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Isaac S. Harris, Ph.D.

Isaac S. Harris, Ph.D.

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Office (585) 273-4353

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About Me

Isaac is from Ottawa, Canada. He received both his undergraduate and graduate degrees from the University of Toronto where he conducted research in the lab of Dr. Tak Mak at Princess Margaret Cancer Center. Afterwards, he joined the lab of Dr. Joan Brugge at Harvard Medical School in Boston. In Sept...
Isaac is from Ottawa, Canada. He received both his undergraduate and graduate degrees from the University of Toronto where he conducted research in the lab of Dr. Tak Mak at Princess Margaret Cancer Center. Afterwards, he joined the lab of Dr. Joan Brugge at Harvard Medical School in Boston. In September 2019, Isaac moved to Rochester, NY to open his independent lab at the University of Rochester and Wilmot Cancer Institute.

Faculty Appointments

Assistant Professor - Department of Biomedical Genetics (SMD)

Assistant Professor - Department of Pharmacology and Physiology (SMD) - Joint

Research

There has been a long-standing belief that supplementation with antioxidants could prevent or treat cancer. However, results of large-scale clinical trials have proven the opposite: supplementation with antioxidants promote, rather than prevent, cancer. The Harris Lab at the University of Rochester ...
There has been a long-standing belief that supplementation with antioxidants could prevent or treat cancer. However, results of large-scale clinical trials have proven the opposite: supplementation with antioxidants promote, rather than prevent, cancer. The Harris Lab at the University of Rochester Medical Center and Wilmot Cancer Institute focuses on uncovering the various roles of antioxidants in cancer by using in vivo mouse modeling approaches and high-throughput pharmacologic screening techniques.

Publications

Journal Articles

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy.

Rawat V, DeLear P, Prashanth P, Ozgurses ME, Tebeje A, Burns PA, Conger KO, Solís C, Hasnain Y, Novikova A, Endress JE, González-Sánchez P, Dong W, Stephanopoulos G, DeNicola GM, Harris IS, Sept D, Mason FM, Coloff JL

JCI insight.. 2024 May 309 (13)Epub 05/30/2024.

United They Stand, Divided They Fall.

Harris IS, Brugge JS

Cell metabolism.. 2019 October 130 (4):624-625. Epub 1900 01 01.

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS

Cell metabolism.. 2019 May 729 (5):1166-1181.e6. Epub 02/21/2019.

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3.

Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MC

Proceedings of the National Academy of Sciences of the United States of America.. 2018 July 3115 (27):7057-7062. Epub 06/18/2018.

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.

Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS

Cancer cell.. 2018 June 1133 (6):985-1003.e7. Epub 05/24/2018.

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G

Cell death and differentiation.. 2018 March 25 (3):486-541. Epub 01/23/2018.

Identification of cancer genes that are independent of dominant proliferation and lineage programs.

Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL

Proceedings of the National Academy of Sciences of the United States of America.. 2017 December 26114 (52):E11276-E11284. Epub 12/11/2017.

Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D

Immunity.. 2017 June 2046 (6):1089-1090. Epub 1900 01 01.

Glutathione Primes T Cell Metabolism for Inflammation.

Mak TW, Grusdat M, Duncan GS, Dostert C, Nonnenmacher Y, Cox M, Binsfeld C, Hao Z, Brüstle A, Itsumi M, Jäger C, Chen Y, Pinkenburg O, Camara B, Ollert M, Bindslev-Jensen C, Vasiliou V, Gorrini C, Lang PA, Lohoff M, Harris IS, Hiller K, Brenner D

Immunity.. 2017 April 1846 (4):675-689. Epub 1900 01 01.

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS

Cell metabolism.. 2016 May 1023 (5):867-80. Epub 04/28/2016.

Cancer: The enemy of my enemy is my friend.

Harris IS, Brugge JS

Nature.. 2015 November 12527 (7577):170-1. Epub 10/21/2015.

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression.

Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, Molyneux SD, Mason JM, Li WY, Yamamoto K, Wakeham A, Berman HK, Khokha R, Done SJ, Kavanagh TJ, Lam CW, Mak TW

Cancer cell.. 2015 February 927 (2):211-22. Epub 01/22/2015.

Human somatic cell mutagenesis creates genetically tractable sarcomas.

Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, Iszvak Z, Lupien M, Mak TW, Khokha R

Nature genetics.. 2014 September 46 (9):964-72. Epub 08/17/2014.

TAp73 is required for spermatogenesis and the maintenance of male fertility.

Inoue S, Tomasini R, Rufini A, Elia AJ, Agostini M, Amelio I, Cescon D, Dinsdale D, Zhou L, Harris IS, Lac S, Silvester J, Li WY, Sasaki M, Haight J, Brüstle A, Wakeham A, McKerlie C, Jurisicova A, Melino G, Mak TW

Proceedings of the National Academy of Sciences of the United States of America.. 2014 February 4111 (5):1843-8. Epub 01/21/2014.

Modulation of oxidative stress as an anticancer strategy.

Gorrini C, Harris IS, Mak TW

Nature reviews. Drug discovery.. 2013 December 12 (12):931-47. Epub 1900 01 01.

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.

Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, Brenner D, Tseng A, Musgrave M, Berman HK, Khokha R, Jonkers J, Mak TW, Gauthier ML

The Journal of experimental medicine.. 2013 July 29210 (8):1529-44. Epub 07/15/2013.

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15.

Inoue S, Hao Z, Elia AJ, Cescon D, Zhou L, Silvester J, Snow B, Harris IS, Sasaki M, Li WY, Itsumi M, Yamamoto K, Ueda T, Dominguez-Brauer C, Gorrini C, Chio II, Haight J, You-Ten A, McCracken S, Wakeham A, Ghazarian D, Penn LJ, Melino G, Mak TW

Genes & development.. 2013 May 1527 (10):1101-14. Epub 1900 01 01.

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.

Sasaki M, Knobbe CB, Itsumi M, Elia AJ, Harris IS, Chio II, Cairns RA, McCracken S, Wakeham A, Haight J, Ten AY, Snow B, Ueda T, Inoue S, Yamamoto K, Ko M, Rao A, Yen KE, Su SM, Mak TW

Genes & development.. 2012 September 1526 (18):2038-49. Epub 08/27/2012.

TAp73 depletion accelerates aging through metabolic dysregulation.

Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW

Genes & development.. 2012 September 1526 (18):2009-14. Epub 1900 01 01.

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics.

Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW

Nature.. 2012 August 30488 (7413):656-9. Epub 1900 01 01.

Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".

Karisch R, Fernandez M, Taylor P, Virtanen C, St-Germain JR, Jin LL, Harris IS, Mori J, Mak TW, Senis YA, Östman A, Moran MF, Neel BG

Cell.. 2011 September 2146 (5):826-40. Epub 1900 01 01.

Regulation of cancer cell metabolism.

Cairns RA, Harris IS, Mak TW

Nature reviews. Cancer.. 2011 February 11 (2):85-95. Epub 1900 01 01.

FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2.

Bakker WJ, Harris IS, Mak TW

Molecular cell.. 2007 December 2828 (6):941-53. Epub 1900 01 01.