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Jing Wu, Ph.D.

Jing Wu, Ph.D.

About Me

Faculty Appointments

Assistant Professor - Department of Medicine, Nephrology (SMD)

Assistant Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Education

PhD | Vanderbilt University School of Medicine. Pharmacology. 2014

BMed | Peking University. Preventive Medicine. 2009

Awards

URMC Bioimaging Pilot Award: The Vascular-Immune Interface: Role of Cullin3 Ubiquitin Ligase. 2023 - 2023

Fellow of American Heart Association. 2023

Role of PFAS in Hypertension. 2023 - 2026

AHA Council on Hypertension Rising Star Lecture. 2023

John H. Laragh Research Award. 2023

EHSC Pilot Award: Role of PFAS in Hypertension and Chronic Kidney Disease. 2022 - 2023

American Heart Association Council on Hypertension Stephanie Watts Career Development Award. 2021

K01 Research Scientist Development Award: Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology. 2021 - 2025

Research

I am interested in mechanisms regulating redox balance and inflammation in renal-cardiovascular health and disease. Specifically, research in my laboratory emphasizes adaptive immunity, vascular-immune interface, gene-environmental interactions, and hemodynamics in the pathogenesis of hypertension a...
I am interested in mechanisms regulating redox balance and inflammation in renal-cardiovascular health and disease. Specifically, research in my laboratory emphasizes adaptive immunity, vascular-immune interface, gene-environmental interactions, and hemodynamics in the pathogenesis of hypertension and chronic kidney disease. The long-term research objectives are to understand the nature of autoregulation in the kidney, the ability of the renal circulation to regulate electrolyte transport, and the vulnerability of these processes to genetic variations, inflammation, and environmental toxins.

Active projects include:
1. Novel Mechanisms Regulating Renal Perfusion and Kidney Redox Biology: Role in Salt Sensitive Hypertension (funded by a NIDDK K01, 2021-2025)

2. Roles of Per- and Polyfluoroalkyl Substances (PFAS) in Hypertension (funded by an AHA Second Century Early Faculty Independence Award, 2023-2026)

3. The Role of Cullin3 Ubiquitin Ligase in the Vascular-Immune Interface in Hypertension (funded by a University of Rochester Program for Advanced Immune Bioimaging Pilot Award, 2023)

My research is continuously supported by extramural funding from the NIH and American Heart Association. Our original research has been published on JCI, JCI Insight, Circulation Research, Cardiovascular Research, Hypertension, and Function including multiple first-author and/or corresponding-author publications. With a dedication to professional service, I am an Editorial Fellow at the Journal of American Society of Nephrology, an Associate Editor at Frontiers in Physiology (Sections of Vascular Physiology and Renal and Epithelial Physiology), and a chair on the organization committee for the ASN Basic Research Forum for Emerging Kidney Scientists. I also serve on the AHA Fellowship/IPA Study Sections.

I am committed to promoting innovative, collaborative, inclusive academic research and to mentoring young members of the research team. My ultimate career goal is to apply our findings to translational research that may lead to the development of novel therapies for renal and cardiovascular diseases.

Email Address: Jing_Wu@URMC.Rochester.edu
Twitter Handle: @JingWu_URMC

Publications

Journal Articles

The Pathogenesis and Impact of Arterial Stiffening in Hypertension: The 2023 John H. Laragh Research Award.

Liu J, Wu J

American journal of hypertension.. 2024 March 1537 (4):241-247. Epub 1900 01 01.

Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms.

Drury ER, Wu J, Gigliotti JC, Le TH

Physiological reviews.. 2024 January 1104 (1):199-251. Epub 07/21/2023.

Autoregulatory mission impossible: when afferent arterioles lose contractility.

Wu J, Le TH

Kidney international.. 2023 October 104 (4):649-651. Epub 1900 01 01.

Paradigm Shift in Hyperglycemic Glomerular Hyperfiltration: Blunted Tubuloglomerular Feedback or Preglomerular Vasodilation?

Wu J

Hypertension.. 2023 August 80 (8):1611-1613. Epub 07/20/2023.

Editorial: Nuclear receptors in hemodynamics and blood pressure control.

Imig JD, Wu J, Gohar EY

Frontiers in physiology.. 2023 14 :1290411. Epub 09/27/2023.

RhoBTB1 reverses established arterial stiffness in angiotensin II-induced hypertension by promoting actin depolymerization.

Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD

JCI insight.. 2022 May 97 (9)Epub 05/09/2022.

Comorbidities Caused by a Corrupt Cullin 3: Lessons Learned From Bedside to Bench.

Wu J, Sigmund CD

Hypertension.. 2022 January 79 (1):76-78. Epub 12/08/2021.

Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension.

Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD

Function.. 2022 3 (3):zqac017. Epub 04/08/2022.

Role of the Peroxisome Proliferator Activated Receptors in Hypertension.

Fang S, Livergood MC, Nakagawa P, Wu J, Sigmund CD

Circulation research.. 2021 April 2128 (7):1021-1039. Epub 04/01/2021.

EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension.

Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD

Hypertension.. 2021 April 77 (4):1399-1411. Epub 03/01/2021.

Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores.

Klemens CA, Chulkov EG, Wu J, Hye Khan MA, Levchenko V, Flister MJ, Imig JD, Kriegel AJ, Palygin O, Staruschenko A

Hypertension.. 2021 February 77 (2):582-593. Epub 01/04/2021.

Failure to vasodilate in response to salt loading blunts renal blood flow and causes salt-sensitive hypertension.

Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD

Cardiovascular research.. 2021 January 1117 (1):308-319. Epub 1900 01 01.

Cullin-3: Renal and Vascular Mechanisms Regulating Blood Pressure.

Wu J, McCormick JA, Sigmund CD

Current hypertension reports.. 2020 August 2722 (9):61. Epub 08/27/2020.

Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.

Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD

Hypertension.. 2020 August 76 (2):468-477. Epub 06/08/2020.

The effect of the EP3 antagonist DG-041 on male mice with diet-induced obesity.

Ceddia RP, Downey JD, Morrison RD, Kraemer MP, Davis SE, Wu J, Lindsley CW, Yin H, Daniels JS, Breyer RM

Prostaglandins & other lipid mediators.. 2019 October 144 :106353. Epub 07/02/2019.

Endothelial PPAR? (Peroxisome Proliferator-Activated Receptor-?) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension.

Nair AR, Silva SD, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD

Hypertension.. 2019 July 74 (1):173-183. Epub 05/20/2019.

Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.

Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD

JCI insight.. 2019 June 115 (14)Epub 06/11/2019.

Tumour necrosis factor ? sets area postrema on fire in renovascular hypertension.

Liu J, Wu J

Cardiovascular research.. 2019 May 1115 (6):995-997. Epub 1900 01 01.

RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity.

Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu KT, Guo DF, Davis DR, Keen HL, Quelle FW, Sigmund CD

The Journal of clinical investigation.. 2019 March 21129 (6):2318-2332. Epub 03/21/2019.

Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-? Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation.

Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD

Hypertension.. 2018 November 72 (5):1227-1235. Epub 1900 01 01.

Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice.

Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, Bowdler NC, Usachev YM, Santillan DA, Potthoff MJ, Pierce GL, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL

JCI insight.. 2018 October 43 (19)Epub 10/04/2018.

A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage.

Norlander AE, Saleh MA, Pandey AK, Itani HA, Wu J, Xiao L, Kang J, Dale BL, Goleva SB, Laroumanie F, Du L, Harrison DG, Madhur MS

JCI insight.. 2017 July 62 (13)Epub 07/06/2017.

Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor ? Impairs Nuclear Export of Nuclear Factor-?B p65 in Vascular Smooth Muscle.

Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD

Hypertension.. 2017 July 70 (1):174-182. Epub 05/15/2017.

Retinol-binding protein 7 is an endothelium-specific PPAR cofactor mediating an antioxidant response through adiponectin.

Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD

JCI insight.. 2017 March 232 (6):e91738. Epub 03/23/2017.

Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism.

Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD

JCI insight.. 2016 November 171 (19):e91015. Epub 11/17/2016.

Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension.

Mikolajczyk TP, Nosalski R, Szczepaniak P, Budzyn K, Osmenda G, Skiba D, Sagan A, Wu J, Vinh A, Marvar PJ, Guzik B, Podolec J, Drummond G, Lob HE, Harrison DG, Guzik TJ

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 May 30 (5):1987-99. Epub 02/12/2016.

Excessive Adventitial Remodeling Leads to Early Aortic Maladaptation in Angiotensin-Induced Hypertension.

Bersi MR, Bellini C, Wu J, Montaniel KRC, Harrison DG, Humphrey JD

Hypertension.. 2016 May 67 (5):890-896. Epub 03/21/2016.

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.

Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG

Circulation research.. 2016 April 15118 (8):1233-43. Epub 03/17/2016.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG

The Journal of clinical investigation.. 2016 April 1126 (4):1607. Epub 04/01/2016.

Hypertension: A Disease That Strikes Around the Clock.

Wu J, Sigmund CD

Hypertension.. 2016 March 67 (3):493-5. Epub 01/18/2016.

Origin of Matrix-Producing Cells That Contribute to Aortic Fibrosis in Hypertension.

Wu J, Montaniel KR, Saleh MA, Xiao L, Chen W, Owens GK, Humphrey JD, Majesky MW, Paik DT, Hatzopoulos AK, Madhur MS, Harrison DG

Hypertension.. 2016 February 67 (2):461-8. Epub 12/22/2015.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ, Madhur MS, Harrison DG

The Journal of clinical investigation.. 2016 January 126 (1):50-67. Epub 11/23/2015.

Inhibition of JAK2 Reverses Paclitaxel Resistance in Human Ovarian Cancer Cells.

Xu Y, Zhang J, Wu J, Zhong S, Li H

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.. 2015 November 25 (9):1557-64. Epub 1900 01 01.

Renal Denervation Prevents Immune Cell Activation and Renal Inflammation in Angiotensin II-Induced Hypertension.

Xiao L, Kirabo A, Wu J, Saleh MA, Zhu L, Wang F, Takahashi T, Loperena R, Foss JD, Mernaugh RL, Chen W, Roberts J, Osborn JW, Itani HA, Harrison DG

Circulation research.. 2015 August 28117 (6):547-57. Epub 07/08/2015.

Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.

Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA, Michell D, Huan T, Zhang Y, Takaki S, Titze J, Levy D, Harrison DG, Madhur MS

The Journal of clinical investigation.. 2015 March 2125 (3):1189-202. Epub 02/09/2015.

Oligoclonal CD8+ T cells play a critical role in the development of hypertension.

Trott DW, Thabet SR, Kirabo A, Saleh MA, Itani H, Norlander AE, Wu J, Goldstein A, Arendshorst WJ, Madhur MS, Chen W, Li CI, Shyr Y, Harrison DG

Hypertension.. 2014 November 64 (5):1108-15. Epub 08/04/2014.

DC isoketal-modified proteins activate T cells and promote hypertension.

Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J, Harrison DG

The Journal of clinical investigation.. 2014 October 124 (10):4642-56. Epub 09/17/2014.

Calcitonin gene-related peptide (CGRP) in autonomic cardiovascular regulation and vascular structure.

Mai TH, Wu J, Diedrich A, Garland EM, Robertson D

Journal of the American Society of Hypertension : JASH.. 2014 May 8 (5):286-96. Epub 03/13/2014.

Folic acid-coupled nano-paclitaxel liposome reverses drug resistance in SKOV3/TAX ovarian cancer cells.

Tong L, Chen W, Wu J, Li H

Anti-cancer drugs.. 2014 March 25 (3):244-54. Epub 1900 01 01.

Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase.

Wu J, Thabet SR, Kirabo A, Trott DW, Saleh MA, Xiao L, Madhur MS, Chen W, Harrison DG

Circulation research.. 2014 February 14114 (4):616-25. Epub 12/17/2013.

Mineralocorticoid-receptor signalling in vascular smooth muscle.

Wu J, Luft FC

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.. 2013 June 28 (6):1360-2. Epub 02/24/2013.

[Long-term regulation of arterial pressure and essential hypertension--II. Essential hypertension].

Fan SG, Wu J, Lv A

Sheng li ke xue jin zhan [Progress in physiology].. 2007 January 38 (1):49-57. Epub 1900 01 01.

[Long-term regulation of arterial pressure and essential hypertension--I. Long-term regulation of arterial pressure].

Fan SG, Wu J, Lv A

Sheng li ke xue jin zhan [Progress in physiology].. 2006 October 37 (4):339-46. Epub 1900 01 01.

Books

Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases (2014)

Chapter: Oxidative stress and hypertension

Authors: Wu J, Harrison DG

Publisher: Springer-Verlag, London 2014