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Lauren M. Hablitz, Ph.D.

Lauren M. Hablitz, Ph.D.

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About Me

Dr. Hablitz earned a B.S. in Biology from The Pennsylvania State University in 2010. In 2015, Dr. Hablitz earned a Ph.D. in Cell, Molecular, and Developmental Biology from the University of Alabama Birmingham from the lab of Dr. Karen Gamble investigating conserved molecular mechanisms of nonphotic ...
Dr. Hablitz earned a B.S. in Biology from The Pennsylvania State University in 2010. In 2015, Dr. Hablitz earned a Ph.D. in Cell, Molecular, and Developmental Biology from the University of Alabama Birmingham from the lab of Dr. Karen Gamble investigating conserved molecular mechanisms of nonphotic entrainment. After completing a postdoctoral research position at Oregon Health & Science University with Dr. Charles Allen, understanding the role of astrocytes in modulating cannabinoid signaling in the suprachiasmatic nucleus, Dr. Hablitz joined the Center for Translational Neuromedicine at the University of Rochester in 2017. Together with Dr. Maiken Nedergaard, Dr. Hablitz defined the endogenous, circadian rhythm of the glymphatic system and discovered a new rhythm in CSF distribution between the brain and the body.

Faculty Appointments

Assistant Professor - Department of Neurology, Center for Translational Neuromedicine (SMD)

Credentials

Education

PhD | University of Alabama at Birmingham. Cell and Molecular Biology. 2015

BS | Pennsylvania State University. Biology. 2010

Awards

2021 Outstanding Early Investigator Award.

2020 Merit Award.

2016 Tartar Trust Foundation Fellowship.

2014 Trainee Award.

Research

Dr. Hablitz’s research focuses on basic biological mechanisms of circadian synchrony and entrainment in health and disease. Most recently, Dr. Hablitz has been using circadian rhythms and sleep to improve glymphatic, neuronal, and cerebrovascular function in pre-clinical models of chronic neuropathi...
Dr. Hablitz’s research focuses on basic biological mechanisms of circadian synchrony and entrainment in health and disease. Most recently, Dr. Hablitz has been using circadian rhythms and sleep to improve glymphatic, neuronal, and cerebrovascular function in pre-clinical models of chronic neuropathic pain and stroke.

Publications

Journal Articles

Circadian rhythms of macrophages are altered by the acidic tumor microenvironment.

Knudsen-Clark AM, Mwangi D, Cazarin J, Morris K, Baker C, Hablitz LM, McCall MN, Kim M, Altman BJ

EMBO reports.. 2024 November 25 (11):5080-5112. Epub 10/16/2024.

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.

Gomolka RS, Hablitz LM, Mestre H, Giannetto M, Du T, Hauglund NL, Xie L, Peng W, Martinez PM, Nedergaard M, Mori Y

eLife.. 2023 February 912 Epub 02/09/2023.

Reading to the end(foot): translational readthrough of AQP4 increases amyloid-? clearance.

Giannetto MJ, Hablitz LM

Brain : a journal of neurology.. 2022 September 14145 (9):2943-2945. Epub 1900 01 01.

A real-time in vivo clearance assay for quantification of glymphatic efflux.

Plá V, Bork P, Harnpramukkul A, Olveda G, Ladrón-de-Guevara A, Giannetto MJ, Hussain R, Wang W, Kelley DH, Hablitz LM, Nedergaard M

Cell reports.. 2022 September 1340 (11):111320. Epub 1900 01 01.

The glymphatic system.

Hablitz LM, Nedergaard M

Current biology : CB.. 2021 October 2531 (20):R1371-R1375. Epub 1900 01 01.

The Glymphatic System: A Novel Component of Fundamental Neurobiology.

Hablitz LM, Nedergaard M

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2021 September 1541 (37):7698-7711. Epub 1900 01 01.

The Glymphatic System and Pain.

Goldman N, Hablitz LM, Mori Y, Nedergaard M

Medical acupuncture.. 2020 December 132 (6):373-376. Epub 12/16/2020.

Biological sex does not predict glymphatic influx in healthy young, middle aged or old mice.

Giannetto M, Xia M, Stæger FF, Metcalfe T, Vinitsky HS, Dang JAML, Xavier ALR, Kress BT, Nedergaard M, Hablitz LM

Scientific reports.. 2020 September 3010 (1):16073. Epub 09/30/2020.

Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations.

Todd WD, Venner A, Anaclet C, Broadhurst RY, De Luca R, Bandaru SS, Issokson L, Hablitz LM, Cravetchi O, Arrigoni E, Campbell JN, Allen CN, Olson DP, Fuller PM

Nature communications.. 2020 September 211 (1):4410. Epub 09/02/2020.

Circadian control of brain glymphatic and lymphatic fluid flow.

Hablitz LM, Plá V, Giannetto M, Vinitsky HS, Stæger FF, Metcalfe T, Nguyen R, Benrais A, Nedergaard M

Nature communications.. 2020 September 211 (1):4411. Epub 09/02/2020.

Cannabinoid Signaling Recruits Astrocytes to Modulate Presynaptic Function in the Suprachiasmatic Nucleus.

Hablitz LM, Gunesch AN, Cravetchi O, Moldavan M, Allen CN

eNeuro.. 2020 7 (1)Epub 02/13/2020.

Increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia.

Hablitz LM, Vinitsky HS, Sun Q, Stæger FF, Sigurdsson B, Mortensen KN, Lilius TO, Nedergaard M

Science advances.. 2019 February 5 (2):eaav5447. Epub 02/27/2019.

Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M

eLife.. 2018 December 187 Epub 12/18/2018.

Correcting delayed circadian phase with bright light therapy predicts improvement in ADHD symptoms: A pilot study.

Fargason RE, Fobian AD, Hablitz LM, Paul JR, White BA, Cropsey KL, Gamble KL

Journal of psychiatric research.. 2017 August 91 :105-110. Epub 03/06/2017.

GSK3 activity regulates rhythms in hippocampal clock gene expression and synaptic plasticity.

Besing RC, Rogers CO, Paul JR, Hablitz LM, Johnson RL, McMahon LL, Gamble KL

Hippocampus.. 2017 August 27 (8):890-898. Epub 05/27/2017.

GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin.

Hablitz LM, Molzof HE, Abrahamsson KE, Cooper JM, Prosser RA, Gamble KL

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2015 November 1135 (45):14957-65. Epub 1900 01 01.

Circadian rhythmicity of active GSK3 isoforms modulates molecular clock gene rhythms in the suprachiasmatic nucleus.

Besing RC, Paul JR, Hablitz LM, Rogers CO, Johnson RL, Young ME, Gamble KL

Journal of biological rhythms.. 2015 April 30 (2):155-60. Epub 02/27/2015.

Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channels.

Hablitz LM, Molzof HE, Paul JR, Johnson RL, Gamble KL

The Journal of physiology.. 2014 November 15592 (22):5079-92. Epub 09/12/2014.

Neuropeptide Y-induced phase shifts of PER2::LUC rhythms are mediated by long-term suppression of neuronal excitability in a phase-specific manner.

Besing RC, Hablitz LM, Paul JR, Johnson RL, Prosser RA, Gamble KL

Chronobiology international.. 2012 March 29 (2):91-102. Epub 1900 01 01.