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Paul L. Boutz, Ph.D.

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Paul L. Boutz, Ph.D.

About Me
Research
Publications

About Me

Faculty Appointments

Assistant Professor - Department of Biochemistry and Biophysics (SMD)

Research

Publications

Journal Articles

Recurrent oncogenic ZC3H18 mutations stabilize endogenous retroviral RNA.

Tanu T, Cox AM, Karlow J, Sharma P, He X, Wu C, Babu S, Brown J, Brown KM, Chanock SJ, Liu D, Zhang T, Burns KH, Boutz PL, Insco ML

bioRxiv : the preprint server for biology.. 2025 January 14 Epub 01/14/2025.

Putting a finger on histidine methylation.

Boutz PL

Genes & development.. 2023 August 137 (15-16):675-677. Epub 09/06/2023.

Oncogenic mutations impede nuclear RNA surveillance.

Insco ML, Abraham BJ, Dubbury SJ, Kaltheuner IH, Dust S, Wu C, Chen KY, Liu D, Bellaousov S, Cox AM, Martin BJE, Zhang T, Ludwig CG, Fabo T, Modhurima R, Esgdaille DE, Henriques T, Brown KM, Chanock SJ, Geyer M, Adelman K, Sharp PA, Young RA, Boutz PL, Zon LI

Science.. 2023 April 21380 (6642):eabn7625. Epub 04/21/2023.

A UHM-ULM interface with unusual structural features contributes to U2AF2 and SF3B1 association for pre-mRNA splicing.

Galardi JW, Bela VN, Jeffery N, He X, Glasser E, Loerch S, Jenkins JL, Pulvino MJ, Boutz PL, Kielkopf CL

The Journal of biological chemistry.. 2022 August 298 (8):102224. Epub 07/01/2022.

O-GlcNAc regulates gene expression by controlling detained intron splicing.

Tan ZW, Fei G, Paulo JA, Bellaousov S, Martin SES, Duveau DY, Thomas CJ, Gygi SP, Boutz PL, Walker S

Nucleic acids research.. 2020 June 448 (10):5656-5669. Epub 1900 01 01.

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation.

Dubbury SJ, Boutz PL, Sharp PA

Nature.. 2018 December 564 (7734):141-145. Epub 11/28/2018.

Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.

Martin SES, Tan ZW, Itkonen HM, Duveau DY, Paulo JA, Janetzko J, Boutz PL, Törk L, Moss FA, Thomas CJ, Gygi SP, Lazarus MB, Walker S

Journal of the American Chemical Society.. 2018 October 24140 (42):13542-13545. Epub 10/04/2018.

Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.

Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO

eLife.. 2018 January 27 Epub 01/02/2018.

Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma.

Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA

Cancer cell.. 2017 October 932 (4):411-426.e11. Epub 09/28/2017.

Detained introns are a novel, widespread class of post-transcriptionally spliced introns.

Boutz PL, Bhutkar A, Sharp PA

Genes & development.. 2015 January 129 (1):63-80. Epub 1900 01 01.

Rbfox2 controls autoregulation in RNA-binding protein networks.

Jangi M, Boutz PL, Paul P, Sharp PA

Genes & development.. 2014 March 1528 (6):637-51. Epub 1900 01 01.

A post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons.

Boutz PL, Stoilov P, Li Q, Lin CH, Chawla G, Ostrow K, Shiue L, Ares M, Black DL

Genes & development.. 2007 July 121 (13):1636-52. Epub 1900 01 01.

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development.

Boutz PL, Chawla G, Stoilov P, Black DL