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Devin M. Chandler-Militello, M.S.

Devin M. Chandler-Militello, M.S.

she/her/hers

Contact

Fax (585) 276-2298
Administrative (585) 276-4595

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About Me

Faculty Appointments

Senior Associate - Department of Neurology, Center for Translational Neuromedicine (SMD)

Credentials

Education

MS | Boston College. Biology. 2002

BS | University at Buffalo, The State University of New York. Biological Science. 2000

Research

Generation of iPSC and hESC-derived glial progenitor cells for cell therapy.
Generation of iPSC and hESC-derived glial progenitor cells for cell therapy.

Publications

Journal Articles

A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.

Benraiss A, Mariani JN, Tate A, Madsen PM, Clark KM, Welle KA, Solly R, Capellano L, Bentley K, Chandler-Militello D, Goldman SA

Cell reports.. 2022 August 3040 (9):111291. Epub 1900 01 01.

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.

Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA

Cell reports.. 2021 July 636 (1):109308. Epub 1900 01 01.

Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons.

Nolbrant S, Giacomoni J, Hoban DB, Bruzelius A, Birtele M, Chandler-Militello D, Pereira M, Ottosson DR, Goldman SA, Parmar M

Stem cell reports.. 2020 October 1315 (4):869-882. Epub 09/24/2020.

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.

Windrem MS, Schanz SJ, Zou L, Chandler-Militello D, Kuypers NJ, Nedergaard M, Lu Y, Mariani JN, Goldman SA

Cell reports.. 2020 May 1931 (7):107658. Epub 1900 01 01.

Dysregulated Glial Differentiation in Schizophrenia May Be Relieved by Suppression of SMAD4- and REST-Dependent Signaling.

Liu Z, Osipovitch M, Benraiss A, Huynh NPT, Foti R, Bates J, Chandler-Militello D, Findling RL, Tesar PJ, Nedergaard M, Windrem MS, Goldman SA

Cell reports.. 2019 June 2527 (13):3832-3843.e6. Epub 1900 01 01.

Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.

Osipovitch M, Asenjo Martinez A, Mariani JN, Cornwell A, Dhaliwal S, Zou L, Chandler-Militello D, Wang S, Li X, Benraiss SJ, Agate R, Lampp A, Benraiss A, Windrem MS, Goldman SA

Cell stem cell.. 2019 January 324 (1):107-122.e7. Epub 12/13/2018.

Fluorescent Ca indicators directly inhibit the Na,K-ATPase and disrupt cellular functions.

Smith NA, Kress BT, Lu Y, Chandler-Militello D, Benraiss A, Nedergaard M

Science signaling.. 2018 January 3011 (515)Epub 01/30/2018.

Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.

Windrem MS, Osipovitch M, Liu Z, Bates J, Chandler-Militello D, Zou L, Munir J, Schanz S, McCoy K, Miller RH, Wang S, Nedergaard M, Findling RL, Tesar PJ, Goldman SA

Cell stem cell.. 2017 August 321 (2):195-208.e6. Epub 07/20/2017.

Human glia can both induce and rescue aspects of disease phenotype in Huntington disease.

Benraiss A, Wang S, Herrlinger S, Li X, Chandler-Militello D, Mauceri J, Burm HB, Toner M, Osipovitch M, Jim Xu Q, Ding F, Wang F, Kang N, Kang J, Curtin PC, Brunner D, Windrem MS, Munoz-Sanjuan I, Nedergaard M, Goldman SA

Nature communications.. 2016 June 77 :11758. Epub 06/07/2016.

Human glial chimeric mice reveal astrocytic dependence of JC virus infection.

Kondo Y, Windrem MS, Zou L, Chandler-Militello D, Schanz SJ, Auvergne RM, Betstadt SJ, Harrington AR, Johnson M, Kazarov A, Gorelik L, Goldman SA

The Journal of clinical investigation.. 2014 December 124 (12):5323-36. Epub 11/17/2014.

A competitive advantage by neonatally engrafted human glial progenitors yields mice whose brains are chimeric for human glia.

Windrem MS, Schanz SJ, Morrow C, Munir J, Chandler-Militello D, Wang S, Goldman SA

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 November 2634 (48):16153-61. Epub 1900 01 01.

Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes.

Auvergne RM, Sim FJ, Wang S, Chandler-Militello D, Burch J, Al Fanek Y, Davis D, Benraiss A, Walter K, Achanta P, Johnson M, Quinones-Hinojosa A, Natesan S, Ford HL, Goldman SA

Cell reports.. 2013 June 273 (6):2127-41. Epub 05/30/2013.

Human iPSC-derived oligodendrocyte progenitor cells can myelinate and rescue a mouse model of congenital hypomyelination.

Wang, S1; Bates, J; Li, X; Schanz, S; Chandler-Militello, D; Levine, C; Maherali, N; Studer, L; Hochedlinger, K; Windrem, M; Goldman, SA.

Cell Stem Cell. 2013; 12(2): 252-64.

Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts.

Goldman, N; Chandler-Militello, D; Langevin, HM; Nedergaard, M; Takano, T.

Cell Calcium. 2013; 53(4): 297-301.

Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2.

Eyler, CE; Wu, Q; Yan, K; MacSwords, JM; Chandler-Militello, D; Misuraca, KL; Lathia, JD; Forrester, MT; Lee, J; Stamler, JS; Goldman, SA; Bredel, M; McLendon, RE; Sloan, AE; Hjelmeland, AB; Rich, JN.

Cell. 2011; 146(1): 53-66.

Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting.

Wang, S; Chandler-Militello, D; Lu, G; Roy, NS; Zielke, A; Auvergne, R; Stanwood, N; Geschwind, D; Coppola, G; Nicolis, SK; Sim, FJ; Goldman, SA.

Journal of Neuroscience. 2010; 30(44): 14635-48.

Retrovirally mediated telomerase immortalization of neural progenitor cells.

Roy, NS; Chandler-Militello, D; Lu, G; Wang, S; Goldman SA.

Nature Protocols. 2007; 2(11): 2815-25.

Surveillance mechanism linking Bub1 loss to the p53 pathway.

Gjoerup, OV; Wu, J; Chandler-Militello, D; Williams, GL; Zhao, J; Schaffhausen, B; Jat, PS; Roberts, TM.

Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(20): 8334-9.

Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome.

Elsasser, S; Chandler-Militello, D; Müller, B; Hanna, J; Finley, D.

The Journal of Biological Chemistry. 2004; 279(26): 26817-22.

The trypanosome homolog of human p32 interacts with RBP16 and stimulates its gRNA binding activity

Hayman, ML; Miller, MM; Chandler, DM; Goulah, CC; Read, LK.

Nucleic Acids Research. 2001; 29(24): 5216-25.