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Stephano Spano Mello, Ph.D.

Stephano Spano Mello, Ph.D.

Contact

Office (585) 275-0013

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About Me

Faculty Appointments

Assistant Professor - Department of Biomedical Genetics (SMD)

Credentials

Post-doctoral Training & Residency

Postgraduate Research in Cancer Genetics, Stanford University, Stanford, CA 2009 - 2014

Postgraduate Research in Microbiology, University of Sao Paulo, Sao Paulo, Brazil 2007 - 2009

Education

PhD | Brazil-Fac Med Ribeirao Preto. Genetics. 2006

MSc | Brazil-Fac Med Ribeirao Preto. Genetics. 2002

BSc | Brazil - University of Sao Paulo. Biological Science. 1998

Awards

Early Investigator Advancement Program (EIAP) scholar. 2023

J. Martin Brown Award for Excellence in Radiation Sciences. 2017

Individual Grant (support for meeting attendance), nº 07/59639-0. 2008

Young Scientist prize. 2007

Environmental Mutagen Society (EMS) Travel Award, 9th International EMS Conference. 2005

Research

The Mello lab is aimed at understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation. To date, very little is known about the different processes and...
The Mello lab is aimed at understanding how nuclear proteins and non-coding RNAs (ncRNAs) regulate gene transcription in pancreatic preneoplastic lesions, gaining knowledge of the process of cellular transformation and tumor initiation. To date, very little is known about the different processes and cell types that precede cancer. We are committed to describing and characterizing novel genes that play a role during early steps of tumor initiation.

We utilize physiologically relevant in vivo models and a systems biology approach, integrating multiple types of genomic data to delineate important cellular events in tumor initiation. Our research provide insights on early detection of malignant lesions, and in the development of novel strategies to treat pancreatic cancer, pancreatitis and diabetes.

Publications

Journal Articles

MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.

DeRollo RE, Cazarin J, Ahmad Shahidan SNAB, Burchett JB, Mwangi D, Krishnaiah S, Hsieh AL, Walton ZE, Brooks R, Mello SS, Weljie AM, Dang CV, Altman BJ

bioRxiv : the preprint server for biology.. 2023 August 8 Epub 08/08/2023.

MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis.

Cazarin J, DeRollo RE, Shahidan SNABA, Burchett JB, Mwangi D, Krishnaiah S, Hsieh AL, Walton ZE, Brooks R, Mello SS, Weljie AM, Dang CV, Altman BJ

PLoS genetics.. 2023 August 19 (8):e1010904. Epub 08/28/2023.

p53 Regulates the Extent of Fibroblast Proliferation and Fibrosis in Left Ventricle Pressure Overload.

Liu X, Burke RM, Lighthouse JK, Baker CD, Dirkx RA, Kang B, Chakraborty Y, Mickelsen DM, Twardowski J, Mello SS, Ashton JM, Small EM

Circulation research.. 2023 July 21133 (3):271-287. Epub 07/06/2023.

Multifaceted role for p53 in pancreatic cancer suppression.

Mello SS, Flowers BM, Mazur PK, Lee JJ, Müller F, Denny SK, Ferreira S, Hanson K, Kim SK, Greenleaf WJ, Wood LD, Attardi LD

Proceedings of the National Academy of Sciences of the United States of America.. 2023 March 7120 (10):e2211937120. Epub 02/27/2023.

Arid1a mutation suppresses TGF-? signaling and induces cholangiocarcinoma.

Guo B, Friedland SC, Alexander W, Myers JA, Wang W, O'Dell MR, Getman M, Whitney-Miller CL, Agostini-Vulaj D, Huber AR, Mello SS, Vertino PM, Land HK, Steiner LA, Hezel AF

Cell reports.. 2022 August 3040 (9):111253. Epub 1900 01 01.

The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.

Moon EJ, Mello SS, Li CG, Chi JT, Thakkar K, Kirkland JG, Lagory EL, Lee IJ, Diep AN, Miao Y, Rafat M, Vilalta M, Castellini L, Krieg AJ, Graves EE, Attardi LD, Giaccia AJ

Nature communications.. 2021 July 1412 (1):4308. Epub 07/14/2021.

Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program.

Bieging-Rolett KT, Kaiser AM, Morgens DW, Boutelle AM, Seoane JA, Van Nostrand EL, Zhu C, Houlihan SL, Mello SS, Yee BA, McClendon J, Pierce SE, Winters IP, Wang M, Connolly AJ, Lowe SW, Curtis C, Yeo GW, Winslow MM, Bassik MC, Attardi LD

Molecular cell.. 2020 November 580 (3):452-469.e9. Epub 1900 01 01.

p53 deficiency triggers dysregulation of diverse cellular processes in physiological oxygen.

Valente LJ, Tarangelo A, Li AM, Naciri M, Raj N, Boutelle AM, Li Y, Mello SS, Bieging-Rolett K, DeBerardinis RJ, Ye J, Dixon SJ, Attardi LD

The Journal of cell biology.. 2020 November 2219 (11)Epub 1900 01 01.

The Long Noncoding RNA Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways.

Huang J, Sachdeva M, Xu E, Robinson TJ, Luo L, Ma Y, Williams N, Lopez O, Cervia LD, Yuan F, Qin X, Zhang D, Owzar K, Gokgoz N, Seto A, Okada T, Singer S, Andrulis IL, Wunder J, Lazar AJ, Rubin BP, Pipho K, Mello SS, Giudice J, Kirsch DG

Molecular cancer research : MCR.. 2020 October 18 (10):1534-1544. Epub 06/19/2020.

Counting the Minutes.

Mello S, Bohmann D

eLife.. 2020 January 79 Epub 01/07/2020.

Dynamin impacts homology-directed repair and breast cancer response to chemotherapy.

Chernikova SB, Nguyen RB, Truong JT, Mello SS, Stafford JH, Hay MP, Olson A, Solow-Cordero DE, Wood DJ, Henry S, von Eyben R, Deng L, Gephart MH, Aroumougame A, Wiese C, Game JC, Gy?rffy B, Brown JM

The Journal of clinical investigation.. 2018 December 3128 (12):5307-5321. Epub 10/29/2018.

Deciphering p53 signaling in tumor suppression.

Mello SS, Attardi LD

Current opinion in cell biology.. 2018 April 51 :65-72. Epub 11/28/2017.

Neat-en-ing up our understanding of p53 pathways in tumor suppression.

Mello SS, Attardi LD

Cell cycle.. 2018 17 (13):1527-1535. Epub 07/31/2018.

A p53 Super-tumor Suppressor Reveals a Tumor Suppressive p53-Ptpn14-Yap Axis in Pancreatic Cancer.

Mello SS, Valente LJ, Raj N, Seoane JA, Flowers BM, McClendon J, Bieging-Rolett KT, Lee J, Ivanochko D, Kozak MM, Chang DT, Longacre TA, Koong AC, Arrowsmith CH, Kim SK, Vogel H, Wood LD, Hruban RH, Curtis C, Attardi LD

Cancer cell.. 2017 October 932 (4):460-473.e6. Epub 1900 01 01.

is a p53-inducible lincRNA essential for transformation suppression.

Mello SS, Sinow C, Raj N, Mazur PK, Bieging-Rolett K, Broz DK, Imam JFC, Vogel H, Wood LD, Sage J, Hirose T, Nakagawa S, Rinn J, Attardi LD

Genes & development.. 2017 June 131 (11):1095-1108. Epub 07/11/2017.

Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.

Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Erkan M, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT

Nature medicine.. 2015 October 21 (10):1163-71. Epub 09/21/2015.

The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development.

Van Nostrand JL, Brisac A, Mello SS, Jacobs SB, Luong R, Attardi LD

Cancer discovery.. 2015 June 5 (6):622-35. Epub 03/26/2015.

Unravelling mechanisms of p53-mediated tumour suppression.

Bieging KT, Mello SS, Attardi LD

Nature reviews. Cancer.. 2014 May 14 (5):359-70. Epub 04/17/2014.

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression.

Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, Kozak MM, Kenzelmann Broz D, Basak S, Park EJ, McLaughlin ME, Karnezis AN, Attardi LD

Cell.. 2011 May 13145 (4):571-83. Epub 1900 01 01.

Delayed effects of exposure to a moderate radiation dose on transcription profiles in human primary fibroblasts.

Mello SS, Fachin AL, Junta CM, Sandrin-Garcia P, Donadi EA, Passos GA, Sakamoto-Hojo ET

Environmental and molecular mutagenesis.. 2011 March 52 (2):117-29. Epub 1900 01 01.

The non-coding RNA BC1 is down-regulated in the hippocampus of Wistar Audiogenic Rat (WAR) strain after audiogenic kindling.

Gitaí DL, Fachin AL, Mello SS, Elias CF, Bittencourt JC, Leite JP, Passos GA, Garcia-Cairasco N, Paçó-Larson ML

Brain research.. 2011 January 71367 :114-21. Epub 10/23/2010.

Alterations in gene expression profiles correlated with cisplatin cytotoxicity in the glioma U343 cell line.

Carminati PO, Mello SS, Fachin AL, Junta CM, Sandrin-Garcia P, Carlotti CG, Donadi EA, Passos GA, Sakamoto-Hojo ET

Genetics and molecular biology.. 2010 January 33 (1):159-68. Epub 03/01/2010.

Shared and unique gene expression in systemic lupus erythematosus depending on disease activity.

Sandrin-Garcia P, Junta CM, Fachin AL, Mello SS, Baião AM, Rassi DM, Ferreira MC, Trevisan GL, Sakamoto-Hojo ET, Louzada-Júnior P, Passos GA, Donadi EA

Annals of the New York Academy of Sciences.. 2009 September 1173 :493-500. Epub 1900 01 01.

Differential gene expression of peripheral blood mononuclear cells from rheumatoid arthritis patients may discriminate immunogenetic, pathogenic and treatment features.

Junta CM, Sandrin-Garcia P, Fachin-Saltoratto AL, Mello SS, Oliveira RD, Rassi DM, Giuliatti S, Sakamoto-Hojo ET, Louzada-Junior P, Donadi EA, Passos GA

Immunology.. 2009 July 127 (3):365-72. Epub 12/17/2008.

Comprehensive gene expression profiling in lungs of mice infected with Mycobacterium tuberculosis following DNAhsp65 immunotherapy.

Zárate-Bladés CR, Bonato VL, da Silveira EL, Oliveira e Paula M, Junta CM, Sandrin-Garcia P, Fachin AL, Mello SS, Cardoso RS, Galetti FC, Coelho-Castelo AA, Ramos SG, Donadi EA, Sakamoto-Hojo ET, Passos GA, Silva CL

The journal of gene medicine.. 2009 January 11 (1):66-78. Epub 1900 01 01.

Gene expression profiles in radiation workers occupationally exposed to ionizing radiation.

Fachin AL, Mello SS, Sandrin-Garcia P, Junta CM, Ghilardi-Netto T, Donadi EA, Passos GA, Sakamoto-Hojo ET

Journal of radiation research.. 2009 January 50 (1):61-71. Epub 1900 01 01.

Gene expression profiles stratified according to type 1 diabetes mellitus susceptibility regions.

Rassi DM, Junta CM, Fachin AL, Sandrin-Garcia P, Mello S, Silva GL, Evangelista AF, Magalhães DA, Wastowski IJ, Crispim JO, Martelli-Palomino G, Fernandes AP, Deghaide NN, Foss-Freitas MC, Foss MC, Soares CP, Sakamoto-Hojo ET, Passos GA, Donadi EA

Annals of the New York Academy of Sciences.. 2008 December 1150 :282-9. Epub 1900 01 01.

Gene expression profiles in human lymphocytes irradiated in vitro with low doses of gamma rays.

Fachin AL, Mello SS, Sandrin-Garcia P, Junta CM, Donadi EA, Passos GA, Sakamoto-Hojo ET

Radiation research.. 2007 December 168 (6):650-65. Epub 1900 01 01.

cDNA microarray analysis of cyclosporin A (CsA)-treated human peripheral blood mononuclear cells reveal modulation of genes associated with apoptosis, cell-cycle regulation and DNA repair.

Baião AM, Wowk PF, Sandrin-Garcia P, Junta CM, Fachin AL, Mello SS, Sakamoto-Hojo ET, Donadi EA, Passos GA

Molecular and cellular biochemistry.. 2007 October 304 (1-2):235-41. Epub 05/30/2007.

Profiling meta-analysis reveals primarily gene coexpression concordance between systemic lupus erythematosus and rheumatoid arthritis.

Silva GL, Junta CM, Mello SS, Garcia PS, Rassi DM, Sakamoto-Hojo ET, Donadi EA, Passos GA

Annals of the New York Academy of Sciences.. 2007 September 1110 :33-46. Epub 1900 01 01.

Is HLA class II profile relevant for the study of large-scale differentially expressed genes in type 1 diabetes mellitus patients?

Rassi DM, Junta CM, Fachin AL, Sandrin-Garcia P, Mello SS, Fernandes AP, Deghaide NN, Foss-Freitas MC, Foss MC, Sakamoto-Hojo ET, Passos GA, Donadi EA

Annals of the New York Academy of Sciences.. 2006 October 1079 :305-9. Epub 1900 01 01.

Using cDNA microarrays to identify human CD19(+) B cell gene products (ESTs) originated from systemic lupus erythematosus susceptibility loci.

Trevisan GL, Rassi DM, Baião AM, Sandrin-Garcia P, Mello SS, Tamia-Ferreira MC, Junta CM, Fachin AL, Marques MM, Sakamoto-Hojo ET, Donadi EA, Passos GA

Autoimmunity reviews.. 2006 May 5 (5):319-23. Epub 01/06/2006.

Hybridization signatures of gamma-irradiated murine fetal thymus organ culture (FTOC) reveal modulation of genes associated with T-cell receptor V(D)J recombination and DNA repair.

Cardoso RS, Junta CM, Macedo C, Magalhães DA, Silveira EL, Paula MO, Marques MM, Mello SS, Zárate-Bladés CR, Nguyen C, Houlgatte R, Donadi EA, Sakamoto-Hojo ET, Passos GA

Molecular immunology.. 2006 February 43 (5):464-72. Epub 04/13/2005.

Changes in the gene expression profiling of the thymus in response to fibrosarcoma growth.

Marques MM, Junta CM, Cardoso RS, Mello SS, Sakamoto-Hojo ET, Donadi EA, Passos GA

Molecular and cellular biochemistry.. 2005 August 276 (1-2):81-8. Epub 1900 01 01.

Hybridization signatures during thymus ontogeny reveals modulation of genes coding for T-cell signaling proteins.

Magalhães DA, Macedo C, Junta CM, Mello SS, Marques MM, Cardoso RS, Sakamoto-Hojo ET, Donadi EA, Passos GA

Molecular immunology.. 2005 May 42 (9):1043-8. Epub 11/23/2004.

Immunosuppressive therapy modulates T lymphocyte gene expression in patients with systemic lupus erythematosus.

Pereira E, Tamia-Ferreira MC, Cardoso RS, Mello SS, Sakamoto-Hojo ET, Passos GA, Donadi EA

Immunology.. 2004 September 113 (1):99-105. Epub 1900 01 01.

Gene expression profiles in human cells submitted to genotoxic stress.

Sakamoto-Hojo ET, Mello SS, Pereira E, Fachin AL, Cardoso RS, Junta CM, Sandrin-Garcia P, Donadi EA, Passos GA

Mutation research.. 2003 November 544 (2-3):403-13. Epub 1900 01 01.

Chromosomal rearrangements involving telomeric DNA sequences in Balb/3T3 cells transfected with the Ha-ras oncogene.

Peitl P, Mello SS, Camparoto ML, Passos GA, Hande MP, Cardoso RS, Sakamoto-Hojo ET

Mutagenesis.. 2002 January 17 (1):67-72. Epub 1900 01 01.