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William M. Maniscalco, M.D.

William M. Maniscalco, M.D.

About Me

Bronchopulmonary Dysplasia
Bronchopulmonary Dysplasia

Faculty Appointments

Professor Emeritus - Department of Pediatrics, Neonatology (SMD)

Credentials

Post-doctoral Training & Residency

Pediatrics (Neonatology) Fellowship, Yale University School of Medicine, New Haven, CT 1975 - 1978

Residency in Pediatrics, Children's Hospital Medical Center, Boston, MA 1972 - 1975

Education

MD | Johns Hopkins University School of Medicine. Medicine. 1972

BA | University of Massachusetts. Pre-Medical. 1968

Awards

America's Top Doctors. 2016

Buswell Faculty Research Award. 1980 - 1982

Research

Dr. Maniscalco studies pulmonary microvascular development in lung injury. Using various animal models, including a non-human primate model of BPD, this work examines the effects of oxygen and ventilation of immature lung on the development of alveolar capillaries. The major goals of the research ar...
Dr. Maniscalco studies pulmonary microvascular development in lung injury. Using various animal models, including a non-human primate model of BPD, this work examines the effects of oxygen and ventilation of immature lung on the development of alveolar capillaries. The major goals of the research are to characterize microvascular development in lung injury and investigate angiogenic and angiostatic regulators in normal and injured lung. Recent work has linked expression of inflammatory CXC chemokine mediators, which regulate angiogenesis and are part of the pathophysiology of BPD, to impaired lung microangiogenesis.

Publications

Journal Articles

Neonatal Hyperoxia Activates Activating Transcription Factor 4 to Stimulate Folate Metabolism and Alveolar Epithelial Type 2 Cell Proliferation.

Yee M, McDavid AN, Cohen ED, Huyck HL, Poole C, Altman BJ, Maniscalco WM, Deutsch GH, Pryhuber GS, O'Reilly MA

American journal of respiratory cell and molecular biology.. 2022 April 66 (4):402-414. Epub 1900 01 01.

Murine mechanical ventilation stimulates alveolar epithelial cell proliferation.

Chess PR, Benson RP, Maniscalco WM, Wright TW, O'Reilly MA, Johnston CJ

Experimental lung research.. 2010 August 36 (6):331-41. Epub 1900 01 01.

Murine mechanical ventilation stimulates alveolar epithelial cell proliferation

Chess P, Benson R, Maniscalco WM, Wright T, O'Reilly M, Johnston C.

Exp Lung Research. 2010; 36(6): 331-341.

Postnatal estradiol administration upregulates pulmonary NO synthase, improves pulmonary function, and lowers ventilatory support requirements in a primate model of neonatal chronic lung disease of Prematurity.

McCurnin, DC.; Willis, B.; Pierce, RA.; Chang, Ly.; Yoder, BA.; Yuhanna, IS.; Ballard, PA.; Pepe, JK.; Maniscalco, WM.; Crapo, JD.; Grubb, PH.; Shaul, PW.

Am J Respir Crit Care Med. 2009; .

Retinoids increase lung elastin expression but fail to alter morphology or angiogenesis genes in premature ventilated baboons.

Pierce RA, Joyce B, Officer S, Heintz C, Moore C, McCurnin D, Johnston C, Maniscalco W

Pediatric research.. 2007 June 61 (6):703-9. Epub 1900 01 01.

Type II epithelial cells are critical target for hyperoxia-mediated impairment of postnatal lung development.

Yee M, Vitiello PF, Roper JM, Staversky RJ, Wright TW, McGrath-Morrow SA, Maniscalco WM, Finkelstein JN, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2006 November 291 (5):L1101-11. Epub 07/21/2006.

Pathogenesis of bronchopulmonary dysplasia.

Chess PR, D'Angio CT, Pryhuber GS, Maniscalco WM

Seminars in perinatology.. 2006 August 30 (4):171-8. Epub 1900 01 01.

Hyperoxic ventilated premature baboons have increased p53, oxidant DNA damage and decreased VEGF expression.

Maniscalco WM, Watkins RH, Roper JM, Staversky R, O'Reilly MA

Pediatric research.. 2005 September 58 (3):549-56. Epub 1900 01 01.

In vivo exposure to hyperoxia induces DNA damage in a population of alveolar type II epithelial cells.

Roper JM, Mazzatti DJ, Watkins RH, Maniscalco WM, Keng PC, O'Reilly MA

American journal of physiology. Lung cellular and molecular physiology.. 2004 May 286 (5):L1045-54. Epub 01/16/2004.

Alternative strategies for dispensing exogenous surfactant: drug cost implications and in vitro feasibility studies

Stevens TP, Sinkin RA, Notter RH, Wang Z, Consenstein L, Maniscalco WM.

Hosp Pharm. 2004; 39((4)): 338-345.

Bronchopulmonary dysplasia in preterm infants: pathophysiology and management strategies.

D'Angio CT, Maniscalco WM

Paediatric drugs.. 2004 6 (5):303-30. Epub 1900 01 01.

Induced p21Cip1 in premature baboons with CLD: implications for alveolar hypoplasia.

O'Reilly MA, Watkins RH, Staversky RJ, Maniscalco WM

American journal of physiology. Lung cellular and molecular physiology.. 2003 October 285 (4):L964-71. Epub 07/18/2003.

Increased epithelial cell proliferation in very premature baboons with chronic lung disease.

Maniscalco WM, Watkins RH, O'Reilly MA, Shea CP

American journal of physiology. Lung cellular and molecular physiology.. 2002 November 283 (5):L991-L1001. Epub 1900 01 01.

Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1).

Staversky RJ, Watkins RH, Wright TW, Hernady E, LoMonaco MB, D'Angio CT, Williams JP, Maniscalco WM, O'Reilly MA

The American journal of pathology.. 2002 October 161 (4):1383-93. Epub 1900 01 01.

Survival in early- and late-term infants with congenital diaphragmatic hernia treated with extracorporeal membrane oxygenation.

Stevens TP, Chess PR, McConnochie KM, Sinkin RA, Guillet R, Maniscalco WM, Fisher SG

Pediatrics.. 2002 September 110 (3):590-6. Epub 1900 01 01.

The role of vascular growth factors in hyperoxia-induced injury to the developing lung.

D'Angio CT, Maniscalco WM

Frontiers in bioscience : a journal and virtual library.. 2002 July 17 :d1609-23. Epub 07/01/2002.

Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons.

Maniscalco WM, Watkins RH, Pryhuber GS, Bhatt A, Shea C, Huyck H

American journal of physiology. Lung cellular and molecular physiology.. 2002 April 282 (4):L811-23. Epub 1900 01 01.

Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia.

Bhatt AJ, Pryhuber GS, Huyck H, Watkins RH, Metlay LA, Maniscalco WM

American journal of respiratory and critical care medicine.. 2001 November 15164 (10 Pt 1):1971-80. Epub 1900 01 01.

Maturation of carbonic anhydrase IV expression in rabbit kidney.

Winkler CA, Kittelberger AM, Watkins RH, Maniscalco WM, Schwartz GJ

American journal of physiology. Renal physiology.. 2001 May 280 (5):F895-903. Epub 1900 01 01.

Bcl-2 family gene expression during severe hyperoxia induced lung injury.

O'Reilly MA, Staversky RJ, Huyck HL, Watkins RH, LoMonaco MB, D'Angio CT, Baggs RB, Maniscalco WM, Pryhuber GS

Laboratory investigation; a journal of technical methods and pathology.. 2000 December 80 (12):1845-54. Epub 1900 01 01.

Expression of vascular endothelial growth factor and Flk-1 in developing and glucocorticoid-treated mouse lung.

Bhatt AJ, Amin SB, Chess PR, Watkins RH, Maniscalco WM

Pediatric research.. 2000 May 47 (5):606-13. Epub 1900 01 01.

Early dexamethasone-attempting to prevent chronic lung disease.

Sinkin RA, Dweck HS, Horgan MJ, Gallaher KJ, Cox C, Maniscalco WM, Chess PR, D'Angio CT, Guillet R, Kendig JW, Ryan RM, Phelps DL

Pediatrics.. 2000 March 105 (3 Pt 1):542-8. Epub 1900 01 01.

p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia.

O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM, Keng PC

American journal of physiology. Lung cellular and molecular physiology.. 2000 March 278 (3):L552-9. Epub 1900 01 01.

Respiratory syncytial virus and premature infants born at 32 weeks' gestation or earlier: hospitalization and economic implications of prophylaxis.

Stevens TP, Sinkin RA, Hall CB, Maniscalco WM, McConnochie KM

Archives of pediatrics & adolescent medicine.. 2000 January 154 (1):55-61. Epub 1900 01 01.

Vascular endothelial growth factor in pulmonary lavage fluid from premature infants: effects of age and postnatal dexamethasone.

D'Angio CT, Maniscalco WM, Ryan RM, Avissar NE, Basavegowda K, Sinkin RA

Biology of the neonate.. 1999 November 76 (5):266-73. Epub 1900 01 01.

Differential expression of VEGF mRNA splice variants in newborn and adult hyperoxic lung injury.

Watkins RH, D'Angio CT, Ryan RM, Patel A, Maniscalco WM

The American journal of physiology.. 1999 May 276 (5):L858-67. Epub 1900 01 01.

Accumulation of p21(Cip1/WAF1) during hyperoxic lung injury in mice.

O'Reilly MA, Staversky RJ, Watkins RH, Maniscalco WM

American journal of respiratory cell and molecular biology.. 1998 November 19 (5):777-85. Epub 1900 01 01.

Comparison of two strategies for surfactant prophylaxis in very premature infants: a multicenter randomized trial.

Kendig JW, Ryan RM, Sinkin RA, Maniscalco WM, Notter RH, Guillet R, Cox C, Dweck HS, Horgan MJ, Reubens LJ, Risemberg H, Phelps DL

Pediatrics.. 1998 June 101 (6):1006-12. Epub 1900 01 01.

Cell-specific expression of fibronectin and EIIIA and EIIIB splice variants after oxygen injury.

Maniscalco WM, Watkins RH, Chess PR, Sinkin RA, Horowitz S, Toia L

The American journal of physiology.. 1998 April 274 (4):L599-609. Epub 1900 01 01.

Hyperoxic injury decreases alveolar epithelial cell expression of vascular endothelial growth factor (VEGF) in neonatal rabbit lung.

Maniscalco WM, Watkins RH, D'Angio CT, Ryan RM

American journal of respiratory cell and molecular biology.. 1997 May 16 (5):557-67. Epub 1900 01 01.

Changes in decorin expression with hyperoxic injury to developing rat lung.

Veness-Meehan KA, Moats-Staats BM, Maniscalco WM, Watkins RH, Stiles AD

Pediatric research.. 1997 April 41 (4 Pt 1):464-72. Epub 1900 01 01.

Expression of fibronectin mRNA splice variants by rabbit lung in vivo and by alveolar type II cells in vitro.

Maniscalco WM, Watkins RH, Campbell MH

The American journal of physiology.. 1996 December 271 (6 Pt 1):L972-80. Epub 1900 01 01.

A multicenter randomized, masked comparison trial of natural versus synthetic surfactant for the treatment of respiratory distress syndrome.

Hudak ML, Farrell EE, Rosenberg AA, Jung AL, Auten RL, Durand DJ, Horgan MJ, Buckwald S, Belcastro MR, Donohue PK, Carrion V, Maniscalco WW, Balsan MJ, Torres BA, Miller RR, Jansen RD, Graeber JE, Laskay KM, Matteson EJ, Egan EA, Brody AS, Martin DJ, Riddlesberger MM, Montgomery P

The Journal of pediatrics.. 1996 March 128 (3):396-406. Epub 1900 01 01.

Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury.

Maniscalco WM, Watkins RH, Finkelstein JN, Campbell MH

American journal of respiratory cell and molecular biology.. 1995 October 13 (4):377-86. Epub 1900 01 01.

Immunologic response of extremely premature infants to tetanus, Haemophilus influenzae, and polio immunizations.

D'Angio CT, Maniscalco WM, Pichichero ME

Pediatrics.. 1995 July 96 (1 Pt 1):18-22. Epub 1900 01 01.

The use of capnography for recognition of esophageal intubation in the neonatal intensive care unit.

Roberts WA, Maniscalco WM, Cohen AR, Litman RS, Chhibber A

Pediatric pulmonology.. 1995 May 19 (5):262-8. Epub 1900 01 01.

A novel cause of error in capnographic confirmation of intubation in the neonatal intensive care unit.

Roberts WA, Maniscalco WM

Pediatrics.. 1995 January 95 (1):140-2. Epub 1900 01 01.

Transforming growth factor-beta 1 modulates type II cell fibronectin and surfactant protein C expression.

Maniscalco WM, Sinkin RA, Watkins RH, Campbell MH

The American journal of physiology.. 1994 November 267 (5 Pt 1):L569-77. Epub 1900 01 01.

Transforming growth factor-beta induces a chondroitin sulfate/dermatan sulfate proteoglycan in alveolar type II cells.

Maniscalco WM, Campbell MH

The American journal of physiology.. 1994 June 266 (6 Pt 1):L672-80. Epub 1900 01 01.

In vivo and in vitro expression of metallothionein in injured type II alveolar epithelial cells.

Piedboeuf B, Maniscalco W, Hall S, Campbell M, Watkins R, Horowitz S

Chest.. 1994 March 105 (3 Suppl):78S. Epub 1900 01 01.

Use of natural surfactants to prevent and treat respiratory distress syndrome.

Spafford PS, Kendig JW, Maniscalco WM

Seminars in perinatology.. 1993 August 17 (4):285-94. Epub 1900 01 01.

Neonatal Trichosporon beigelii infection: report of a cluster of cases in a neonatal intensive care unit.

Fisher DJ, Christy C, Spafford P, Maniscalco WM, Hardy DJ, Graman PS

The Pediatric infectious disease journal.. 1993 February 12 (2):149-55. Epub 1900 01 01.

Capnographic confirmation of endotracheal intubation

Cohen RA, Roberts WA, Maniscalco WM.

JURMC. 1993; 5((2)): 5-9.

Alveolar type II cells synthesize hydrophobic cell-associated proteoglycans with multiple core proteins.

Maniscalco WM, Campbell MH

The American journal of physiology.. 1992 September 263 (3 Pt 1):L348-56. Epub 1900 01 01.

Prevention of neonatal group B streptococcal infections: advances in maternal vaccine development.

Coleman RT, Sherer DM, Maniscalco WM

Obstetrics and gynecology.. 1992 August 80 (2):301-9. Epub 1900 01 01.

A comparison of surfactant as immediate prophylaxis and as rescue therapy in newborns of less than 30 weeks' gestation.

Kendig JW, Notter RH, Cox C, Reubens LJ, Davis JM, Maniscalco WM, Sinkin RA, Bartoletti A, Dweck HS, Horgan MJ

The New England journal of medicine.. 1991 March 28324 (13):865-71. Epub 1900 01 01.

Uptake of palmitic acid by rabbit alveolar type II cells.

Maniscalco WM, Stremmel W, Heeney-Campbell M

The American journal of physiology.. 1990 October 259 (4 Pt 1):L206-12. Epub 1900 01 01.

Decreased cholestasis with enteral instead of intravenous protein in the very low-birth-weight infant.

Brown MR, Thunberg BJ, Golub L, Maniscalco WM, Cox C, Shapiro DL

Journal of pediatric gastroenterology and nutrition.. 1989 July 9 (1):21-7. Epub 1900 01 01.

Effects of exogenous fatty acids and inhibition of de novo fatty acid synthesis on disaturated phosphatidylcholine production by fetal lung cells and adult type II cells.

Maniscalco WM, Finkelstein JN, Parkhurst AB

Experimental lung research.. 1989 May 15 (3):473-89. Epub 1900 01 01.

Surfactant replacement therapy: impact on hospital charges for premature infants with respiratory distress syndrome.

Maniscalco WM, Kendig JW, Shapiro DL

Pediatrics.. 1989 January 83 (1):1-6. Epub 1900 01 01.

Surfactant replacement therapy at birth: final analysis of a clinical trial and comparisons with similar trials.

Kendig JW, Notter RH, Cox C, Aschner JL, Benn S, Bernstein RM, Hendricks-Munoz K, Maniscalco WM, Metlay LA, Phelps DL

Pediatrics.. 1988 November 82 (5):756-62. Epub 1900 01 01.

Percutaneous central venous catheter colonization with Malassezia furfur: incidence and clinical significance.

Aschner JL, Punsalang A, Maniscalco WM, Menegus MA

Pediatrics.. 1987 October 80 (4):535-9. Epub 1900 01 01.

Effects of methylmercuric chloride, cycloheximide, and colchicine on the reaggregation of dissociated mouse cerebellar cells.

Jacobs AJ, Maniscalco WM, Finkelstein JN

Toxicology and applied pharmacology.. 1986 December 86 (3):362-71. Epub 1900 01 01.

Insulin receptors and insulin effects on type II alveolar epithelial cells.

Shapiro DL, Livingston JN, Maniscalco WM, Finkelstein JN

Biochimica et biophysica acta.. 1986 February 21885 (2):216-20. Epub 1900 01 01.

In vivo and in vitro demonstration of reduced myelin synthesis following early postnatal exposure to ionizing radiation in the rat.

Jacobs AJ, Maniscalco WM, Parkhurst AB, Finkelstein JN

Radiation research.. 1986 January 105 (1):97-104. Epub 1900 01 01.

Dexamethasone increases de novo fatty acid synthesis in fetal rabbit lung explants.

Maniscalco WM, Finkelstein JN, Parkhurst AB

Pediatric research.. 1985 December 19 (12):1272-7. Epub 1900 01 01.

Twin transfusion syndrome causing cutaneous erythropoiesis.

Schwartz JL, Maniscalco WM, Lane AT, Currao WJ

Pediatrics.. 1984 October 74 (4):527-9. Epub 1900 01 01.

Job satisfaction and stress among neonatologists.

Clarke TA, Maniscalco WM, Taylor-Brown S, Roghmann KJ, Shapiro DL, Hannon-Johnson C

Pediatrics.. 1984 July 74 (1):52-7. Epub 1900 01 01.

Properties of freshly isolated type II alveolar epithelial cells.

Finkelstein JN, Maniscalco WM, Shapiro DL

Biochimica et biophysica acta.. 1983 June 2762 (3):398-404. Epub 1900 01 01.

Necrotizing enterocolitis in premature infants transferred back to community hospitals.

Clarke TA, Maniscalco WM, Emmens RW

American journal of diseases of children. 1983 June 137 (6):563-5. Epub 1900 01 01.

De novo fatty acid synthesis by freshly isolated alveolar type II epithelial cells.

Maniscalco WM, Finkelstein JN, Parkhurst AB

Biochimica et biophysica acta.. 1983 May 16751 (3):462-9. Epub 1900 01 01.

Effects of dexamethasone on beta-adrenergic receptors in fetal lung explants.

Maniscalco WM, Shapiro DL

Pediatric research.. 1983 April 17 (4):274-7. Epub 1900 01 01.

Factors influencing neonatal autopsy rate.

Maniscalco WM, Clarke TA

American journal of diseases of children. 1982 September 136 (9):781-4. Epub 1900 01 01.

De novo fatty acid synthesis in developing rat lung.

Maniscalco WM, Finkelstein JN, Parkhurst AB

Biochimica et biophysica acta.. 1982 April 15711 (1):49-58. Epub 1900 01 01.

The influence of hormones on the biochemical development of fetal rat lung in organ culture. II. Insulin.

Gross I, Smith GJ, Wilson CM, Maniscalco WM, Ingleson LD, Brehier A, Rooney SA

Pediatric research.. 1980 June 14 (6):834-8. Epub 1900 01 01.

Influence of aminophylline and cyclic AMP on glycogen metabolism in fetal rat lung in organ culture.

Maniscalco WM, Wilson CM, Gross I

Pediatric research.. 1979 December 13 (12):1319-22. Epub 1900 01 01.

Effects of betamethasone on phospholipid content, composition and biosynthesis in the fetal rabbit lung.

Rooney SA, Gobran LI, Marino PA, Maniscalco WM, Gross I

Biochimica et biophysica acta.. 1979 January 29572 (1):64-76. Epub 1900 01 01.

Development of glycogen and phospholipid metabolism in fetal and newborn rat lung.

Maniscalco WM, Wilson CM, Gross I, Gobran L, Rooney SA, Warshaw JB

Biochimica et biophysica acta.. 1978 September 28530 (3):333-46. Epub 1900 01 01.

An organ culture model for study of biochemical development of fetal rat lung.

Gross I, Smith GJ, Maniscalco WM, Czajka MR, Wilson CM, Rooney SA

Journal of applied physiology: respiratory, environmental and exercise physiology.. 1978 September 45 (3):355-62. Epub 1900 01 01.

Books

Avery's Neonatology Board Review (2019)

Chapter: Respiratory Distress Syndrome/Bronchopulmonary Dysplasia

Informa Healthcare (2009)

Chapter: Disruption of Lung Vascular Development in BPD

Encyclopedia of Respiratory Medicine (2006)

Chapter: Vascular endothelial growth factor.

Sem Perinatol (2006)

Chapter: Pathogenesis of bronchopulmonary dysplasia (BPD)

Surfactant Replacement Therapy (1989)

Chapter: Clinical experience with calf lung surfactant extract.

Assessment of the Newborn: A Guide for Diagnosis (1984)

Chapter: Neonatal hypoglycemia.

Assessment of the Newborn: A Guide for Diagnosis (1984)

Chapter: Neonatal hypocalcemia

Assessment of the Newborn: A Guide for Diagnosis (1984)

Chapter: Perinatal postmortem examination

Intensive Care of the Newborn (1979)

Chapter: Perinatal adaptations in carbohydrate and lipid metabolism.

Temperature Regulation and Energy Metabolism in the Newborn (1978)

Chapter: Cellular energy metabolism during fetal and perinatal development