A genome-wide association analysis reveals new pathogenic pathways in gout.
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Nature genetics.. 2024 November 56 (11):2392-2406. Epub 10/15/2024.
Genome-wide association study of hospitalized patients and acute kidney injury.
Siew ED, Hellwege JN, Hung AM, Birkelo BC, Vincz AJ, Parr SK, Denton J, Greevy RA, Robinson-Cohen C, Liu H, Susztak K, Matheny ME, Velez Edwards DR
Kidney international.. 2024 August 106 (2):291-301. Epub 05/24/2024.
Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression.
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Nature genetics.. 2024 August 56 (8):1712-1724. Epub 07/24/2024.
ACSS2 gene variants determine kidney disease risk by controlling de novo lipogenesis in kidney tubules.
Mukhi D, Li L, Liu H, Doke T, Kolligundla LP, Ha E, Kloetzer K, Abedini A, Mukherjee S, Wu J, Dhillon P, Hu H, Guan D, Funai K, Uehara K, Titchenell PM, Baur JA, Wellen KE, Susztak K
The Journal of clinical investigation.. 2023 December 5134 (4)Epub 12/05/2023.
Deletion of protein tyrosine phosphatase SHP-1 restores SUMOylation of podocin and reverses the progression of diabetic kidney disease.
Lizotte F, Rousseau M, Denhez B, Lévesque D, Guay A, Liu H, Moreau J, Higgins S, Sabbagh R, Susztak K, Boisvert FM, Côté AM, Geraldes P
Kidney international.. 2023 October 104 (4):787-802. Epub 07/27/2023.
Unbiased Human Kidney Tissue Proteomics Identifies Matrix Metalloproteinase 7 as a Kidney Disease Biomarker.
Hirohama D, Abedini A, Moon S, Surapaneni A, Dillon ST, Vassalotti A, Liu H, Doke T, Martinez V, Md Dom Z, Karihaloo A, Palmer MB, Coresh J, Grams ME, Niewczas MA, Susztak K
Journal of the American Society of Nephrology : JASN.. 2023 July 134 (7):1279-1291. Epub 04/05/2023.
Transcriptome- and proteome-wide association studies nominate determinants of kidney function and damage.
Schlosser P, Zhang J, Liu H, Surapaneni AL, Rhee EP, Arking DE, Yu B, Boerwinkle E, Welling PA, Chatterjee N, Susztak K, Coresh J, Grams ME
Genome biology.. 2023 June 2624 (1):150. Epub 06/26/2023.
DNA methylation markers for kidney function and progression of diabetic kidney disease.
Li KY, Tam CHT, Liu H, Day S, Lim CKP, So WY, Huang C, Jiang G, Shi M, Lee HM, , Lan HY, Szeto CC, Hanson RL, Nelson RG, Susztak K, Chan JCN, Yip KY, Ma RCW
Nature communications.. 2023 May 1514 (1):2543. Epub 05/15/2023.
Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.
Sandholm N, Cole JB, Nair V, Sheng X, Liu H, Ahlqvist E, van Zuydam N, Dahlström EH, Fermin D, Smyth LJ, Salem RM, Forsblom C, Valo E, Harjutsalo V, Brennan EP, McKay GJ, Andrews D, Doyle R, Looker HC, Nelson RG, Palmer C, McKnight AJ, Godson C, Maxwell AP, Groop L, McCarthy MI, Kretzler M, Susztak K, Hirschhorn JN, Florez JC, Groop PH,
Diabetologia.. 2022 September 65 (9):1495-1509. Epub 06/28/2022.
Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.
Liu H, Doke T, Guo D, Sheng X, Ma Z, Park J, Vy HMT, Nadkarni GN, Abedini A, Miao Z, Palmer M, Voight BF, Li H, Brown CD, Ritchie MD, Shu Y, Susztak K
Nature genetics.. 2022 July 54 (7):950-962. Epub 06/16/2022.
Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus.
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Nature communications.. 2021 December 912 (1):7173. Epub 12/09/2021.
Meta-analyses identify DNA methylation associated with kidney function and damage.
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Nature communications.. 2021 December 912 (1):7174. Epub 12/09/2021.
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.
Sheng X, Guan Y, Ma Z, Wu J, Liu H, Qiu C, Vitale S, Miao Z, Seasock MJ, Palmer M, Shin MK, Duffin KL, Pullen SS, Edwards TL, Hellwege JN, Hung AM, Li M, Voight BF, Coffman TM, Brown CD, Susztak K
Nature genetics.. 2021 September 53 (9):1322-1333. Epub 08/12/2021.
Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis.
Doke T, Huang S, Qiu C, Liu H, Guan Y, Hu H, Ma Z, Wu J, Miao Z, Sheng X, Zhou J, Cao A, Li J, Kaufman L, Hung A, Brown CD, Pestell R, Susztak K
The Journal of clinical investigation.. 2021 May 17131 (10)Epub 1900 01 01.
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.
Miao Z, Balzer MS, Ma Z, Liu H, Wu J, Shrestha R, Aranyi T, Kwan A, Kondo A, Pontoglio M, Kim J, Li M, Kaestner KH, Susztak K
Nature communications.. 2021 April 1512 (1):2277. Epub 04/15/2021.
Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney.
Abedini A, Zhu YO, Chatterjee S, Halasz G, Devalaraja-Narashimha K, Shrestha R, S Balzer M, Park J, Zhou T, Ma Z, Sullivan KM, Hu H, Sheng X, Liu H, Wei Y, Boustany-Kari CM, Patel U, Almaani S, Palmer M, Townsend R, Blady S, Hogan J, Morton L, Susztak K,
Journal of the American Society of Nephrology : JASN.. 2021 March 32 (3):614-627. Epub 02/02/2021.
The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
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Cell metabolism.. 2021 February 233 (2):379-394.e8. Epub 12/09/2020.
Systematic integrated analysis of genetic and epigenetic variation in diabetic kidney disease.
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Development of highly potent glucocorticoids for steroid-resistant severe asthma.
He Y, Shi J, Nguyen QT, You E, Liu H, Ren X, Wu Z, Li J, Qiu W, Khoo SK, Yang T, Yi W, Sun F, Xi Z, Huang X, Melcher K, Min B, Xu HE
Proceedings of the National Academy of Sciences of the United States of America.. 2019 April 2116 (14):6932-6937. Epub 03/20/2019.
Specific breast cancer prognosis-subtype distinctions based on DNA methylation patterns.
Zhang S, Wang Y, Gu Y, Zhu J, Ci C, Guo Z, Chen C, Wei Y, Lv W, Liu H, Zhang D, Zhang Y
Molecular oncology.. 2018 June 12 (7):1047-1060. Epub 05/21/2018.
DiseaseMeth version 2.0: a major expansion and update of the human disease methylation database.
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Nucleic acids research.. 2017 January 445 (D1):D888-D895. Epub 11/29/2016.
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Briefings in functional genomics.. 2016 November 15 (6):470-484. Epub 08/10/2016.
The identification of age-associated cancer markers by an integrative analysis of dynamic DNA methylation changes.
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Scientific reports.. 2016 March 76 :22722. Epub 03/07/2016.
Systematic identification and annotation of human methylation marks based on bisulfite sequencing methylomes reveals distinct roles of cell type-specific hypomethylation in the regulation of cell identity genes.
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Nucleic acids research.. 2016 January 444 (D1):D172-9. Epub 11/17/2015.
Identification of 4438 novel lincRNAs involved in mouse pre-implantation embryonic development.
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Molecular genetics and genomics : MGG.. 2015 April 290 (2):685-97. Epub 11/27/2014.
Identification and characterization of long intergenic non-coding RNAs related to mouse liver development.
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Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants
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