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John Mariani, Ph.D.

John Mariani, Ph.D.

Contact

Office (585) 276-3141

About Me

Faculty Appointments

Assistant Professor - Department of Neurology, Center for Translational Neuromedicine (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Training | University of Rochester 2016 - 2020

Education

PhD | Icahn School of Medicine at Mount Sinai. Neuroscience. 2016

BS | Binghamton University, State University of New York. Psychobiology. 2009

BMus | Purchase College, State University of New York. Classical Piano Performance. 2007

Awards

ACTRIMS Young Investigator Travel Award. 2019

Award of Excellence. 2015

Undergraduate Research Award. 2008

Jessie Baker Scholarship. 2003 - 2007

Earl Brink Scholarship. 2003 - 2007

Publications

Journal Articles

Repression of developmental transcription factor networks triggers aging-associated gene expression in human glial progenitor cells.

Mariani JN, Mansky B, Madsen PM, Salinas D, Kesmen D, Huynh NPT, Kuypers NJ, Kesel ER, Bates J, Payne C, Chandler-Militello D, Benraiss A, Goldman SA

Nature communications.. 2024 May 815 (1):3873. Epub 05/08/2024.

Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain.

Vieira R, Mariani JN, Huynh NPT, Stephensen HJT, Solly R, Tate A, Schanz S, Cotrupi N, Mousaei M, Sporring J, Benraiss A, Goldman SA

Nature biotechnology.. 2024 May 42 (5):719-730. Epub 07/17/2023.

CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance.

Takasugi M, Ohtani N, Takemura K, Emmrich S, Zakusilo FT, Yoshida Y, Kutsukake N, Mariani JN, Windrem MS, Chandler-Militello D, Goldman SA, Satoh J, Ito S, Seluanov A, Gorbunova V

Cell reports.. 2023 September 2642 (9):113130. Epub 09/13/2023.

Glial progenitor cells of the adult human white and grey matter are contextually distinct.

Osorio MJ, Mariani JN, Zou L, Schanz SJ, Heffernan K, Cornwell A, Goldman SA

Glia.. 2023 March 71 (3):524-540. Epub 11/05/2022.

A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.

Benraiss A, Mariani JN, Tate A, Madsen PM, Clark KM, Welle KA, Solly R, Capellano L, Bentley K, Chandler-Militello D, Goldman SA

Cell reports.. 2022 August 3040 (9):111291. Epub 1900 01 01.

Glial progenitor cell-based repair of the dysmyelinated brain: Progression to the clinic.

Goldman SA, Mariani JN, Madsen PM

Seminars in cell & developmental biology.. 2021 August 116 :62-70. Epub 01/04/2021.

Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.

Benraiss A, Mariani JN, Osipovitch M, Cornwell A, Windrem MS, Villanueva CB, Chandler-Militello D, Goldman SA

Cell reports.. 2021 July 636 (1):109308. Epub 1900 01 01.

Human Glial Progenitor Cells Effectively Remyelinate the Demyelinated Adult Brain.

Windrem MS, Schanz SJ, Zou L, Chandler-Militello D, Kuypers NJ, Nedergaard M, Lu Y, Mariani JN, Goldman SA

Cell reports.. 2020 May 1931 (7):107658. Epub 1900 01 01.

Human ESC-Derived Chimeric Mouse Models of Huntington's Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation.

Osipovitch M, Asenjo Martinez A, Mariani JN, Cornwell A, Dhaliwal S, Zou L, Chandler-Militello D, Wang S, Li X, Benraiss SJ, Agate R, Lampp A, Benraiss A, Windrem MS, Goldman SA

Cell stem cell.. 2019 January 324 (1):107-122.e7. Epub 12/13/2018.

Human Glial Chimeric Mice to Define the Role of Glial Pathology in Human Disease.

Mariani JN, Zou L, Goldman SA

Methods in molecular biology.. 2019 1936 :311-331. Epub 1900 01 01.

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.

Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR

The Journal of clinical investigation.. 2017 August 1127 (8):3136-3151. Epub 07/24/2017.

Karyopherin Alpha Proteins Regulate Oligodendrocyte Differentiation.

Laitman BM, Mariani JN, Zhang C, Sawai S, John GR

PloS one.. 2017 12 (1):e0170477. Epub 01/20/2017.

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

Laitman BM, Asp L, Mariani JN, Zhang J, Liu J, Sawai S, Chapouly C, Horng S, Kramer EG, Mitiku N, Loo H, Burlant N, Pedre X, Hara Y, Nudelman G, Zaslavsky E, Lee YM, Braun DA, Lu QR, Narla G, Raine CS, Friedman SL, Casaccia P, John GR

PLoS biology.. 2016 May 14 (5):e1002467. Epub 05/23/2016.

Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes.

Chapouly C, Yao Q, Vandierdonck S, Larrieu-Lahargue F, Mariani JN, Gadeau AP, Renault MA

Cardiovascular research.. 2016 February 1109 (2):217-27. Epub 12/08/2015.

Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions.

Chapouly C, Tadesse Argaw A, Horng S, Castro K, Zhang J, Asp L, Loo H, Laitman BM, Mariani JN, Straus Farber R, Zaslavsky E, Nudelman G, Raine CS, John GR

Brain : a journal of neurology.. 2015 June 138 (Pt 6):1548-67. Epub 03/23/2015.

Combinatorial actions of Tgf? and Activin ligands promote oligodendrocyte development and CNS myelination.

Dutta DJ, Zameer A, Mariani JN, Zhang J, Asp L, Huynh J, Mahase S, Laitman BM, Argaw AT, Mitiku N, Urbanski M, Melendez-Vasquez CV, Casaccia P, Hayot F, Bottinger EP, Brown CW, John GR

Development.. 2014 June 141 (12):2414-28. Epub 1900 01 01.

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.

Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ, Seto J, Kramer EG, Ferrara N, Sofroniew MV, John GR

The Journal of clinical investigation.. 2012 July 122 (7):2454-68. Epub 06/01/2012.

Promoting myelin repair and return of function in multiple sclerosis.

Zhang J, Kramer EG, Asp L, Dutta DJ, Navrazhina K, Pham T, Mariani JN, Argaw AT, Melendez-Vasquez CV, John GR

FEBS letters.. 2011 December 1585 (23):3813-20. Epub 08/18/2011.

Adolescent C57BL/6J (but not DBA/2J) mice consume greater amounts of limited-access ethanol compared to adults and display continued elevated ethanol intake into adulthood.

Moore EM, Mariani JN, Linsenbardt DN, Melón LC, Boehm SL

Alcoholism, clinical and experimental research.. 2010 April 34 (4):734-42. Epub 01/26/2010.