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Yin Sun, Ph.D.

Yin Sun, Ph.D.

Contact

Office (585) 275-1687

About Me

Faculty Appointments

Research Assistant Professor - Department of Radiation Oncology (SMD)

Credentials

Post-doctoral Training & Residency

Robert Steel Foundation for Pediatric Cancer Research Whithead Institute for Biomedical Research
postdoctoral fellowship 1995 - 1998

Whitehead Institute, Laboratory of Dr. Robert A. Weinberg 1994 - 2000

Chinese government CUSBE Fellowship (China and United States Biochemistry and Molecular Biology Exchange)
University of California Los Angeles 1986 - 1988

Education

PhD | Univ of Cal Los Angeles. Biochemistry. 1993

BS | China - Non-Medical School. Physiology, All Other. 1986

Awards

Postdoctoral Fellowship. 1995 - 1998

Predoctoral Fellowship. 1987

Publications

Journal Articles

KDM3B Single-Nucleotide Polymorphisms Impact Radiation Therapy Toxicity Through Circular RNA-Mediated KDM3B Expression and Inflammatory Responses

Sun Y; Tsai Y; Wood R; Shen B; Chen J; Zhou Z; Zeng G; Marples B; Kerns S; Chen Y.

Int J Radiat Oncol Biol Phys. 2024; 119(1): 251-260.

Differential regulation of LncRNA-SARCC suppresses VHL-mutant RCC cell proliferation yet promotes VHL-normal RCC cell proliferation via modulating androgen receptor/HIF-2?/C-MYC axis under hypoxia.

Zhai W, Sun Y, Jiang M, Wang M, Gasiewicz TA, Zheng J, Chang C

Oncogene.. 2016 September 1535 (37):4866-80. Epub 03/14/2016.

Cisplatin enhances NK cells immunotherapy efficacy to suppress HCC progression via altering the androgen receptor (AR)-ULBP2 signals.

Shi L, Lin H, Li G, Sun Y, Shen J, Xu J, Yeh S, Cai X, Chang C

Cancer letters.. 2016 April 1373 (1):45-56. Epub 01/19/2016.

The Role of CD44 in Glucose Metabolism in Prostatic Small Cell Neuroendocrine Carcinoma.

Li W, Cohen A, Sun Y, Squires J, Braas D, Graeber TG, Du L, Li G, Li Z, Xu X, Chen X, Huang J

Molecular cancer research : MCR.. 2016 April 14 (4):344-53. Epub 02/01/2016.

Targeting Androgen Receptor (AR)?IL12A Signal Enhances Efficacy of Sorafenib plus NK Cells Immunotherapy to Better Suppress HCC Progression.

Shi L, Lin H, Li G, Jin RA, Xu J, Sun Y, Ma WL, Yeh S, Cai X, Chang C

Molecular cancer therapeutics.. 2016 April 15 (4):731-742. Epub 03/03/2016.

Neuroendocrine prostate cancer (NEPCa) increased the neighboring PCa chemo-resistance via altering the PTHrP/p38/Hsp27/androgen receptor (AR)/p21 signal

Cui Y; Sun Y; Hu S; Luo J; Li L; Li X; Yeh SY; Jin J; Chang C.

Oncogene. 2016; in press.

Androgen receptor (AR) suppresses miRNA-145 to promote renal cell carcinoma (RCC) progression independent of VHL status.

Chen Y, Sun Y, Rao Q, Xu H, Li L, Chang C

Oncotarget.. 2015 October 136 (31):31203-15. Epub 1900 01 01.

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W

Molecular cell.. 2015 September 1759 (6):917-30. Epub 09/03/2015.

TR4 nuclear receptor increases prostate cancer invasion via decreasing the miR-373-3p expression to alter TGF?R2/p-Smad3 signals.

Qiu X, Zhu J, Sun Y, Fan K, Yang DR, Li G, Yang G, Chang C

Oncotarget.. 2015 June 206 (17):15397-409. Epub 1900 01 01.

TR4 Nuclear Receptor Alters the Prostate Cancer CD133+ Stem/Progenitor Cell Invasion via Modulating the EZH2-Related Metastasis Gene Expression.

Zhu J, Yang DR, Sun Y, Qiu X, Chang HC, Li G, Shan Y, Chang C

Molecular cancer therapeutics.. 2015 June 14 (6):1445-53. Epub 04/01/2015.

p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma.

Li Z, Sun Y, Chen X, Squires J, Nowroozizadeh B, Liang C, Huang J

Molecular cancer research : MCR.. 2015 March 13 (3):584-91. Epub 12/15/2014.

Molecular pathology of prostate cancer revealed by next-generation sequencing: opportunities for genome-based personalized therapy.

Huang J, Wang JK, Sun Y

Current opinion in urology.. 2013 May 23 (3):189-93. Epub 1900 01 01.

Neuroendocrine differentiation of prostate cancer.

Li Z, Chen CJ, Wang JK, Hsia E, Li W, Squires J, Sun Y, Huang J

Asian journal of andrology.. 2013 May 15 (3):328-32. Epub 03/18/2013.

Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis.

Liu N, Tai S, Ding B, Thor RK, Bhuta S, Sun Y, Huang J

Endocrine-related cancer.. 2012 October 19 (5):711-23. Epub 09/21/2012.

Pathogenesis of prostatic small cell carcinoma involves the inactivation of the P53 pathway.

Chen H, Sun Y, Wu C, Magyar C, Li X, Cheng L, Yao JL, Shen S, Osunkoya AO, Liang C, Huang J

Endocrine-related cancer.. 2012 June 19 (3):321-31. Epub 05/24/2012.

Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells.

Tai S, Sun Y, Liu N, Ding B, Hsia E, Bhuta S, Thor RK, Damoiseaux R, Liang C, Huang J

Molecular cancer therapeutics.. 2012 June 11 (6):1320-31. Epub 04/05/2012.

Overexpression of SKI oncoprotein leads to p53 degradation through regulation of MDM2 protein sumoylation.

Ding B, Sun Y, Huang J

The Journal of biological chemistry.. 2012 April 27287 (18):14621-30. Epub 03/12/2012.

PC3 is a cell line characteristic of prostatic small cell carcinoma.

Tai S, Sun Y, Squires JM, Zhang H, Oh WK, Liang CZ, Huang J

The Prostate.. 2011 November 71 (15):1668-79. Epub 03/22/2011.

SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein.

Sun Y, Perera J, Rubin BP, Huang J

The Journal of biological chemistry.. 2011 May 27286 (21):18623-32. Epub 03/24/2011.

Novel genetic loci associated with prostate cancer in the Japanese population.

Sun Y, Huang JT

Asian journal of andrology.. 2011 January 13 (1):120-1. Epub 10/11/2010.

Neuroendocrine differentiation in prostate cancer.

Sun Y, Niu J, Huang J

American journal of translational research.. 2009 February 51 (2):148-62. Epub 02/05/2009.

IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1.

Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S

Oncogene.. 2006 February 1625 (7):1042-52. Epub 1900 01 01.

Ski/Sno and TGF-beta signaling.

Liu X, Sun Y, Weinberg RA, Lodish HF

Cytokine & growth factor reviews.. 2001 March 12 (1):1-8. Epub 1900 01 01.

Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization.

Liu X, Sun Y, Ehrlich M, Lu T, Kloog Y, Weinberg RA, Lodish HF, Henis YI

Oncogene.. 2000 November 3019 (51):5926-35. Epub 1900 01 01.

Generation of mammalian cells stably expressing multiple genes at predetermined levels.

Liu X, Constantinescu SN, Sun Y, Bogan JS, Hirsch D, Weinberg RA, Lodish HF

Analytical biochemistry.. 2000 April 10280 (1):20-8. Epub 1900 01 01.

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor beta signaling.

Sun Y, Liu X, Ng-Eaton E, Lodish HF, Weinberg RA

Proceedings of the National Academy of Sciences of the United States of America.. 1999 October 2696 (22):12442-7. Epub 1900 01 01.

Interaction of the Ski oncoprotein with Smad3 regulates TGF-beta signaling.

Sun Y, Liu X, Eaton EN, Lane WS, Lodish HF, Weinberg RA

Molecular cell.. 1999 October 4 (4):499-509. Epub 1900 01 01.

Transforming growth factor-beta induces formation of a dithiothreitol-resistant type I/Type II receptor complex in live cells.

Wells RG, Gilboa L, Sun Y, Liu X, Henis YI, Lodish HF

The Journal of biological chemistry.. 1999 February 26274 (9):5716-22. Epub 1900 01 01.

Transforming growth factor beta-induced phosphorylation of Smad3 is required for growth inhibition and transcriptional induction in epithelial cells.

Liu X, Sun Y, Constantinescu SN, Karam E, Weinberg RA, Lodish HF

Proceedings of the National Academy of Sciences of the United States of America.. 1997 September 3094 (20):10669-74. Epub 1900 01 01.

Functional characterization of the 180-kD ribosome receptor in vivo.

Wanker EE, Sun Y, Savitz AJ, Meyer DI

The Journal of cell biology.. 1995 July 130 (1):29-39. Epub 1900 01 01.