A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex.
Chatrikhi R, Feeney CF, Pulvino MJ, Alachouzos G, MacRae AJ, Falls Z, Rai S, Brennessel WW, Jenkins JL, Walter MJ, Graubert TA, Samudrala R, Jurica MS, Frontier AJ, Kielkopf CL
Cell chemical biology.. 2021 August 1928 (8):1145-1157.e6. Epub 03/08/2021.
A small-molecule competitive inhibitor of phosphatidic acid binding by the AAA+ protein NSF/Sec18 blocks the SNARE-priming stage of vacuole fusion.
Sparks RP, Arango AS, Starr ML, Aboff ZL, Hurst LR, Rivera-Kohr DA, Zhang C, Harden KA, Jenkins JL, Guida WC, Tajkhorshid E, Fratti RA
The Journal of biological chemistry.. 2019 November 15294 (46):17168-17185. Epub 09/12/2019.
Platelet-derived ?2M regulates monocyte inflammatory responses.
Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante A, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN
JCI insight.. 2019 March 74 (5)Epub 03/07/2019.
Solution Conformation and Thermodynamic Characteristics of RNA binding by Splicing Factor U2AF65
Jenkins, J.L; Shen H.; Green M.R.; Kielkopf.
J. Biol. Chem. 2008; 283: 33641-33649.
Structural Basis of the Transcriptional Regulation of the Proline Utilization Regulon by Multifunctional PutA
Zhou Y.; Larson J.D.; Bottoms C.A.; Arturo E.C.; Henzl M.T.; Jenkins, J.L; Nix J.C.; Becker D.F.; Tanner, J.J.
J. Mol. Biol. 2008; 381: 174-188.
Crystal Structures of the DNA-binding Domain of Escherichia coli Proline Utilization A Flavoprotein and Analysis of the Role of Lys9 in DNA Recognition
Larson, J.D.; Jenkins, J.L.; Schuermann, J.P.; Zhou, Y.; Becker, D.F.; Tanner, J.J.
Protein Science. 2006; v15: 2630-2641.
High Resolution Crystal Structure of Human D-Glyceraldehyde-3-Phosphate Dehydrogenase
Jenkins, J.L.; Tanner, J.J.
Acta Crystallogr. 2006; D62: 290-301.