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Barbara Herr, M.S.

Barbara Herr, M.S.

About Me

Faculty Appointments

Assistant Professor (Svc) (Part-Time) - Department of Neurology, Central Admin - Research (SMD)

Credentials

Education

MS | University of Rochester School of Medicine & Dentistry. Community Health Services. 1982

B.A. | William Smith College. Psychology. 1966

Awards

Phi Beta Kappa. 1966

Epsilon Pi Sigma, Science Honor Society. 1965

Research

I work collaboratively with Channelopathy and Muscle Study Project Unit faculty to design clinical treatment trials in rare neuromuscular diseases and to write grant applications to NIH, FDA, and the Muscular Dystrophy Association. I serve as co-investigator on funded projects, making suggestions fo...
I work collaboratively with Channelopathy and Muscle Study Project Unit faculty to design clinical treatment trials in rare neuromuscular diseases and to write grant applications to NIH, FDA, and the Muscular Dystrophy Association. I serve as co-investigator on funded projects, making suggestions for recruitment techniques and needed design modifications while the trial is in progress, and co-write manuscripts based on trial results. I assist in the T32 program, Experimental Therapeutics in Neurological Disease.

Publications

Journal Articles

Episodic Ataxia Type 1: Natural History and Effect on Quality of Life.

Graves TD, Griggs RC, Bundy BN, Jen JC, Baloh RW, Hanna MG,

The cerebellum.. 2023 August 22 (4):578-586. Epub 06/03/2022.

Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial.

Guglieri M, Bushby K, McDermott MP, Hart KA, Tawil R, Martens WB, Herr BE, McColl E, Speed C, Wilkinson J, Kirschner J, King WM, Eagle M, Brown MW, Willis T, Griggs RC, , Straub V, van Ruiten H, Childs AM, Ciafaloni E, Shieh PB, Spinty S, Maggi L, Baranello G, Butterfield RJ, Horrocks IA, Roper H, Alhaswani Z, Flanigan KM, Kuntz NL, Manzur A, Darras BT, Kang PB, Morrison L, Krzesniak-Swinarska M, Mah JK, Mongini TE, Ricci F, von der Hagen M, Finkel RS, O'Reardon K, Wicklund M, Kumar A, McDonald CM, Han JJ, Joyce N, Henricson EK, Schara-Schmidt U, Gangfuss A, Wilichowski E, Barohn RJ, Statland JM, Campbell C, Vita G, Vita GL, Howard JF, Hughes I, McMillan HJ, Pegoraro E, Bello L, Burnette WB, Thangarajh M, Chang T

JAMA.. 2022 April 19327 (15):1456-1468. Epub 1900 01 01.

Marfan Syndrome Caused by Disruption of the Gene due to A Reciprocal Chromosome Translocation.

Schnause AC, Komlosi K, Herr B, Neesen J, Dremsek P, Schwarz T, Tzschach A, Jägle S, Lausch E, Fischer J, Gläser B

Genes.. 2021 November 2112 (11)Epub 11/21/2021.

Randomized, placebo-controlled trials of dichlorphenamide in periodic paralysis.

Sansone VA, Burge J, McDermott MP, Smith PC, Herr B, Tawil R, Pandya S, Kissel J, Ciafaloni E, Shieh P, Ralph JW, Amato A, Cannon SC, Trivedi J, Barohn R, Crum B, Mitsumoto H, Pestronk A, Meola G, Conwit R, Hanna MG, Griggs RC,

Neurology.. 2016 April 1286 (15):1408-1416. Epub 02/10/2016.

Episodic ataxia type 1: clinical characterization, quality of life and genotype-phenotype correlation.

Graves TD, Cha YH, Hahn AF, Barohn R, Salajegheh MK, Griggs RC, Bundy BN, Jen JC, Baloh RW, Hanna MG,

Brain : a journal of neurology.. 2014 April 137 (Pt 4):1009-18. Epub 02/26/2014.

Rare disease centers for periodic paralysis: China versus the United States and United Kingdom.

Ke Q, Qi M, Wu W, Luo B, Hanna M, Herr B, Griggs RC,

Muscle & nerve.. 2014 February 49 (2):171-4. Epub 1900 01 01.

Corticosteroids in Duchenne muscular dystrophy: major variations in practice.

Griggs RC, Herr BE, Reha A, Elfring G, Atkinson L, Cwik V, McColl E, Tawil R, Pandya S, McDermott MP, Bushby K

Muscle & nerve.. 2013 July 48 (1):27-31. Epub 04/25/2013.

Non-dystrophic myotonia: prospective study of objective and patient reported outcomes.

Trivedi JR, Bundy B, Statland J, Salajegheh M, Rayan DR, Venance SL, Wang Y, Fialho D, Matthews E, Cleland J, Gorham N, Herbelin L, Cannon S, Amato A, Griggs RC, Hanna MG, Barohn RJ,

Brain : a journal of neurology.. 2013 July 136 (Pt 7):2189-200. Epub 06/13/2013.

Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial.

Statland JM, Bundy BN, Wang Y, Rayan DR, Trivedi JR, Sansone VA, Salajegheh MK, Venance SL, Ciafaloni E, Matthews E, Meola G, Herbelin L, Griggs RC, Barohn RJ, Hanna MG,

JAMA.. 2012 October 3308 (13):1357-65. Epub 1900 01 01.

A quantitative measure of handgrip myotonia in non-dystrophic myotonia.

Statland JM, Bundy BN, Wang Y, Trivedi JR, Raja Rayan D, Herbelin L, Donlan M, McLin R, Eichinger KJ, Findlater K, Dewar L, Pandya S, Martens WB, Venance SL, Matthews E, Amato AA, Hanna MG, Griggs RC, Barohn RJ,

Muscle & nerve.. 2012 October 46 (4):482-9. Epub 1900 01 01.

Unintended effects of orphan product designation for rare neurological diseases.

Murphy SM, Puwanant A, Griggs RC,

Annals of neurology.. 2012 October 72 (4):481-90. Epub 1900 01 01.

An interactive voice response diary for patients with non-dystrophic myotonia.

Statland JM, Wang Y, Richesson R, Bundy B, Herbelin L, Gomes J, Trivedi J, Venance S, Amato A, Hanna M, Griggs R, Barohn RJ,

Muscle & nerve.. 2011 July 44 (1):30-5. Epub 1900 01 01.

Large Genomic Deletions in CACNA1A Cause Episodic Ataxia Type 2.

Wan J, Mamsa H, Johnston JL, Spriggs EL, Singer HS, Zee DS, Al-Bayati AR, Baloh RW, Jen JC,

Frontiers in neurology. 2011 2 :51. Epub 09/09/2011.

The non-dystrophic myotonias: molecular pathogenesis, diagnosis and treatment.

Matthews E, Fialho D, Tan SV, Venance SL, Cannon SC, Sternberg D, Fontaine B, Amato AA, Barohn RJ, Griggs RC, Hanna MG,

Brain : a journal of neurology.. 2010 January 133 (Pt 1):9-22. Epub 11/16/2009.

Clinical research for rare disease: opportunities, challenges, and solutions.

Griggs RC, Batshaw M, Dunkle M, Gopal-Srivastava R, Kaye E, Krischer J, Nguyen T, Paulus K, Merkel PA,

Molecular genetics and metabolism.. 2009 January 96 (1):20-6. Epub 11/13/2008.

Primary episodic ataxias: diagnosis, pathogenesis and treatment.

Jen JC, Graves TD, Hess EJ, Hanna MG, Griggs RC, Baloh RW,

Brain : a journal of neurology.. 2007 October 130 (Pt 10):2484-93. Epub 06/15/2007.

145th ENMC International Workshop: planning for an International Trial of Steroid Dosage Regimes in DMD (FOR DMD), 22-24th October 2006, Naarden, The Netherlands.

Bushby K, Griggs R,

Neuromuscular disorders : NMD.. 2007 May 17 (5):423-8. Epub 04/11/2007.

Challenges in the design and conduct of therapeutic trials in channel disorders.

Venance SL, Herr BE, Griggs RC

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.. 2007 April 4 (2):199-204. Epub 1900 01 01.

The primary periodic paralyses: diagnosis, pathogenesis and treatment.

Venance SL, Cannon SC, Fialho D, Fontaine B, Hanna MG, Ptacek LJ, Tristani-Firouzi M, Tawil R, Griggs RC,

Brain : a journal of neurology.. 2006 January 129 (Pt 1):8-17. Epub 09/29/2005.

Randomized, double-blind, placebo-controlled trial of albuterol in facioscapulohumeral dystrophy.

Kissel JT, McDermott MP, Mendell JR, King WM, Pandya S, Griggs RC, Tawil R,

Neurology.. 2001 October 2357 (8):1434-40. Epub 1900 01 01.

Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.

Tawil R, McDermott MP, Brown R, Shapiro BC, Ptacek LJ, McManis PG, Dalakas MC, Spector SA, Mendell JR, Hahn AF, Griggs RC

Annals of neurology.. 2000 January 47 (1):46-53. Epub 1900 01 01.

Pilot trial of albuterol in facioscapulohumeral muscular dystrophy. FSH-DY Group.

Kissel JT, McDermott MP, Natarajan R, Mendell JR, Pandya S, King WM, Griggs RC, Tawil R

Neurology.. 1998 May 50 (5):1402-6. Epub 1900 01 01.

Removing the barriers to performing clinical trials in academic settings.

Pelusio R; Herr BE.

Good Clinical Practice Journal. 1998; 5: 17-19.

A prospective, quantitative study of the natural history of facioscapulohumeral muscular dystrophy (FSHD): implications for therapeutic trials. The FSH-DY Group.

Neurology.. 1997 January 48 (1):38-46. Epub 1900 01 01.

A pilot trial of prednisone in facioscapulohumeral muscular dystrophy. FSH-DY Group.

Tawil R, McDermott MP, Pandya S, King W, Kissel J, Mendell JR, Griggs RC

Neurology.. 1997 January 48 (1):46-9. Epub 1900 01 01.

Evidence for anticipation and association of deletion size with severity in facioscapulohumeral muscular dystrophy. The FSH-DY Group.

Tawil R, Forrester J, Griggs RC, Mendell J, Kissel J, McDermott M, King W, Weiffenbach B, Figlewicz D

Annals of neurology.. 1996 June 39 (6):744-8. Epub 1900 01 01.

Monozygotic twins with facioscapulohumeral dystrophy (FSHD): implications for genotype/phenotype correlation. FSH-DY Group.

Griggs RC, Tawil R, McDermott M, Forrester J, Figlewicz D, Weiffenbach B

Muscle & nerve. Supplement. 1995 2 :S50-5. Epub 1900 01 01.

Facioscapulohumeral dystrophy natural history study: standardization of testing procedures and reliability of measurements. The FSH DY Group.

Personius KE, Pandya S, King WM, Tawil R, McDermott MP

Physical therapy.. 1994 March 74 (3):253-63. Epub 1900 01 01.

Facioscapulohumeral muscular dystrophy (FSHD): design of natural history study and results of baseline testing. FSH-DY Group.

Tawil R, McDermott MP, Mendell JR, Kissel J, Griggs RC

Neurology.. 1994 March 44 (3 Pt 1):442-6. Epub 1900 01 01.

Clinical Trials: A Co-operative Effort

Herr BE.

Challenge Magazine. 1994; 2: 21.

Sequence of changes in body composition induced by testosterone and reversal of changes after drug is stopped.

Forbes GB, Porta CR, Herr BE, Griggs RC

JAMA.. 1992 January 15267 (3):397-9. Epub 1900 01 01.

Mechanism of muscle wasting in myotonic dystrophy.

Griggs RC, Jozefowicz R, Kingston W, Nair KS, Herr BE, Halliday D

Annals of neurology.. 1990 May 27 (5):505-12. Epub 1900 01 01.

Randomized controlled trial of testosterone in myotonic dystrophy.

Griggs RC, Pandya S, Florence JM, Brooke MH, Kingston W, Miller JP, Chutkow J, Herr BE, Moxley RT

Neurology.. 1989 February 39 (2 Pt 1):219-22. Epub 1900 01 01.

Effect of testosterone on muscle mass and muscle protein synthesis.

Griggs RC, Kingston W, Jozefowicz RF, Herr BE, Forbes G, Halliday D

Journal of applied physiology.. 1989 January 66 (1):498-503. Epub 1900 01 01.

Lack of relationship of hypogonadism to muscle wasting in myotonic dystrophy.

Griggs RC, Kingston W, Herr BE, Forbes G, Moxley RT

Archives of neurology.. 1985 September 42 (9):881-5. Epub 1900 01 01.

Myotonic dystrophy: effect of testosterone on total body potassium and on creatinine excretion.

Griggs RC, Kingston W, Herr BE, Forbes G, Moxley RT

Neurology.. 1985 July 35 (7):1035-40. Epub 1900 01 01.

The assessment of muscle mass in progressive neuromuscular disease.

Griggs RC, Forbes G, Moxley RT, Herr BE

Neurology.. 1983 February 33 (2):158-65. Epub 1900 01 01.

Neuromuscular diagnostic procedures.

Ross AJ, Herr BE, Norwood ML, Donohoe KM, Moxley RT

The Nursing clinics of North America.. 1979 March 14 (1):107-21. Epub 1900 01 01.

Decreased insulin sensitivity of forearm muscle in myotonic dystrophy.

Moxley RT, Griggs RC, Goldblatt D, VanGelder V, Herr BE, Thiel R

The Journal of clinical investigation.. 1978 October 62 (4):857-67. Epub 1900 01 01.

Distal myopathy: electron microscopic and histochemical studies.

Markesbery WR, Griggs RC, Herr B

Neurology.. 1977 August 27 (8):727-35. Epub 1900 01 01.

A Bodian method for mounted frozen sections.

Herr BE, Coleman PD, Griggs RC

Stain technology. 1976 September 51 (5):261-5. Epub 1900 01 01.