
Matthew D. Rand, Ph.D.
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Matthew D. Rand, Ph.D.
About Me
Faculty Appointments
Associate Professor - Department of Environmental Medicine (SMD)
Credentials
Post-doctoral Training & Residency
Research Fellow. Harvard Medical School, Cancer Center, Massachusetts General Hospital, Charlestown, MA.
Advisor: Spyros Artavanis-Tsakonas, Ph.D. Research interests: Mechanisms of signal transduction in neurogenesis. Biochemical characterization of Notch receptor interaction with the Delta ligand. The role of the ADAM metalloprotease Kuzbanian in the proteolytic processing of the Notch ligands. 1998 - 2000
Research Fellow. Howard Hughes Medical Institute, Department of Cell Biology, Yale University School of Medicine, New Haven, CT.
Advisor: Spyros Artavanis- Tsakonas, Ph.D. Research Interests: Interaction of the Notch receptor with its ligand Delta at the cellular level. Proteolytic processing of the Notch receptor and the Delta ligand. 1997 - 1998
Postdoctoral Fellowship. Department of Clinical Chemistry, Lund University, University Hospital, Malmo, Sweden.
Advisor: Johan Stenflo, MD., Ph.D. Research Interests: Expression and characterization of tandem calcium-binding epidermal growth factor-like (EGF) modules from the ligand binding region of the human Notch receptor. 1995 - 1997
Doctoral Training- Department of Biochemistry, College of Medicine, University of Vermont, Burlington, VT.
Advisor: Kenneth G. Mann, Ph.D. Research Interests: Phosphorylation of the coagulation cofactor factor Va by platelet kinasis. Characterization and determination of clearance rates of baboon factor V/Va. Development of a novel assay system to simultaneously quantitate activation of coagulation factors, inhibitor-enzyme complex formation and platelet activation during extrinsic pathway initiated clotting in whole blood. 1991 - 1995
Education
Ph.D. | University of Vermont, College of Medicine. Biochemistry. 1995
B.S. | University of New Hampshire. Biology. 1986
Awards
UVM,"Inventor Hall of Fame". 2011
Research
Dr. Rand's research focuses on the mechanisms of neural developmental toxicity of the persistent environmental toxin methylmercury (MeHg). Human exposure to MeHg through dietary intake of fish continues to be a major health concern. MeHg prefere...
Publications
Journal Articles
Beamish CR, Becker J, Tam LM, Love T, Rand MD
Toxicological sciences : an official journal of the Society of Toxicology.. 2025 February 14 Epub 02/14/2025.
Tam LM, Rand MD
Archives of toxicology.. 2024 June 98 (6):1645-1658. Epub 03/28/2024.
Klus JK, Thurston SW, Myers G, Watson GE, Rand MD, Love TM, Yeates AJ, Mulhern MS, McSorley EM, Strain JJ, Shamlaye C, van Wijngaarden E
Neurotoxicology.. 2023 December 99 :115-119. Epub 10/11/2023.
Books
Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategi (2011)
Chapter: Methylmercury Effects on Neural Developmental Signaling Pathways.