S-nitrosating agent SNO-MPG in cardiac ischemia-reperfusion injury
Nadtochiy SM, Burwell LS, Brookes PS.
J Mol Cell Cardiol. 2007; 42: 812-825.
Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection
Biochem. J. 2006; 395: 611-8.
Direct Evidence of Mitochondrial Complex I S-nitrosation.
Burwell LS, Nadtochiy SM, Tompkins AJ, Young SM, Brookes PS.
Biochem. J. 2006; 394: 627-34.
Effect of hypoxic preconditioning on the development of post-reperfusion disturbances of heart function and activation of mitochondrial permeability transition.
Sagach VF, Shimanskay TV, Nadtochiy SM, Dobrovolskiy FV.
Reports of the National Academy of Sciences of Ukraine. 2006; 3: 158-162.
Role of nitric oxide and mitochondrial permeability pore in changes of oxygen consumption in the working skeletal muscle.
Sagach VF, Bohuslavs'kyi AIu, Dmytriieva AV, Nadtochiy SM.
Fiziol Zh. 2004; 50: 19-26.
Factor released under heart reperfusion may be marker of opening of the mitochondrial permeability transition pore.
Sagach VF, Shymanskaya TV, Nadtochiy SM.
Fiziol. Zh. 2003; 49: 6-12.
Determination of the stable mitochondrial factor in vivo
Nadtochiy SM, Boguslavskiy AY, Sagach VF.
Fiziol Zh. 2003; 49: 25-31.
Protection of heart from reperfusion injury by annexin II
Sagach VF, Shimanskay TV, Nadtochiy SM, Babiychuk VS, Drager A.
Reports of the National Academy of Sciences of Ukraine. 2003; 9: 170-177.
Factor released under heart reperfusion; investigation of its effect on myocardium, coronary and peripheral vessels.
Sagach VF, Dmitrieva AV, Shimanskay TV, Nadtochiy SM.
Fiziol. Zh. 2002; 48: 3-8.
Protection of heart from reperfusion injury and ineffective oxygen consumption by inhibitors of the mitochondrial permeability transition pore
Sagach VF, Shymanskaya TV, Nadtochiy SM.
Fiziol. Zh. 2002; 48: 3-9.
The role of nitric oxide in the changes of oxygen consumption and oxygen cost of myocardial work.
Sagach VF, Shimanskay TV, Nadtochiy SM.
Fiziol. Zh. 2000; 46: 33-38.
