Skip to content
Home
Jeevisha Bajaj, Ph.D.

Jeevisha Bajaj, Ph.D.

Contact

Call Center (585) 276-3000

Connect with Jeevisha Bajaj, Ph.D.

@Jeevisha_Bajaj

Looking for more Information?

Visit my lab website to learn more about my research, collaborators, latest news, etc.

Visit Research Lab Website

About Me

Faculty Appointments

Assistant Professor - Department of Biomedical Genetics (SMD)

Research

Poorly differentiated aggressive myeloid diseases are often resistant to standard therapy and associated with significantly poor survival in both children and adults. There is thus a significant need for a better understanding of the mechanisms that drive disease progression and for finding novel th...
Poorly differentiated aggressive myeloid diseases are often resistant to standard therapy and associated with significantly poor survival in both children and adults. There is thus a significant need for a better understanding of the mechanisms that drive disease progression and for finding novel therapeutic targets. While intrinsic signals that drive myeloid cancer progression are well described, little is known about how interactions with the surrounding microenvironment can control leukemic growth and propagation. The primary goal of the Bajaj lab is to define the role of cancer stem cell interactions with their microenvironment in disease progression. To address these questions, we use genetic mouse models of human disease and primary human patient samples, CRISPR screening, as well as real time imaging techniques. In the long term, these studies will not only add to our understanding of the niche in the development and progression of hematological malignancies, but may also contribute to the design of novel therapies.

Publications

Journal Articles

Ultralow-dose irradiation enables engraftment and intravital tracking of disease initiating niches in clonal hematopoiesis.

Lee K, Dissanayake W, MacLiesh M, Hong CL, Yin Z, Kawano Y, Kaszuba CM, Kawano H, Quarato ER, Marples B, Becker M, Bajaj J, Calvi LM, Yeh SA

Scientific reports.. 2024 September 314 (1):20486. Epub 09/03/2024.

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia.

Rodems BJ, Sharma S, Baker CD, Kaszuba CM, Ito T, Liesveld JL, Calvi LM, Becker MW, Jordan CT, Ashton JM, Bajaj J

bioRxiv : the preprint server for biology.. 2024 May 14 Epub 05/14/2024.

Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia.

Spinler K, Hamilton M, Bajaj J, Shima Y, Diaz E, Kritzik M, Reya T

bioRxiv : the preprint server for biology.. 2023 December 29 Epub 12/29/2023.

Identifying Bone Marrow Microenvironmental Populations in Myelodysplastic Syndrome and Acute Myeloid Leukemia.

Kaszuba CM, Rodems BJ, Sharma S, Franco EI, Ashton JM, Calvi LM, Bajaj J

Journal of visualized experiments : JoVE.. 2023 November 10 (201)Epub 11/10/2023.

AMD1 is required for the maintenance of leukemic stem cells and promotes chronic myeloid leukemic growth.

Sari IN, Yang YG, Wijaya YT, Jun N, Lee S, Kim KS, Bajaj J, Oehler VG, Kim SH, Choi SY, Park SH, Kim DW, Reya T, Han J, Kwon HY

Oncogene.. 2021 January 40 (3):603-617. Epub 11/17/2020.

Serotonin receptor 5-HT7 in Drosophila mushroom body neurons mediates larval appetitive olfactory learning.

Ganguly A, Qi C, Bajaj J, Lee D

Scientific reports.. 2020 December 410 (1):21267. Epub 12/04/2020.

A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia.

Spinler K, Bajaj J, Ito T, Zimdahl B, Hamilton M, Ahmadi A, Koechlein CS, Lytle N, Kwon HY, Anower-E-Khuda F, Sun H, Blevins A, Weeks J, Kritzik M, Karlseder J, Ginsberg MH, Park PW, Esko JD, Reya T

Nature communications.. 2020 November 2611 (1):5998. Epub 11/26/2020.

An in vivo genome-wide CRISPR screen identifies the RNA-binding protein Staufen2 as a key regulator of myeloid leukemia.

Bajaj J, Hamilton M, Shima Y, Chambers K, Spinler K, Van Nostrand EL, Yee BA, Blue SM, Chen M, Rizzeri D, Chuah C, Oehler VG, Broome HE, Sasik R, Scott-Browne J, Rao A, Yeo GW, Reya T

Nature cancer.. 2020 April 1 (4):410-422. Epub 04/20/2020.

Stem cells in cancer initiation and progression.

Bajaj J, Diaz E, Reya T

The Journal of cell biology.. 2020 January 6219 (1)Epub 1900 01 01.

CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia.

Bajaj J, Konuma T, Lytle NK, Kwon HY, Ablack JN, Cantor JM, Rizzieri D, Chuah C, Oehler VG, Broome EH, Ball ED, van der Horst EH, Ginsberg MH, Reya T

Cancer cell.. 2016 November 1430 (5):792-805. Epub 10/27/2016.

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.

Fox RG, Lytle NK, Jaquish DV, Park FD, Ito T, Bajaj J, Koechlein CS, Zimdahl B, Yano M, Kopp J, Kritzik M, Sicklick J, Sander M, Grandgenett PM, Hollingsworth MA, Shibata S, Pizzo D, Valasek M, Sasik R, Scadeng M, Okano H, Kim Y, MacLeod AR, Lowy AM, Reya T

Nature.. 2016 June 16534 (7607):407-411. Epub 06/06/2016.

Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.

Kwon HY, Bajaj J, Ito T, Blevins A, Konuma T, Weeks J, Lytle NK, Koechlein CS, Rizzieri D, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T

Cell stem cell.. 2015 August 617 (2):152-164. Epub 07/23/2015.

Fearful symmetry: subversion of asymmetric division in cancer development and progression.

Bajaj J, Zimdahl B, Reya T

Cancer research.. 2015 March 175 (5):792-7. Epub 02/13/2015.

CD66+ cells in cervical precancers are partially differentiated progenitors with neoplastic traits.

Pattabiraman C, Hong S, Gunasekharan VK, Pranatharthi A, Bajaj J, Srivastava S, Krishnamurthy H, Ammothumkandy A, Giri VG, Laimins LA, Krishna S

Cancer research.. 2014 November 1574 (22):6682-92. Epub 09/29/2014.

Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.

Zimdahl B, Ito T, Blevins A, Bajaj J, Konuma T, Weeks J, Koechlein CS, Kwon HY, Arami O, Rizzieri D, Broome HE, Chuah C, Oehler VG, Sasik R, Hardiman G, Reya T

Nature genetics.. 2014 March 46 (3):245-52. Epub 02/02/2014.

Notch signaling in CD66+ cells drives the progression of human cervical cancers.

Bajaj J, Maliekal TT, Vivien E, Pattabiraman C, Srivastava S, Krishnamurthy H, Giri V, Subramanyam D, Krishna S

Cancer research.. 2011 July 1571 (14):4888-97. Epub 06/06/2011.

The role of Notch signaling in human cervical cancer: implications for solid tumors.

Maliekal TT, Bajaj J, Giri V, Subramanyam D, Krishna S

Oncogene.. 2008 September 127 (38):5110-4. Epub 1900 01 01.