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Marion W. Anders, D.V.M., Ph.D.

Marion W. Anders, D.V.M., Ph.D.

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Call Center (585) 276-3000

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About Me

Faculty Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD)

Professor Emeritus - Department of Anesthesiology and Perioperative Medicine (SMD) - Joint

Professor Emeritus - Department of Environmental Medicine (SMD) - Joint

Credentials

Education

PhD | Univ Minnesota. Pharmacology. 1964

DVM | Iowa State University. Veterinary Medicine. 1960

Awards

Merit Award, Society of Toxicology 2003 - 2003

Symposium on "Bioactivation of Foreign Compounds Challenges for the Future." Held in honor of Professor Drag Anders. Hosted by the Center for Molecular Toxicology, Vanderbilt University, Nashville, TN 2002 - 2002

Bernard B. Brodie Award in Drug Metabolism, American Society for Pharmacology and Experimental Therapeutics 1999 - 1999

MERIT Awardee, National Institute of Environmental Health Sciences 1986 - 1996

Research

Patents

Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochhondria and Use Thereof

Issue date: September 08, 2009

Patent #: 7,585,846

Country: United States

Inventors: Marion W Anders, Virendra K Sharma, Shey-Shing Sheu, Lin Xu

Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use

Issue date: June 25, 2013

Patent #: 8,470,861

Country: United States

Inventors: Marion W Anders, Paul S Brookes, Leif Olson, Richard L Parton, James L Robotham, Shey-Shing Sheu, Jalai Shojaie

Publications

Journal Articles

Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria.

Anders MW

Mitochondrion.. 2013 September 13 (5):454-63. Epub 11/01/2012.

Putting bioactivation reactions to work: Targeting antioxidants to mitochondria.

Anders MW

Chemico-biological interactions.. 2011 June 30192 (1-2):8-13. Epub 11/18/2010.

Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice.

Board PG, Anders MW

Drug metabolism reviews.. 2011 May 43 (2):215-25. Epub 02/08/2011.

Mitochondrial biotransformation of omega-(phenoxy)alkanoic acids, 3-(phenoxy)acrylic acids, and omega-(1-methyl-1H-imidazol-2-ylthio)alkanoic acids: a prodrug strategy for targeting cytoprotective antioxidants to mitochondria.

Roser KS, Brookes PS, Wojtovich AP, Olson LP, Shojaie J, Parton RL, Anders MW

Bioorganic & medicinal chemistry.. 2010 February 1518 (4):1441-8. Epub 01/15/2010.

N-glucuronidation of perfluorooctanesulfonamide by human, rat, dog, and monkey liver microsomes and by expressed rat and human UDP-glucuronosyltransferases.

Xu L, Krenitsky DM, Seacat AM, Butenhoff JL, Tephly TR, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 2006 August 34 (8):1406-10. Epub 05/23/2006.

Workshop overview: reassessment of the cancer risk of dichloromethane in humans.

Starr TB, Matanoski G, Anders MW, Andersen ME

Toxicological sciences : an official journal of the Society of Toxicology.. 2006 May 91 (1):20-8. Epub 02/28/2006.

Polymorphisms in the human glutathione transferase zeta promoter.

Fang YY, Kashkarov U, Anders MW, Board PG

Pharmacogenetics and genomics.. 2006 May 16 (5):307-13. Epub 1900 01 01.

Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.

Blackburn AC, Matthaei KI, Lim C, Taylor MC, Cappello JY, Hayes JD, Anders MW, Board PG

Molecular pharmacology.. 2006 February 69 (2):650-7. Epub 11/08/2005.

Targeting antioxidants to mitochondria: a new therapeutic direction.

Sheu SS, Nauduri D, Anders MW

Biochimica et biophysica acta.. 2006 February 1762 (2):256-65. Epub 11/08/2005.

Mitochondria: new drug targets for oxidative stress-induced diseases.

Anders MW, Robotham JL, Sheu SS

Expert opinion on drug metabolism & toxicology.. 2006 February 2 (1):71-9. Epub 1900 01 01.

Formation and toxicity of anesthetic degradation products.

Anders MW

Annual review of pharmacology and toxicology.. 2005 45 :147-76. Epub 1900 01 01.

Human glutathione transferase zeta.

Board PG, Anders MW

Methods in enzymology.. 2005 401 :61-77. Epub 1900 01 01.

Calcium, ATP, and ROS: a mitochondrial love-hate triangle.

Brookes PS, Yoon Y, Robotham JL, Anders MW, Sheu SS

American journal of physiology. Cell physiology.. 2004 October 287 (4):C817-33. Epub 1900 01 01.

Glutathione-dependent bioactivation of haloalkanes and haloalkenes.

Anders MW

Drug metabolism reviews.. 2004 October 36 (3-4):583-94. Epub 1900 01 01.

Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases.

Lim CE, Matthaei KI, Blackburn AC, Davis RP, Dahlstrom JE, Koina ME, Anders MW, Board PG

The American journal of pathology.. 2004 August 165 (2):679-93. Epub 1900 01 01.

Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450.

Xu L, Krenitsky DM, Seacat AM, Butenhoff JL, Anders MW

Chemical research in toxicology.. 2004 June 17 (6):767-75. Epub 1900 01 01.

Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.

Anderson WB, Board PG, Anders MW

Chemical research in toxicology.. 2004 May 17 (5):650-62. Epub 1900 01 01.

Acivicin-induced alterations in renal and hepatic glutathione concentrations and in gamma-glutamyltransferase activities.

Lantum HB, Iyer RA, Anders MW

Biochemical pharmacology.. 2004 April 167 (7):1421-6. Epub 1900 01 01.

Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique.

Board PG, Taylor MC, Coggan M, Parker MW, Lantum HB, Anders MW

The Biochemical journal.. 2003 September 15374 (Pt 3):731-7. Epub 1900 01 01.

Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic Acid-induced glutathione transferase zeta deficiency.

Lantum HB, Cornejo J, Pierce RH, Anders MW

Toxicological sciences : an official journal of the Society of Toxicology.. 2003 July 74 (1):192-202. Epub 05/02/2003.

Computational and experimental studies on the distribution of addition and substitution products of the microsomal glutathione transferase 1-catalyzed conjugation of glutathione with fluoroalkenes.

Jolivette LJ, Anders MW

Chemical research in toxicology.. 2003 February 16 (2):137-44. Epub 1900 01 01.

Nephrotoxicity of chlorofluoroacetic acid in rats.

Lantum HB, Baggs RB, Krenitsky DM, Anders MW

Toxicological sciences : an official journal of the Society of Toxicology.. 2002 December 70 (2):261-8. Epub 1900 01 01.

Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta.

Anderson WB, Liebler DC, Board PG, Anders MW

Chemical research in toxicology.. 2002 November 15 (11):1387-97. Epub 1900 01 01.

Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition.

Enomoto A, Wempe MF, Tsuchida H, Shin HJ, Cha SH, Anzai N, Goto A, Sakamoto A, Niwa T, Kanai Y, Anders MW, Endou H

The Journal of biological chemistry.. 2002 September 27277 (39):36262-71. Epub 06/27/2002.

Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism.

Cooper AJ, Bruschi SA, Anders MW

Biochemical pharmacology.. 2002 August 1564 (4):553-64. Epub 1900 01 01.

Structure-activity relationship for the biotransformation of haloalkenes by rat liver microsomal glutathione transferase 1.

Jolivette LJ, Anders MW

Chemical research in toxicology.. 2002 August 15 (8):1036-41. Epub 1900 01 01.

Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1).

Lantum HB, Board PG, Anders MW

Chemical research in toxicology.. 2002 July 15 (7):957-63. Epub 1900 01 01.

Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues.

Lantum HB, Baggs RB, Krenitsky DM, Board PG, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 2002 June 30 (6):616-25. Epub 1900 01 01.

Reactive intermediate formation from the 2-(Fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived cysteine S-conjugate S-[2-(Fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-L-cysteine in pyridoxal model systems.

Tong Z, Anders MW

Chemical research in toxicology.. 2002 May 15 (5):623-8. Epub 1900 01 01.

Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.

Lantum HB, Liebler DC, Board PG, Anders MW

Chemical research in toxicology.. 2002 May 15 (5):707-16. Epub 1900 01 01.

Biotransformation of 1,1,1,3,3-Pentafluoropropane (HFC-245fa).

Bayer T, Amberg A, Bertermann R, Rusch GM, Anders MW, Dekant W

Chemical research in toxicology.. 2002 May 15 (5):723-33. Epub 1900 01 01.

Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition.

Uchino H, Kanai Y, Kim DK, Wempe MF, Chairoungdua A, Morimoto E, Anders MW, Endou H

Molecular pharmacology.. 2002 April 61 (4):729-37. Epub 1900 01 01.

Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1.

Pombrio JM, Giangreco A, Li L, Wempe MF, Anders MW, Sweet DH, Pritchard JB, Ballatori N

Molecular pharmacology.. 2001 November 60 (5):1091-9. Epub 1900 01 01.

GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase.

Blackburn AC, Coggan M, Tzeng HF, Lantum H, Polekhina G, Parker MW, Anders MW, Board PG

Pharmacogenetics. 2001 November 11 (8):671-8. Epub 1900 01 01.

Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons.

DeCory HH, Piech-Dumas KM, Sheu SS, Federoff HJ, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 2001 October 29 (10):1256-62. Epub 1900 01 01.

Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis.

Board PG, Chelvanayagam G, Jermiin LS, Tetlow N, Tzeng HF, Anders MW, Blackburn AC

Drug metabolism and disposition : the biological fate of chemicals.. 2001 April 29 (4 Pt 2):544-7. Epub 1900 01 01.

Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis.

Chen Y, Cai J, Anders MW, Stevens JL, Jones DP

Toxicology and applied pharmacology.. 2001 February 1170 (3):172-80. Epub 1900 01 01.

Formation and fate of reactive intermediates of haloalkanes, haloalkenes, and alpha-haloacids.

Anders MW

Advances in experimental medicine and biology.. 2001 500 :113-20. Epub 1900 01 01.

Inactivation of polymorphic variants of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone.

Lantum HB, Board PG, Anders MW

Advances in experimental medicine and biology.. 2001 500 :339-42. Epub 1900 01 01.

Bioactivation mechanisms of haloalkene cysteine S-conjugates modeled by gas-phase, ion-molecule reactions.

Luu NC, Iyer RA, Anders MW, Ridge DP

Chemical research in toxicology.. 2000 July 13 (7):610-5. Epub 1900 01 01.

Immunohistochemical localization of the acylases that catalyze the deacetylation of N-acetyl-L-cysteine and haloalkene-derived mercapturates.

Uttamsingh V, Baggs RB, Krenitsky DM, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 2000 June 28 (6):625-32. Epub 1900 01 01.

Porcine kidney microsomal cysteine S-conjugate N-acetyltransferase-catalyzed N-acetylation of haloalkene-derived cysteine S-conjugates.

Kraus T, Uttamsingh V, Anders MW, Wolf S

Drug metabolism and disposition : the biological fate of chemicals.. 2000 April 28 (4):440-5. Epub 1900 01 01.

Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate.

Tzeng HF, Blackburn AC, Board PG, Anders MW

Chemical research in toxicology.. 2000 April 13 (4):231-6. Epub 1900 01 01.

Profiles in toxicology. Harold Carpenter Hodge (1904-1990).

Morrow PE, Witschi H, Vore M, Hakkinen PE, MacGregor J, MacGregor J, Anders MW, Willhite C

Toxicological sciences : an official journal of the Society of Toxicology.. 2000 February 53 (2):157-8. Epub 1900 01 01.

Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.

Blackburn AC, Tzeng HF, Anders MW, Board PG

Pharmacogenetics. 2000 February 10 (1):49-57. Epub 1900 01 01.

Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking alpha-haloalkanoic acids.

Anderson WB, Board PG, Gargano B, Anders MW

Chemical research in toxicology.. 1999 December 12 (12):1144-9. Epub 1900 01 01.

Acylase-catalyzed deacetylation of haloalkene-derived mercapturates.

Uttamsingh V, Anders MW

Chemical research in toxicology.. 1999 October 12 (10):937-42. Epub 1900 01 01.

Glutathione transferase zeta-catalyzed biotransformation of deuterated dihaloacetic acids.

Wempe MF, Anderson WB, Tzeng HF, Board PG, Anders MW

Biochemical and biophysical research communications.. 1999 August 11261 (3):779-83. Epub 1900 01 01.

Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis.

Tu Z, Anders MW

The Biochemical journal.. 1998 December 15336 ( Pt 3) (Pt 3):675-80. Epub 1900 01 01.

Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids.

Tong Z, Board PG, Anders MW

Chemical research in toxicology.. 1998 November 11 (11):1332-8. Epub 1900 01 01.

Fate and toxicity of 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A)-derived mercapturates in male, Fischer 344 rats.

Uttamsingh V, Iyer RA, Baggs RB, Anders MW

Anesthesiology.. 1998 November 89 (5):1174-83. Epub 1900 01 01.

Metabolism of 1,1-dichloro-1-fluoroethane (HCFC-141b) in human volunteers.

Tong Z, Utell MJ, Morrow PE, Rusch GM, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1998 July 26 (7):711-3. Epub 1900 01 01.

Thietanium ion formation from the food mutagen 2-chloro-4-(methylthio)butanoic acid.

Jolivette LJ, Kende AS, Anders MW

Chemical research in toxicology.. 1998 July 11 (7):794-9. Epub 1900 01 01.

Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines.

Uttamsingh V, Keller DA, Anders MW

Chemical research in toxicology.. 1998 July 11 (7):800-9. Epub 1900 01 01.

Expression and characterization of human glutamate-cysteine ligase.

Tu Z, Anders MW

Archives of biochemistry and biophysics.. 1998 June 15354 (2):247-54. Epub 1900 01 01.

Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid.

Tong Z, Board PG, Anders MW

The Biochemical journal.. 1998 April 15331 ( Pt 2) (Pt 2):371-4. Epub 1900 01 01.

Up-regulation of glutamate-cysteine ligase gene expression by butylated hydroxytoluene is mediated by transcription factor AP-1.

Tu Z, Anders MW

Biochemical and biophysical research communications.. 1998 March 27244 (3):801-5. Epub 1900 01 01.

Cysteine conjugate beta-lyase-dependent metabolism of compound A (2-[fluoromethoxy]-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given compound A.

Iyer RA, Frink EJ, Ebert TJ, Anders MW

Anesthesiology.. 1998 March 88 (3):611-8. Epub 1900 01 01.

Elimination reactions in the medium-chain acyl-CoA dehydrogenase: bioactivation of cytotoxic 4-thiaalkanoic acids.

Baker-Malcolm JF, Haeffner-Gormley L, Wang L, Anders MW, Thorpe C

Biochemistry.. 1998 February 337 (5):1383-93. Epub 1900 01 01.

Glutathione-dependent bioactivation of haloalkenes.

Anders MW, Dekant W

Annual review of pharmacology and toxicology.. 1998 38 :501-37. Epub 1900 01 01.

Nephrotoxicity of the glutathione and cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3, 3-pentafluoro-1-propene (Compound A) in male Fischer 344 rats.

Iyer RA, Baggs RB, Anders MW

The Journal of pharmacology and experimental therapeutics.. 1997 December 283 (3):1544-51. Epub 1900 01 01.

Enhancement of gene expression by transcription factor AP-1 is dependent on orientation of AP-1 element.

Tu Z, Anders MW

Biochemical and biophysical research communications.. 1997 September 18238 (2):285-8. Epub 1900 01 01.

Cysteine S-conjugates activate transcription factor NF-kappa B in cultured renal epithelial cells.

Otieno MA, Anders MW

The American journal of physiology.. 1997 July 273 (1 Pt 2):F136-43. Epub 1900 01 01.

Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (compound A).

Iyer RA, Anders MW

Chemical research in toxicology.. 1997 July 10 (7):811-9. Epub 1900 01 01.

Stable transfection of LLC-PK1 cells with human microsomal glutathione S-transferase gene increases haloalkene glutathione S-conjugate formation and cytotoxicity.

Otieno MA, Anders MW

Biochemical and biophysical research communications.. 1997 May 19234 (2):481-4. Epub 1900 01 01.

Immunolocalization of microsomal glutathione S-transferase in rat tissues.

Otieno MA, Baggs RB, Hayes JD, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1997 January 25 (1):12-20. Epub 1900 01 01.

Physiologically based pharmacokinetic analysis of the concentration-dependent metabolism of halothane.

Loizou GD, Tran CL, Anders MW

Xenobiotica; the fate of foreign compounds in biological systems.. 1997 January 27 (1):87-99. Epub 1900 01 01.

Liver abnormalities and hydrochlorofluorocarbons

Anders,M. W.; Dekant,W.;.

Lancet. 1997; 350(9086): 1249; author reply 1249-50.

Cysteine conjugate beta-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product compound A in human, nonhuman primate, and rat kidney cytosol and mitochondria.

Iyer RA, Anders MW

Anesthesiology.. 1996 December 85 (6):1454-61. Epub 1900 01 01.

Enantioselective depletion of mitochondrial glutathione concentrations by (S)- and (R)-3-hydroxy-4-pentenoate.

Hashmi M, Gräf S, Braun M, Anders MW

Chemical research in toxicology.. 1996 March 9 (2):361-4. Epub 1900 01 01.

Preferential proteolysis and activation of oxidatively modified liver microsomal glutathione S-transferase of rat.

Shimoji M, Aniya Y, Anders MW

Biological & pharmaceutical bulletin.. 1996 February 19 (2):209-13. Epub 1900 01 01.

Application of computational chemistry in the study of biologically reactive intermediates.

Anders MW, Yin H, Jones JP

Advances in experimental medicine and biology.. 1996 387 :347-53. Epub 1900 01 01.

Bone marrow and renal injury associated with haloalkene cysteine conjugates in calves.

Lock EA, Sani Y, Moore RB, Finkelstein MB, Anders MW, Seawright AA

Archives of toxicology.. 1996 70 (10):607-19. Epub 1900 01 01.

Reaction of trifluoroacetaldehyde with amino acids, nucleotides, lipid nucleophiles, and their analogs.

Yin H, Crowder RJ, Jones JP, Anders MW

Chemical research in toxicology.. 1996 9 (1):140-6. Epub 1900 01 01.

Cysteine conjugate beta-lyase-catalyzed bioactivation of bromine-containing cysteine S-conjugates: stoichiometry and formation of 2,2-difluoro-3-halothiiranes.

Finkelstein MB, Dekant W, Anders MW

Chemical research in toxicology.. 1996 9 (1):227-31. Epub 1900 01 01.

Metabolism of 1,2-dichloro-1-fluoroethane and 1-fluoro-1,2,2-trichloroethane: electronic factors govern the regioselectivity of cytochrome P450-dependent oxidation.

Yin H, Anders MW, Jones JP

Chemical research in toxicology.. 1996 9 (1):50-7. Epub 1900 01 01.

Designing safer chemicals: predicting the rates of metabolism of halogenated alkanes.

Yin H, Anders MW, Korzekwa KR, Higgins L, Thummel KE, Kharasch ED, Jones JP

Proceedings of the National Academy of Sciences of the United States of America.. 1995 November 2192 (24):11076-80. Epub 1900 01 01.

Gas-uptake pharmacokinetics and metabolism of 2-chloro-1,1,1,2-tetrafluoroethane (HCFC-124) in the rat, mouse, and hamster.

Loizou GD, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1995 August 23 (8):875-80. Epub 1900 01 01.

Mitochondrial bioactivation of cysteine S-conjugates and 4-thiaalkanoates: implications for mitochondrial dysfunction and mitochondrial diseases.

Anders MW

Biochimica et biophysica acta.. 1995 May 241271 (1):51-7. Epub 1900 01 01.

Medium-chain acyl-CoA dehydrogenase- and enoyl-CoA hydratase-dependent bioactivation of 5,6-dichloro-4-thia-5-hexenoyl-CoA.

Fitzsimmons ME, Thorpe C, Anders MW

Biochemistry.. 1995 April 434 (13):4276-86. Epub 1900 01 01.

Metabolism of 1-fluoro-1,1,2-trichloroethane, 1,2-dichloro-1,1-difluoroethane, and 1,1,1-trifluoro-2-chloroethane.

Yin H, Jones JP, Anders MW

Chemical research in toxicology.. 1995 March 8 (2):262-8. Epub 1900 01 01.

Metabolism of [14C]- and [35S]S-(1,2-dichlorovinyl)-L-cysteine in the male Fischer 344 rat.

Finkelstein MB, Patel NJ, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1995 January 23 (1):124-8. Epub 1900 01 01.

Biosynthesis of S-(2-chloro-1,1,2-trifluoroethyl)glutathione in rat and human hepatocytes and in Hep G2 cells.

Tanaka E, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1995 January 23 (1):48-54. Epub 1900 01 01.

Fourier-transform ion cyclotron resonance mass spectrometric evidence for the formation of alpha-chloroenethiolates and thioketenes from chloroalkene-derived, cytotoxic 4-thiaalkanoates.

Zhang TL, Wang L, Hashmi M, Anders MW, Thorpe C, Ridge DP

Chemical research in toxicology.. 1995 8 (7):907-10. Epub 1900 01 01.

Nephrotoxicity and hepatotoxicity of 5,6-dichloro-4-thia-5-hexenoic acid: evidence for fatty acid beta-oxidation-dependent bioactivation.

Fitzsimmons ME, Baggs RB, Anders MW

The Journal of pharmacology and experimental therapeutics.. 1994 October 271 (1):515-23. Epub 1900 01 01.

Metabolism of tetrachloroethene in rats: identification of N epsilon-(dichloroacetyl)-L-lysine and N epsilon-(trichloroacetyl)-L-lysine as protein adducts.

Birner G, Richling C, Henschler D, Anders MW, Dekant W

Chemical research in toxicology.. 1994 7 (6):724-32. Epub 1900 01 01.

Tissue distribution and stereoselectivity of remacemide-glycine hydrolase.

Heyn H, Bankmann YG, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1994 22 (6):973-4. Epub 1900 01 01.

Gas-uptake pharmacokinetics of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123).

Loizou GD, Urban G, Dekant W, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1994 22 (4):511-7. Epub 1900 01 01.

Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway.

Dekant W, Vamvakas S, Anders MW

Advances in pharmacology.. 1994 27 :115-62. Epub 1900 01 01.

Aminoacylases.

Anders MW, Dekant W

Advances in pharmacology.. 1994 27 :431-48. Epub 1900 01 01.

Bioconversion of prodrugs by conjugate-processing enzymes.

Vamvakas S, Anders MW

Advances in pharmacology.. 1994 27 :479-99. Epub 1900 01 01.

Brain uptake and biotransformation of remacemide hydrochloride, a novel anticonvulsant.

Heyn H, McCarthy DJ, Curry SH, Eisman MS, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1994 22 (3):443-6. Epub 1900 01 01.

Bioactivation of [13C]dichloromethane in mouse, rat, and human liver cytosol: 13C nuclear magnetic resonance spectroscopic studies.

Hashmi M, Dechert S, Dekant W, Anders MW

Chemical research in toxicology.. 1994 7 (3):291-6. Epub 1900 01 01.

Glutathione-dependent biosynthesis and bioactivation of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of dichloroacetylene, in rat tissues and subcellular fractions.

Patel N, Birner G, Dekant W, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1994 22 (1):143-7. Epub 1900 01 01.

Structure-mutagenicity and structure-cytotoxicity studies on bromine-containing cysteine S-conjugates and related compounds.

Finkelstein MB, Vamvakas S, Bittner D, Anders MW

Chemical research in toxicology.. 1994 7 (2):157-63. Epub 1900 01 01.

Brain uptake of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of the neurotoxin dichloroacetylene.

Patel NJ, Fullone JS, Anders MW

Brain research. Molecular brain research.. 1993 January 17 (1-2):53-8. Epub 1900 01 01.

Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b).

Loizou GD, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1993 21 (4):634-9. Epub 1900 01 01.

Slow-binding inhibition of carboxylesterase and other serine hydrolases by chlorodifluoroacetaldehyde.

Yin H, Jones JP, Anders MW

Chemical research in toxicology.. 1993 6 (5):630-4. Epub 1900 01 01.

Fatty acid beta-oxidation-dependent bioactivation of halogenated thiaalkanoic acids in isolated rat hepatocytes.

Fitzsimmons ME, Anders MW

Chemical research in toxicology.. 1993 6 (5):662-8. Epub 1900 01 01.

Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death.

Shan X, Jones DP, Hashmi M, Anders MW

Chemical research in toxicology.. 1993 6 (1):75-81. Epub 1900 01 01.

Events that precede and that follow S-(1,2-dichlorovinyl)-L-cysteine-induced release of mitochondrial Ca2+ and their association with cytotoxicity to renal cells.

Vamvakas S, Bittner D, Dekant W, Anders MW

Biochemical pharmacology.. 1992 September 2544 (6):1131-8. Epub 1900 01 01.

L-cysteine and S-(1,2-dichlorovinyl)-L-cysteine transport in rat liver canalicular membrane vesicles: potential reabsorption mechanisms for biliary metabolites of glutathione and its S-conjugates.

Simmons TW, Anders MW, Ballatori N

The Journal of pharmacology and experimental therapeutics.. 1992 September 262 (3):1182-8. Epub 1900 01 01.

Synthesis of [2-3H-ethyl]S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine and its use in covalent-binding studies.

Harris JW, Fitzsimmons ME, Anders MW

Analytical biochemistry.. 1992 August 1204 (2):300-4. Epub 1900 01 01.

Activation of rat liver microsomal glutathione S-transferase by hydrogen peroxide: role for protein-dimer formation.

Aniya Y, Anders MW

Archives of biochemistry and biophysics.. 1992 August 1296 (2):611-6. Epub 1900 01 01.

Nephrotoxicity of the glutathione and cysteine conjugates of 2-bromo-2-chloro-1,1-difluoroethene.

Finkelstein MB, Baggs RB, Anders MW

The Journal of pharmacology and experimental therapeutics.. 1992 June 261 (3):1248-52. Epub 1900 01 01.

Enhancement of biological activity by conjugation reactions.

Olson JA, Moon RC, Anders MW, Fenselau C, Shane B

The Journal of nutrition.. 1992 March 122 (3 Suppl):615-24. Epub 1900 01 01.

Glutathione-dependent toxicity.

Anders MW, Dekant W, Vamvakas S

Xenobiotica; the fate of foreign compounds in biological systems.. 1992 22 (9-10):1135-45. Epub 1900 01 01.

Pentahaloethane-based chlorofluorocarbon substitutes and halothane: correlation of in vivo hepatic protein trifluoroacetylation and urinary trifluoroacetic acid excretion with calculated enthalpies of activation.

Harris JW, Jones JP, Martin JL, LaRosa AC, Olson MJ, Pohl LR, Anders MW

Chemical research in toxicology.. 1992 5 (5):720-5. Epub 1900 01 01.

Bioactivation mechanism of S-(3-oxopropyl)-N-acetyl-L-cysteine, the mercapturic acid of acrolein.

Hashmi M, Vamvakas S, Anders MW

Chemical research in toxicology.. 1992 5 (3):360-5. Epub 1900 01 01.

In vivo detection and characterization of protein adducts resulting from bioactivation of haloethene cysteine S-conjugates by 19F NMR: chlorotrifluoroethene and tetrafluoroethene.

Harris JW, Dekant W, Anders MW

Chemical research in toxicology.. 1992 5 (1):34-41. Epub 1900 01 01.

Flavin-containing monooxygenase-dependent stereoselective S-oxygenation and cytotoxicity of cysteine S-conjugates and mercapturates.

Park SB, Osterloh JD, Vamvakas S, Hashmi M, Anders MW, Cashman JR

Chemical research in toxicology.. 1992 5 (2):193-201. Epub 1900 01 01.

Metabolism and toxicity of hydrochlorofluorocarbons: current knowledge and needs for the future.

Anders MW

Environmental health perspectives.. 1991 December 96 :185-91. Epub 1900 01 01.

Immunochemical detection of covalently modified kidney proteins in S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-treated rats.

Hargus SJ, Anders MW

Biochemical pharmacology.. 1991 October 2442 (10):R17-20. Epub 1900 01 01.

Enzymatic reaction of beta-N-methylaminoalanine with L-amino acid oxidase.

Hashmi M, Anders MW

Biochimica et biophysica acta.. 1991 May 241074 (1):36-9. Epub 1900 01 01.

In vivo metabolism of the hydrochlorofluorocarbon 1,1-dichloro-1-fluoroethane (HCFC-141b).

Harris JW, Anders MW

Biochemical pharmacology.. 1991 May 141 (9):R13-6. Epub 1900 01 01.

Tissue acylation by the chlorofluorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane.

Harris JW, Pohl LR, Martin JL, Anders MW

Proceedings of the National Academy of Sciences of the United States of America.. 1991 February 1588 (4):1407-10. Epub 1900 01 01.

Stereochemistry of the microsomal glutathione S-transferase catalyzed addition of glutathione to chlorotrifluoroethene.

Hargus SJ, Fitzsimmons ME, Aniya Y, Anders MW

Biochemistry.. 1991 January 2230 (3):717-21. Epub 1900 01 01.

Biosynthesis and biliary excretion of S-conjugates of hexachlorobuta-1,3-diene in the perfused rat liver.

Gietl YS, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1991 19 (1):274-7. Epub 1900 01 01.

Intestinal absorption of S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene.

Gietl Y, Vamvakas S, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1991 19 (3):703-7. Epub 1900 01 01.

Metabolism of the hydrochlorofluorocarbon 1,2-dichloro-1,1-difluoroethane.

Harris JW, Anders MW

Chemical research in toxicology.. 1991 4 (2):180-6. Epub 1900 01 01.

Formation of reactive intermediates by phase II enzymes: glutathione-dependent bioactivation reactions.

Vamvakas S, Anders MW

Advances in experimental medicine and biology.. 1991 283 :13-24. Epub 1900 01 01.

Fatty acid beta-oxidation-dependent bioactivation of 5,6-dichloro-4-thia-5-hexenoate and analogs in isolated rat hepatocytes.

Fitzsimmons ME, Anders MW

Advances in experimental medicine and biology.. 1991 283 :281-4. Epub 1900 01 01.

Stereochemistry of the microsomal glutathione S-transferase-catalyzed addition of glutathione to chlorotrifluoroethene in isolated rat hepatocytes.

Hargus SJ, Fitzsimmons ME, Anders MW

Advances in experimental medicine and biology.. 1991 283 :289-93. Epub 1900 01 01.

The use of 19F NMR in the study of protein alkylation by fluorinated reactive intermediates.

Harris JW, Anders MW

Advances in experimental medicine and biology.. 1991 283 :735-8. Epub 1900 01 01.

Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates.

Vamvakas S, Sharma VK, Sheu SS, Anders MW

Molecular pharmacology.. 1990 October 38 (4):455-61. Epub 1900 01 01.

Glutathione conjugate mediated toxicities.

Monks TJ, Anders MW, Dekant W, Stevens JL, Lau SS, van Bladeren PJ

Toxicology and applied pharmacology.. 1990 October 106 (1):1-19. Epub 1900 01 01.

Perturbation of calcium homeostasis as a link between acute cell injury and carcinogenesis in the kidney.

Vamvakas S, Anders MW

Toxicology letters.. 1990 September 53 (1-2):115-20. Epub 1900 01 01.

Biosynthesis, bioactivation, and mutagenicity of S-conjugates.

Dekant W, Vamvakas S, Anders MW

Toxicology letters.. 1990 September 53 (1-2):53-8. Epub 1900 01 01.

Bioactivation of hexachlorobutadiene by glutathione conjugation.

Dekant W, Vamvakas S, Anders MW

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.. 1990 April 28 (4):285-93. Epub 1900 01 01.

Bioactivation mechanism of cytotoxic homocysteine S-conjugates.

Lash LH, Elfarra AA, Rakiewicz-Nemeth D, Anders MW

Archives of biochemistry and biophysics.. 1990 February 1276 (2):322-30. Epub 1900 01 01.

Glutathione-dependent bioactivation of xenobiotics: implications for mutagenicity and carcinogenicity.

Anders MW

Princess Takamatsu symposia. 1990 21 :89-99. Epub 1900 01 01.

Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity.

Lash LH, Nelson RM, Van Dyke RA, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1990 18 (1):50-4. Epub 1900 01 01.

Glutamine transaminase K and cysteine conjugate beta-lyase.

Cooper AJ, Anders MW

Annals of the New York Academy of Sciences.. 1990 585 :118-27. Epub 1900 01 01.

Formation of highly reactive vinylglyoxylate (2-oxo-3-butenoate) from amino acids with good leaving groups in the gamma-position. Toxicological implications and therapeutic potential.

Cooper AJ, Hollander MM, Anders MW

Biochemical pharmacology.. 1989 November 1538 (22):3895-901. Epub 1900 01 01.

Bioactivation mechanism of L-thiomorpholine-3-carboxylic acid.

Webster KD, Anders MW

Archives of biochemistry and biophysics.. 1989 September 273 (2):562-71. Epub 1900 01 01.

Inhibition of rat kidney mitochondrial DNA, RNA and protein synthesis by halogenated cysteine S-conjugates.

Banki K, Anders MW

Carcinogenesis.. 1989 April 10 (4):767-72. Epub 1900 01 01.

Regulation of rat liver microsomal glutathione S-transferase activity by thiol/disulfide exchange.

Aniya Y, Anders MW

Archives of biochemistry and biophysics.. 1989 April 270 (1):330-4. Epub 1900 01 01.

Mutagenicity of benzyl S-haloalkyl and S-haloalkenyl sulfides in the Ames-test.

Vamvakas S, Dekant W, Anders MW

Biochemical pharmacology.. 1989 March 1538 (6):935-9. Epub 1900 01 01.

Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species.

Aniya Y, Anders MW

The Journal of biological chemistry.. 1989 February 5264 (4):1998-2002. Epub 1900 01 01.

Uptake of nephrotoxic S-conjugates by isolated rat renal proximal tubular cells.

Lash LH, Anders MW

The Journal of pharmacology and experimental therapeutics.. 1989 February 248 (2):531-7. Epub 1900 01 01.

Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate beta-lyase.

Dekant W, Vamvakas S, Anders MW

Drug metabolism reviews.. 1989 20 (1):43-83. Epub 1900 01 01.

Mutagenicity of amino acid and glutathione S-conjugates in the Ames test.

Vamvakas S, Elfarra AA, Dekant W, Henschler D, Anders MW

Mutation research.. 1988 September 206 (1):83-90. Epub 1900 01 01.

Isozyme selective arylation of cytosolic glutathione S-transferase by [14C]bromobenzene metabolites.

Aniya Y, McLenithan JC, Anders MW

Biochemical pharmacology.. 1988 January 1537 (2):251-7. Epub 1900 01 01.

Enzymatic conjugation of hexachloro-1,3-butadiene with glutathione. Formation of 1-(glutathion-S-yl)-1,2,3,4,4-pentachlorobuta-1,3-diene and 1,4-bis(glutathion-S-yl)-1,2,3,4-tetrachlorobuta-1,3-diene.

Dekant W, Vamvakas S, Henschler D, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1988 16 (5):701-6. Epub 1900 01 01.

Cytotoxicity and bioactivation mechanism of benzyl 2-chloro-1,1,2-trifluoroethyl sulfide and benzyl 1,2,3,4,4-pentachlorobuta-1,3-dienyl sulfide.

Veltman JC, Dekant W, Guengerich FP, Anders MW

Chemical research in toxicology.. 1988 1 (1):35-40. Epub 1900 01 01.

Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate beta-lyase.

Dekant W, Berthold K, Vamvakas S, Henschler D, Anders MW

Chemical research in toxicology.. 1988 1 (3):175-8. Epub 1900 01 01.

Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites.

Anders MW, Lash L, Dekant W, Elfarra AA, Dohn DR

Critical reviews in toxicology.. 1988 18 (4):311-41. Epub 1900 01 01.

Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine.

Dekant W, Lash LH, Anders MW

Proceedings of the National Academy of Sciences of the United States of America.. 1987 November 84 (21):7443-7. Epub 1900 01 01.

Cytotoxicity of N,N-bis(2-chloroethyl)-N-nitrosourea in hypoxic rat hepatocytes.

Veltman JC, Anders MW

Cancer research.. 1987 October 147 (19):5087-91. Epub 1900 01 01.

Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity.

Lash LH, Anders MW

Molecular pharmacology.. 1987 October 32 (4):549-56. Epub 1900 01 01.

Role for an episulfonium ion in S-(2-chloroethyl)-DL-cysteine-induced cytotoxicity and its reaction with glutathione.

Webb WW, Elfarra AA, Webster KD, Thom RE, Anders MW

Biochemistry.. 1987 June 226 (11):3017-23. Epub 1900 01 01.

Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine.

Elfarra AA, Lash LH, Anders MW

Molecular pharmacology.. 1987 February 31 (2):208-12. Epub 1900 01 01.

Cellular effects of reactive intermediates: nephrotoxicity of S-conjugates of amino acids.

Anders MW, Elfarra AA, Lash LH

Archives of toxicology.. 1987 60 (1-3):103-8. Epub 1900 01 01.

S-(1,2-dichlorovinyl)-L-homocysteine-induced cytotoxicity in isolated rat kidney cells.

Lash LH, Elfarra AA, Anders MW

Archives of biochemistry and biophysics.. 1986 December 251 (2):432-9. Epub 1900 01 01.

Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells.

Lash LH, Anders MW

The Journal of biological chemistry.. 1986 October 5261 (28):13076-81. Epub 1900 01 01.

Metabolism of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine to hydrogen sulfide and the role of hydrogen sulfide in S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine-induced mitochondrial toxicity.

Banki K, Elfarra AA, Lash LH, Anders MW

Biochemical and biophysical research communications.. 1986 July 31138 (2):707-13. Epub 1900 01 01.

Thiol stimulation of the cytochrome P-450-dependent reduction of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD).

Kelner MJ, McLenithan JC, Anders MW

Biochemical pharmacology.. 1986 June 135 (11):1805-7. Epub 1900 01 01.

Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane.

Lash LH, Elfarra AA, Anders MW

The Journal of biological chemistry.. 1986 May 5261 (13):5930-5. Epub 1900 01 01.

Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates.

Elfarra AA, Lash LH, Anders MW

Proceedings of the National Academy of Sciences of the United States of America.. 1986 April 83 (8):2667-71. Epub 1900 01 01.

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity.

Elfarra AA, Jakobson I, Anders MW

Biochemical pharmacology.. 1986 January 1535 (2):283-8. Epub 1900 01 01.

Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation.

Anders MW, Lash LH, Elfarra AA

Advances in experimental medicine and biology.. 1986 197 :443-55. Epub 1900 01 01.

Coupling of ATP synthesis to reversal of rat liver microsomal Ca2+-ATPase.

Webb WW, Anders MW

Biochemistry.. 1985 December 1724 (26):7741-5. Epub 1900 01 01.

Alteration of hepatic glutathione S-transferases and release into serum after treatment with bromobenzene, carbon tetrachloride, or N-nitrosodimethylamine.

Aniya Y, Anders MW

Biochemical pharmacology.. 1985 December 1534 (24):4239-44. Epub 1900 01 01.

Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene.

Dohn DR, Leininger JR, Lash LH, Quebbemann AJ, Anders MW

The Journal of pharmacology and experimental therapeutics.. 1985 December 235 (3):851-7. Epub 1900 01 01.

Purification and characterization of S-phenacylglutathione reductase from rat liver.

Kitada M, McLenithan JC, Anders MW

The Journal of biological chemistry.. 1985 September 25260 (21):11749-54. Epub 1900 01 01.

Enzymatic reaction of chlorotrifluoroethene with glutathione: 19F NMR evidence for stereochemical control of the reaction.

Dohn DR, Quebbemann AJ, Borch RF, Anders MW

Biochemistry.. 1985 September 1024 (19):5137-43. Epub 1900 01 01.

Structure-nephrotoxicity relationships of S-(2-chloroethyl)-DL-cysteine and analogs: role for an episulfonium ion.

Elfarra AA, Baggs RB, Anders MW

The Journal of pharmacology and experimental therapeutics.. 1985 May 233 (2):512-6. Epub 1900 01 01.

Chloroform-induced alteration of glutathione S-transferase activity.

Aniya Y, Anders MW

Biochemical pharmacology.. 1985 January 1534 (2):249-55. Epub 1900 01 01.

Evidence for the metabolism of N-nitrosodimethylamine and carbon tetrachloride by a common isozyme of cytochrome P-450.

English JC, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1985 13 (4):449-52. Epub 1900 01 01.

Biotransformation of halogenated solvents.

Anders MW, Jakobson I

Scandinavian journal of work, environment & health.. 1985 11 Suppl 1 :23-32. Epub 1900 01 01.

Renal processing of glutathione conjugates. Role in nephrotoxicity.

Elfarra AA, Anders MW

Biochemical pharmacology.. 1984 December 133 (23):3729-32. Epub 1900 01 01.

Mechanism of the metabolism of 1,3-benzodioxoles to carbon monoxide.

Anders MW, Sunram JM, Wilkinson CF

Biochemical pharmacology.. 1984 February 1533 (4):577-80. Epub 1900 01 01.

The enzymatic reaction of chlorotrifluoroethylene with glutathione.

Dohn DR, Anders MW

Biochemical and biophysical research communications.. 1982 December 31109 (4):1339-45. Epub 1900 01 01.

Effect of hypoxia on carbon tetrachloride hepatotoxicity.

Shen ES, Garry VF, Anders MW

Biochemical pharmacology.. 1982 December 131 (23):3787-93. Epub 1900 01 01.

Glutathione-dependent reductive dehalogenation of 2,2',4'-trichloroacetophenone to 2',4'-dichloroacetophenone.

Brundin A, Ratnayake JH, Sunram JM, Anders MW

Biochemical pharmacology.. 1982 December 131 (23):3885-90. Epub 1900 01 01.

Transplacental passage of dichloromethane and carbon monoxide.

Anders MW, Sunram JM

Toxicology letters.. 1982 August 12 (4):231-4. Epub 1900 01 01.

Bioactivation of halogenated hydrocarbons.

Anders MW

Journal of toxicology. Clinical toxicology.. 1982 August 19 (6-7):699-706. Epub 1900 01 01.

Interactive hepatotoxicity of chloroform and carbon tetrachloride.

Harris RN, Ratnayake JH, Garry VF, Anders MW

Toxicology and applied pharmacology.. 1982 April 63 (2):281-91. Epub 1900 01 01.

Assay of cysteine conjugate beta-lyase activity with S-(2-benzothiazolyl)cysteine as the substrate.

Dohn DR, Anders MW

Analytical biochemistry.. 1982 March 1120 (2):379-86. Epub 1900 01 01.

Gas chromatographic-mass spectrometric analysis of [13C]carbon monoxide.

Swanson AR, Anders MW

Journal of chromatography.. 1982 January 1234 (1):268. Epub 1900 01 01.

Stereochemistry of the glutathione-dependent biotransformation of vicinal-dihaloalkanes to alkenes.

Livesey JC, Anders MW, Langvardt PW, Putzig CL, Reitz RH

Drug metabolism and disposition : the biological fate of chemicals.. 1982 10 (3):201-4. Epub 1900 01 01.

Salicylate enhancement of renal glucuronide conjugation and tubular excretory transfer of phenols.

Diamond GL, Anders MW, Tremaine LM, Quebbemann AJ

Drug metabolism and disposition : the biological fate of chemicals.. 1982 10 (6):573-8. Epub 1900 01 01.

Metabolism of haloforms to carbon monoxide. IV. studies on the reaction mechanism in vivo.

Stevens JL, Anders MW

Chemico-biological interactions.. 1981 November 37 (3):365-74. Epub 1900 01 01.

Effect of cysteine, diethyl maleate, and phenobarbital treatments on the hepatotoxicity of [1H]chloroform.

Stevens JL, Anders MW

Chemico-biological interactions.. 1981 October 37 (1-2):207-17. Epub 1900 01 01.

Phosgene: a possible role in the potentiation of carbon tetrachloride hepatotoxicity by 2-propanol.

Harris RN, Anders MW

Life sciences.. 1981 August 329 (5):503-7. Epub 1900 01 01.

Mechanism of the microsomal reduction of carbon tetrachloride and halothane.

Kubic VL, Anders MW

Chemico-biological interactions.. 1981 March 134 (2):201-7. Epub 1900 01 01.

Sulfoxide reduction. In vitro reduction of sulindac by rat hepatic cytosolic enzymes.

Ratnayake JH, Hanna PE, Anders MW, Duggan DE

Drug metabolism and disposition : the biological fate of chemicals.. 1981 9 (2):85-7. Epub 1900 01 01.

Thioredoxin-dependent sulfoxide reduction by rat renal cytosol.

Anders MW, Ratnayake JH, Hanna PE, Fuchs JA

Drug metabolism and disposition : the biological fate of chemicals.. 1981 9 (4):307-10. Epub 1900 01 01.

2-Propanol treatment induces selectively the metabolism of carbon tetrachloride to phosgene. Implications for carbon tetrachloride hepatotoxicity.

Harris RN, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1981 9 (6):551-6. Epub 1900 01 01.

Effect of 2-propanol treatment on carbon tetrachloride metabolism and toxicity.

Anders MW, Harris RN

Advances in experimental medicine and biology.. 1981 136 Pt A :591-602. Epub 1900 01 01.

Involvement of thioredoxin in sulfoxide reduction by mammalian tissues.

Anders MW, Ratnayake JH, Hanna PE, Fuchs JA

Biochemical and biophysical research communications.. 1980 December 1697 (3):846-51. Epub 1900 01 01.

Halogenated methanes: metabolism and toxicity.

Ahmed AE, Kubic VL, Stevens JL, Anders MW

Federation proceedings.. 1980 November 39 (13):3150-5. Epub 1900 01 01.

Metabolism of drugs by the kidney.

Anders MW

Kidney international.. 1980 November 18 (5):636-47. Epub 1900 01 01.

Effect of fasting, diethyl maleate, and alcohols on carbon tetrachloride-induced hepatotoxicity.

Harris RN, Anders MW

Toxicology and applied pharmacology.. 1980 November 56 (2):191-8. Epub 1900 01 01.

Metabolism of dihalomethanes to carbon monoxide. IV. Studies in isolated rat hepatocytes.

Stevens JL, Ratnayake JH, Anders MW

Toxicology and applied pharmacology.. 1980 September 3055 (3):484-9. Epub 1900 01 01.

Metabolism of carbon tetrachloride to phosgene.

Kubic VL, Anders MW

Life sciences.. 1980 June 2326 (25):2151-5. Epub 1900 01 01.

Generation of carbon monoxide during the microsomal metabolism of methylenedioxyphenyl compounds.

Yu LS, Wilkinson CF, Anders MW

Biochemical pharmacology.. 1980 April 1529 (8):1113-22. Epub 1900 01 01.

Generation of hydroxyl radical by enzymes, chemicals, and human phagocytes in vitro. Detection with the anti-inflammatory agent, dimethyl sulfoxide.

Repine JE, Eaton JW, Anders MW, Hoidal JR, Fox RB

The Journal of clinical investigation.. 1979 December 64 (6):1642-51. Epub 1900 01 01.

Metabolism of haloforms to carbon monoxide--III. Studies on the mechanism of the reaction.

Stevens JL, Anders MW

Biochemical pharmacology.. 1979 November 128 (21):3189-94. Epub 1900 01 01.

Acetone enhancement of cumene hydroperoxide supported microsomal aniline hydroxylation.

Anders MW, Gander JE

Life sciences.. 1979 September 1725 (12):1085-9. Epub 1900 01 01.

Phthalate interference in gas-chromatographic determination of long-chain fatty acids in plasma.

Geisler C, Swanson AR, Zieve L, Anders MW

Clinical chemistry.. 1979 February 25 (2):308-10. Epub 1900 01 01.

In vitro metabolism of 1,2-dihaloethanes to ethylene.

Livesey JC, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1979 7 (4):199-203. Epub 1900 01 01.

Oxygen metabolism in rabbit bone marrow and liver.

Hanson SK, Anders MW, Montgomery MR

Biochemical and biophysical research communications.. 1978 November 2985 (2):783-7. Epub 1900 01 01.

Microdetermination of caffeine in blood by gas chromatography--mass spectrometry.

Merriman RL, Swanson A, Anders MW, Sladek NE

Journal of chromatography.. 1978 July 1146 (1):85-90. Epub 1900 01 01.

Inhibition and enhancement of microsomal drug metabolism by diethyl maleate.

Anders MW

Biochemical pharmacology.. 1978 April 127 (7):1098-101. Epub 1900 01 01.

Effect of agents known to alter carbon tetrachloride hepatotoxicity and cytochrome P-450 levels on carbon tetrachloride-stimulated lipid peroxidation and ethane expiration in the intact rat.

Lindstrom TD, Anders MW

Biochemical pharmacology.. 1978 February 1527 (4):563-7. Epub 1900 01 01.

Effect of phenobarbital and diethyl maleate on carbon tetrachloride toxicity in isolated rat hepatocytes.

Lindstrom TD, Anders MW, Remmer H

Experimental and molecular pathology.. 1978 February 28 (1):48-57. Epub 1900 01 01.

Microsomal N-hydroxylation of trans-4'-alkoxy-4-acetamidostilbenes.

Gammans RE, Sehon RD, Anders MW, Hanna PE

Drug metabolism and disposition : the biological fate of chemicals.. 1978 6 (3):226-31. Epub 1900 01 01.

Metabolism of haloforms to carbon monoxide. II. In vivo studies.

Anders MW, Stevens JL, Sprague RW, Shaath Z, Ahmed AE

Drug metabolism and disposition : the biological fate of chemicals.. 1978 6 (5):556-60. Epub 1900 01 01.

Metabolism of dihalomethanes to formaldehyde and inorganic halide--II. Studies on the mechanism of the reaction.

Ahmed AE, Anders MW

Biochemical pharmacology.. 1978 27 (16):2021-5. Epub 1900 01 01.

Metabolism of dihalomethanes to carbon monoxide--III. Studies on the mechanism of the reaction.

Kubic VL, Anders MW

Biochemical pharmacology.. 1978 27 (19):2349-55. Epub 1900 01 01.

Metabolic disposition of cephalothin and deacetylcephalothin in children and adults: comparison of high-performance liquid chromatographic and microbial assay procedures.

Rolewicz TF, Mirkin BL, Cooper MJ, Anders MW

Clinical pharmacology and therapeutics.. 1977 December 22 (6):928-35. Epub 1900 01 01.

Effect of cycloheximide and actinomycin D on carbon tetrachloride hepatotoxicity.

Lindstrom TD, Anders MW

Toxicology and applied pharmacology.. 1977 October 42 (1):167-73. Epub 1900 01 01.

A rapid micromethod for the high-performance liquid chromatographic determination of theophylline in human serum.

Cooper MJ, Mirkin BL, Anders MW

Journal of chromatography.. 1977 May 1143 (3):324-6. Epub 1900 01 01.

Metabolism of haloforms to carbon monoxide. I. In vitro studies.

Ahmed AE, Kubic VL, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1977 5 (2):198-204. Epub 1900 01 01.

Microsomal N-hydroxylation of trans-4'-halo-4-acetamidostilbenes.

Gammans RE, Sehon RD, Anders MW, Hanna PE

Drug metabolism and disposition : the biological fate of chemicals.. 1977 5 (3):310-6. Epub 1900 01 01.

Metabolism of halogenated methanes and macromolecular binding.

Anders MW, Kubic VL, Ahmed AE

Journal of environmental pathology and toxicology. 1977 1 (2):117-24. Epub 1900 01 01.

Human intoxication following inhalation exposure to synthetic jet lubricating oil.

Montgomery MR, Wier GT, Zieve FJ, Anders MW

Clinical toxicology. 1977 11 (4):423-6. Epub 1900 01 01.

High pressure liquid chromatographic determination of hydrochlorothiazide in human serum and urine.

Cooper MJ, Sinaiko AR, Anders MW, Mirkin BL

Analytical chemistry.. 1976 July 48 (8):1110-1. Epub 1900 01 01.

Metabolism of dihalomethanes to formaldehyde and inorganic halide. I. In vitro studies.

Ahmed AE, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1976 4 (4):357-61. Epub 1900 01 01.

High pressure liquid chromatography of fatty acids and lipids.

Cooper MJ, Anders MW

Journal of chromatographic science.. 1975 September 13 (9):407-11. Epub 1900 01 01.

Gas chromatographic microdetermination of acetanilide in blood.

Cooper MJ, anders MW

Journal of chromatography.. 1975 January 29104 (1):215-6. Epub 1900 01 01.

Metabolism of dihalomethanes to carbon monoxide. II. In vitro studies.

Kubic VL, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1975 3 (2):104-12. Epub 1900 01 01.

Metabolic and pharmacodynamic interactions of enantiomers of propoxyphene and methorphan.

Cooper MJ, Anders MW

Life sciences.. 1974 November 115 (9):1665-72. Epub 1900 01 01.

Determination of long chain fatty acids as 2-naphthacyl esters by high pressure liquid chromatography and mass spectrometry.

Cooper MJ, Anders MW

Analytical chemistry.. 1974 October 46 (12):1849-52. Epub 1900 01 01.

Conformationally restricted analogs of histamine H1 receptor antagonists. 2-Phenyl- and 2-benzyl-1,2,3,4-tetrahydro-4-dimethylaminoisoquinoline.

Hanna PE, Grund VR, Anders MW

Journal of medicinal chemistry.. 1974 September 17 (9):1020-3. Epub 1900 01 01.

Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins.

Maines MD, Anders MW, Muller-Eberhard U

Molecular pharmacology.. 1974 March 10 (2):204-13. Epub 1900 01 01.

Metabolism of dihalomethanes to carbon monoxide. I. In vivo studies.

Kubic VL, Anders MW, Engel RR, Barlow CH, Caughey WS

Drug metabolism and disposition : the biological fate of chemicals.. 1974 2 (1):53-7. Epub 1900 01 01.

Characterization of the heme of cytochrome P-450 using gas chromatography-mass spectrometry.

Maines MD, Anders MW

Archives of biochemistry and biophysics.. 1973 November 159 (1):201-5. Epub 1900 01 01.

Aflatoxin detection by high-speed liquid chromatography and mass spectrometry.

Rao GH, Anders MW

Journal of chromatography.. 1973 September 2684 (2):402-6. Epub 1900 01 01.

High-speed liquid chromatographic analysis of prostaglandins in rat kidney.

Dunham EW, Anders MW

Prostaglandins.. 1973 July 4 (1):85-92. Epub 1900 01 01.

Effect of phenobarbital treatment of the sterochemistry of the in vitro metabolism of ethylbenzene.

Maylin GA, Cooper MJ, Anders MW

Journal of medicinal chemistry.. 1973 June 16 (6):606-10. Epub 1900 01 01.

Renal tubular conjugation and excretion of phenol and p-nitrophenol in the chicken: differing mechanisms of renal transfer.

Quebbemann AJ, Anders MW

The Journal of pharmacology and experimental therapeutics.. 1973 March 184 (3):695-708. Epub 1900 01 01.

Reconstitution of carbon monoxide-binding particles after removal of heme by serum albumin.

Maines MD, Anders MW

Molecular pharmacology.. 1973 March 9 (2):219-28. Epub 1900 01 01.

Inhibition of microsomal drug metabolism by anticholinesterase insecticides.

Gundu Rao HR, Anders MW

Bulletin of environmental contamination and toxicology.. 1973 January 9 (1):4-9. Epub 1900 01 01.

The possible implication of heme transfer from cytochrome P-420 to albumin in the metabolism of cytochrome P-450.

Maines MD, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1973 1 (1):293-8. Epub 1900 01 01.

Kinetics of microsomal metabolism and binding of enantiomerically related substrates.

Anders MW, Cooper MJ, Takemori AE

Drug metabolism and disposition : the biological fate of chemicals.. 1973 1 (4):642-4. Epub 1900 01 01.

Ion-pair extraction and high-speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine.

Cooper MJ, Anders MW, Mirkin BL

Drug metabolism and disposition : the biological fate of chemicals.. 1973 1 (5):659-62. Epub 1900 01 01.

Effect of phenobarbital and 3-methylcholanthrene administration on the in vitro enhancement of microsomal aromatic hydroxylation.

Anders MW

Archives of biochemistry and biophysics.. 1972 December 153 (2):502-7. Epub 1900 01 01.

High-speed liquid chromatography of glucuronide and sulfate conjugates.

Anders MW, Latorre JP

Journal of chromatography.. 1971 March 355 (2):409-13. Epub 1900 01 01.

Enhancement and inhibition of drug metabolism.

Anders MW

Annual review of pharmacology. 1971 11 :37-56. Epub 1900 01 01.

High-speed ion exchange chromatography of barbiturates, diphenylhydantoin, and their hydroxylated metabolites.

Anders MW, Latorre JP

Analytical chemistry.. 1970 October 42 (12):1430-2. Epub 1900 01 01.

Stimulation in vitro of microsomal aniline hydroxylation by 2,2'-bipyridine.

Anders MW

Biochemical pharmacology.. 1969 October 18 (10):2561-5. Epub 1900 01 01.

Stereoselective metabolism of the enantiomers of hexobarbital.

Furner RL, McCarthy JS, Stitzel RE, Anders MW

The Journal of pharmacology and experimental therapeutics.. 1969 October 169 (2):153-8. Epub 1900 01 01.

Inhibition of microsomal drug metabolism by methylenedioxybenzenes.

Anders MW

Biochemical pharmacology.. 1968 November 17 (11):2367-70. Epub 1900 01 01.

Acetone enhancement of microsomal aniline para-hydroxylase activity.

Anders MW

Archives of biochemistry and biophysics.. 1968 July 126 (1):269-75. Epub 1900 01 01.

Application of gas chromatography to toxicology.

Anders MW, Mannering GJ

Progress in chemical toxicology. 1967 3 :121-218. Epub 1900 01 01.

Rapid micromethod for gas chromatographic determination of blood barbiturates.

Anders MW

Analytical chemistry.. 1966 December 38 (13):1945-7. Epub 1900 01 01.

Inhibition of drug metabolism. I. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and related compounds.

Anders MW, Mannering GJ

Molecular pharmacology.. 1966 July 2 (4):319-27. Epub 1900 01 01.

Inhibition of drug metabolism. II. Metabolism of 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A).

Anders MW, Alvares AP, Mannering GJ

Molecular pharmacology.. 1966 July 2 (4):328-34. Epub 1900 01 01.

Inhibition of drug metabolism. 3. Inhibition of hexobarbital metabolism in the intact rat and in the isolated perfused liver by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and its N-deethylated derivatives.

Stitzel RE, Anders MW, Mannering GJ

Molecular pharmacology.. 1966 July 2 (4):335-40. Epub 1900 01 01.

Inhibition of drug metabolism. IV. Induction of drug metabolism by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and 2,4-dichloro-6-phenylphenoxyethylamine HBr (Lilly 18947) and the effect of induction on the inhibitory properties of SKF 525-A type compounds.

Anders MW, Mannering GJ

Molecular pharmacology.. 1966 July 2 (4):341-6. Epub 1900 01 01.

Books

Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds (1994)

Authors: Anders, M. W., and Dekant, W., Eds.

Publisher: Academic Press, San Diego 1994

Renal Disposition and Nephrotoxicity of Xenobiotics (1993)

Authors: Anders, M. W., Dekant, W., Henschler, D., Oberleithner, H., and Silbernagl, S., Eds.

Publisher: Academic Press, San Diego 1993

The Liver: Biology and Pathobiology (1988)

Chapter: Bioactivation mechanisms and hepatocellular damage.

Authors: Anders, M. W.

Publisher: Raven Press, New York 1988

Bioactivation of Foreign Compounds (1985)

Authors: Anders, M. W., Ed.

Publisher: Academic Press, Orlando 1985

Toxicology: Determinants of Susceptibility and Predictability (1984)

Authors: Anders, M. W., and Carlson, R. G., Eds.

Publisher: Williams and Wilkins, Baltimore 1984