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Bradley N. Mills, Ph.D.

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Bradley N. Mills, Ph.D.

About Me
Credentials
Research
Publications

About Me

Faculty Appointments

Research Assistant Professor - Department of Surgery, Research (SMD)

Credentials

Post-doctoral Training & Residency

University of Rochester Medical Center | Tumor Immunology 2017 - 2021

Education

PhD | University of Rochester School of Medicine & Dentistry. Pathology. 2017

BS | University of Rochester. Biomedical Engineering. 2010

Research

Publications

Journal Articles

Integrating IL-12 mRNA nanotechnology with SBRT eliminates T cell exhaustion in preclinical models of pancreatic cancer.

Hughson AL, Hannon G, Salama NA, Vrooman TG, Stockwell CA, Mills BN, Garrett-Larsen J, Qiu H, Katerji R, Benoodt L, Johnston CJ, Murphy JD, Kruger E, Ye J, Gavras NW, Keeley DC, Qin SS, Lesch ML, Muhitch JB, Love TMT, Calvi LM, Lord EM, Luheshi N, Elyes J, Linehan DC, Gerber SA

Molecular therapy. Nucleic acids.. 2024 December 1035 (4):102350. Epub 09/30/2024.

High-Density Polyethylene Custom Focusing Lenses for High-Resolution Transient Terahertz Biomedical Imaging Sensors.

Chakraborty D, Boni R, Mills BN, Cheng J, Komissarov I, Gerber SA, Sobolewski R

Sensors.. 2024 March 2424 (7)Epub 03/24/2024.

Local Delivery of SBRT and IL12 by mRNA Technology Overcomes Immunosuppressive Barriers to Eliminate Pancreatic Cancer.

bioRxiv : the preprint server for biology.. 2023 November 2 Epub 11/02/2023.

New insights into the responder/nonresponder divide in rectal cancer: Damage-induced Type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy.

Uccello TP, Lesch ML, Kintzel SA, Gradzewicz LB, Lamrous L, Murphy SP, Fleming FJ, Mills BN, Murphy JD, Hughson A, Hannon G, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Keeley DC, Love TMT, Repasky EA, Lord EM, Linehan DC, Gerber SA

Cell death & disease.. 2023 July 2614 (7):470. Epub 07/26/2023.

Development of Terahertz Imaging Markers for Pancreatic Ductal Adenocarcinoma using Maximum Probability (MAP) Estimation.

Chakraborty D, Mills BN, Cheng J, Komissarov I, Gerber SA, Sobolewski R

ACS omega.. 2023 March 218 (11):9925-9933. Epub 03/08/2023.

Radiation Therapy Exacerbates Tumor-Promoting Innervation and Nerve Signaling in Rectal Cancer.

Uccello TP, Lecsh ML, Ullman NA, Kintzel SA, Gradzewicz LB, Velagaleti T, Fleming FJ, Mills BN, Murphy JD, Garrett-Larsen J, Qiu H, Drage MG, Ye J, Gavras NW, Johnston CJ, Love TMT, Repasky EA, Linehan DC, Lord EM, Gerber SA

International journal of radiation oncology, biology, physics.. 2023 March 1115 (3):733-745. Epub 10/04/2022.

Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer.

Ye J, Mills BN, Qin SS, Garrett-Larsen J, Murphy JD, Uccello TP, Han BJ, Vrooman TG, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA

Journal for immunotherapy of cancer.. 2022 July 10 (7)Epub 1900 01 01.

Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy.

Mills BN, Qiu H, Drage MG, Chen C, Mathew JS, Garrett-Larsen J, Ye J, Uccello TP, Murphy JD, Belt BA, Lord EM, Katz AW, Linehan DC, Gerber SA

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2022 January 128 (1):150-162. Epub 12/03/2021.

Development of an Orthotopic Murine Model of Rectal Cancer in Conjunction With Targeted Short-Course Radiation Therapy.

Uccello TP, Kintzel SA, Mills BN, Murphy JD, Garrett-Larsen J, Battaglia NG, Rodriguez CJ, Drage MG, Ye J, Love TMT, Johnston CJ, Repasky EA, Qiu H, Linehan DC, Lord EM, Gerber SA

Advances in radiation oncology.. 2022 7 (2):100867. Epub 12/09/2021.

Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma.

Han BJ, Murphy JD, Qin S, Ye J, Uccello TP, Garrett-Larsen J, Belt BA, Prieto PA, Egilmez NK, Lord EM, Linehan DC, Mills BN, Gerber SA

Immunological investigations.. 2020 October 49 (7):808-823. Epub 06/04/2020.

Shear Wave Elastography Can Differentiate between Radiation-Responsive and Non-responsive Pancreatic Tumors: An ex Vivo Study with Murine Models.

Wang H, Mills B, Mislati R, Ahmed R, Gerber SA, Linehan D, Doyley MM

Ultrasound in medicine & biology.. 2020 February 46 (2):393-404. Epub 11/11/2019.

Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer.

Ye J, Mills BN, Zhao T, Han BJ, Murphy JD, Patel AP, Johnston CJ, Lord EM, Belt BA, Linehan DC, Gerber SA

Cancer immunology research.. 2020 January 8 (1):94-107. Epub 11/12/2019.

Dual Energy X-ray Absorptiometry (DEXA) as a longitudinal outcome measure of cancer-related muscle wasting in mice.

Cole CL, Beck CA, Robinson D, Ye J, Mills B, Gerber SA, Schwarz EM, Linehan D

PloS one.. 2020 15 (6):e0230695. Epub 06/19/2020.

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment.

Mills BN, Connolly KA, Ye J, Murphy JD, Uccello TP, Han BJ, Zhao T, Drage MG, Murthy A, Qiu H, Patel A, Figueroa NM, Johnston CJ, Prieto PA, Egilmez NK, Belt BA, Lord EM, Linehan DC, Gerber SA

Cell reports.. 2019 October 829 (2):406-421.e5. Epub 1900 01 01.

PGE2 Receptor Subtype 1 (EP1) Regulates Mesenchymal Stromal Cell Osteogenic Differentiation by Modulating Cellular Energy Metabolism.

Feigenson M, Eliseev RA, Jonason JH, Mills BN, O'Keefe RJ

Journal of cellular biochemistry.. 2017 December 118 (12):4383-4393. Epub 05/31/2017.

Expression Profiling of the MAP Kinase Phosphatase Family Reveals a Role for DUSP1 in the Glioblastoma Stem Cell Niche.

Mills BN, Albert GP, Halterman MW

Cancer microenvironment : official journal of the International Cancer Microenvironment Society.. 2017 December 10 (1-3):57-68. Epub 08/18/2017.

Energy Metabolism in Mesenchymal Stem Cells During Osteogenic Differentiation.

Shum LC, White NS, Mills BN, de Mesy Bentley KL, Eliseev RA

Stem cells and development.. 2016 January 1525 (2):114-22. Epub 12/10/2015.

Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT.

Bisson JA, Mills B, Paul Helt JC, Zwaka TP, Cohen ED

Developmental biology.. 2015 February 1398 (1):80-96. Epub 12/05/2014.

Quantitative crawling wave sonoelastography of benign and malignant thyroid nodules.

Walsh J, An L, Mills B, Hah Z, Moalem J, Miller M, Giampoli E, Parker K, Rubens D

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.. 2012 August 147 (2):233-8. Epub 04/02/2012.

Shear wave dispersion measures liver steatosis.

Barry CT, Mills B, Hah Z, Mooney RA, Ryan CK, Rubens DJ, Parker KJ

Ultrasound in medicine & biology.. 2012 February 38 (2):175-82. Epub 12/16/2011.

Integration of crawling waves in an ultrasound imaging system. Part 2: signal processing and applications.

Hah Z, Hazard C, Mills B, Barry C, Rubens D, Parker K

Ultrasound in medicine & biology.. 2012 February 38 (2):312-23. Epub 12/16/2011.

Crawling wave detection of prostate cancer: preliminary in vitro results.

An L, Mills B, Hah Z, Mao S, Yao J, Joseph J, Rubens DJ, Strang J, Parker KJ

Medical physics.. 2011 May 38 (5):2563-71. Epub 1900 01 01.