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Anne E. Nichols, Ph.D.

Anne E. Nichols, Ph.D.

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About Me

Faculty Appointments

Assistant Professor - Department of Orthopaedics, Center for Musculoskeletal Research (SMD)

Credentials

Post-doctoral Training & Residency

Postdoctoral Fellow, Center for Musculoskeletal Research, University of Rochester Medical Center 2018 - 2022

Education

PhD | Virginia Polytechnic Inst & State University (Virginia Tech). Biomedical and Veterinary Sciences, Regenerative Medicine. 2018

BS | James Madison University. 2008

Awards

Pathway to Independence Award (K99/R00). 2022 - 2027

Outstanding Postdoctoral Researcher Award. 2022

ORS New Investigator Recognition Award. 2021

Orthoregeneration Network Foundation Education Grant. 2020

Alice L. Jee Young Investigator Award. 2019

Stamps Family Graduate Fellowship. 2012 - 2018

Research

Publications

Journal Articles

Correction: Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype.

Korcari A, Nichols AEC, Buckley MR, Loiselle AE

eLife.. 2024 January 313 Epub 01/03/2024.

Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.

Ackerman JE, Muscat SN, Adjei-Sowah E, Korcari A, Nichols AEC, Buckley MR, Loiselle AE

Matrix biology : journal of the International Society for Matrix Biology.. 2024 January 125 :59-72. Epub 12/13/2023.

Development of a Nanoparticle-Based Tendon-Targeting Drug Delivery System to Pharmacologically Modulate Tendon Healing.

Adjei-Sowah E, Chandrasiri I, Xiao B, Liu Y, Ackerman JE, Soto C, Nichols AEC, Nolan K, Benoit DSW, Loiselle AE

bioRxiv : the preprint server for biology.. 2023 November 30 Epub 11/30/2023.

Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.

Ackerman JE, Adjei-Sowah E, Korcari A, Muscat SN, Nichols AEC, Buckley MR, Loiselle AE

bioRxiv : the preprint server for biology.. 2023 July 21 Epub 07/21/2023.

Epitenon-derived cells comprise a distinct progenitor population that contributes to both tendon fibrosis and regeneration following acute injury.

Nichols AEC, Wagner NW, Ketonis C, Loiselle AE

bioRxiv : the preprint server for biology.. 2023 February 1 Epub 02/01/2023.

Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype.

Korcari A, Nichols AEC, Buckley MR, Loiselle AE

eLife.. 2023 January 1912 Epub 01/19/2023.

Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function.

Ackerman JE, Best KT, Muscat SN, Pritchett EM, Nichols AEC, Wu CL, Loiselle AE

Cell reports.. 2022 November 2241 (8):111706. Epub 1900 01 01.

CCR2 is expressed by tendon resident macrophage and T cells, while CCR2 deficiency impairs tendon healing via blunted involvement of tendon-resident and circulating monocytes/macrophages.

Muscat S, Nichols AEC, Gira E, Loiselle AE

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2022 November 36 (11):e22607. Epub 1900 01 01.

Effects of tamoxifen on tendon homeostasis and healing: Considerations for the use of tamoxifen-inducible mouse models.

Best KT, Studentsova V, Ackerman JE, Nichols AEC, Myers M, Cobb J, Knapp E, Awad HA, Loiselle AE

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2021 July 39 (7):1572-1580. Epub 06/09/2020.

Impact of isolation method on cellular activation and presence of specific tendon cell subpopulations during in vitro culture.

Nichols AEC, Muscat SN, Miller SE, Green LJ, Richards MS, Loiselle AE

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2021 July 35 (7):e21733. Epub 1900 01 01.

A novel murine muscle loading model to investigate Achilles musculotendinous adaptation.

Rezvani SN, Nichols AEC, Grange RW, Dahlgren LA, Brolinson PG, Wang VM

Journal of applied physiology.. 2021 April 1130 (4):1043-1051. Epub 02/11/2021.

Scleraxis-lineage cell depletion improves tendon healing and disrupts adult tendon homeostasis.

Best KT, Korcari A, Mora KE, Nichols AE, Muscat SN, Knapp E, Buckley MR, Loiselle AE

eLife.. 2021 January 2210 Epub 01/22/2021.

NF-?B activation persists into the remodeling phase of tendon healing and promotes myofibroblast survival.

Best KT, Nichols AEC, Knapp E, Hammert WC, Ketonis C, Jonason JH, Awad HA, Loiselle AE

Science signaling.. 2020 November 1713 (658)Epub 11/17/2020.

Effects of Type II Diabetes Mellitus on Tendon Homeostasis and Healing.

Loiselle AE, Oh I, Nichols AEC

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2020 January 38 (1):13-22. Epub 06/24/2019.

Urinary Bladder Matrix Does Not Improve Tenogenesis in an In Vitro Equine Model.

Khatibzadeh SM, Menarim BC, Nichols AEC, Werre SR, Dahlgren LA

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 August 37 (8):1848-1859. Epub 05/15/2019.

The cellular basis of fibrotic tendon healing: challenges and opportunities.

Nichols AEC, Best KT, Loiselle AE

Translational research : the journal of laboratory and clinical medicine.. 2019 July 209 :156-168. Epub 02/08/2019.

Adipose-Derived Stromal Vascular Fraction and Cultured Stromal Cells as Trophic Mediators for Tendon Healing.

Polly SS, Nichols AEC, Donnini E, Inman DJ, Scott TJ, Apple SM, Werre SR, Dahlgren LA

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 June 37 (6):1429-1439. Epub 04/29/2019.

Cell non-autonomous functions of S100a4 drive fibrotic tendon healing.

Ackerman JE, Nichols AE, Studentsova V, Best KT, Knapp E, Loiselle AE

eLife.. 2019 May 248 Epub 05/24/2019.

Transient Scleraxis Overexpression Combined with Cyclic Strain Enhances Ligament Cell Differentiation.

Nichols AEC, Werre SR, Dahlgren LA

Tissue engineering. Part A.. 2018 October 24 (19-20):1444-1455. Epub 05/10/2018.

Novel roles for scleraxis in regulating adult tenocyte function.

Nichols AEC, Settlage RE, Werre SR, Dahlgren LA

BMC cell biology.. 2018 August 719 (1):14. Epub 08/07/2018.

Cytokine and Growth Factor Concentrations in Canine Autologous Conditioned Serum.

Sawyere DM, Lanz OI, Dahlgren LA, Barry SL, Nichols AC, Werre SR

Veterinary surgery : VS.. 2016 July 45 (5):582-6. Epub 1900 01 01.

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM

Cell.. 2011 August 5146 (3):408-20. Epub 1900 01 01.

Lipin proteins form homo- and hetero-oligomers.

Liu GH, Qu J, Carmack AE, Kim HB, Chen C, Ren H, Morris AJ, Finck BN, Harris TE

The Biochemical journal.. 2010 November 15432 (1):65-76. Epub 1900 01 01.

Books

AAOS Comprehensive Review (2022)

Chapter: Tendons and Ligaments

Authors: Nichols AEC, Loiselle AE

Publisher: Wolters Kluwer 2022

Musculoskeletal Tissue Engineering (2021)

Chapter: Tendon and Ligament Tissue Engineering

Authors: A Korcari, AEC Nichols, M O'Neil, AE Loiselle.

Publisher: Elsevier 2021