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Chia-Lung Wu, Ph.D.

Chia-Lung Wu, Ph.D.

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Office (585) 275-1335

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About Me

Dr. Chia-Lung Wu earned his bachelor's and Master’s degree in Material Science and Engineering from National Taipei University of Technology and National Taiwan University, respectively. He obtained his doctoral degree in Biomedical Engineering at Duke University in 2015. Dr. Wu then completed his p...
Dr. Chia-Lung Wu earned his bachelor's and Master’s degree in Material Science and Engineering from National Taipei University of Technology and National Taiwan University, respectively. He obtained his doctoral degree in Biomedical Engineering at Duke University in 2015. Dr. Wu then completed his post-doctoral training with Dr. Farshid Guilak in Orthopedic Surgery Department at Washington University in Saint Louis in 2020.

Faculty Appointments

Assistant Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Assistant Professor - Department of Biomedical Engineering (SMD) - Joint

Credentials

Awards

ON Foundation Award. 2020

NIH NIAMS K99/R00 Pathway to Independence Award – 1K99AR075899. 2019

The New Investigator Recognition Awards (NIRA), Post-doctoral research associate. 2018

The New Investigator Recognition Awards (NIRA), Graduate student. 2014

Taiwan Government Student Studying Aboard Scholarship (2-year funding). 2012

Research

Dr. Wu’s research focuses on identifying the molecular mechanisms by which genetic and epigenetic regulators modulate development, homeostasis and disease progression of musculoskeletal tissues, with a particular focus on cartilage and bone. His approach utilizes bioengineering, cellular biology, ne...
Dr. Wu’s research focuses on identifying the molecular mechanisms by which genetic and epigenetic regulators modulate development, homeostasis and disease progression of musculoskeletal tissues, with a particular focus on cartilage and bone. His approach utilizes bioengineering, cellular biology, next-generation sequencing techniques and genome editing tools, complemented by animal and biomechanical models to uncover these fundamental principles. The long-term goal of his research program is to apply this knowledge to improve tissue engineering outcomes, regeneration and repair for musculoskeletal disorders.

Publications

Journal Articles

Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function.

Ackerman JE, Best KT, Muscat SN, Pritchett EM, Nichols AEC, Wu CL, Loiselle AE

Cell reports.. 2022 November 2241 (8):111706. Epub 1900 01 01.

Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model.

Kenney HM, Wu CL, Loiselle AE, Xing L, Ritchlin CT, Schwarz EM

Arthritis research & therapy.. 2022 March 724 (1):64. Epub 03/07/2022.

Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis.

Wu CL, Dicks A, Steward N, Tang R, Katz DB, Choi YR, Guilak F

Nature communications.. 2021 January 1312 (1):362. Epub 01/13/2021.

Is Obesity a Disease of Stem Cells?

Oestreich AK, Collins KH, Harasymowicz NS, Wu CL, Guilak F

Cell stem cell.. 2020 July 227 (1):15-18. Epub 1900 01 01.

The role of macrophages in osteoarthritis and cartilage repair.

Wu CL, Harasymowicz NS, Klimak MA, Collins KH, Guilak F

Osteoarthritis and cartilage. 2020 May 28 (5):544-554. Epub 01/08/2020.

Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee.

Bailey KN, Furman BD, Zeitlin J, Kimmerling KA, Wu CL, Guilak F, Olson SA

Osteoarthritis and cartilage. 2020 May 28 (5):626-638. Epub 02/08/2020.

Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity.

Tang R, Harasymowicz NS, Wu CL, Collins KH, Choi YR, Oswald SJ, Guilak F

Science advances.. 2020 May 6 (19):eaaz7492. Epub 05/08/2020.

Transgenic conversion of ?-6 to ?-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis.

Kimmerling KA, Oswald SJ, Huebner JL, Little D, Kraus VB, Kang JX, Wu CL, Guilak F

Arthritis research & therapy.. 2020 April 1522 (1):83. Epub 04/15/2020.

Intergenerational Transmission of Diet-Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice.

Harasymowicz NS, Choi YR, Wu CL, Iannucci L, Tang R, Guilak F

Arthritis & rheumatology.. 2020 April 72 (4):632-644. Epub 03/05/2020.

Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter.

Dicks A, Wu CL, Steward N, Adkar SS, Gersbach CA, Guilak F

Stem cell research & therapy.. 2020 February 1811 (1):66. Epub 02/18/2020.

Effects of dietary fatty acid content on humeral cartilage and bone structure in a mouse model of diet-induced obesity.

Votava L, Schwartz AG, Harasymowicz NS, Wu CL, Guilak F

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 March 37 (3):779-788. Epub 02/12/2019.

Physiologic and pathologic effects of dietary free fatty acids on cells of the joint.

Harasymowicz NS, Dicks A, Wu CL, Guilak F

Annals of the New York Academy of Sciences.. 2019 March 1440 (1):36-53. Epub 01/15/2019.

Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing.

Adkar SS, Wu CL, Willard VP, Dicks A, Ettyreddy A, Steward N, Bhutani N, Gersbach CA, Guilak F

Stem cells.. 2019 January 37 (1):65-76. Epub 10/31/2018.

Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug Delivery.

Choi, Y.-R.; Collins, K. H.; Springer, L. E.; Pferdehirt, L.; Ross, A. K.; Wu, C.-L.; Moutos, F. T.; Harasymowicz, N. S.; Brunger, J. M.; Pham, C. T.

bioRxiv. 2019; 535609.

Osteoarthritis as a disease of the cartilage pericellular matrix.

Guilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I

Matrix biology : journal of the International Society for Matrix Biology.. 2018 October 71-72 :40-50. Epub 05/22/2018.

Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells.

Tang R, Jing L, Willard VP, Wu CL, Guilak F, Chen J, Setton LA

Stem cell research & therapy.. 2018 March 99 (1):61. Epub 03/09/2018.

Genome Engineering for Personalized Arthritis Therapeutics.

Adkar SS, Brunger JM, Willard VP, Wu CL, Gersbach CA, Guilak F

Trends in molecular medicine.. 2017 October 23 (10):917-931. Epub 09/05/2017.

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.

Wu CL, McNeill J, Goon K, Little D, Kimmerling K, Huebner J, Kraus V, Guilak F

Arthritis & rheumatology.. 2017 September 69 (9):1772-1783. Epub 08/08/2017.

Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair.

Wu CL, Kimmerling KA, Little D, Guilak F

Scientific reports.. 2017 March 207 :44315. Epub 03/20/2017.

Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis.

O'Conor CJ, Ramalingam S, Zelenski NA, Benefield HC, Rigo I, Little D, Wu CL, Chen D, Liedtke W, McNulty AL, Guilak F

Scientific reports.. 2016 July 86 :29053. Epub 07/08/2016.

Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury.

Wu CL, Jain D, McNeill JN, Little D, Anderson JA, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Guilak F

Annals of the rheumatic diseases.. 2015 November 74 (11):2076-83. Epub 07/10/2014.

Life-long caloric restriction does not alter the severity of age-related osteoarthritis.

McNeill JN, Wu CL, Rabey KN, Schmitt D, Guilak F

Age.. 2014 36 (4):9669. Epub 07/01/2014.

Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids.

Wu CL, Diekman BO, Jain D, Guilak F

International journal of obesity : journal of the International Association for the Study of Obesity.. 2013 August 37 (8):1079-87. Epub 11/20/2012.

Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis.

Diekman BO, Wu CL, Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F

Cell transplantation.. 2013 22 (8):1395-408. Epub 08/10/2012.

Books

Post-Traumatic Arthritis (2015)

Chapter: Animal Models of Meniscal Injury in Post-Traumatic Arthritis

Post-Traumatic Arthritis (2015)

Chapter: Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question