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Rashad Hussain, Ph.D.

Rashad Hussain, Ph.D.

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Office (585) 276-6390

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About Me

Faculty Appointments

Research Assistant Professor - Department of Neurology, Center for Translational Neuromedicine (SMD)

Credentials

Awards

Très Honorable (Most Honorable, Highest Ph.D grade). 2011

Research

The objective of my work is to understand the cellular and molecular mechanisms underlying different neurological disorders. Previously, I made significant contribution in the area of Multiple Sclerosis aimed at developing therapeutics i.e. discovery of neural androgen receptors as a major mediator ...
The objective of my work is to understand the cellular and molecular mechanisms underlying different neurological disorders. Previously, I made significant contribution in the area of Multiple Sclerosis aimed at developing therapeutics i.e. discovery of neural androgen receptors as a major mediator of process of myelination and remyelination. I possess strong technical abilities involving transgenic animal resources, corticospinal axonal tracts tracing using state of the art stereotaxic technology, pharmacological and genetic manipulation of nuclear/membrane receptors and resulting changes in intracellular signaling cascade. I am also proficient in manuscript writing for peer reviewed journals, highly dynamic team leader while working as research associate and assistant professor, managing my own energies as well as my group to develop a high performance team that succeeds. My strong intrapersonal skills and ability to effectively collaborate with other scientists in matrix environment help me to focus on short term and long term strategic goals and publish in high impact journals.

My current research interests are: (a) understanding of glia function in health and disease in central nervous system in context of glymphatic system; a brain metabolite clearance pathway. (b) I am also interested in understanding key cellular and molecular mechanisms and signaling pathways maintaining glial homeostasis within brain and (c) glia neuron interactions.

Publications

Journal Articles

Air pollution, glymphatic impairment, and Alzheimer's disease.

Hussain R, Graham U, Elder A, Nedergaard M

Trends in neurosciences.. 2023 November 46 (11):901-911. Epub 09/28/2023.

A real-time in vivo clearance assay for quantification of glymphatic efflux.

Plá V, Bork P, Harnpramukkul A, Olveda G, Ladrón-de-Guevara A, Giannetto MJ, Hussain R, Wang W, Kelley DH, Hablitz LM, Nedergaard M

Cell reports.. 2022 September 1340 (11):111320. Epub 1900 01 01.

Morphometric and Myelin Basic Protein Expression Changes in Arcuate Nucleus Kisspeptin Neurons Underlie Activation of Hypothalamic Pituitary Gonadal-axis in Monkeys () during the Breeding Season.

Zubair H, Shamas S, Ullah H, Nabi G, Huma T, Ullah R, Hussain R, Shahab M

Endocrine research.. 2022 47 (3-4):113-123. Epub 07/22/2022.

Roles of Progesterone, Testosterone and Their Nuclear Receptors in Central Nervous System Myelination and Remyelination.

Ghoumari AM, Abi Ghanem C, Asbelaoui N, Schumacher M, Hussain R

International journal of molecular sciences.. 2020 April 3021 (9)Epub 04/30/2020.

Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery.

Hussain G, Wang J, Rasul A, Anwar H, Qasim M, Zafar S, Aziz N, Razzaq A, Hussain R, de Aguilar JG, Sun T

International journal of biological sciences.. 2020 16 (1):116-134. Epub 01/01/2020.

Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches.

Hussain R, Zubair H, Pursell S, Shahab M

Brain sciences.. 2018 September 158 (9)Epub 09/15/2018.

Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function.

Lundgaard I, Wang W, Eberhardt A, Vinitsky HS, Reeves BC, Peng S, Lou N, Hussain R, Nedergaard M

Scientific reports.. 2018 February 28 (1):2246. Epub 02/02/2018.

Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches

Rashad Hussain; Hira Zubair;Sarah Pursell;Muhammad Shahab ?.

Brain Sci. 2018; 8(9): 177.

Long-lasting masculinizing effects of postnatal androgens on myelin governed by the brain androgen receptor.

Abi Ghanem C, Degerny C, Hussain R, Liere P, Pianos A, Tourpin S, Habert R, Macklin WB, Schumacher M, Ghoumari AM

PLoS genetics.. 2017 November 13 (11):e1007049. Epub 11/06/2017.

Protein tyrosine phosphatase ? regulates autoimmune encephalomyelitis development.

Ohtake Y, Kong W, Hussain R, Horiuchi M, Tremblay ML, Ganea D, Li S

Brain, behavior, and immunity.. 2017 October 65 :111-124. Epub 05/27/2017.

Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle.

Hussain R, Macklin WB

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2017 January 1137 (2):397-412. Epub 1900 01 01.

The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination.

Hussain R, Ghoumari AM, Bielecki B, Steibel J, Boehm N, Liere P, Macklin WB, Kumar N, Habert R, Mhaouty-Kodja S, Tronche F, Sitruk-Ware R, Schumacher M, Ghandour MS

Brain : a journal of neurology.. 2013 January 136 (Pt 1):132-46. Epub 1900 01 01.

Progesterone synthesis in the nervous system: implications for myelination and myelin repair.

Schumacher M, Hussain R, Gago N, Oudinet JP, Mattern C, Ghoumari AM

Frontiers in neuroscience.. 2012 6 :10. Epub 02/08/2012.

Progesterone and Nestorone facilitate axon remyelination: a role for progesterone receptors.

Hussain R, El-Etr M, Gaci O, Rakotomamonjy J, Macklin WB, Kumar N, Sitruk-Ware R, Schumacher M, Ghoumari AM

Endocrinology.. 2011 October 152 (10):3820-31. Epub 08/09/2011.

Effect of Season on Average Number of Culturable Oocytes Recovered From Cattle and Buffalo Ovaries

HUSSAIN R, NEMATULLAH AND S AKHTER.

Pakistan J. Zool. 2005; 37(4): 283.

In vitro maturation and vitrification of cattle and buffalo oocytes. Int. J. Biol. Biotech., 2:110-116

Int. J. Biol. Biotech. 2005; 2: 110.