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Manoela V. Fogaca, Ph.D.

Manoela V. Fogaca, Ph.D.

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About Me

Faculty Appointments

Assistant Professor - Department of Pharmacology and Physiology (SMD)

Assistant Professor - Department of Neuroscience (SMD) - Joint

Credentials

Post-doctoral Training & Residency

Yale University, Department of Psychiatry, Dr. Ronald Duman and Dr. Marina Picciotto labs. 2016 - 2022

Awards

K99/R00 Pathway to Independence Award. 2022

NARSAD Young Investigator Award. 2020

Research

Research in the Fogaça lab focuses on understanding the molecular basis of behaviors relevant to stress and the actions of fast antidepressant and anxiolytic drugs, aiming to identify specific circuits, neuronal subpopulations and synaptic mechanisms involved in these responses. Because currently av...
Research in the Fogaça lab focuses on understanding the molecular basis of behaviors relevant to stress and the actions of fast antidepressant and anxiolytic drugs, aiming to identify specific circuits, neuronal subpopulations and synaptic mechanisms involved in these responses. Because currently available antidepressants have serious limitations for treating Major Depressive Disorder (MDD), including low response rates, a significant number of treatment resistant patients, and a time-lag before there is a therapeutic response, the lab is interested in exploring new pharmacological strategies to treat MDD, including compounds that target the glutamatergic and/or the GABAergic systems in the brain, such as ketamine, ketamine-like drugs and GABA receptor modulators. To this goal, we combine molecular neuropharmacology, genetic approaches and circuit-level studies of neurobiological systems to investigate how specific subpopulations of GABAergic (notably somatostatin and parvalbumin interneurons) and glutamatergic neurons crosstalk to modulate excitation and inhibition network dynamics that lead to phenotypes relevant to stress disorders and to the actions of fast antidepressants.

Publications

Journal Articles

M1 acetylcholine receptors in somatostatin interneurons contribute to GABAergic and glutamatergic plasticity in the mPFC and antidepressant-like responses.

Fogaça MV, Wu M, Li C, Li XY, Duman RS, Picciotto MR

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2023 August 48 (9):1277-1287. Epub 05/04/2023.

Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapid antidepressant responses.

Fogaça MV, Wu M, Li C, Li XY, Picciotto MR, Duman RS

Molecular psychiatry.. 2021 July 26 (7):3277-3291. Epub 10/17/2020.

Role of BDNF in the pathophysiology and treatment of depression: Activity-dependent effects distinguish rapid-acting antidepressants.

Duman RS, Deyama S, Fogaça MV

The European journal of neuroscience.. 2021 January 53 (1):126-139. Epub 12/20/2019.

Medial PFC AMPA receptor and BDNF signaling are required for the rapid and sustained antidepressant-like effects of 5-HT receptor stimulation.

Fukumoto K, Fogaça MV, Liu RJ, Duman CH, Li XY, Chaki S, Duman RS

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2020 September 45 (10):1725-1734. Epub 05/12/2020.

Ketamine rapidly reverses stress-induced impairments in GABAergic transmission in the prefrontal cortex in male rodents.

Ghosal S, Duman CH, Liu RJ, Wu M, Terwilliger R, Girgenti MJ, Wohleb E, Fogaca MV, Teichman EM, Hare B, Duman RS

Neurobiology of disease.. 2020 February 134 :104669. Epub 11/07/2019.

Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function.

Duman RS, Shinohara R, Fogaça MV, Hare B

Molecular psychiatry.. 2019 December 24 (12):1816-1832. Epub 03/20/2019.

N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects.

Fogaça MV, Fukumoto K, Franklin T, Liu RJ, Duman CH, Vitolo OV, Duman RS

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2019 December 44 (13):2230-2238. Epub 08/27/2019.

Prefrontal cortex interneurons display dynamic sex-specific stress-induced transcriptomes.

Girgenti MJ, Wohleb ES, Mehta S, Ghosal S, Fogaca MV, Duman RS

Translational psychiatry.. 2019 November 119 (1):292. Epub 11/11/2019.

Cannabidiol Induces Rapid and Sustained Antidepressant-Like Effects Through Increased BDNF Signaling and Synaptogenesis in the Prefrontal Cortex.

Sales AJ, Fogaça MV, Sartim AG, Pereira VS, Wegener G, Guimarães FS, Joca SRL

Molecular neurobiology.. 2019 February 56 (2):1070-1081. Epub 06/04/2018.

Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2,6)-hydroxynorketamine.

Fukumoto K, Fogaça MV, Liu RJ, Duman C, Kato T, Li XY, Duman RS

Proceedings of the National Academy of Sciences of the United States of America.. 2019 January 2116 (1):297-302. Epub 12/17/2018.

Cortical GABAergic Dysfunction in Stress and Depression: New Insights for Therapeutic Interventions.

Fogaça MV, Duman RS

Frontiers in cellular neuroscience.. 2019 13 :87. Epub 03/12/2019.

Paradoxical Effect of LTB on the Regulation of Stress-Induced Corticosterone Production.

Locachevic GA, Prado MKB, Zoccal KF, Pereira PAT, Sorgi CA, Bortolanza M, Peti APF, Fogaça MV, Guimarães FS, Del Bel E, Faccioli LH

Frontiers in behavioral neuroscience.. 2019 13 :73. Epub 04/16/2019.

BDNF release and signaling are required for the antidepressant actions of GLYX-13.

Kato T, Fogaça MV, Deyama S, Li XY, Fukumoto K, Duman RS

Molecular psychiatry.. 2018 October 23 (10):2007-2017. Epub 12/05/2017.

The anxiolytic effects of cannabidiol in chronically stressed mice are mediated by the endocannabinoid system: Role of neurogenesis and dendritic remodeling.

Fogaça MV, Campos AC, Coelho LD, Duman RS, Guimarães FS

Neuropharmacology.. 2018 June 135 :22-33. Epub 03/03/2018.

Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior.

Franklin TC, Wohleb ES, Zhang Y, Fogaça M, Hare B, Duman RS

Biological psychiatry.. 2018 January 183 (1):50-60. Epub 07/21/2017.

Effects of indirubin and isatin on cell viability, mutagenicity, genotoxicity and BAX/ERCC1 gene expression.

Fogaça MV, Cândido-Bacani PM, Benicio LM, Zapata LM, Cardoso PF, de Oliveira MT, Calvo TR, Varanda EA, Vilegas W, de Syllos Cólus IM

Pharmaceutical biology.. 2017 December 55 (1):2005-2014. Epub 1900 01 01.

A novel peptide that improves metabolic parameters without adverse central nervous system effects.

Reckziegel P, Festuccia WT, Britto LRG, Jang KLL, Romão CM, Heimann JC, Fogaça MV, Rodrigues NS, Silva NR, Guimarães FS, Eichler RAS, Gupta A, Gomes I, Devi LA, Heimann AS, Ferro ES

Scientific reports.. 2017 November 17 (1):14781. Epub 11/01/2017.

A serotonergic deficit in the dorsal periaqueductal gray matter may underpin enhanced panic-like behavior in diabetic rats.

Gambeta E, Sestile CC, Fogaça MV, Guimarães FS, Audi EA, da Cunha JM, Zangrossi H, Shimene de Melo Yamashita P, Zanoveli JM

Behavioural pharmacology.. 2017 October 28 (7):558-564. Epub 1900 01 01.

Plastic and Neuroprotective Mechanisms Involved in the Therapeutic Effects of Cannabidiol in Psychiatric Disorders.

Campos AC, Fogaça MV, Scarante FF, Joca SRL, Sales AJ, Gomes FV, Sonego AB, Rodrigues NS, Galve-Roperh I, Guimarães FS

Frontiers in pharmacology.. 2017 8 :269. Epub 05/23/2017.

Cannabidiol, neuroprotection and neuropsychiatric disorders.

Campos AC, Fogaça MV, Sonego AB, Guimarães FS

Pharmacological research.. 2016 October 112 :119-127. Epub 02/01/2016.

Rapid Activation of Glucocorticoid Receptors in the Prefrontal Cortex Mediates the Expression of Contextual Conditioned Fear in Rats.

Reis FM, Almada RC, Fogaça MV, Brandão ML

Cerebral cortex.. 2016 June 26 (6):2639-49. Epub 05/13/2015.

Involvement of M1 and CB? receptors in the anxiogenic-like effects induced by neostigmine injected into the rat prelimbic medial prefrontal cortex.

Fogaça MV, Fedoce AG, Ferreira-Junior NC, Guimarães FS, Resstel LB

Psychopharmacology.. 2016 April 233 (8):1377-85. Epub 02/13/2016.

Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.

Breuer A, Haj CG, Fogaça MV, Gomes FV, Silva NR, Pedrazzi JF, Del Bel EA, Hallak JC, Crippa JA, Zuardi AW, Mechoulam R, Guimarães FS

PloS one.. 2016 11 (7):e0158779. Epub 07/14/2016.

Correction: Fluorinated Cannabidiol Derivatives: Enhancement of Activity in Mice Models Predictive of Anxiolytic, Antidepressant and Antipsychotic Effects.

Breuer A, Haj CG, Fogaça MV, Gomes FV, Silva NR, Pedrazzi JF, Del Bel EA, Hallak JC, Crippa JA, Zuardi AW, Mechoulam R, Guimarães FS

PloS one.. 2016 11 (8):e0162087. Epub 08/25/2016.

The endocannabinoid, endovanilloid and nitrergic systems could interact in the rat dorsolateral periaqueductal gray matter to control anxiety-like behaviors.

Batista PA, Fogaça MV, Guimarães FS

Behavioural brain research.. 2015 October 15293 :182-8. Epub 07/14/2015.

Effects of intra-infralimbic prefrontal cortex injections of cannabidiol in the modulation of emotional behaviors in rats: contribution of 5HT?A receptors and stressful experiences.

Marinho AL, Vila-Verde C, Fogaça MV, Guimarães FS

Behavioural brain research.. 2015 June 1286 :49-56. Epub 02/19/2015.

Anxiogenic-like effects induced by hemopressin in rats.

Fogaça MV, Sonego AB, Rioli V, Gozzo FC, Dale CS, Ferro ES, Guimarães FS

Pharmacology, biochemistry, and behavior.. 2015 February 129 :7-13. Epub 11/22/2014.

Modulation of defensive behavior by Transient Receptor Potential Vanilloid Type-1 (TRPV1) channels.

Aguiar DC, Moreira FA, Terzian AL, Fogaça MV, Lisboa SF, Wotjak CT, Guimaraes FS

Neuroscience and biobehavioral reviews.. 2014 October 46 Pt 3 :418-28. Epub 04/13/2014.

Effects of intra-prelimbic prefrontal cortex injection of cannabidiol on anxiety-like behavior: involvement of 5HT1A receptors and previous stressful experience.

Fogaça MV, Reis FM, Campos AC, Guimarães FS

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.. 2014 March 24 (3):410-9. Epub 10/31/2013.

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.

Campos AC, Ortega Z, Palazuelos J, Fogaça MV, Aguiar DC, Díaz-Alonso J, Ortega-Gutiérrez S, Vázquez-Villa H, Moreira FA, Guzmán M, Galve-Roperh I, Guimarães FS

The international journal of neuropsychopharmacology. 2013 July 16 (6):1407-19. Epub 01/09/2013.

Cannabinoids, Neurogenesis and Antidepressant Drugs: Is there a Link?

Fogaça MV, Galve-Roperh I, Guimarães FS, Campos AC

Current neuropharmacology.. 2013 May 11 (3):263-75. Epub 1900 01 01.

Effects of glutamate NMDA and TRPV1 receptor antagonists on the biphasic responses to anandamide injected into the dorsolateral periaqueductal grey of Wistar rats.

Fogaça MV, Gomes FV, Moreira FA, Guimarães FS, Aguiar DC

Psychopharmacology.. 2013 April 226 (3):579-87. Epub 11/27/2012.

Animal models of anxiety disorders and stress.

Campos AC, Fogaça MV, Aguiar DC, Guimarães FS

Revista brasileira de psiquiatria : orga?o oficial da Associac?a?o Brasileira de Psiquiatria, Asociacio?n Psiquia?trica de la Ame?rica Latina.. 2013 35 Suppl 2 :S101-11. Epub 1900 01 01.

The endocannabinoid and endovanilloid systems interact in the rat prelimbic medial prefrontal cortex to control anxiety-like behavior.

Fogaça MV, Aguiar DC, Moreira FA, Guimarães FS

Neuropharmacology.. 2012 August 63 (2):202-10. Epub 03/28/2012.

Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters.

Fogaça MV, Lisboa SF, Aguiar DC, Moreira FA, Gomes FV, Casarotto PC, Guimarães FS

Brazilian journal of medical and biological research = Revista brasileira de pesquisas me?dicas e biolo?gicas. 2012 April 45 (4):357-65. Epub 03/08/2012.

Books

Lipidomics of Stem Cells (2017)

Chapter: Cannabinoids as Regulators of Neural Development and Adult Neurogenesis

Neuropathology of Drug Addictions and Substance Misuse (2016)

Chapter: Cannabidiol and 5-HT1A Receptors