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Richard A. Insel, M.D.

Contact

Office (585) 273-5667

About Me

Faculty Appointments

Research Professor (Part-Time) - Department of Pediatrics, Pediatric Allergy/Immunology (SMD)

Credentials

Post-doctoral Training & Residency

1974-76 Fellow in Medicine (Immunology), Children's Hospital Medical Center, Boston, MA. 1974 - 1976

Fellow in Pediatrics (Research), Harvard Medical School, Boston, MA 1974 - 1977

Medical Officer, Laboratory of Parasitic Immunochemistry, Center for Disease Control, Atlanta, GA 1972 - 1974

Registrar in Pediatrics, St. Mary's Medical College, London, England 1971 - 1972

Pediatric Intern and Resident, Children's Hospital Medical Center, Boston, MA 1969 - 1971

Education

MD | Jefferson Medical College of Thomas Jefferson University. Medicine. 1969

BS | Pennsylvania State University, State College. Pre-Medical. 1967

Awards

Alumni Achievement Award, Jefferson Medical College, Philadelphia, PA. 2000

Publications

Journal Articles

Gut microbiome in the first 1000 days and risk for childhood food allergy.

Davis EC, Monaco C, Insel R, Järvinen KM

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.. 2024 September 133 (3):252-261. Epub 03/16/2024.

Early skin inflammatory biomarker is predictive of development and persistence of atopic dermatitis in infants.

Stamatas GN, Sato T, Chaoimh CN, Oddos T, Insel R, Hourihane JO, Irvine AD

The Journal of allergy and clinical immunology.. 2024 June 153 (6):1597-1603.e4. Epub 03/07/2024.

Skin surface biomarkers are associated with future development of atopic dermatitis in children with family history of allergic disease.

Sato T, Nikolovski J, Gould R, Lboukili I, Roux PF, Al-Ghalith G, Orie J, Insel R, Stamatas GN

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI).. 2023 October 29 (10):e13470. Epub 1900 01 01.

Rationale for enteroviral vaccination and antiviral therapies in human type 1 diabetes.

Dunne JL, Richardson SJ, Atkinson MA, Craig ME, Dahl-Jørgensen K, Flodström-Tullberg M, Hyöty H, Insel RA, Lernmark Å, Lloyd RE, Morgan NG, Pugliese A

Diabetologia.. 2019 May 62 (5):744-753. Epub 01/23/2019.

Prospects for primary prevention of type 1 diabetes by restoring a disappearing microbe.

Insel R, Knip M

Pediatric diabetes.. 2018 December 19 (8):1400-1406. Epub 09/25/2018.

Screening, staging, and naming of presymptomatic type 1 diabetes.

Becker D, Insel R

Pediatric diabetes.. 2018 February 19 (1):7-10. Epub 11/29/2017.

Type 1 Diabetes: Disease Stratification.

Insel R, Dutta S, Hedrick J

Biomedicine hub.. 2017 2 (Suppl 1):111-126. Epub 11/21/2017.

JDRF's vision and strategy for prevention of type 1 diabetes.

Insel R, Dunne JL

Pediatric diabetes.. 2016 July 17 Suppl 22 :87-92. Epub 1900 01 01.

American Diabetes Association and JDRF Research Symposium: Diabetes and the Microbiome.

Semenkovich CF, Danska J, Darsow T, Dunne JL, Huttenhower C, Insel RA, McElvaine AT, Ratner RE, Shuldiner AR, Blaser MJ

Diabetes.. 2015 December 64 (12):3967-77. Epub 09/29/2015.

Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association.

Insel RA, Dunne JL, Atkinson MA, Chiang JL, Dabelea D, Gottlieb PA, Greenbaum CJ, Herold KC, Krischer JP, Lernmark Å, Ratner RE, Rewers MJ, Schatz DA, Skyler JS, Sosenko JM, Ziegler AG

Diabetes care.. 2015 October 38 (10):1964-74. Epub 1900 01 01.

General population screening for type 1 diabetes: has its time come?

Insel RA, Dunne JL, Ziegler AG

Current opinion in endocrinology, diabetes, and obesity.. 2015 August 22 (4):270-6. Epub 1900 01 01.

The intestinal microbiome in type 1 diabetes.

Dunne JL, Triplett EW, Gevers D, Xavier R, Insel R, Danska J, Atkinson MA

Clinical and experimental immunology.. 2014 July 177 (1):30-7. Epub 1900 01 01.

Delivering on George Eisenbarth's visionary pursuit of understanding pathogenesis and prevention of type 1 diabetes.

Insel RA

Diabetes technology & therapeutics.. 2013 June 15 Suppl 2 :S2-4-S2-7. Epub 1900 01 01.

Recent lessons learned from prevention and recent-onset type 1 diabetes immunotherapy trials.

Staeva TP, Chatenoud L, Insel R, Atkinson MA

Diabetes.. 2013 January 62 (1):9-17. Epub 1900 01 01.

Juvenile Diabetes Research Foundation: mission, strategy, and priorities.

Insel RA, Deecher DC, Brewer J

Diabetes.. 2012 January 61 (1):30-5. Epub 1900 01 01.

Mad1 is a transcriptional repressor of Bcl-6.

Lee SC, Bottaro A, Chen L, Insel RA

Molecular immunology.. 2006 May 43 (12):1965-71. Epub 01/19/2006.

Reply to "Bitter criticism sours new diabetes research plan".

Insel R

Nature medicine.. 2005 June 11 (6):589-90. Epub 1900 01 01.

Human embryonic stem cell research and the Juvenile Diabetes Research Foundation International - a work in progress.

Nierras CR, Stallard J, Goldstein RA, Insel R

Pediatric diabetes.. 2004 5 Suppl 2 :94-8. Epub 1900 01 01.

Activation of terminal B cell differentiation by inhibition of histone deacetylation.

Lee SC, Bottaro A, Insel RA

Molecular immunology.. 2003 May 39 (15):923-32. Epub 1900 01 01.

Recombinant human antibody single chain variable fragments reactive with Candida albicans surface antigens.

Haidaris CG, Malone J, Sherrill LA, Bliss JM, Gaspari AA, Insel RA, Sullivan MA

Journal of immunological methods.. 2001 November 1257 (1-2):185-202. Epub 1900 01 01.

Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance.

Pugh-Bernard AE, Silverman GJ, Cappione AJ, Villano ME, Ryan DH, Insel RA, Sanz I

The Journal of clinical investigation.. 2001 October 108 (7):1061-70. Epub 1900 01 01.

Tetracyclines inhibit activated B cell function.

Kuzin II, Snyder JE, Ugine GD, Wu D, Lee S, Bushnell T, Insel RA, Young FM, Bottaro A

International immunology.. 2001 July 13 (7):921-31. Epub 1900 01 01.

Monoclonal antibodies specific for Neisseria meningitidis group B polysaccharide and their peptide mimotopes.

Shin JS, Lin JS, Anderson PW, Insel RA, Nahm MH

Infection and immunity.. 2001 May 69 (5):3335-42. Epub 1900 01 01.

Flavopiridol induces apoptosis and caspase-3 activation of a newly characterized Burkitt's lymphoma cell line containing mutant p53 genes.

Rapoport AP, Simons-Evelyn M, Chen T, Sidell R, Luhowskyj S, Rosell K, Obrig T, Hicks D, Hinkle PM, Nahm M, Insel RA, Abboud CN

Blood cells, molecules & diseases.. 2001 27 (3):610-24. Epub 1900 01 01.

Up-regulation of telomerase in human B lymphocytes occurs independently of cellular proliferation and with expression of the telomerase catalytic subunit.

Hu BT, Insel RA

European journal of immunology.. 1999 November 29 (11):3745-53. Epub 1900 01 01.

David Hamilton Smith, M.D., 1932-1999: a tribute.

Insel RA, Smith AL

The Journal of infectious diseases.. 1999 September 180 (3):577-8. Epub 1900 01 01.

The challenges of vaccinating the very young: lessons from a very old system of host defense.

Valiante NM, Rappuoli R, Insel RA, McInnes P, Hoeveler A

Vaccine.. 1999 July 1617 (22):2757-62. Epub 1900 01 01.

Inherent properties of somatic hypermutation as revealed by human non-productive VH6 immunoglobulin rearrangements.

Varade WS, Carnahan JA, Kingsley PD, Insel RA

Immunology.. 1998 February 93 (2):171-6. Epub 1900 01 01.

Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A.

Hall CB, Caserta MT, Schnabel KC, Long C, Epstein LG, Insel RA, Dewhurst S

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.. 1998 January 26 (1):132-7. Epub 1900 01 01.

Characteristics of somatic hypermutation of human immunoglobulin genes.

Insel RA, Varade WS

Current topics in microbiology and immunology.. 1998 229 :33-44. Epub 1900 01 01.

Telomerase is up-regulated in human germinal center B cells in vivo and can be re-expressed in memory B cells activated in vitro.

Hu BT, Lee SC, Marin E, Ryan DH, Insel RA

The Journal of immunology : official journal of the American Association of Immunologists.. 1997 August 1159 (3):1068-71. Epub 1900 01 01.

Expression of interleukin-7 receptor by lineage-negative human bone marrow progenitors with enhanced lymphoid proliferative potential and B-lineage differentiation capacity.

Ryan DH, Nuccie BL, Ritterman I, Liesveld JL, Abboud CN, Insel RA

Blood.. 1997 February 189 (3):929-40. Epub 1900 01 01.

Securing the future.

McAnarney ER, Weitzman M, Insel RA

Archives of pediatrics & adolescent medicine.. 1996 January 150 (1):15-6. Epub 1900 01 01.

The V-region repertoire of Haemophilus influenzae type b polysaccharide antibodies induced by immunization of infants.

Chung GH, Kim KH, Daum RS, Insel RA, Siber GR, Sood S, Gupta RK, Marchant C, Nahm MH

Infection and immunity.. 1995 November 63 (11):4219-23. Epub 1900 01 01.

Somatic mutation of human immunoglobulin V genes: bias, rate, and regulation.

Insel RA, Varade WS, Chu YW, Marin E, Fuleihan R, Geha RS

Annals of the New York Academy of Sciences.. 1995 September 29764 :158-69. Epub 1900 01 01.

VH gene repertoire of mantle cell lymphomas.

Varade W, Marin E, Milano M, Insel R, Swerdlow S, Williams M

Annals of the New York Academy of Sciences.. 1995 September 29764 :504-6. Epub 1900 01 01.

Potential alterations in immunogenicity by combining or simultaneously administering vaccine components.

Insel RA

Annals of the New York Academy of Sciences.. 1995 May 31754 :35-47. Epub 1900 01 01.

Somatic mutation of human immunoglobulin V genes in the X-linked HyperIgM syndrome.

Chu YW, Marin E, Fuleihan R, Ramesh N, Rosen FS, Geha RS, Insel RA

The Journal of clinical investigation.. 1995 March 95 (3):1389-93. Epub 1900 01 01.

Neuroinvasion and persistence of human herpesvirus 6 in children.

Caserta MT, Hall CB, Schnabel K, McIntyre K, Long C, Costanzo M, Dewhurst S, Insel R, Epstein LG

The Journal of infectious diseases.. 1994 December 170 (6):1586-9. Epub 1900 01 01.

Bias in somatic hypermutation of human VH genes.

Insel RA, Varade WS

International immunology.. 1994 September 6 (9):1437-43. Epub 1900 01 01.

Human herpesvirus-6 infection in children. A prospective study of complications and reactivation.

Hall CB, Long CE, Schnabel KC, Caserta MT, McIntyre KM, Costanzo MA, Knott A, Dewhurst S, Insel RA, Epstein LG

The New England journal of medicine.. 1994 August 18331 (7):432-8. Epub 1900 01 01.

Human splenic IgM immunoglobulin transcripts are mutated at high frequency.

Insel RA, Varade WS, Marin E

Molecular immunology.. 1994 April 31 (5):383-92. Epub 1900 01 01.

Human monoclonal lambda light chain protein exhibits specific binding to the variable region of monoclonal anti-IgE antibody.

Ludwig LB, Schwartz SA, Insel RA

Cellular immunology.. 1994 January 153 (1):117-30. Epub 1900 01 01.

Maternal immunization to prevent infectious diseases in the neonate or infant.

Insel RA, Amstey M, Woodin K, Pichichero M

International journal of technology assessment in health care.. 1994 10 (1):143-53. Epub 1900 01 01.

Severe combined immunodeficiency of reduced severity due to homozygosity for an adenosine deaminase missense mutation (Arg253Pro).

Hirschhorn R, Yang DR, Insel RA, Ballow M

Cellular immunology.. 1993 December 152 (2):383-93. Epub 1900 01 01.

Use of the most JH-proximal human Ig H chain V region gene, VH6, in the expressed immune repertoire.

Varade WS, Marin E, Kittelberger AM, Insel RA

The Journal of immunology : official journal of the American Association of Immunologists.. 1993 June 1150 (11):4985-95. Epub 1900 01 01.

Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide. Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens.

Adderson EE, Shackelford PG, Quinn A, Wilson PM, Cunningham MW, Insel RA, Carroll WL

The Journal of clinical investigation.. 1993 June 91 (6):2734-43. Epub 1900 01 01.

Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.

Varade WS, Insel RA

The Journal of clinical investigation.. 1993 April 91 (4):1838-42. Epub 1900 01 01.

Oncogene elements within an endogenous retrovirus.

Whartenby KA, Insel RA, Freeman SM, Keng P, Abraham GN

Acta virologica. 1993 37 (2-3):113-22. Epub 1900 01 01.

Primary human herpesvirus 6 infection in young children.

Pruksananonda P, Hall CB, Insel RA, McIntyre K, Pellett PE, Long CE, Schnabel KC, Pincus PH, Stamey FR, Dambaugh TR

The New England journal of medicine.. 1992 May 28326 (22):1445-50. Epub 1900 01 01.

Frequency of medium-chain acyl-CoA dehydrogenase deficiency G-985 mutation in sudden infant death syndrome.

Miller ME, Brooks JG, Forbes N, Insel R

Pediatric research.. 1992 April 31 (4 Pt 1):305-7. Epub 1900 01 01.

Immunoglobulin light chain variable region gene sequences for human antibodies to Haemophilus influenzae type b capsular polysaccharide are dominated by a limited number of V kappa and V lambda segments and VJ combinations.

Adderson EE, Shackelford PG, Insel RA, Quinn A, Wilson PM, Carroll WL

The Journal of clinical investigation.. 1992 March 89 (3):729-38. Epub 1900 01 01.

CD43 is expressed normally on Wiskott-Aldrich-derived lymphocytes.

Dragone L, Pallant A, Insel R, Frelinger JG

Experimental and clinical immunogenetics.. 1992 9 (3):130-40. Epub 1900 01 01.

Frequency of G-985 mutation in medium chain acyl-coenzyme A dehydrogenase (MCAD) deficiency in sudden infant death syndrome (SIDS).

Miller M, Brooks J, Forbes N, Insel R

Progress in clinical and biological research.. 1992 375 :495-8. Epub 1900 01 01.

The repertoire of human antibody to the Haemophilus influenzae type b capsular polysaccharide.

Insel RA, Adderson EE, Carroll WL

International reviews of immunology.. 1992 9 (1):25-43. Epub 1900 01 01.

Two identical active X chromosomes in human mammary carcinoma cells.

Wang N, Cedrone E, Skuse GR, Insel R, Dry J

Cancer genetics and cytogenetics.. 1990 June 46 (2):271-80. Epub 1900 01 01.

Response to a Haemophilus influenzae type b diphtheria CRM197 conjugate vaccine in children with a defect of antibody production to Haemophilus influenzae type b polysaccharide.

Schneider LC, Insel RA, Howie G, Madore DV, Geha RS

The Journal of allergy and clinical immunology.. 1990 May 85 (5):948-53. Epub 1900 01 01.

Selective concentration of IgD class-specific antibodies in human milk.

Litwin SD, Zehr BD, Insel RA

Clinical and experimental immunology.. 1990 May 80 (2):263-7. Epub 1900 01 01.

Alterations of T helper/inducer and T suppressor/inducer cells in patients with recurrent aphthous ulcers.

Landesberg R, Fallon M, Insel R

Oral surgery, oral medicine, and oral pathology.. 1990 February 69 (2):205-8. Epub 1900 01 01.

Loss of tolerance associated with disappearance of B cells in a patient sequentially transplanted with paternal and maternal bone marrow for the treatment of severe combined immunodeficiency disease.

Keever CA, Flomenberg N, Small T, Brochstein J, Collins N, Young-Yang S, Insel R, Dupont B, O'Reilly RJ

Human immunology.. 1989 September 26 (1):27-38. Epub 1900 01 01.

Selective antibody deficiency to Haemophilus influenzae type B capsular polysaccharide vaccination in children with recurrent respiratory tract infection.

Herrod HG, Gross S, Insel R

Journal of clinical immunology.. 1989 September 9 (5):429-34. Epub 1900 01 01.

Effect of oligosaccharide chain length, exposed terminal group, and hapten loading on the antibody response of human adults and infants to vaccines consisting of Haemophilus influenzae type b capsular antigen unterminally coupled to the diphtheria protein CRM197.

Anderson PW, Pichichero ME, Stein EC, Porcelli S, Betts RF, Connuck DM, Korones D, Insel RA, Zahradnik JM, Eby R

The Journal of immunology : official journal of the American Association of Immunologists.. 1989 April 1142 (7):2464-8. Epub 1900 01 01.

Autologous mixed lymphocyte reaction in human neonatal lymphocytes.

Landesberg R, Insel RA

Human immunology.. 1989 April 24 (4):231-8. Epub 1900 01 01.

Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia.

Logtenberg T, Schutte ME, Inghirami G, Berman JE, Gmelig-Meyling FH, Insel RA, Knowles DM, Alt FW

International immunology.. 1989 1 (4):362-6. Epub 1900 01 01.

Background and indications for Haemophilus influenzae type b vaccines consisting of capsular antigen coupled to protein carriers.

Anderson PW, Stein EC, Insel RA

Contributions to microbiology and immunology.. 1989 10 :115-24. Epub 1900 01 01.

Haemophilus b oligosaccharide-CRM197 and other Haemophilus b conjugate vaccines: a status report.

Smith DH, Madore DV, Eby RJ, Anderson PW, Insel RA, Johnson CL

Advances in experimental medicine and biology.. 1989 251 :65-82. Epub 1900 01 01.

Maternal immunization to prevent neonatal infections.

Insel RA

The New England journal of medicine.. 1988 November 3319 (18):1219-20. Epub 1900 01 01.

Alterations in helper-inducer and suppressor-inducer T-cell subsets in human neonatal blood.

Landesberg R, Fallon M, Insel R

Immunology.. 1988 October 65 (2):323-5. Epub 1900 01 01.

Immunodeficiency associated with recurrent infections and an isolated in vivo inability to respond to bacterial polysaccharides.

Gigliotti F, Herrod HG, Kalwinsky DK, Insel RA

The Pediatric infectious disease journal.. 1988 June 7 (6):417-20. Epub 1900 01 01.

Prospects for overcoming maturational and genetic barriers to the human antibody response to the capsular polysaccharide of Haemophilus influenzae type b.

Anderson P, Insel RA

Vaccine.. 1988 April 6 (2):188-91. Epub 1900 01 01.

The IgG1 subclass preference of selected, naturally occurring antipolysaccharide antibodies.

Hammarström L, Insel RA, Persson MA, Smith CI

Monographs in allergy.. 1988 23 :18-26. Epub 1900 01 01.

IgG subclass distribution of antibody induced by immunization with the isolated and protein-conjugated polysaccharide of H. influenzae b and G2m(n) distribution of serum IgG2 in man.

Insel RA, Anderson PW

Monographs in allergy.. 1988 23 :128-37. Epub 1900 01 01.

Altered T4/T8 ratios in a patient with severe recurrent aphthous ulcers: report of a case.

Landesberg R, Fallon M, Insel R

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.. 1987 November 45 (11):980-2. Epub 1900 01 01.

Priming and induction of Haemophilus influenzae type b capsular antibodies in early infancy by Dpo20, an oligosaccharide-protein conjugate vaccine.

Anderson P, Pichichero M, Edwards K, Porch CR, Insel R

The Journal of pediatrics.. 1987 November 111 (5):644-50. Epub 1900 01 01.

Immunochemical variables affecting radioantigen-binding assays of antibody to Haemophilus influenzae type b capsular polysaccharide in childrens' sera.

Anderson P, Insel RA, Porcelli S, Ward JI

The Journal of infectious diseases.. 1987 October 156 (4):582-90. Epub 1900 01 01.

In vitro human antibody production to the Haemophilus influenzae type b capsular polysaccharide.

Munoz JL, Insel RA

The Journal of immunology : official journal of the American Association of Immunologists.. 1987 September 15139 (6):2026-31. Epub 1900 01 01.

IgG penetration into the cerebrospinal fluid in a rabbit model of meningitis.

Gigliotti F, Lee D, Insel RA, Scheld WM

The Journal of infectious diseases.. 1987 August 156 (2):394-8. Epub 1900 01 01.

Functional characterization of renal infiltrating cells following allograft nephrectomy.

Nikaein A, McQueen K, Boyer B, Landesberg R, Ryan DH, Insel RA

Transplantation proceedings.. 1987 February 19 (1 Pt 1):398-400. Epub 1900 01 01.

Response to oligosaccharide-protein conjugate vaccine against Hemophilus influenzae b in two patients with IgG2 deficiency unresponsive to capsular polysaccharide vaccine.

Insel RA, Anderson PW

The New England journal of medicine.. 1986 August 21315 (8):499-503. Epub 1900 01 01.

Vaccines consisting of periodate-cleaved oligosaccharides from the capsule of Haemophilus influenzae type b coupled to a protein carrier: structural and temporal requirements for priming in the human infant.

Anderson PW, Pichichero ME, Insel RA, Betts R, Eby R, Smith DH

The Journal of immunology : official journal of the American Association of Immunologists.. 1986 August 15137 (4):1181-6. Epub 1900 01 01.

Oligosaccharide-protein conjugate vaccines induce and prime for oligoclonal IgG antibody responses to the Haemophilus influenzae b capsular polysaccharide in human infants.

Insel RA, Anderson PW

The Journal of experimental medicine.. 1986 February 1163 (2):262-9. Epub 1900 01 01.

Fetal-neonatal passive immunization against Hemophilus influenzae, type b.

Amstey MS, Insel R, Munoz J, Pichichero M

American journal of obstetrics and gynecology.. 1985 November 15153 (6):607-11. Epub 1900 01 01.

Isoelectric focusing of human antibody to the Haemophilus influenzae b capsular polysaccharide: restricted and identical spectrotypes in adults.

Insel RA, Kittelberger A, Anderson P

The Journal of immunology : official journal of the American Association of Immunologists.. 1985 October 135 (4):2810-6. Epub 1900 01 01.

Capsular antigens noncovalently or covalently associated with protein as vaccines to Haemophilus influenzae type b: comparison in two-year-old children.

Anderson P, Pichichero M, Insel R, Farsad P, Santosham M

The Journal of infectious diseases.. 1985 September 152 (3):634-6. Epub 1900 01 01.

Immunization of 2-month-old infants with protein-coupled oligosaccharides derived from the capsule of Haemophilus influenzae type b.

Anderson P, Pichichero ME, Insel RA

The Journal of pediatrics.. 1985 September 107 (3):346-51. Epub 1900 01 01.

Postimmunization antibody to the Haemophilus influenzae type b capsule in breast milk.

Insel RA, Amstey M, Pichichero ME

The Journal of infectious diseases.. 1985 August 152 (2):407-8. Epub 1900 01 01.

Immunogens consisting of oligosaccharides from the capsule of Haemophilus influenzae type b coupled to diphtheria toxoid or the toxin protein CRM197.

Anderson P, Pichichero ME, Insel RA

The Journal of clinical investigation.. 1985 July 76 (1):52-9. Epub 1900 01 01.

In vivo production of human hybridoma antibody to the Haemophilus influenzae B capsule in athymic nude mice.

Insel RA

The Journal of infectious diseases.. 1984 December 150 (6):959-60. Epub 1900 01 01.

Reproducible production of protective human monoclonal antibodies by fusion of peripheral blood lymphocytes with a mouse myeloma cell line.

Gigliotti F, Smith L, Insel RA

The Journal of infectious diseases.. 1984 January 149 (1):43-7. Epub 1900 01 01.

Neonatal passive immunization by maternal vaccination.

Amstey MS, Insel RA, Pichichero ME

Obstetrics and gynecology.. 1984 January 63 (1):105-9. Epub 1900 01 01.

Severe diffuse adenovirus 7a pneumonia in a child with combined immunodeficiency: possible therapeutic effect of human immune serum globulin containing specific neutralizing antibody.

Dagan R, Schwartz RH, Insel RA, Menegus MA

Pediatric infectious disease.. 1984 3 (3):246-51. Epub 1900 01 01.

Mucosal antibody response to parenteral vaccination with Haemophilus influenzae type b capsule.

Pichichero ME, Insel RA

The Journal of allergy and clinical immunology.. 1983 November 72 (5 Pt 1):481-6. Epub 1900 01 01.

Monoclonal antibodies. Clinical relevance to pediatrics.

Insel RA, Gigliotti F

American journal of diseases of children. 1983 January 137 (1):69-76. Epub 1900 01 01.

Protective human hybridoma antibody to tetanus toxin.

Gigliotti F, Insel RA

The Journal of clinical investigation.. 1982 December 70 (6):1306-9. Epub 1900 01 01.

Immunospecificity and quantitation of an enzyme-linked immunosorbent assay for group B streptococcal antibody.

Anthony BF, Concepcion NF, McGeary SA, Ward JI, Heiner DC, Shapshak P, Insel RA

Journal of clinical microbiology.. 1982 August 16 (2):350-4. Epub 1900 01 01.

Relationship between naturally occurring human mucosal and serum antibody to the capsular polysaccharide of Haemophilus influenzae type b.

Pichichero ME, Insel RA

The Journal of infectious diseases.. 1982 August 146 (2):243-8. Epub 1900 01 01.

Protection from infection with Haemophilus influenzae type b by monoclonal antibody to the capsule.

Gigliotti F, Insel RA

The Journal of infectious diseases.. 1982 August 146 (2):249-54. Epub 1900 01 01.

Cross-reactivity with Escherichia coli K100 in the human serum anticapsular antibody response to Haemophilus influenzae type B.

Insel RA, Anderson PW

The Journal of immunology : official journal of the American Association of Immunologists.. 1982 March 128 (3):1267-70. Epub 1900 01 01.

A polysaccharide-protein complex from Haemophilus influenzae type b. I. Activity in weanling rabbits and human T lymphocytes.

Anderson P, Insel RA

The Journal of infectious diseases.. 1981 December 144 (6):509-20. Epub 1900 01 01.

A polysaccharide-protein complex from Haemophilus influenzae type b. II. Human antibodies to its somatic components.

Insel RA, Anderson P, Loeb MR, Smith DH

The Journal of infectious diseases.. 1981 December 144 (6):521-9. Epub 1900 01 01.

A polysaccharide-protein complex from Haemophilus influenzae type b. III. Vaccine trial in human adults.

Anderson P, Insel RA, Smith DH, Cate TR, Couch RB, Glezen WP

The Journal of infectious diseases.. 1981 December 144 (6):530-8. Epub 1900 01 01.

Management of recurrent invasive Haemophilus influenzae infection.

Fruchter L, Insel R

American journal of diseases of children. 1981 October 135 (10):927-9. Epub 1900 01 01.

A mucosal antibody response following systemic Haemophilus influenzae type B infection in children.

Pichichero ME, Hall CB, Insel RA

The Journal of clinical investigation.. 1981 May 67 (5):1482-9. Epub 1900 01 01.

Breast milk antibody to the capsular polysaccharide of Haemophilus influenzae type b.

Pichichero ME, Sommerfelt AE, Steinhoff MC, Insel RA

The Journal of infectious diseases.. 1980 November 142 (5):694-8. Epub 1900 01 01.

Characterization of lipopolysaccharide of Haemophilus influenzae.

Flesher AR, Insel RA

The Journal of infectious diseases.. 1978 December 138 (6):719-30. Epub 1900 01 01.

The necessity for T cell help for human tonsil B cell responses to pokeweed mitogens: induction of DNA synthesis, immunoglobulin, and specific antibody production with a T cell helper factor produced with pokeweed mitogen.

Insel RA, Merler E

The Journal of immunology : official journal of the American Association of Immunologists.. 1977 June 118 (6):2009-14. Epub 1900 01 01.

Induction of a specific antibody response in human B cells: role of a human antigenic nonspecific T-cell soluble factor and requirement for antigen.

Insel RA, Merler E, Rosen FS

Cellular immunology.. 1977 May 30 (2):321-31. Epub 1900 01 01.

Inhibition of maturation of human precursor lymphocytes by coformycin, an inhibitor of the enzyme adenosine deaminase.

Ballet JJ, Insel R, Merler E, Rosen FS

The Journal of experimental medicine.. 1976 May 1143 (5):1271-6. Epub 1900 01 01.

Surface receptors in B lymphocyte activation by antigens.

La Via MF, Insel RA, Kinkade JM, Pollock RR, La Via DS

Advances in experimental medicine and biology.. 1976 73 PT-A :315-27. Epub 1900 01 01.

Morphology, surface markers, and in vitro responses of a human leukemic T cell.

Insel RA, Melewicz FM, La Via MF, Balch CM

Clinical immunology and immunopathology.. 1975 September 4 (3):382-91. Epub 1900 01 01.

Books

Diabetes and Viruses. (2012)

Chapter: Speculation on prevention of type 1 diabetes.

Immunologic Disorders in Infants and Children (2004)

Chapter: The B-Lymphocyte System: Fundamental Immunology

Hematology:Basic Principles and Practice (2000)

Chapter: Disorders of lymphocyte function

Current Topics in Microbiology and Immunology - Somatic Diversification of Immune Responses (1998)

Chapter: Characteristics of somatic hypermutation of human immunoglobulin genes

The Biology of Germinal Centers in Lymphoid Tissue (1998)

Chapter: T and B lymphocytes in germinal centers.

Development and Clinical Uses of Haemophilus b Vaccine. (1994)

Chapter: Molecular basis of antibody diversity in Haemophilus influenzae b conjugate vaccines.

Proceedings of the 2nd International Symposium on Clinical, Biochemical, and Molecular Aspects of Fatty Acid Oxidation. (1992)

Chapter: Frequency of G-985 mutation in medium chain acetyl-CoA dehydrogenase deficiency in sudden infant death syndrome.

Hematology: Basic Principles and Practice. (1991)

Chapter: Disorders of lymphocyte function.

Pediatrics (1990)

Chapter: Immunity and Immunization.

Conjugate Vaccines (1989)

Chapter: Background and indications for Haemophilus influenzae type b vaccines consisting of capsular antigen coupled to protein carriers.

Manual of Clinical Laboratory Immunology, (1986)

Chapter: Haemophilus influenzae type b: Assays for the capsular polysaccharide and for anti-polysaccharide antibody.

Hematology: Basic Principles and Practice (1985)

Chapter: Disorders of lymphocyte function

Bedside Pediatrics (1983)

Chapter: The child with recurrent infections.

Bedside Pediatrics (1983)

Chapter: Rapid diagnosis of infectious disease.

Bacterial Vaccines - Seminars in Infectious Diseases (1982)

Chapter: Types and frequency of Haemophilus influenzae IgA1 proteases.

Bacterial Vaccines - Seminars in Infectious Diseases (1982)

Chapter: Immunogenicity of a protein-carbohydrate complex prepared from membrane released in cultures of Haemophilus influenzae type b

Bacterial Vaccines - Seminars in Infectious Diseases (1982)

Chapter: Purified capsular polysaccharide of Haemophilus influenzae type b as an immunogen: Progress and prospects.

Hemophilus influenzae (1982)

Chapter: Anticapsular antibody to Haemophilus influenzae.

Hemophilus influenzae (1982)

Chapter: The immunogenicity of "aggregated PRP", "PRP-complex", and covalent conjugates of PRP with a diphtheria toxoid.

Hemophilus influenzae (1982)

Chapter: Progress and prospects for active immunization for Hemophilus influenzae diseases

Manual of Pediatric Therapeutics (1980)

Chapter: Inflammatory and immunodeficiency disorders

Manual of Clinical Immunology (1980)

Chapter: Haemophilus influenzae type b assays for the capsular polysaccharide and for anti-polysaccharide antibody.