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Benjamin J. Frisch, Ph.D.

Benjamin J. Frisch, Ph.D.

Contact

Office (585) 276-7148

About Me

Faculty Appointments

Assistant Professor - Department of Pathology and Laboratory Medicine (SMD)

Assistant Professor - Department of Biomedical Engineering (SMD) - Joint

Research

Since 2007 my research career has had a translational focus, with a particular interest in microenvironmental support for the hematopoietic stem cell (HSC). Discovery of mechanisms of support for HSCs during both homeostatic and stressed hematopoiesis has evolved to the identification of novel thera...
Since 2007 my research career has had a translational focus, with a particular interest in microenvironmental support for the hematopoietic stem cell (HSC). Discovery of mechanisms of support for HSCs during both homeostatic and stressed hematopoiesis has evolved to the identification of novel therapeutic targets in malignant hematopoiesis, such as acute myeloid leukemia. My current research is focused on alterations of the bone marrow microenvironment induced by myeloid malignancies. This research has led to the identification of the chemokine CCL3 as a potential target for the treatment of acute myeloid leukemia. My future interests are in further characterization of the interactions between malignant hematopoiesis and the bone marrow microenvironment, with the ultimate goal of translation of novel therapeutic targets to clinical use.

Patents

Compositions and Methods for Controlled Localized Delivery of Bone Forming Therapeutic Agents

Issue date: February 05, 2019

Publications

Journal Articles

The hematopoietic stem cell niche: What's so special about bone?

Frisch BJ

Bone.. 2019 February 119 :8-12. Epub 05/17/2018.

EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription.

Ayoub E, Wilson MP, McGrath KE, Li AJ, Frisch BJ, Palis J, Calvi LM, Zhang Y, Perkins AS

Nature communications.. 2018 October 129 (1):4239. Epub 10/12/2018.

The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers.

Staversky RJ, Byun DK, Georger MA, Zaffuto BJ, Goodman A, Becker MW, Calvi LM, Frisch BJ

Scientific reports.. 2018 October 28 (1):14691. Epub 10/02/2018.

The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool.

Lawal RA, Zhou X, Batey K, Hoffman CM, Georger MA, Radtke F, Hilton MJ, Xing L, Frisch BJ, Calvi LM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2017 June 32 (6):1320-1331. Epub 03/09/2017.

Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury.

Porter RL, Georger M, Bromberg O, McGrath KE, Frisch BJ, Becker MW, Calvi LM

Stem cells.. 2013 February 31 (2):372-83. Epub 1900 01 01.

Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells.

Bromberg O, Frisch BJ, Weber JM, Porter RL, Civitelli R, Calvi LM

Blood.. 2012 July 12120 (2):303-13. Epub 05/17/2012.

Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells.

Calvi LM, Bromberg O, Rhee Y, Weber JM, Smith JN, Basil M, Frisch BJ, Bellido T

Blood.. 2012 March 15119 (11):2489-99. Epub 01/18/2012.

Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia.

Frisch BJ, Ashton JM, Xing L, Becker MW, Jordan CT, Calvi LM

Blood.. 2012 January 12119 (2):540-50. Epub 09/28/2011.

Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury.

Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ

PloS one.. 2012 7 (7):e40602. Epub 07/11/2012.

In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells.

Frisch BJ, Porter RL, Gigliotti BJ, Olm-Shipman AJ, Weber JM, O'Keefe RJ, Jordan CT, Calvi LM

Blood.. 2009 November 5114 (19):4054-63. Epub 09/02/2009.

Hematopoietic niche and bone meet.

Frisch BJ, Porter RL, Calvi LM

Current opinion in supportive and palliative care.. 2008 September 2 (3):211-7. Epub 1900 01 01.

Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells.

Weber JM, Forsythe SR, Christianson CA, Frisch BJ, Gigliotti BJ, Jordan CT, Milner LA, Guzman ML, Calvi LM

Bone.. 2006 September 39 (3):485-93. Epub 05/02/2006.

Books

Methods in Molecular Biology (2014)

Chapter: Hematopoietic Stem Cell Cultures and Assays

Primer on Metabolic Bone Diseases and Disorders of Mineral Nutrition (2013)

Chapter: Hematopoiesis and Bone