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Ting Du, M.D., Ph.D.

Ting Du, M.D., Ph.D.

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About Me

Faculty Appointments

Assistant Professor - Department of Neurology, Center for Translational Neuromedicine (SMD)

Research

Publications

Journal Articles

Restoration of cervical lymphatic vessel function in aging rescues cerebrospinal fluid drainage.

Du T, Raghunandan A, Mestre H, Plá V, Liu G, Ladrón-de-Guevara A, Newbold E, Tobin P, Gahn-Martinez D, Pattanayak S, Huang Q, Peng W, Nedergaard M, Kelley DH

Nature aging.. 2024 October 4 (10):1418-1431. Epub 08/15/2024.

Age- and glaucoma-induced changes to the ocular glymphatic system.

Wang X, Delle C, Peng W, Plá V, Giannetto M, Kusk P, Sigurdsson B, Sakurai S, Sweeney A, Sun Q, Du T, Libby RT, Nedergaard M

Neurobiology of disease.. 2023 November 188 :106322. Epub 10/12/2023.

Sizes and shapes of perivascular spaces surrounding murine pial arteries.

Raicevic N, Forer JM, Ladrón-de-Guevara A, Du T, Nedergaard M, Kelley DH, Boster K

Fluids and barriers of the CNS.. 2023 July 1720 (1):56. Epub 07/17/2023.

Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows.

Boster KAS, Cai S, Ladrón-de-Guevara A, Sun J, Zheng X, Du T, Thomas JH, Nedergaard M, Karniadakis GE, Kelley DH

Proceedings of the National Academy of Sciences of the United States of America.. 2023 April 4120 (14):e2217744120. Epub 03/29/2023.

Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation.

Gomolka RS, Hablitz LM, Mestre H, Giannetto M, Du T, Hauglund NL, Xie L, Peng W, Martinez PM, Nedergaard M, Mori Y

eLife.. 2023 February 912 Epub 02/09/2023.

Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies.

Liu G, Ladrón-de-Guevara A, Izhiman Y, Nedergaard M, Du T

Fluids and barriers of the CNS.. 2022 December 1519 (1):101. Epub 12/15/2022.

Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema.

Du T, Mestre H, Kress BT, Liu G, Sweeney AM, Samson AJ, Rasmussen MK, Mortensen KN, Bork PAR, Peng W, Olveda GE, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Hirase H, Mori Y, Nedergaard M

Brain : a journal of neurology.. 2022 April 18145 (2):787-797. Epub 1900 01 01.

Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection.

Raghunandan A, Ladron-de-Guevara A, Tithof J, Mestre H, Du T, Nedergaard M, Thomas JH, Kelley DH

eLife.. 2021 March 910 Epub 03/09/2021.

Direct Measurement of Cerebrospinal Fluid Production in Mice.

Liu G, Mestre H, Sweeney AM, Sun Q, Weikop P, Du T, Nedergaard M

Cell reports.. 2020 December 2233 (12):108524. Epub 1900 01 01.

Surface periarterial spaces of the mouse brain are open, not porous.

Min Rivas F, Liu J, Martell BC, Du T, Mestre H, Nedergaard M, Tithof J, Thomas JH, Kelley DH

Journal of the Royal Society, Interface. 2020 November 17 (172):20200593. Epub 11/11/2020.

Cerebrospinal fluid influx drives acute ischemic tissue swelling.

Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M

Science.. 2020 March 13367 (6483)Epub 01/30/2020.

In Vivo Imaging of Cerebrospinal Fluid Transport through the Intact Mouse Skull using Fluorescence Macroscopy.

Sweeney AM, Plá V, Du T, Liu G, Sun Q, Peng S, Plog BA, Kress BT, Wang X, Mestre H, Nedergaard M

Journal of visualized experiments : JoVE.. 2019 July 29 (149)Epub 07/29/2019.

Dexmedetomidine enhances glymphatic brain delivery of intrathecally administered drugs.

Lilius TO, Blomqvist K, Hauglund NL, Liu G, Stæger FF, Bærentzen S, Du T, Ahlström F, Backman JT, Kalso EA, Rauhala PV, Nedergaard M

Journal of controlled release : official journal of the Controlled Release Society.. 2019 June 28304 :29-38. Epub 05/05/2019.

Aquaporin-4-dependent glymphatic solute transport in the rodent brain.

Mestre H, Hablitz LM, Xavier AL, Feng W, Zou W, Pu T, Monai H, Murlidharan G, Castellanos Rivera RM, Simon MJ, Pike MM, Plá V, Du T, Kress BT, Wang X, Plog BA, Thrane AS, Lundgaard I, Abe Y, Yasui M, Thomas JH, Xiao M, Hirase H, Asokan A, Iliff JJ, Nedergaard M

eLife.. 2018 December 187 Epub 12/18/2018.

Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension.

Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, Olveda G, Thomas JH, Nedergaard M, Kelley DH

Nature communications.. 2018 November 199 (1):4878. Epub 11/19/2018.

Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain.

Plog BA, Mestre H, Olveda GE, Sweeney AM, Kenney HM, Cove A, Dholakia KY, Tithof J, Nevins TD, Lundgaard I, Du T, Kelley DH, Nedergaard M

JCI insight.. 2018 October 183 (20)Epub 10/18/2018.

Chronic Treatment with Anti-bipolar Drugs Down-Regulates Gene Expression of TRPC1 in Neurones.

Du T, Rong Y, Feng R, Verkhratsky A, Peng L

Frontiers in cellular neuroscience.. 2016 10 :305. Epub 01/10/2017.

Ammonium increases Ca(2+) signalling and upregulates expression of Cav1.2 gene in astrocytes in primary cultures and in the in vivo brain.

Wang F, Du T, Liang C, Verkhratsky A, Peng L

Acta physiologica. 2015 June 214 (2):261-74. Epub 04/18/2015.

Astrocytic glycogenolysis: mechanisms and functions.

Hertz L, Xu J, Song D, Du T, Li B, Yan E, Peng L

Metabolic brain disease.. 2015 February 30 (1):317-33. Epub 04/18/2014.

Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion.

Zhou J, Du T, Li B, Rong Y, Verkhratsky A, Peng L

ASN neuro.. 2015 7 (5)Epub 10/06/2015.

Sequential Astrocytic 5-HT2B Receptor Stimulation, [Ca(2+)]i Regulation, Glycogenolysis, Glutamate Synthesis, and K(+) Homeostasis are Similar but Not Identical in Learning and Mood Regulation.

Chen Y, Du T, Peng L, Gibbs ME, Hertz L

Frontiers in integrative neuroscience.. 2015 9 :67. Epub 01/08/2016.

Ammonium increases Ca(2+) signalling and up-regulates expression of TRPC1 gene in astrocytes in primary cultures and in the in vivo brain.

Liang C, Du T, Zhou J, Verkhratsky A, Peng L

Neurochemical research.. 2014 November 39 (11):2127-35. Epub 08/12/2014.

Antagonists of the Vasopressin V1 Receptor and of the ?(1)-Adrenoceptor Inhibit Cytotoxic Brain Edema in Stroke by Effects on Astrocytes - but the Mechanisms Differ.

Hertz L, Xu J, Chen Y, Gibbs ME, Du T, Hertz L, Xu J, Chen Y, Gibbs ME, Du T

Current neuropharmacology.. 2014 July 12 (4):308-23. Epub 1900 01 01.

Ammonium activates ouabain-activated signalling pathway in astrocytes: therapeutic potential of ouabain antagonist.

Song D, Du T

Current neuropharmacology.. 2014 July 12 (4):334-41. Epub 1900 01 01.

Chronic fluoxetine administration increases expression of the L-channel gene Cav1.2 in astrocytes from the brain of treated mice and in culture and augments K(+)-induced increase in [Ca(2+)]i.

Du T, Liang C, Li B, Hertz L, Peng L

Cell calcium.. 2014 March 55 (3):166-74. Epub 01/22/2014.

Signal Transduction in Astrocytes during Chronic or Acute Treatment with Drugs (SSRIs, Antibipolar Drugs, GABA-ergic Drugs, and Benzodiazepines) Ameliorating Mood Disorders.

Hertz L, Song D, Li B, Du T, Xu J, Gu L, Chen Y, Peng L

Journal of signal transduction. 2014 2014 :593934. Epub 02/24/2014.

Inhibition of brain swelling after ischemia-reperfusion by ?-adrenergic antagonists: correlation with increased K+ and decreased Ca2+ concentrations in extracellular fluid.

Song D, Xu J, Du T, Yan E, Hertz L, Walz W, Peng L

BioMed research international.. 2014 2014 :873590. Epub 11/13/2014.

When can AQP4 assist transporter-mediated K? uptake?

Hertz L, Song D, Xu J, Du T, Gu L, Peng L

The Journal of general physiology.. 2013 July 142 (1):87-9. Epub 06/10/2013.

Brain glycogenolysis, adrenoceptors, pyruvate carboxylase, Na(+),K(+)-ATPase and Marie E. Gibbs' pioneering learning studies.

Hertz L, Xu J, Song D, Du T, Yan E, Peng L

Frontiers in integrative neuroscience.. 2013 7 :20. Epub 04/03/2013.

Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: role of glutamine redefined.

Desjardins P, Du T, Jiang W, Peng L, Butterworth RF

Neurochemistry international.. 2012 June 60 (7):690-6. Epub 02/21/2012.

Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function?

Peng L, Li B, Du T, Wang F, Hertz L

Pharmacology, biochemistry, and behavior.. 2012 February 100 (4):712-25. Epub 04/02/2011.

Astrocyte ERK phosphorylation precedes K(+)-induced swelling but follows hypotonicity-induced swelling.

Cai L, Du T, Song D, Li B, Hertz L, Peng L

Neuropathology : official journal of the Japanese Society of Neuropathology.. 2011 June 31 (3):250-64. Epub 12/01/2010.

Astrocytic transactivation by alpha2A-adrenergic and 5-HT2B serotonergic signaling.

Peng L, Li B, Du T, Kong EK, Hu X, Zhang S, Shan X, Zhang M

Neurochemistry international.. 2010 November 57 (4):421-31. Epub 05/05/2010.

Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent.

Du T, Li B, Li H, Li M, Hertz L, Peng L

Journal of neurochemistry.. 2010 November 115 (4):1007-23. Epub 10/05/2010.

ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.

Du T, Li B, Liu S, Zang P, Prevot V, Hertz L, Peng L

Neurochemistry international.. 2009 December 55 (7):593-600. Epub 06/06/2009.

Astrocytic alkalinization by therapeutically relevant lithium concentrations: implications for myo-inositol depletion.

Song D, Du T, Li B, Cai L, Gu L, Li H, Chen Y, Hertz L, Peng L

Psychopharmacology.. 2008 October 200 (2):187-95. Epub 05/28/2008.

Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.

Du T, Song D, Li H, Li B, Cai L, Hertz L, Peng L

European journal of pharmacology.. 2008 June 10587 (1-3):73-7. Epub 04/03/2008.

Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons.

Li B, Du T, Li H, Gu L, Zhang H, Huang J, Hertz L, Peng L

British journal of pharmacology.. 2008 May 154 (1):191-203. Epub 03/03/2008.

Books

Noradrenergic Signaling and Astroglia (2017)

Chapter: Signaling Pathway of ?- Adrenergic Receptor in Astrocytes and its Relevance to Brain Edema