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Ted B. Begenisich, Ph.D.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD)

Credentials

Education

PhD | Univ of Maryland Sch Medicine. Biophysics. 1974

MA | Univ of Cal Irvine. Physics. 1971

BS | Univ of Cal Davis. Physics. 1968

Publications

Journal Articles

Selectivity filter gating in large-conductance Ca(2+)-activated K+ channels.

Thompson J, Begenisich T

The Journal of general physiology.. 2012 March 139 (3):235-44. Epub 1900 01 01.

Apical Ca2+-activated potassium channels in mouse parotid acinar cells.

Almassy J, Won JH, Begenisich TB, Yule DI

The Journal of general physiology.. 2012 February 139 (2):121-33. Epub 1900 01 01.

The LRRC26 protein selectively alters the efficacy of BK channel activators.

Almassy J, Begenisich T

Molecular pharmacology.. 2012 January 81 (1):21-30. Epub 10/07/2011.

The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels.

Romanenko VG, Roser K, Melvin JE, Begenisich T

American journal of physiology. Cell physiology.. 2009 April 296 (4):C878-88. Epub 01/28/2009.

Mechanistic details of BK chanel inhibition by the intermediate conductance, Ca (2+)-activated K channel.

Thompson, J.; Begenisich, T.

Channels. 2009; 3: 194-204.

Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland.

Nakamoto T, Romanenko VG, Takahashi A, Begenisich T, Melvin JE

American journal of physiology. Cell physiology.. 2008 March 294 (3):C810-9. Epub 01/23/2008.

Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands.

Romanenko VG, Nakamoto T, Srivastava A, Begenisich T, Melvin JE

The Journal of physiology.. 2007 June 1581 (Pt 2):801-17. Epub 03/22/2007.

Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells.

Nakamoto T, Srivastava A, Romanenko VG, Ovitt CE, Perez-Cornejo P, Arreola J, Begenisich T, Melvin JE

American journal of physiology. Regulatory, integrative and comparative physiology.. 2007 June 292 (6):R2380-90. Epub 03/08/2007.

Molecular identification and physiological roles of parotid acinar cell maxi-K channels.

Romanenko V, Nakamoto T, Srivastava A, Melvin JE, Begenisich T

The Journal of biological chemistry.. 2006 September 22281 (38):27964-72. Epub 07/27/2006.

Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel.

Thompson J, Begenisich T

The Journal of general physiology.. 2006 February 127 (2):159-69. Epub 01/17/2006.

Pharmacology and surface electrostatics of the K channel outer pore vestibule.

Quinn CC, Begenisich T

The Journal of membrane biology.. 2006 212 (1):51-60. Epub 01/06/2007.

Two stable, conducting conformations of the selectivity filter in Shaker K+ channels.

Thompson J, Begenisich T

The Journal of general physiology.. 2005 June 125 (6):619-29. Epub 05/16/2005.

Regulation of fluid and electrolyte secretion in salivary gland acinar cells.

Melvin JE, Yule D, Shuttleworth T, Begenisich T

Annual review of physiology.. 2005 67 :445-69. Epub 1900 01 01.

Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4.

Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE

The Journal of biological chemistry.. 2004 November 12279 (46):47681-7. Epub 09/03/2004.

External TEA block of shaker K+ channels is coupled to the movement of K+ ions within the selectivity filter.

Thompson J, Begenisich T

The Journal of general physiology.. 2003 August 122 (2):239-46. Epub 1900 01 01.

Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channels.

Thompson J, Begenisich T

The Journal of physiology.. 2003 May 15549 (Pt 1):107-20. Epub 03/28/2003.

Molecular identification of Ca2+-activated K+ channels in parotid acinar cells.

Nehrke K, Quinn CC, Begenisich T

American journal of physiology. Cell physiology.. 2003 February 284 (2):C535-46. Epub 10/16/2002.

Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene.

Arreola J, Begenisich T, Nehrke K, Nguyen HV, Park K, Richardson L, Yang B, Schutte BC, Lamb FS, Melvin JE

The Journal of physiology.. 2002 November 15545 (1):207-16. Epub 1900 01 01.

Conformation-dependent regulation of inward rectifier chloride channel gating by extracellular protons.

Arreola J, Begenisich T, Melvin JE

The Journal of physiology.. 2002 May 15541 (Pt 1):103-12. Epub 1900 01 01.

The influence of surface charges on quaternary ammonium block of shaker K+ channels.

Quinn CC, Begenisich T

The Journal of membrane biology.. 2001 August 1182 (3):233-43. Epub 1900 01 01.

Protein kinase A activation phosphorylates the rat ClC-2 Cl- channel but does not change activity.

Park K, Begenisich T, Melvin JE

The Journal of membrane biology.. 2001 July 1182 (1):31-7. Epub 1900 01 01.

Affinity and location of an internal K+ ion binding site in shaker K channels.

Thompson J, Begenisich T

The Journal of general physiology.. 2001 May 117 (5):373-84. Epub 1900 01 01.

Interaction between quaternary ammonium ions in the pore of potassium channels. Evidence against an electrostatic repulsion mechanism.

Thompson J, Begenisich T

The Journal of general physiology.. 2000 June 115 (6):769-82. Epub 1900 01 01.

Electrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels.

Thompson J, Begenisich T

Biophysical journal.. 2000 May 78 (5):2382-91. Epub 1900 01 01.

Nonindependent K+ movement through the pore in IRK1 potassium channels.

Stampe P, Arreola J, Pérez-Cornejo P, Begenisich T

The Journal of general physiology.. 1998 October 112 (4):475-84. Epub 1900 01 01.

Comparison of voltage-activated Cl- channels in rat parotid acinar cells with ClC-2 in a mammalian expression system.

Park K, Arreola J, Begenisich T, Melvin JE

The Journal of membrane biology.. 1998 May 15163 (2):87-95. Epub 1900 01 01.

Proton probing of the charybdotoxin binding site of Shaker K+ channels.

Perez-Cornejo P, Stampe P, Begenisich T

The Journal of general physiology.. 1998 March 111 (3):441-50. Epub 1900 01 01.

Differences in regulation of Ca(2+)-activated Cl- channels in colonic and parotid secretory cells.

Arreola J, Melvin JE, Begenisich T

The American journal of physiology.. 1998 January 274 (1):C161-6. Epub 1900 01 01.

Determining ion channel permeation properties.

Begenisich T

Methods in enzymology.. 1998 293 :383-90. Epub 1900 01 01.

Unidirectional fluxes through ion channels expressed in Xenopus oocytes.

Stampe P, Begenisich T

Methods in enzymology.. 1998 293 :556-64. Epub 1900 01 01.

Activation of calcium-dependent chloride channels in rat parotid acinar cells.

Arreola J, Melvin JE, Begenisich T

The Journal of general physiology.. 1996 July 108 (1):35-47. Epub 1900 01 01.

Unidirectional K+ fluxes through recombinant Shaker potassium channels expressed in single Xenopus oocytes.

Stampe P, Begenisich T

The Journal of general physiology.. 1996 April 107 (4):449-57. Epub 1900 01 01.

Three distinct chloride channels control anion movements in rat parotid acinar cells.

Arreola J, Park K, Melvin JE, Begenisich T

The Journal of physiology.. 1996 January 15490 ( Pt 2) (Pt 2):351-62. Epub 1900 01 01.

Inhibition of Ca(2+)-dependent Cl- channels from secretory epithelial cells by low internal pH.

Arreola J, Melvin JE, Begenisich T

The Journal of membrane biology.. 1995 September 147 (1):95-104. Epub 1900 01 01.

Volume-activated chloride channels in rat parotid acinar cells.

Arreola J, Melvin JE, Begenisich T

The Journal of physiology.. 1995 May 1484 ( Pt 3) (Pt 3):677-87. Epub 1900 01 01.

Voltage-independent gating transitions in squid axon potassium channels.

Spires S, Begenisich T

Biophysical journal.. 1995 February 68 (2):491-500. Epub 1900 01 01.

Modulation of potassium channel gating by external divalent cations.

Spires S, Begenisich T

The Journal of general physiology.. 1994 October 104 (4):675-92. Epub 1900 01 01.

The multi-ion nature of the pore in Shaker K+ channels.

Pérez-Cornejo P, Begenisich T

Biophysical journal.. 1994 June 66 (6):1929-38. Epub 1900 01 01.

Na+ channels in cardiac and neuronal cells derived from a mouse embryonal carcinoma cell line.

Arreola J, Spires S, Begenisich T

The Journal of physiology.. 1993 December 472 :289-303. Epub 1900 01 01.

Potassium channels in squid neuron cell bodies: comparison to axonal channels.

Nealey T, Spires S, Eatock RA, Begenisich T

The Journal of membrane biology.. 1993 February 132 (1):13-25. Epub 1900 01 01.

Chemical properties of the divalent cation binding site on potassium channels.

Spires S, Begenisich T

The Journal of general physiology.. 1992 August 100 (2):181-93. Epub 1900 01 01.

Modification of potassium channel kinetics by amino group reagents.

Spires S, Begenisich T

The Journal of general physiology.. 1992 January 99 (1):109-29. Epub 1900 01 01.

Ion channel selectivity, permeation, and block.

Begenisich T

Methods in enzymology.. 1992 207 :92-100. Epub 1900 01 01.

Induction of K-channel expression in a neuroblastoma cell line.

Smith-Maxwell CJ, Eatock RA, Begenisich T

Journal of neurobiology.. 1991 June 22 (4):327-41. Epub 1900 01 01.

Modification of potassium channel kinetics by histidine-specific reagents.

Spires S, Begenisich T

The Journal of general physiology.. 1990 October 96 (4):757-75. Epub 1900 01 01.

Beta-adrenergic modulation of cardiac ion channels. Differential temperature sensitivity of potassium and calcium currents.

Walsh KB, Begenisich TB, Kass RS

The Journal of general physiology.. 1989 May 93 (5):841-54. Epub 1900 01 01.

Nonstationary fluctuation analysis of the delayed rectifier K channel in cardiac Purkinje fibers. Actions of norepinephrine on single-channel current.

Bennett PB, Kass R, Begenisich T

Biophysical journal.. 1989 April 55 (4):731-8. Epub 1900 01 01.

Pharmacological and kinetic analysis of K channel gating currents.

Spires S, Begenisich T

The Journal of general physiology.. 1989 February 93 (2):263-83. Epub 1900 01 01.

Beta-adrenergic modulation in the heart. Independent regulation of K and Ca channels.

Walsh KB, Begenisich TB, Kass RS

Pflu?gers Archiv : European journal of physiology.. 1988 February 411 (2):232-4. Epub 1900 01 01.

Guanidinium analogues as probes of the squid axon sodium pore. Evidence for internal surface charges.

Smith-Maxwell C, Begenisich T

The Journal of general physiology.. 1987 September 90 (3):361-74. Epub 1900 01 01.

Catecholamines modulate the delayed rectifying potassium current (IK) in guinea pig ventricular myocytes.

Bennett PB, Begenisich TB

Pflu?gers Archiv : European journal of physiology.. 1987 September 410 (1-2):217-9. Epub 1900 01 01.

Capture, transport, and maintenance of live squid (Loligo pealei) for electrophysiological studies.

Chabala LD, Morello RS, Busath D, Danko M, Smith-Maxwell CJ, Begenisich T

Pflu?gers Archiv : European journal of physiology.. 1986 July 407 (1):105-8. Epub 1900 01 01.

Adrenergic modulation of the delayed rectifier potassium channel in calf cardiac Purkinje fibers.

Bennett P, McKinney L, Begenisich T, Kass RS

Biophysical journal.. 1986 April 49 (4):839-48. Epub 1900 01 01.

Block of sodium channels by internal mono- and divalent guanidinium analogues. Modulation by sodium ion concentration.

Danko M, Smith-Maxwell C, McKinney L, Begenisich T

Biophysical journal.. 1986 February 49 (2):509-19. Epub 1900 01 01.

Delayed rectification in the calf cardiac Purkinje fiber. Evidence for multiple state kinetics.

Bennett PB, McKinney LC, Kass RS, Begenisich T

Biophysical journal.. 1985 October 48 (4):553-67. Epub 1900 01 01.

Permeability of the squid giant axon to organic cations and small nonelectrolytes.

McKinney LC, Danko M, Smith CJ, Begenisich T

The Journal of membrane biology.. 1985 83 (1-2):177-86. Epub 1900 01 01.

Determination of the active form of phenytoin.

Morello RS, Begenisich T, Yeh JZ

The Journal of pharmacology and experimental therapeutics.. 1984 July 230 (1):156-61. Epub 1900 01 01.

Hydrogen ion block of the sodium pore in squid giant axons.

Begenisich T, Danko M

The Journal of general physiology.. 1983 November 82 (5):599-618. Epub 1900 01 01.

Unidirectional sodium and potassium fluxes through the sodium channel of squid giant axons.

Busath D, Begenisich T

Biophysical journal.. 1982 October 40 (1):41-9. Epub 1900 01 01.

Sodium flux ratio in voltage-clamped squid giant axons.

Begenisich T, Busath D

The Journal of general physiology.. 1981 May 77 (5):489-502. Epub 1900 01 01.

Sodium channel permeation in squid axons. I: Reversal potential experiments.

Begenisich TB, Cahalan MD

The Journal of physiology.. 1980 October 307 :217-42. Epub 1900 01 01.

Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations.

Begenisich TB, Cahalan MD

The Journal of physiology.. 1980 October 307 :243-57. Epub 1900 01 01.

Interaction of nonylguanidine with the sodium channel.

Morello R, Begenisich T, Trzos W, Reed JK

Biophysical journal.. 1980 September 31 (3):435-40. Epub 1900 01 01.

Potassium flux ratio in voltage-clamped squid giant axons.

Begenisich T, De Weer P

The Journal of general physiology.. 1980 July 76 (1):83-98. Epub 1900 01 01.

Conditioning hyperpolarization-induced delays in the potassium channels of myelinated nerve.

Begenisich T

Biophysical journal.. 1979 August 27 (2):257-65. Epub 1900 01 01.

Ionic interactions in the potassium channel of squid giant axons.

Begenisich T, De Weer P

Nature.. 1977 October 20269 (5630):710-1. Epub 1900 01 01.

Sodium channel selectivity. Dependence on internal permeant ion concentration.

Cahalan M, Begenisich T

The Journal of general physiology.. 1976 August 68 (2):111-25. Epub 1900 01 01.

Letter: Sodium flux, action potential and temperature dependence.

Goldman L, Hahin R, Begenisich T

Nature.. 1975 October 9257 (5526):516-7. Epub 1900 01 01.

How many conductance states do potassium channels have?

Begenisich T, Stevens CF

Biophysical journal.. 1975 August 15 (8):843-6. Epub 1900 01 01.

Magnitude and location of surface charges on Myxicola giant axons.

Begenisich T

The Journal of general physiology.. 1975 July 66 (1):47-65. Epub 1900 01 01.

Effects of internal divalent cations on voltage-clamped squid axons.

Begenisich T, Lynch C

The Journal of general physiology.. 1974 June 63 (6):675-89. Epub 1900 01 01.