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Ingrid H. Sarelius, Ph.D.

Ingrid H. Sarelius, Ph.D.

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About Me

Faculty Appointments

Professor Emeritus - Department of Pharmacology and Physiology (SMD)

Credentials

Education

PhD | University of Auckland, New Zealand. Physiology. 1978

MSc(Hons) | Massey University. Physiology. 1972

BSc | Massey University. Physiology. 1968

Research

My research focus is on vascular cell communication and signaling. Our lab is specifically interested in how the cells of the blood vessel wall communicate with each other, with the surrounding tissue, and with the blood itself. Basically, we're interested in figuring out how microvessels work! Sinc...
My research focus is on vascular cell communication and signaling. Our lab is specifically interested in how the cells of the blood vessel wall communicate with each other, with the surrounding tissue, and with the blood itself. Basically, we're interested in figuring out how microvessels work! Since cardiovascular disease is a major killer of adult populations, and since much of this is vascular disease or disorder, understanding normal blood vessel function seems like a good place to start.
The major tool that we use to ask our questions is confocal immunofluorescent intravital microscopy; we are one of a handful of labs worldwide that is able to image local events in cells of the vascular wall in real time in blood perfused microvessels in living animals. We also use single microparticle tracking to define the local fluid dynamic environment in vivo, and confocal imaging of signaling molecules and leukocyte populations in the in situ blood vessel.

Publications

Journal Articles

Extracellular matrix fibronectin initiates endothelium-dependent arteriolar dilatation via the heparin-binding, matricryptic RWRPK sequence of the first type III repeat of fibrillar fibronectin.

Sarelius IH, Titus PA, Maimon N, Okech W, Wilke-Mounts SJ, Brennan JR, Hocking DC

The Journal of physiology.. 2016 February 1594 (3):687-97. Epub 01/15/2016.

Local control of blood flow during active hyperaemia: what kinds of integration are important?

Murrant CL, Sarelius IH

The Journal of physiology.. 2015 November 1593 (21):4699-711. Epub 09/29/2015.

Control of vascular permeability by adhesion molecules.

Sarelius IH, Glading AJ

Tissue barriers.. 2015 3 (1-2):e985954. Epub 04/03/2015.

Simulation and Analysis of Tethering Behavior of Neutrophils with Pseudopods.

Rocheleau AD, Sumagin R, Sarelius IH, King MR

PloS one.. 2015 10 (6):e0128378. Epub 06/19/2015.

KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling.

Distefano PV, Kuebel JM, Sarelius IH, Glading AJ

The Journal of biological chemistry.. 2014 November 21289 (47):33054-65. Epub 10/15/2014.

Pre-exposure to adenosine, acting via A(2A) receptors on endothelial cells, alters the protein kinase A dependence of adenosine-induced dilation in skeletal muscle resistance arterioles.

Maimon N, Titus PA, Sarelius IH

The Journal of physiology.. 2014 June 15592 (12):2575-90. Epub 03/31/2014.

Emerging understanding of roles for arterioles in inflammation.

Sumagin R, Sarelius IH

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2013 November 20 (8):679-92. Epub 1900 01 01.

Decreased Krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo.

Corr M, Lerman I, Keubel JM, Ronacher L, Misra R, Lund F, Sarelius IH, Glading AJ

Arteriosclerosis, thrombosis, and vascular biology.. 2012 November 32 (11):2702-10. Epub 08/23/2012.

Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels.

Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M

The Journal of experimental medicine.. 2012 July 2209 (7):1349-62. Epub 06/18/2012.

Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1.

Sumagin R, Kuebel JM, Sarelius IH

American journal of physiology. Cell physiology.. 2011 October 301 (4):C804-13. Epub 06/08/2011.

LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ.

Sumagin R, Prizant H, Lomakina E, Waugh RE, Sarelius IH

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 December 1185 (11):7057-66. Epub 10/29/2010.

Control of muscle blood flow during exercise: local factors and integrative mechanisms.

Sarelius I, Pohl U

Acta physiologica. 2010 August 199 (4):349-65. Epub 03/26/2010.

Intercellular adhesion molecule-1 enrichment near tricellular endothelial junctions is preferentially associated with leukocyte transmigration and signals for reorganization of these junctions to accommodate leukocyte passage.

Sumagin R, Sarelius IH

The Journal of immunology : official journal of the American Association of Immunologists.. 2010 May 1184 (9):5242-52. Epub 04/02/2010.

A separate role for ICAM-1 and fluid shear in regulating leukocyte interactions with straight regions of venular wall and venular convergences.

Sumagin R, Lamkin-Kennard KA, Sarelius IH

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2009 August 16 (6):508-20. Epub 05/26/2009.

Vessel diameter measurement from intravital microscopy.

Lee J, Jirapatnakul AC, Reeves AP, Crowe WE, Sarelius IH

Annals of biomedical engineering.. 2009 May 37 (5):913-26. Epub 03/11/2009.

Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling.

Sumagin R, Lomakina E, Sarelius IH

American journal of physiology. Heart and circulatory physiology.. 2008 September 295 (3):H969-H977. Epub 07/18/2008.

Microvascular endothelial cells exhibit optimal aspect ratio for minimizing flow resistance.

Sumagin R, Brown CW, Sarelius IH, King MR

Annals of biomedical engineering.. 2008 April 36 (4):580-5. Epub 03/04/2008.

Extracellular matrix fibronectin mechanically couples skeletal muscle contraction with local vasodilation.

Hocking DC, Titus PA, Sumagin R, Sarelius IH

Circulation research.. 2008 February 15102 (3):372-9. Epub 11/21/2007.

A role for ICAM-1 in maintenance of leukocyte-endothelial cell rolling interactions in inflamed arterioles.

Sumagin R, Sarelius IH

American journal of physiology. Heart and circulatory physiology.. 2007 November 293 (5):H2786-98. Epub 08/17/2007.

Adaptation of coronary microvascular exchange in arterioles and venules to exercise training and a role for sex in determining permeability responses.

Huxley VH, Wang JJ, Sarelius IH

American journal of physiology. Heart and circulatory physiology.. 2007 August 293 (2):H1196-205. Epub 04/13/2007.

Macromolecule permeability of in situ and excised rodent skeletal muscle arterioles and venules.

Sarelius IH, Kuebel JM, Wang J, Huxley VH

American journal of physiology. Heart and circulatory physiology.. 2006 January 290 (1):H474-80. Epub 08/26/2005.

TNF-{alpha} activation of arterioles and venules alters the distribution and levels of ICAM-1 and affects leukocyte-endothelial cell interactions

Sumagin, R.; Sarelius, I.H.;.

Am J Physiol Heart Circ Physiol. 2006; .

Preferential binding of leukocytes to the endothelial junction region in venules in situ.

Wojciechowski JC, Sarelius IH

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2005 June 12 (4):349-59. Epub 1900 01 01.

Solute permeability of in situ skeletal muscle microvessels (Abstract)

Sarelius, I.H.; Kuebel, J.M.; Huxley, V.H.;.

Faseb Journal. 2005; 19: A179.

The distribution of rolling neutrophils in venular convergences.

Lamkin-Kennard KA, Chuang JY, Kim MB, Sarelius IH, King MR

Biorheology. 2005 42 (5):363-83. Epub 1900 01 01.

Role of shear forces and adhesion molecule distribution on P-selectin-mediated leukocyte rolling in postcapillary venules.

Kim MB, Sarelius IH

American journal of physiology. Heart and circulatory physiology.. 2004 December 287 (6):H2705-11. Epub 08/26/2004.

Localized transient increases in endothelial cell Ca2+ in arterioles in situ: implications for coordination of vascular function.

Duza T, Sarelius IH

American journal of physiology. Heart and circulatory physiology.. 2004 June 286 (6):H2322-31. Epub 02/12/2004.

The effect of hematocrit and leukocyte adherence on flow direction in the microcirculation.

King MR, Bansal D, Kim MB, Sarelius IH

Annals of biomedical engineering.. 2004 June 32 (6):803-14. Epub 1900 01 01.

Increase in endothelial cell Ca(2+) in response to mouse cremaster muscle contraction.

Duza T, Sarelius IH

The Journal of physiology.. 2004 March 1555 (Pt 2):459-69. Epub 12/23/2003.

Arteriolar dilations induced by contraction of hamster cremaster muscle are dependent on changes in endothelial cell calcium.

Murrant CL, Duza T, Kim MB, Cohen KD, Sarelius IH

Acta physiologica Scandinavica. 2004 March 180 (3):231-8. Epub 1900 01 01.

Regulation of leukocyte recruitment by local wall shear rate and leukocyte delivery.

Kim MB, Sarelius IH

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2004 11 (1):55-67. Epub 1900 01 01.

Hydrodynamic interactions between rolling leukocytes in vivo.

King MR, Kim MB, Sarelius IH, Hammer DA

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2003 October 10 (5):401-9. Epub 1900 01 01.

Conducted dilations initiated by purines in arterioles are endothelium dependent and require endothelial Ca2+.

Duza T, Sarelius IH

American journal of physiology. Heart and circulatory physiology.. 2003 July 285 (1):H26-37. Epub 03/13/2003.

Distributions of wall shear stress in venular convergences of mouse cremaster muscle.

Kim MB, Sarelius IH

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2003 April 10 (2):167-78. Epub 1900 01 01.

Multiple dilator pathways in skeletal muscle contraction-induced arteriolar dilations.

Murrant CL, Sarelius IH

American journal of physiology. Regulatory, integrative and comparative physiology.. 2002 April 282 (4):R969-78. Epub 1900 01 01.

Muscle contraction under capillaries in hamster muscle induces arteriolar dilatation via K(ATP) channels and nitric oxide.

Cohen KD, Sarelius IH

The Journal of physiology.. 2002 March 1539 (Pt 2):547-55. Epub 1900 01 01.

Flow-induced cytoskeletal changes in endothelial cells growing on curved surfaces.

Frame MD, Sarelius IH

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 2000 December 7 (6 Pt 1):419-27. Epub 1900 01 01.

Local and remote arteriolar dilations initiated by skeletal muscle contraction.

Murrant CL, Sarelius IH

American journal of physiology. Heart and circulatory physiology.. 2000 November 279 (5):H2285-94. Epub 1900 01 01.

Adaptation and survival of surface-deprived red blood cells in mice.

Murdock RC, Reynolds C, Sarelius IH, Waugh RE

American journal of physiology. Cell physiology.. 2000 October 279 (4):C970-80. Epub 1900 01 01.

Role for capillaries in coupling blood flow with metabolism.

Sarelius IH, Cohen KD, Murrant CL

Clinical and experimental pharmacology & physiology.. 2000 October 27 (10):826-9. Epub 1900 01 01.

Remote arteriolar dilations in response to muscle contraction under capillaries.

Cohen KD, Berg BR, Sarelius IH

American journal of physiology. Heart and circulatory physiology.. 2000 June 278 (6):H1916-23. Epub 1900 01 01.

Coupling of muscle metabolism and muscle blood flow in capillary units during contraction.

Murrant CL, Sarelius IH

Acta physiologica Scandinavica. 2000 April 168 (4):531-41. Epub 1900 01 01.

nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle.

Lau KS, Grange RW, Isotani E, Sarelius IH, Kamm KE, Huang PL, Stull JT

Physiological genomics.. 2000 January 242 (1):21-7. Epub 01/24/2000.

Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide.

Lau KS, Grange RW, Chang WJ, Kamm KE, Sarelius I, Stull JT

FEBS letters.. 1998 July 10431 (1):71-4. Epub 1900 01 01.

Shear stress gradient over endothelial cells in a curved microchannel system.

Frame MD, Chapman GB, Makino Y, Sarelius IH

Biorheology. 1998 35 (4-5):245-61. Epub 1900 01 01.

Direct coupling between blood flow and metabolism at the capillary level in striated muscle.

Berg BR, Cohen KD, Sarelius IH

The American journal of physiology.. 1997 June 272 (6 Pt 2):H2693-700. Epub 1900 01 01.

Effects of lost surface area on red blood cells and red blood cell survival in mice.

Waugh RE, Sarelius IH

The American journal of physiology.. 1996 December 271 (6 Pt 1):C1847-52. Epub 1900 01 01.

Erythrocyte flux in capillary networks during maturation: implications for oxygen delivery.

Berg BR, Sarelius IH

The American journal of physiology.. 1996 December 271 (6 Pt 2):H2263-73. Epub 1900 01 01.

Endothelial cell dilatory pathways link flow and wall shear stress in an intact arteriolar network.

Frame MD, Sarelius IH

Journal of applied physiology.. 1996 November 81 (5):2105-14. Epub 1900 01 01.

Vascular communication and endothelial cell function in the control of arteriolar flow distribution.

Frame MD, Sarelius IH

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 1996 June 3 (2):233-5. Epub 1900 01 01.

Combined use of fluorescence microscopy and micromechanical measurement to assess cell and membrane properties.

Waugh RE, Hwang WC, Sarelius IH

Pflu?gers Archiv : European journal of physiology.. 1996 431 (6 Suppl 2):R271-2. Epub 1900 01 01.

A system for culture of endothelial cells in 20-50-microns branching tubes.

Frame MD, Sarelius IH

Microcirculation : the official journal of the Microcirculatory Society, Inc.. 1995 December 2 (4):377-85. Epub 1900 01 01.

Energy optimization and bifurcation angles in the microcirculation.

Frame MD, Sarelius IH

Microvascular research.. 1995 November 50 (3):301-10. Epub 1900 01 01.

L-arginine-induced conducted signals alter upstream arteriolar responsivity to L-arginine.

Frame MD, Sarelius IH

Circulation research.. 1995 October 77 (4):695-701. Epub 1900 01 01.

Invited editorial on "Effect of RBC shape and deformability on pulmonary O2 diffusing capacity and resistance to flow in rabbit lungs".

Sarelius IH

Journal of applied physiology.. 1995 March 78 (3):763-4. Epub 1900 01 01.

Functional capillary organization in striated muscle.

Berg BR, Sarelius IH

The American journal of physiology.. 1995 March 268 (3 Pt 2):H1215-22. Epub 1900 01 01.

Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms.

Kiani MF, Pries AR, Hsu LL, Sarelius IH, Cokelet GR

The American journal of physiology.. 1994 May 266 (5 Pt 2):H1822-8. Epub 1900 01 01.

Cell and oxygen flow in arterioles controlling capillary perfusion.

Sarelius IH

The American journal of physiology.. 1993 November 265 (5 Pt 2):H1682-7. Epub 1900 01 01.

Arteriolar bifurcation angles vary with position and when flow is changed.

Frame MD, Sarelius IH

Microvascular research.. 1993 September 46 (2):190-205. Epub 1900 01 01.

Regulation of capillary perfusion by small arterioles is spatially organized.

Frame MD, Sarelius IH

Circulation research.. 1993 July 73 (1):155-63. Epub 1900 01 01.

Effect of diameter variability along a microvessel segment on pressure drop.

Kiani MF, Cokelet GR, Sarelius IH

Microvascular research.. 1993 May 45 (3):219-32. Epub 1900 01 01.

Perceived vessel lumen and cell-blood velocity ratio: impact on in vivo blood flow rate determination.

Cokelet GR, Sarelius IH

The American journal of physiology.. 1992 April 262 (4 Pt 2):H1156-63. Epub 1900 01 01.

Spatial heterogeneity in striated muscle arteriolar tone, cell flow, and capillarity.

Sweeney TE, Sarelius IH

The American journal of physiology.. 1990 July 259 (1 Pt 2):H124-36. Epub 1900 01 01.

An analysis of microcirculatory flow heterogeneity using measurements of transit time.

Sarelius IH

Microvascular research.. 1990 July 40 (1):88-98. Epub 1900 01 01.

A direct effect of atrial peptide on arterioles of the terminal microvasculature.

Sarelius IH, Huxley VH

The American journal of physiology.. 1990 May 258 (5 Pt 2):R1224-9. Epub 1900 01 01.

Microcirculation in striated muscle after acute reduction in systemic hematocrit.

Sarelius IH

Respiration physiology.. 1989 October 78 (1):7-17. Epub 1900 01 01.

Arteriolar control of capillary cell flow in striated muscle.

Sweeney TE, Sarelius IH

Circulation research.. 1989 January 64 (1):112-20. Epub 1900 01 01.

Variability in microvascular estimates of capillary surface area for exchange.

Sarelius IH, Nealey TA, Sweeney TE

Advances in experimental medicine and biology.. 1988 242 :17-21. Epub 1900 01 01.

Cell flow path influences transit time through striated muscle capillaries.

Sarelius IH

The American journal of physiology.. 1986 June 250 (6 Pt 2):H899-907. Epub 1900 01 01.

Use of flow cytometry to extend and improve in vivo determinations of microvessel hematocrit and cell flux.

Sweeney TE, Sarelius IH

Microvascular research.. 1986 March 31 (2):184-96. Epub 1900 01 01.

Statistical constraints on microvascular measurements using fluorescent erythrocytes.

Sarelius IH, McKinlay SM

The American journal of physiology.. 1985 April 248 (4 Pt 2):H577-86. Epub 1900 01 01.

An examination of the contribution of red cell spacing to the uniformity of oxygen flux at the capillary wall.

Federspiel WJ, Sarelius IH

Microvascular research.. 1984 May 27 (3):273-85. Epub 1900 01 01.

Capillarity and fiber types in the cremaster muscle of rat and hamster.

Sarelius IH, Maxwell LC, Gray SD, Duling BR

The American journal of physiology.. 1983 August 245 (2):H368-74. Epub 1900 01 01.

Direct measurement of microvessel hematocrit, red cell flux, velocity, and transit time.

Sarelius IH, Duling BR

The American journal of physiology.. 1982 December 243 (6):H1018-26. Epub 1900 01 01.

A comparison of microvascular estimates of capillary blood flow with direct measurements of total striated muscle flow.

Duling BR, Sarelius IH, Jackson WF

International journal of microcirculation, clinical and experimental

Effects of urethane-chloralose anaesthesia on respiration in the rat.

Hughes EW, Martin-Body RL, Sarelius IH, Sinclair JD

Clinical and experimental pharmacology & physiology.. 1982 9 (2):119-27. Epub 1900 01 01.

Microvascular adaptations during maturation of striated muscle.

Sarelius IH, Damon DN, Duling BR

The American journal of physiology.. 1981 September 241 (3):H317-24. Epub 1900 01 01.

Effects of small changes of blood volume on oxygen delivery and tissue oxygenation.

Sarelius IH, Sinclair JD

The American journal of physiology.. 1981 February 240 (2):H177-84. Epub 1900 01 01.

The respiratory role of the ventral surface of the medulla studied in the anaesthetized rat.

Malcolm JL, Sarelius IH, Sinclair JD

The Journal of physiology.. 1980 October 307 :503-15. Epub 1900 01 01.

The marathon man: the physiology of the long-distance runner.

Sinclair JD, Sarelius IH

The New Zealand medical journal.. 1979 November 1490 (647):383-7. Epub 1900 01 01.

Plasma volume shifts during moderate exercise in splenectomized greyhounds.

Sarelius IH

The Journal of physiology.. 1979 July 292 :391-405. Epub 1900 01 01.

Blood volume and exercise in dogs.

Sarelius IH

The New Zealand medical journal.. 1976 October 1384 (573):275-6. Epub 1900 01 01.

Estimation of maximal oxygen uptake in New Zealanders of three age groups.

Sarelius IH, Quinn JP

The New Zealand medical journal.. 1975 June 2581 (542):549-52. Epub 1900 01 01.

Rhythmic fluctuations in the urine composition of sheep: separation of feed-dependent from other rhythms.

Sarelius IH, Greenway RM

Pflu?gers Archiv : European journal of physiology.. 1975 March 26355 (3):243-59. Epub 1900 01 01.

Books

Microvascular Research: Biology and Pathology (2005)

Chapter: Vascular control mechanisms in skeletal muscle.

Authors: Sarelius, I.H.

Publisher: Academic Press 2005