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Eric J. Wagner, Ph.D.

Eric J. Wagner, Ph.D.

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Office (585) 276-3425

Connect with Eric J. Wagner, Ph.D.

@wagnerlab_rna

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About Me

Faculty Appointments

Professor - Department of Biochemistry and Biophysics (SMD)

Credentials

Education

PhD | Duke University. Molecular Cancer Biology. 2002

BS | University of Rochester. Molecular Genetics. 1997

Postdoctoral Fellow | Univ. North Carolina at Chapel Hill. 0

Research

Publications

Journal Articles

Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear function.

Lin MH, Jensen MK, Elrod ND, Chu HF, Haseley M, Beam AC, Huang KL, Chiang W, Russell WK, Williams K, Pröschel C, Wagner EJ, Tong L

Molecular cell.. 2024 August 884 (15):2900-2917.e10. Epub 07/19/2024.

Regulation of the transcriptome by Pumilio and the CCR4-NOT deadenylase complex.

Haugen RJ, Barnier C, Elrod ND, Luo H, Jensen MK, Ji P, Smibert CA, Lipshitz HD, Wagner EJ, Freddolino PL, Goldstrohm AC

RNA.. 2024 June 1730 (7):866-890. Epub 06/17/2024.

PolyAMiner-Bulk is a deep learning-based algorithm that decodes alternative polyadenylation dynamics from bulk RNA-seq data.

Jonnakuti VS, Wagner EJ, Maleti?-Savati? M, Liu Z, Yalamanchili HK

Cell reports methods.. 2024 February 264 (2):100707. Epub 02/06/2024.

Regulation of the Drosophila transcriptome by Pumilio and CCR4-NOT deadenylase.

Haugen RJ, Barnier C, Elrod ND, Luo H, Jensen MK, Ji P, Smibert CA, Lipshitz HD, Wagner EJ, Freddolino PL, Goldstrohm AC

bioRxiv : the preprint server for biology.. 2023 August 30 Epub 08/30/2023.

NUDT21 alters glioma migration through differential alternative polyadenylation of LAMC1.

Jonnakuti VS, Ji P, Gao Y, Lin A, Chu Y, Elrod N, Huang KL, Li W, Yalamanchili HK, Wagner EJ

Journal of neuro-oncology.. 2023 July 163 (3):623-634. Epub 06/30/2023.

Bi-allelic variants in INTS11 are associated with a complex neurological disorder.

Tepe B, Macke EL, Niceta M, Weisz Hubshman M, Kanca O, Schultz-Rogers L, Zarate YA, Schaefer GB, Granadillo De Luque JL, Wegner DJ, Cogne B, Gilbert-Dussardier B, Le Guillou X, Wagner EJ, Pais LS, Neil JE, Mochida GH, Walsh CA, Magal N, Drasinover V, Shohat M, Schwab T, Schmitz C, Clark K, Fine A, Lanpher B, Gavrilova R, Blanc P, Burglen L, Afenjar A, Steel D, Kurian MA, Prabhakar P, Gößwein S, Di Donato N, Bertini ES, , Wangler MF, Yamamoto S, Tartaglia M, Klee EW, Bellen HJ

American journal of human genetics.. 2023 May 4110 (5):774-789. Epub 04/12/2023.

Alternative polyadenylation alters protein dosage by switching between intronic and 3'UTR sites.

de Prisco N, Ford C, Elrod ND, Lee W, Tang LC, Huang KL, Lin A, Ji P, Jonnakuti VS, Boyle L, Cabaj M, Botta S, Õunap K, Reinson K, Wojcik MH, Rosenfeld JA, Bi W, Tveten K, Prescott T, Gerstner T, Schroeder A, Fong CT, George-Abraham JK, Buchanan CA, Hanson-Khan A, Bernstein JA, Nella AA, Chung WK, Brandt V, Jovanovic M, Targoff KL, Yalamanchili HK, Wagner EJ, Gennarino VA

Science advances.. 2023 February 179 (7):eade4814. Epub 02/17/2023.

Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders.

Cui Y, Arnold FJ, Peng F, Wang D, Li JS, Michels S, Wagner EJ, La Spada AR, Li W

Nature communications.. 2023 February 314 (1):583. Epub 02/03/2023.

Integrator is a global promoter-proximal termination complex.

Wagner EJ, Tong L, Adelman K

Molecular cell.. 2023 February 283 (3):416-427. Epub 01/11/2023.

The Integrator complex desensitizes cellular response to TGF-?/BMP signaling.

Liu S, Baeg GH, Yang Y, Goh FG, Bao H, Wagner EJ, Yang X, Cai Y

Cell reports.. 2023 January 3142 (1):112007. Epub 01/14/2023.

PolyAMiner-Bulk: A Machine Learning Based Bioinformatics Algorithm to Infer and Decode Alternative Polyadenylation Dynamics from bulk RNA-seq data.

Jonnakuti VS, Wagner EJ, Maleti?-Savati? M, Liu Z, Yalamanchili HK

bioRxiv : the preprint server for biology.. 2023 January 24 Epub 01/24/2023.

Coevolution combined with molecular dynamics simulations provides structural and mechanistic insights into the interactions between the integrator complex subunits.

Fongang B, Wadop YN, Zhu Y, Wagner EJ, Kudlicki A, Rowicka M

Computational and structural biotechnology journal.. 2023 21 :5686-5697. Epub 11/19/2023.

Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci.

Stein CB, Field AR, Mimoso CA, Zhao C, Huang KL, Wagner EJ, Adelman K

Molecular cell.. 2022 November 1782 (22):4232-4245.e11. Epub 10/28/2022.

INTS13 variants causing a recessive developmental ciliopathy disrupt assembly of the Integrator complex.

Mascibroda LG, Shboul M, Elrod ND, Colleaux L, Hamamy H, Huang KL, Peart N, Singh MK, Lee H, Merriman B, Jodoin JN, Sitaram P, Lee LA, Fathalla R, Al-Rawashdeh B, Ababneh O, El-Khateeb M, Escande-Beillard N, Nelson SF, Wu Y, Tong L, Kenney LJ, Roy S, Russell WK, Amiel J, Reversade B, Wagner EJ

Nature communications.. 2022 October 1313 (1):6054. Epub 10/13/2022.

Inositol hexakisphosphate is required for Integrator function.

Lin MH, Jensen MK, Elrod ND, Huang KL, Welle KA, Wagner EJ, Tong L

Nature communications.. 2022 September 3013 (1):5742. Epub 09/30/2022.

3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension.

Tseng V, Collum S, Allawzi A, Crotty K, Yeligar S, Trammell A, Ryan Smith M, Kang BY, Sutliff RL, Ingram JL, Jyothula SS, Thandavarayan RA, Huang HJ, Nozik ES, Wagner EJ, Michael Hart C, Karmouty-Quintana H

Matrix biology : journal of the International Society for Matrix Biology.. 2022 August 111 :53-75. Epub 06/04/2022.

Sine oculis homeobox homolog 1 plays a critical role in pulmonary fibrosis.

Wilson C, Mertens TC, Shivshankar P, Bi W, Collum SD, Wareing N, Ko J, Weng T, Naikawadi RP, Wolters PJ, Maire P, Jyothula SS, Thandavarayan RA, Ren D, Elrod ND, Wagner EJ, Huang HJ, Dickey BF, Ford HL, Karmouty-Quintana H

JCI insight.. 2022 May 237 (10)Epub 05/23/2022.

Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration.

LaForce GR, Farr JS, Liu J, Akesson C, Gumus E, Pinkard O, Miranda HC, Johnson K, Sweet TJ, Ji P, Lin A, Coller J, Philippidou P, Wagner EJ, Schaffer AE

Neuron.. 2022 April 20110 (8):1340-1357.e7. Epub 02/08/2022.

CstF64-Induced Shortening of the 3'UTR Promotes Esophageal Squamous Cell Carcinoma Progression by Disrupting ceRNA Cross-talk with .

Lin A, Ji P, Niu X, Zhao X, Chen Y, Liu W, Liu Y, Fan W, Sun Y, Miao C, Zhang S, Tan W, Lin D, Wagner EJ, Wu C

Cancer research.. 2021 November 1581 (22):5638-5651. Epub 10/04/2021.

RBFOX2 is critical for maintaining alternative polyadenylation patterns and mitochondrial health in rat myoblasts.

Cao J, Verma SK, Jaworski E, Mohan S, Nagasawa CK, Rayavara K, Sooter A, Miller SN, Holcomb RJ, Powell MJ, Ji P, Elrod ND, Yildirim E, Wagner EJ, Popov V, Garg NJ, Routh AL, Kuyumcu-Martinez MN

Cell reports.. 2021 November 237 (5):109910. Epub 1900 01 01.

An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability.

Li L, Huang KL, Gao Y, Cui Y, Wang G, Elrod ND, Li Y, Chen YE, Ji P, Peng F, Russell WK, Wagner EJ, Li W

Nature genetics.. 2021 July 53 (7):994-1005. Epub 05/13/2021.

Human Pumilio proteins directly bind the CCR4-NOT deadenylase complex to regulate the transcriptome.

Enwerem III, Elrod ND, Chang CT, Lin A, Ji P, Bohn JA, Levdansky Y, Wagner EJ, Valkov E, Goldstrohm AC

RNA.. 2021 April 27 (4):445-464. Epub 01/04/2021.

Alternative polyadenylation of mRNA and its role in cancer.

Yuan F, Hankey W, Wagner EJ, Li W, Wang Q

Genes & diseases.. 2021 January 8 (1):61-72. Epub 10/25/2019.

Application and design considerations for 3'-end sequencing using click-chemistry.

Jensen MK, Elrod ND, Yalamanchili HK, Ji P, Lin A, Liu Z, Wagner EJ

Methods in enzymology.. 2021 655 :1-23. Epub 05/04/2021.

A computational pipeline to infer alternative poly-adenylation from 3' sequencing data.

Yalamanchili HK, Elrod ND, Jensen MK, Ji P, Lin A, Wagner EJ, Liu Z

Methods in enzymology.. 2021 655 :185-204. Epub 06/05/2021.

Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.

Huang KL, Jee D, Stein CB, Elrod ND, Henriques T, Mascibroda LG, Baillat D, Russell WK, Adelman K, Wagner EJ

Molecular cell.. 2020 October 1580 (2):345-358.e9. Epub 09/22/2020.

PolyA-miner: accurate assessment of differential alternative poly-adenylation from 3'Seq data using vector projections and non-negative matrix factorization.

Yalamanchili HK, Alcott CE, Ji P, Wagner EJ, Zoghbi HY, Liu Z

Nucleic acids research.. 2020 July 948 (12):e69. Epub 1900 01 01.

Partial loss of CFIm25 causes learning deficits and aberrant neuronal alternative polyadenylation.

Alcott CE, Yalamanchili HK, Ji P, van der Heijden ME, Saltzman A, Elrod N, Lin A, Leng M, Bhatt B, Hao S, Wang Q, Saliba A, Tang J, Malovannaya A, Wagner EJ, Liu Z, Zoghbi HY

eLife.. 2020 April 229 Epub 04/22/2020.

Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation.

Weng T, Huang J, Wagner EJ, Ko J, Wu M, Wareing NE, Xiang Y, Chen NY, Ji P, Molina JG, Volcik KA, Han L, Mayes MD, Blackburn MR, Assassi S

The Journal of experimental medicine.. 2020 February 3217 (2)Epub 1900 01 01.

The Integrator Complex Attenuates Promoter-Proximal Transcription at Protein-Coding Genes.

Elrod ND, Henriques T, Huang KL, Tatomer DC, Wilusz JE, Wagner EJ, Adelman K

Molecular cell.. 2019 December 576 (5):738-752.e7. Epub 1900 01 01.

The Integrator complex cleaves nascent mRNAs to attenuate transcription.

Tatomer DC, Elrod ND, Liang D, Xiao MS, Jiang JZ, Jonathan M, Huang KL, Wagner EJ, Cherry S, Wilusz JE

Genes & development.. 2019 November 133 (21-22):1525-1538. Epub 09/17/2019.

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.

Yoshimi A, Lin KT, Wiseman DH, Rahman MA, Pastore A, Wang B, Lee SC, Micol JB, Zhang XJ, de Botton S, Penard-Lacronique V, Stein EM, Cho H, Miles RE, Inoue D, Albrecht TR, Somervaille TCP, Batta K, Amaral F, Simeoni F, Wilks DP, Cargo C, Intlekofer AM, Levine RL, Dvinge H, Bradley RK, Wagner EJ, Krainer AR, Abdel-Wahab O

Nature.. 2019 October 574 (7777):273-277. Epub 10/02/2019.

Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation.

Weng T, Ko J, Masamha CP, Xia Z, Xiang Y, Chen NY, Molina JG, Collum S, Mertens TC, Luo F, Philip K, Davies J, Huang J, Wilson C, Thandavarayan RA, Bruckner BA, Jyothula SS, Volcik KA, Li L, Han L, Li W, Assassi S, Karmouty-Quintana H, Wagner EJ, Blackburn MR

The Journal of clinical investigation.. 2019 May 1129 (5):1984-1999. Epub 02/28/2019.

Nudt21 regulates the alternative polyadenylation of Pak1 and is predictive in the prognosis of glioblastoma patients.

Chu Y, Elrod N, Wang C, Li L, Chen T, Routh A, Xia Z, Li W, Wagner EJ, Ji P

Oncogene.. 2019 May 38 (21):4154-4168. Epub 01/31/2019.

Development of Poly(A)-ClickSeq as a tool enabling simultaneous genome-wide poly(A)-site identification and differential expression analysis.

Elrod ND, Jaworski EA, Ji P, Wagner EJ, Routh A

Methods : a companion to Methods in enzymology.. 2019 February 15155 :20-29. Epub 01/06/2019.

Biochemical and Next Generation Sequencing Approaches to Study RNA Regulation.

Wagner EJ, Goldstrohm AC

Methods : a companion to Methods in enzymology.. 2019 February 15155 :1-2. Epub 1900 01 01.

Composition of the Survival Motor Neuron (SMN) Complex in .

Matera AG, Raimer AC, Schmidt CA, Kelly JA, Droby GN, Baillat D, Ten Have S, Lamond AI, Wagner EJ, Gray KM

G3 : genes - genomes - genetics.. 2019 February 79 (2):491-503. Epub 02/07/2019.

3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk.

Park HJ, Ji P, Kim S, Xia Z, Rodriguez B, Li L, Su J, Chen K, Masamha CP, Baillat D, Fontes-Garfias CR, Shyu AB, Neilson JR, Wagner EJ, Li W

Nature genetics.. 2018 June 50 (6):783-789. Epub 05/21/2018.

Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module.

Albrecht TR, Shevtsov SP, Wu Y, Mascibroda LG, Peart NJ, Huang KL, Sawyer IA, Tong L, Dundr M, Wagner EJ

Nucleic acids research.. 2018 May 446 (8):4241-4255. Epub 1900 01 01.

Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCF degron.

Gray KM, Kaifer KA, Baillat D, Wen Y, Bonacci TR, Ebert AD, Raimer AC, Spring AM, Have ST, Glascock JJ, Gupta K, Van Duyne GD, Emanuele MJ, Lamond AI, Wagner EJ, Lorson CL, Matera AG

Molecular biology of the cell.. 2018 January 1529 (2):96-110. Epub 11/22/2017.

The contribution of alternative polyadenylation to the cancer phenotype.

Masamha CP, Wagner EJ

Carcinogenesis.. 2018 January 1239 (1):2-10. Epub 1900 01 01.

TC3A: The Cancer 3' UTR Atlas.

Feng X, Li L, Wagner EJ, Li W

Nucleic acids research.. 2018 January 446 (D1):D1027-D1030. Epub 1900 01 01.

A distal auxiliary element facilitates cleavage and polyadenylation of Dux4 mRNA in the pathogenic haplotype of FSHD.

Peart N, Wagner EJ

Human genetics.. 2017 September 136 (9):1291-1301. Epub 05/24/2017.

Correction: Human mutations in integrator complex subunits link transcriptome integrity to brain development.

Oegema R, Baillat D, Schot R, van Unen LM, Brooks A, Kia SK, Hoogeboom AJM, Xia Z, Li W, Cesaroni M, Lequin MH, van Slegtenhorst M, Dobyns WB, de Coo IFM, van den Berg D, Verheijen FW, Kremer A, van der Spek PJ, Heijsman D, Wagner EJ, Fornerod M, Mancini GMS

PLoS genetics.. 2017 August 13 (8):e1006923. Epub 08/01/2017.

Poly(A)-ClickSeq: click-chemistry for next-generation 3?-end sequencing without RNA enrichment or fragmentation.

Routh A, Ji P, Jaworski E, Xia Z, Li W, Wagner EJ

Nucleic acids research.. 2017 July 745 (12):e112. Epub 1900 01 01.

Human mutations in integrator complex subunits link transcriptome integrity to brain development.

Oegema R, Baillat D, Schot R, van Unen LM, Brooks A, Kia SK, Hoogeboom AJM, Xia Z, Li W, Cesaroni M, Lequin MH, van Slegtenhorst M, Dobyns WB, de Coo IFM, Verheijen FW, Kremer A, van der Spek PJ, Heijsman D, Wagner EJ, Fornerod M, Mancini GMS

PLoS genetics.. 2017 May 13 (5):e1006809. Epub 05/25/2017.

Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance.

Wu Y, Albrecht TR, Baillat D, Wagner EJ, Tong L

Proceedings of the National Academy of Sciences of the United States of America.. 2017 April 25114 (17):4394-4399. Epub 04/10/2017.

Genome-Wide RNAi Screens for RNA Processing Events in Drosophila melanogaster S2 Cells.

Peart N, Wagner EJ

Methods in molecular biology.. 2017 1648 :235-245. Epub 1900 01 01.

CRISPR-Cas9 mediated genetic engineering for the purification of the endogenous integrator complex from mammalian cells.

Baillat D, Russell WK, Wagner EJ

Protein expression and purification.. 2016 December 128 :101-8. Epub 08/19/2016.

CFIm25 regulates glutaminase alternative terminal exon definition to modulate miR-23 function.

Masamha CP, Xia Z, Peart N, Collum S, Li W, Wagner EJ, Shyu AB

RNA.. 2016 June 22 (6):830-8. Epub 04/19/2016.

Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma.

Masamha CP, Albrecht TR, Wagner EJ

Journal of hematology & oncology.. 2016 March 299 :30. Epub 03/29/2016.

Gain-of-function reporters for analysis of mRNA 3'-end formation: Design and optimization.

Peart N, Wagner EJ

BioTechniques.. 2016 60 (3):137-40. Epub 03/01/2016.

Integrator: surprisingly diverse functions in gene expression.

Baillat D, Wagner EJ

Trends in biochemical sciences.. 2015 May 40 (5):257-64. Epub 04/13/2015.

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.

Xia Z, Donehower LA, Cooper TA, Neilson JR, Wheeler DA, Wagner EJ, Li W

Nature communications.. 2014 November 205 :5274. Epub 11/20/2014.

Integrator regulates transcriptional initiation and pause release following activation.

Gardini A, Baillat D, Cesaroni M, Hu D, Marinis JM, Wagner EJ, Lazar MA, Shilatifard A, Shiekhattar R

Molecular cell.. 2014 October 256 (1):128-139. Epub 09/04/2014.

CFIm25 links alternative polyadenylation to glioblastoma tumour suppression.

Masamha CP, Xia Z, Yang J, Albrecht TR, Li M, Shyu AB, Li W, Wagner EJ

Nature.. 2014 June 19510 (7505):412-6. Epub 05/11/2014.

MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab.

Zhang KL, Zhou X, Han L, Chen LY, Chen LC, Shi ZD, Yang M, Ren Y, Yang JX, Frank TS, Zhang CB, Zhang JX, Pu PY, Zhang JN, Jiang T, Wagner EJ, Li M, Kang CS

Molecular cancer.. 2014 March 2013 :63. Epub 03/20/2014.

The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms.

Jodoin JN, Shboul M, Albrecht TR, Lee E, Wagner EJ, Reversade B, Lee LA

Biology open.. 2013 December 152 (12):1390-6. Epub 12/15/2013.

Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex.

Jodoin JN, Sitaram P, Albrecht TR, May SB, Shboul M, Lee E, Reversade B, Wagner EJ, Lee LA

Molecular biology of the cell.. 2013 September 24 (18):2954-65. Epub 07/31/2013.

Half pint/Puf68 is required for negative regulation of splicing by the SR splicing factor Transformer2.

Wang S, Wagner EJ, Mattox W

RNA biology.. 2013 August 10 (8):1396-406. Epub 07/09/2013.

Functional analysis of the integrator subunit 12 identifies a microdomain that mediates activation of the Drosophila integrator complex.

Chen J, Waltenspiel B, Warren WD, Wagner EJ

The Journal of biological chemistry.. 2013 February 15288 (7):4867-77. Epub 01/03/2013.

Non-mRNA 3' end formation: how the other half lives.

Peart N, Sataluri A, Baillat D, Wagner EJ

Wiley interdisciplinary reviews. RNA.. 2013 4 (5):491-506. Epub 06/10/2013.

An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation.

Chen J, Ezzeddine N, Waltenspiel B, Albrecht TR, Warren WD, Marzluff WF, Wagner EJ

RNA.. 2012 December 18 (12):2148-56. Epub 10/24/2012.

snRNA 3' end formation requires heterodimeric association of integrator subunits.

Albrecht TR, Wagner EJ

Molecular and cellular biology.. 2012 March 32 (6):1112-23. Epub 01/17/2012.

Understanding the language of Lys36 methylation at histone H3.

Wagner EJ, Carpenter PB

Nature reviews. Molecular cell biology.. 2012 January 2313 (2):115-26. Epub 01/23/2012.

A brief survey of mRNA surveillance.

van Hoof A, Wagner EJ

Trends in biochemical sciences.. 2011 November 36 (11):585-92. Epub 09/06/2011.

A subset of Drosophila integrator proteins is essential for efficient U7 snRNA and spliceosomal snRNA 3'-end formation.

Ezzeddine N, Chen J, Waltenspiel B, Burch B, Albrecht T, Zhuo M, Warren WD, Marzluff WF, Wagner EJ

Molecular and cellular biology.. 2011 January 31 (2):328-41. Epub 11/15/2010.

snRNA 3' end formation: the dawn of the Integrator complex.

Chen J, Wagner EJ

Biochemical Society transactions.. 2010 August 38 (4):1082-7. Epub 1900 01 01.

Knockdown of SLBP results in nuclear retention of histone mRNA.

Sullivan KD, Mullen TE, Marzluff WF, Wagner EJ

RNA.. 2009 March 15 (3):459-72. Epub 01/20/2009.

Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail.

Marzluff WF, Wagner EJ, Duronio RJ

Nature reviews. Genetics.. 2008 November 9 (11):843-54. Epub 1900 01 01.

SLIP1, a factor required for activation of histone mRNA translation by the stem-loop binding protein.

Cakmakci NG, Lerner RS, Wagner EJ, Zheng L, Marzluff WF

Molecular and cellular biology.. 2008 February 28 (3):1182-94. Epub 11/19/2007.

A genome-wide RNA interference screen reveals that variant histones are necessary for replication-dependent histone pre-mRNA processing.

Wagner EJ, Burch BD, Godfrey AC, Salzler HR, Duronio RJ, Marzluff WF

Molecular cell.. 2007 November 3028 (4):692-9. Epub 1900 01 01.

ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase.

Wagner EJ, Marzluff WF

Molecular and cellular biology.. 2006 September 26 (17):6702-12. Epub 1900 01 01.

Nuclear autoantigenic sperm protein (NASP), a linker histone chaperone that is required for cell proliferation.

Richardson RT, Alekseev OM, Grossman G, Widgren EE, Thresher R, Wagner EJ, Sullivan KD, Marzluff WF, O'Rand MG

The Journal of biological chemistry.. 2006 July 28281 (30):21526-21534. Epub 05/25/2006.

Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein.

Wagner EJ, Ospina JK, Hu Y, Dundr M, Matera AG, Marzluff WF

RNA.. 2006 July 12 (7):1206-18. Epub 05/18/2006.

Nuclear import of the stem-loop binding protein and localization during the cell cycle.

Erkmann JA, Wagner EJ, Dong J, Zhang Y, Kutay U, Marzluff WF

Molecular biology of the cell.. 2005 June 16 (6):2960-71. Epub 04/13/2005.

Expression of an RNAi-resistant SLBP restores proper S-phase progression.

Wagner EJ, Berkow A, Marzluff WF

Biochemical Society transactions.. 2005 June 33 (Pt 3):471-3. Epub 1900 01 01.

The polypyrimidine tract binding protein is required for efficient picornavirus gene expression and propagation.

Florez PM, Sessions OM, Wagner EJ, Gromeier M, Garcia-Blanco MA

Journal of virology.. 2005 May 79 (10):6172-9. Epub 1900 01 01.

Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb.

Wagner EJ, Baraniak AP, Sessions OM, Mauger D, Moskowitz E, Garcia-Blanco MA

The Journal of biological chemistry.. 2005 April 8280 (14):14017-27. Epub 01/31/2005.

A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100.

Dominski Z, Yang XC, Purdy M, Wagner EJ, Marzluff WF

Molecular and cellular biology.. 2005 February 25 (4):1489-500. Epub 1900 01 01.

Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay.

Wollerton MC, Gooding C, Wagner EJ, Garcia-Blanco MA, Smith CW

Molecular cell.. 2004 January 1613 (1):91-100. Epub 1900 01 01.

Imaging alternative splicing in living cells.

Wagner EJ, Baines A, Albrecht T, Brazas RM, Garcia-Blanco MA

Methods in molecular biology.. 2004 257 :29-46. Epub 1900 01 01.

Quantification of alternatively spliced FGFR2 RNAs using the RNA invasive cleavage assay.

Wagner EJ, Curtis ML, Robson ND, Baraniak AP, Eis PS, Garcia-Blanco MA

RNA.. 2003 December 9 (12):1552-61. Epub 1900 01 01.

A stem structure in fibroblast growth factor receptor 2 transcripts mediates cell-type-specific splicing by approximating intronic control elements.

Baraniak AP, Lasda EL, Wagner EJ, Garcia-Blanco MA

Molecular and cellular biology.. 2003 December 23 (24):9327-37. Epub 1900 01 01.

Of urchins and men: evolution of an alternative splicing unit in fibroblast growth factor receptor genes.

Mistry N, Harrington W, Lasda E, Wagner EJ, Garcia-Blanco MA

RNA.. 2003 February 9 (2):209-17. Epub 1900 01 01.

RNAi-mediated PTB depletion leads to enhanced exon definition.

Wagner EJ, Garcia-Blanco MA

Molecular cell.. 2002 October 10 (4):943-9. Epub 1900 01 01.

Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells.

Zeng Y, Wagner EJ, Cullen BR

Molecular cell.. 2002 June 9 (6):1327-33. Epub 1900 01 01.

Polypyrimidine tract binding protein antagonizes exon definition.

Wagner EJ, Garcia-Blanco MA

Molecular and cellular biology.. 2001 May 21 (10):3281-8. Epub 1900 01 01.

A novel isoform ratio switch of the polypyrimidine tract binding protein.

Wagner EJ, Carstens RP, Garcia-Blanco MA

Electrophoresis.. 1999 20 (4-5):1082-6. Epub 1900 01 01.