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Charles W. Francis, M.D.

Charles W. Francis, M.D.

Contact

Appointment (585) 275-5823
Fax (585) 273-1042

About Me

Dr. Francis is Professor of Medicine and of Pathology and Laboratory Medicine at the University of Rochester. He obtained his MD degree at the University of Pittsburgh and was then an Intern and Resident in Medicine at the University of North Carolina. He joined the University of Rochester as a Fe...
Dr. Francis is Professor of Medicine and of Pathology and Laboratory Medicine at the University of Rochester. He obtained his MD degree at the University of Pittsburgh and was then an Intern and Resident in Medicine at the University of North Carolina. He joined the University of Rochester as a Fellow in Hematology in 1976, and he has remained at that institution where he is Director of the Hemostasis and Thrombosis program. Dr. Francis has been recipient of a Clinical Investigator Award from the NHLBI and an Established Investigator Award from the American Heart Association. He has served on numerous NIH Review and Advisory Committees. He is a past Chairman of the Scientific and Standardization Committee of the ISTH and Program Chair of the XVIIth International Congress on Hemostasis and Thrombosis. He serves as the Editor-in-Chief of Thrombosis Research. Dr. Francis has both clinical and laboratory research interests. Laboratory research has focused on the structure of fibrinogen and fibrin and mechanisms of fibrinolysis. Current work relates to the work of fibrinogen and fibrin in modulating the effects of FGF-2 on endothelial cells. Clinical research has been in the areas of venous thrombosis and new anticoagulants.

Faculty Appointments

Professor Emeritus - Department of Medicine, Hematology/Oncology (SMD)

Credentials

Education

MD | Univ Pittsburgh Sch Medicine. Medicine. 1973

BA | Johns Hopkins University. Biological Science. 1969

Awards

Phi Beta Kappa

Alpha Omega Alpha

Established Investigator, American Heart Association

Clinical Investigator Award, National Institutes of Health

Inclusion in "The Best Doctors in America", Woodward/White, Inc, Publishers, 1994, 1995, 1996, 1998, 2000-2006

Research

Dr. Francis does both clinical and basic research in the areas of thrombosis, hemostasis and vascular biology. Fibrinogen and fibrin have been an area of extensive research. He first described the structures of plasmic degradation products of crosslinked fibrin and developed a molecular model of f...
Dr. Francis does both clinical and basic research in the areas of thrombosis, hemostasis and vascular biology. Fibrinogen and fibrin have been an area of extensive research. He first described the structures of plasmic degradation products of crosslinked fibrin and developed a molecular model of fibrinolysis. He identified an important structural variant of fibrinogen that differs at the carboxyl terminus of the gamma chain. He was one of the first to demonstrate that ultrasound accelerates enzymatic fibrinolysis, identified the mechanisms responsible and defined the ultrasound parameters for effective fibrinolysis augmentation. Studies in recent years have characterized the interaction of FGF-2, EGF and IL-² beta with fibrinogen and fibrin. The binding sites for interaction have been identified, and augmented functional activity of FGF-2 and IL-² beta in the bound form demonstrated. Extensive clinical research helped to define the structures of crosslinked fibrin degradation products in fibrinolytic states. Numerous studies have been conducted to improve prophylaxis of deep vein thrombosis and pulmonary embolism. These have included clinical trials using warfarin, antithrombin, low-molecular-weight heparin and direct thrombin inhibitors. Recent clinical studies have examined risk factors for arterial thrombosis and the effects of thiazolidinediones on lipid and hemostatic risk factors for thrombosis.

Patents

Method of Treating a Patient with a Neurodegenerative Disease Using Ultrasound

Issue date: May 01, 2007

Patent #: 7,211,054

Country: United States

Inventors: Charles W Francis, Valentina Suchkova

A Method to Improve Circulation to Ischemic Tissue

Issue date: April 09, 2013

Patent #: 2,350,028

Country: Canada

Inventors: Charles W Francis, Valentina Suchkova

Assay for Soluble Crosslinked Fibrin Polymers

Issue date: April 27, 1993

Patent #: 5,206,140

Country: United States

Inventors: Charles W Francis, Victor J Marder

Publications

Journal Articles

Risk prediction of cancer-associated thrombosis: Appraising the first decade and developing the future.

Khorana AA, Francis CW

Thrombosis research.. 2018 April 164 Suppl 1 :S70-S76. Epub 01/31/2018.

Reduced anticoagulation variability in patients on warfarin monitored with Fiix-prothrombin time associates with reduced thromboembolism: The Fiix-trial.

Oskarsdóttir AR, Gudmundsdottir BR, Indridason OS, Lund SH, Arnar DO, Bjornsson ES, Magnusson MK, Jensdottir HM, Vidarsson B, Francis CW, Onundarson PT

Journal of thrombosis and thrombolysis.. 2017 May 43 (4):550-561. Epub 1900 01 01.

Extended Thromboprophylaxis with Betrixaban in Acutely Ill Medical Patients.

Cohen AT, Harrington RA, Goldhaber SZ, Hull RD, Wiens BL, Gold A, Hernandez AF, Gibson CM,

The New England journal of medicine.. 2016 August 11375 (6):534-44. Epub 05/27/2016.

Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group.

Key NS, Khorana AA, Mackman N, McCarty OJ, White GC, Francis CW, McCrae KR, Palumbo JS, Raskob GE, Chan AT, Sood AK

Cancer research.. 2016 July 176 (13):3671-5. Epub 06/20/2016.

A Validated Risk Score for Venous Thromboembolism Is Predictive of Cancer Progression and Mortality.

Kuderer NM, Culakova E, Lyman GH, Francis C, Falanga A, Khorana AA

The oncologist.. 2016 July 21 (7):861-7. Epub 04/28/2016.

A single test to assay warfarin, dabigatran, rivaroxaban, apixaban, unfractionated heparin, and enoxaparin in plasma.

Letertre LR, Gudmundsdottir BR, Francis CW, Gosselin RC, Skeppholm M, Malmstrom RE, Moll S, Hawes E, Francart S, Onundarson PT

Journal of thrombosis and haemostasis : JTH.. 2016 May 14 (5):1043-53. Epub 03/30/2016.

Fiix-prothrombin time monitoring improves warfarin anticoagulation outcome in atrial fibrillation: a systematic review of randomized trials comparing Fiix-warfarin or direct oral anticoagulants to standard PT-warfarin.

Onundarson PT, Arnar DO, Lund SH, Gudmundsdottir BR, Francis CW, Indridason OS

International journal of laboratory hematology.. 2016 May 38 Suppl 1 :78-90. Epub 1900 01 01.

ABO-immune complex formation and impact on platelet function, red cell structural integrity and haemostasis: an in vitro model of ABO non-identical transfusion.

Zaffuto BJ, Conley GW, Connolly GC, Henrichs KF, Francis CW, Heal JM, Blumberg N, Refaai MA

Vox sanguinis.. 2016 April 110 (3):219-26. Epub 11/03/2015.

Victor J. Marder, M.D.: physician, scientist, founder, lover of the arts, teacher, leader (1934-2015).

White GC, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2015 July 13 (7):1354-7. Epub 06/11/2015.

Treatment of venous thromboembolism in cancer patients with dalteparin for up to 12 months: the DALTECAN Study.

Francis CW, Kessler CM, Goldhaber SZ, Kovacs MJ, Monreal M, Huisman MV, Bergqvist D, Turpie AG, Ortel TL, Spyropoulos AC, Pabinger I, Kakkar AK

Journal of thrombosis and haemostasis : JTH.. 2015 June 13 (6):1028-35. Epub 05/10/2015.

Fiix-prothrombin time versus standard prothrombin time for monitoring of warfarin anticoagulation: a single centre, double-blind, randomised, non-inferiority trial.

Onundarson PT, Francis CW, Indridason OS, Arnar DO, Bjornsson ES, Magnusson MK, Juliusson SJ, Jensdottir HM, Vidarsson B, Gunnarsson PS, Lund SH, Gudmundsdottir BR

The Lancet. Haematology.. 2015 June 2 (6):e231-40. Epub 05/25/2015.

Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014.

Lyman GH, Bohlke K, Khorana AA, Kuderer NM, Lee AY, Arcelus JI, Balaban EP, Clarke JM, Flowers CR, Francis CW, Gates LE, Kakkar AK, Key NS, Levine MN, Liebman HA, Tempero MA, Wong SL, Somerfield MR, Falanga A

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2015 February 2033 (6):654-6. Epub 01/20/2015.

Improving Clinical Practice Guidelines for Practicing Cardiologists

A. Moss, C. Francis.

American Journal of Cardiology. 2015; .

"ABO-immune complex formation and impact on platelet function, red cell structural integrity and haemostasis: an in vitro model of ABO non-identical transfusion."

B. J. Zaffuto, G. W. Conley, G. C. Connolly, K. F. Henrichs, C. W. Francis, J. M. Heal, N. Blumberg, M. A. Refaai.

VoxSanguinis The International Journal of Transfusion Medicine 2015 September 11; 1-4. 2015; : 1-4.

Screening high-risk cancer patients for VTE: a prospective observational study.

Khorana AA, Rubens D, Francis CW

Thrombosis research.. 2014 December 134 (6):1205-7. Epub 09/20/2014.

Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro.

Spinelli SL, Lannan KL, Casey AE, Croasdell A, Curran TM, Henrichs KF, Pollock SJ, Milne GA, Refaai MA, Francis CW, Phipps RP, Blumberg N

Transfusion.. 2014 June 54 (6):1569-79. Epub 11/05/2013.

Platelets and cancer-associated thrombosis.

Connolly GC, Phipps RP, Francis CW

Seminars in oncology.. 2014 June 41 (3):302-10. Epub 04/24/2014.

Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro

Spinelli, Sherry L; Lannan, Katie L; Casey, Ann E;Croasdell, Amanda; Curran, Timothy M; Henrichs, Kelly F; Pollock, Stephen J; Milne, Ginger A; Refaai, Majed A; Francis, Charles F; Phipps, Richard P; Blumberg, Neil.

Blood Components. 2014; 54: 1569-1579.

Prevalence and clinical significance of incidental and clinically suspected venous thromboembolism in lung cancer patients.

Connolly GC, Menapace L, Safadjou S, Francis CW, Khorana AA

Clinical lung cancer.. 2013 November 14 (6):713-8. Epub 07/26/2013.

Venous thromboembolism prophylaxis and treatment in patients with cancer: American Society of Clinical Oncology clinical practice guideline update.

Lyman GH, Khorana AA, Kuderer NM, Lee AY, Arcelus JI, Balaban EP, Clarke JM, Flowers CR, Francis CW, Gates LE, Kakkar AK, Key NS, Levine MN, Liebman HA, Tempero MA, Wong SL, Prestrud AA, Falanga A

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2013 June 1031 (17):2189-204. Epub 05/13/2013.

Prevention of VTE in patients having major orthopedic surgery.

Francis CW

Journal of thrombosis and thrombolysis.. 2013 April 35 (3):359-67. Epub 1900 01 01.

Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B.

Refaai MA, Carter J, Henrichs KF, Davidson DC, Pollock SJ, Casey AE, Spinelli SL, Phipps RP, Francis CW, Blumberg N

Transfusion.. 2013 February 53 (2):382-93. Epub 05/25/2012.

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: American Society of Clinical Oncology Practice Guideline Update.

Lyman, GH; Khorana, AA; Kuderer, NM; Lee, AY; Arcelus, JI; Balaban, EP; Clarke, JM; Flowers, CR; Francis,CW; Gates, LE; Kakkar, AJ; Key, NS; Levine, MN; Liebman, HA; Tempero, MA; Wong, SL; Prestrud, AA; Falanga, A.

Journal of Clinical Oncology. 2013; .

Prevalence and clinical significance of incidental and clinically suspected venous thromboembolism in lung cancer patients.

Connolly, G; Menapace, L; Safadjou, S; Francis, CW; Khorana, A.

Clinical Lung cancer. 2013; : In Press.

A Validated Risk Score for VTE is Predictive Of Early Cancer Progression and Mortality

Kuderer, NM; Culakova, E; Lyman, GH; Francis, C; Falanga, A; Khorana, AA.

Journal of Clinical Oncology - Submitted. 2013; .

Isoporstane and isofuran lipid mediators accumulate in stored red blood cell concentrates and influence platelet function in vitro

Spinelli, SL; Lannan, KL; Case, AE; Croasdell, A; Curran, TM; Henrichs, KF; Pollock, SJ; Refaai, MA; Francis, CW; Milne, GA; Phipps, RP; Blumberg, N.

Transfusion. 2013; .

Isoprostane and isofuran lipid mediators accumulate in stored red blood cells and influence platelet function in vitro

Spinelli, SL; Lannan, KL; Casey, AE; Croasdell, A; Curran, TM; Henrichs, KF; Pollock, SJ; Milne, GA; Refaai, MA; Francis, CW; Phipps, P and Blumberg, N.

Transfusion. 2013; [Epub ahead of print].

Cancer-associated thrombosis.

Connolly GC, Francis CW

Hematology. 2013 2013 :684-91. Epub 1900 01 01.

Critical role of factors II and X during coumarin anticoagulation and their combined measurement with a new Fiix-prothrombin time.

Gudmundsdottir BR, Francis CW, Bjornsdottir AM, Nellbring M, Onundarson PT

Thrombosis research.. 2012 October 130 (4):674-81. Epub 01/04/2012.

Vaginal bleeding in early pregnancy and circulating markers of thrombin generation.

Hackney DN, Miller RK, Pressman EK, Francis CW, Simhan HN

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.. 2012 August 25 (8):1479-82. Epub 01/24/2012.

Preventing VTE in Outpatients With Cancer.

Khorana AA, Spyropoulos AC, Zwicker J, Lyman GH, Francis CW

Chest.. 2012 July 142 (1):265-266. Epub 1900 01 01.

Pioglitazone inhibits platelet function and potentiates the effects of aspirin: a prospective observation study.

Mongan J, Mieszczanska HZ, Smith BH, Messing SP, Phipps RP, Francis CW

Thrombosis research.. 2012 June 129 (6):760-4. Epub 01/04/2012.

Challenges of rare disease research: limited patients and competing priorities.

Ragni MV, Moore CG, Bias V, Key NS, Kouides PA, Francis CW,

Haemophilia : the official journal of the World Federation of Hemophilia.. 2012 May 18 (3):e192-4. Epub 09/13/2011.

Approach to outcome measurement in the prevention of thrombosis in surgical and medical patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Guyatt GH, Eikelboom JW, Gould MK, Garcia DA, Crowther M, Murad MH, Kahn SR, Falck-Ytter Y, Francis CW, Lansberg MG, Akl EA, Hirsh J

Chest.. 2012 February 141 (2 Suppl):e185S-e194S. Epub 1900 01 01.

Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Falck-Ytter Y, Francis CW, Johanson NA, Curley C, Dahl OE, Schulman S, Ortel TL, Pauker SG, Colwell CW

Chest.. 2012 February 141 (2 Suppl):e278S-e325S. Epub 1900 01 01.

An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients.

Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N

Vox sanguinis.. 2011 July 101 (1):55-60. Epub 03/18/2011.

Collaborative clinical trials.

Moss AJ, Francis CW, Ryan D

The New England journal of medicine.. 2011 March 3364 (9):789-91. Epub 1900 01 01.

Platelet Activation Following Exposure to Anti-ABO Antibodies-An In Vitro Study.

Refaai MA, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Francis CW, Blumberg N

US oncology & hematology.. 2011 January 17 (1):72-74. Epub 1900 01 01.

Platelet Activation Following Exposure to Anti-ABO Antibodies-An In Vitro Study.

Refaai, MA; Henrichs, KF; Spinelli, SL; Phipps, RP; Masel, E; Smith, BH; Francis, CW; Blumberg, N.

US Oncology & Hematology. 2011; 7(1): 72-4.

Dabigatran versus enoxaparin for prevention of venous thromboembolism after hip or knee arthroplasty: a pooled analysis of three trials.

Friedman RJ, Dahl OE, Rosencher N, Caprini JA, Kurth AA, Francis CW, Clemens A, Hantel S, Schnee JM, Eriksson BI,

Thrombosis research.. 2010 September 126 (3):175-82. Epub 05/15/2010.

Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy.

Connolly GC, Khorana AA, Kuderer NM, Culakova E, Francis CW, Lyman GH

Thrombosis research.. 2010 August 126 (2):113-8. Epub 1900 01 01.

A computerized prompt for thromboprophylaxis in hospitalized cancer patients.

Candelario GD, Francis CW, Panzer R, McAdam KS, Cockrell D, Baird T, Khorana AA

Thrombosis research.. 2010 July 126 (1):32-4. Epub 10/30/2009.

Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy.

Connolly GC, Khorana AA, Kuderer NM, Culakova E, Francis CW, Lyman GH

Thrombosis research.. 2010 June 5 Epub 6/5/2010.

Outcomes after platelet transfusion in patients with heparin-induced thrombocytopenia.

Refaai MA, Chuang C, Menegus M, Blumberg N, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2010 June 8 (6):1419-21. Epub 03/19/2010.

Platelets and megakaryocytes contain functional nuclear factor-kappaB.

Spinelli SL, Casey AE, Pollock SJ, Gertz JM, McMillan DH, Narasipura SD, Mody NA, King MR, Maggirwar SB, Francis CW, Taubman MB, Blumberg N, Phipps RP

Arteriosclerosis, thrombosis, and vascular biology.. 2010 March 30 (3):591-8. Epub 12/30/2009.

The platelet as an immune cell-CD40 ligand and transfusion immunomodulation.

Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP

Immunologic research.. 2009 December 45 (2-3):251-60. Epub 01/29/2009.

Foxp3 regulates megakaryopoiesis and platelet function.

Bernard JJ, Seweryniak KE, Koniski AD, Spinelli SL, Blumberg N, Francis CW, Taubman MB, Palis J, Phipps RP

Arteriosclerosis, thrombosis, and vascular biology.. 2009 November 29 (11):1874-82. Epub 08/06/2009.

Prevention of venous thromboembolism in hospitalized patients with cancer.

Francis CW

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2009 October 1027 (29):4874-80. Epub 08/24/2009.

Impact of venous thromboembolism and anticoagulation on cancer and cancer survival.

Kuderer NM, Ortel TL, Francis CW

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2009 October 1027 (29):4902-11. Epub 09/08/2009.

The effect of high circulating estradiol levels on thrombin generation during in vitro fertilization.

Brummel-Ziedins KE, Gissel M, Francis C, Queenan J, Mann KG

Thrombosis research.. 2009 September 124 (4):505-7. Epub 03/17/2009.

Thrombosis Research: Introduction of e-pages.

Sandset PM, Francis C

Thrombosis research.. 2009 July 124 (3):251. Epub 1900 01 01.

Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray study.

Yao JL, Ryan CK, Francis CW, Kohli M, Taubman MB, Khorana AA

Cancer investigation.. 2009 May 27 (4):430-4. Epub 1900 01 01.

Platelet proteome changes associated with diabetes and during platelet storage for transfusion.

Springer D, Miller J, Spinelli S, Pasa-Tolic L, Purvine S, Daly D, Zangar R, Jin S, Blumberg N, Francis C, Taubman M, Casey A, Wittlin S, Phipps R

Journal of proteome research.. 2009 May 8 (5):2261-72. Epub 1900 01 01.

Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery.

, Ginsberg JS, Davidson BL, Comp PC, Francis CW, Friedman RJ, Huo MH, Lieberman JR, Muntz JE, Raskob GE, Clements ML, Hantel S, Schnee JM, Caprini JA

The Journal of arthroplasty.. 2009 January 24 (1):1-9. Epub 04/14/2008.

15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis.

O'Brien JJ, Baglole CJ, Garcia-Bates TM, Blumberg N, Francis CW, Phipps RP

Journal of thrombosis and haemostasis : JTH.. 2009 January 7 (1):182-9. Epub 10/10/2008.

Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer.

Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH

Archives of internal medicine.. 2008 November 24168 (21):2377-81. Epub 1900 01 01.

15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes.

O'Brien JJ, Spinelli SL, Tober J, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP

Blood.. 2008 November 15112 (10):4051-60. Epub 08/28/2008.

Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer.

Khorana AA, Francis CW, Menzies KE, Wang JG, Hyrien O, Hathcock J, Mackman N, Taubman MB

Journal of thrombosis and haemostasis : JTH.. 2008 November 6 (11):1983-5. Epub 09/15/2008.

Development and validation of a predictive model for chemotherapy-associated thrombosis.

Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW

Blood.. 2008 May 15111 (10):4902-7. Epub 01/23/2008.

Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2).

Sahni A, Simpson-Haidaris PJ, Sahni SK, Vaday GG, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2008 January 6 (1):176-83. Epub 10/22/2007.

Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles.

Ray DM, Spinelli SL, Pollock SJ, Murant TI, O'Brien JJ, Blumberg N, Francis CW, Taubman MB, Phipps RP

Thrombosis and haemostasis.. 2008 January 99 (1):86-95. Epub 1900 01 01.

15-deoxy-&d12, 14-PGJ2 enhances platelet production from megakaryocytes

O'Brien JJ; Spinelli S; Tober J; Blumberg N; Francis CW; Taubman M;.

Blood. 2008; .

The oral thrombin inhibitor debigatran etexilate vs the North American enoxaparin regimen for the prevention of venous thromboembolism after knee replacement surgery: the RE-MOBILIZE trial

Ginsberg JS; Davidson BL; Comp PC; Francis CW; Friedman RJ; Hyo MH; Lieberman J; Muntz JE; Raskob GE; Clements ML; Hantel S; Schnee JM; Caprini JA for the RE-MOBILIZE Study Group.

J Arthroplasty. 2008; .

The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects.

Spinelli SL, O'Brien JJ, Bancos S, Lehmann GM, Springer DL, Blumberg N, Francis CW, Taubman MB, Phipps RP

PPAR research. 2008 2008 :328172. Epub 1900 01 01.

Warfarin: an historical perspective.

Francis CW

Hematology. 2008 :251. Epub 1900 01 01.

New issues in oral anticoagulants.

Francis CW

Hematology. 2008 :259-65. Epub 1900 01 01.

American Society of Clinical Oncology guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer.

Lyman GH, Khorana AA, Falanga A, Clarke-Pearson D, Flowers C, Jahanzeb M, Kakkar A, Kuderer NM, Levine MN, Liebman H, Mendelson D, Raskob G, Somerfield MR, Thodiyil P, Trent D, Francis CW,

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2007 December 125 (34):5490-505. Epub 10/29/2007.

Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients.

Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH

Cancer.. 2007 November 15110 (10):2339-46. Epub 1900 01 01.

A meta-analysis and systematic review of the efficacy and safety of anticoagulants as cancer treatment: impact on survival and bleeding complications.

Kuderer NM, Khorana AA, Lyman GH, Francis CW

Cancer.. 2007 September 1110 (5):1149-61. Epub 1900 01 01.

Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer.

Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, Hostetter G, Harvey J, Taubman MB

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2007 May 1513 (10):2870-5. Epub 1900 01 01.

Effects of pioglitazone on fasting and postprandial levels of lipid and hemostatic variables in overweight non-diabetic patients with coronary artery disease.

Mieszczanska H, Kaba NK, Francis CW, Gerich JE, Dodis R, Schwarz KQ, Phipps RP, Smith BH, Lee M, Messing S, Taubman MB

Journal of thrombosis and haemostasis : JTH.. 2007 May 5 (5):942-9. Epub 1900 01 01.

Clinical practice. Prophylaxis for thromboembolism in hospitalized medical patients.

Francis CW

The New England journal of medicine.. 2007 April 5356 (14):1438-44. Epub 1900 01 01.

Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy.

Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH

Journal of thrombosis and haemostasis : JTH.. 2007 March 5 (3):632-4. Epub 1900 01 01.

The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands.

O'Brien JJ, Ray DM, Spinelli SL, Blumberg N, Taubman MB, Francis CW, Wittlin SD, Phipps RP

Prostaglandins & other lipid mediators.. 2007 January 82 (1-4):68-76. Epub 07/10/2006.

A Meta-Analysis and Systematic Review of the Efficacy and Safety of Anticoagulants as Cancer Treatment: Impact on survival and Bleeding Complications

Kuderer NM; Khorana AA; Lyman GH; Francis CW.

Cancer. 2007; 5: 1149-1161.

Venous thromboembolism in patients with diffuse large B-cell lymphoma.

Komrokji RS, Uppal NP, Khorana AA, Lyman GH, Kaplan KL, Fisher RI, Francis CW

Leukemia & lymphoma.. 2006 June 47 (6):1029-33. Epub 1900 01 01.

Thromboembolism in hospitalized neutropenic cancer patients.

Khorana AA, Francis CW, Culakova E, Fisher RI, Kuderer NM, Lyman GH

Journal of clinical oncology : official journal of the American Society of Clinical Oncology.. 2006 January 2024 (3):484-90. Epub 1900 01 01.

FGF-2 binding to fibrin(ogen) is required for augmented angiogenesis.

Sahni A, Khorana AA, Baggs RB, Peng H, Francis CW

Blood.. 2006 January 1107 (1):126-31. Epub 09/13/2005.

Thromboembolism in hospitalized neutropenic cancer patients

Khorana AA; Francis CW; Culakova E; Fisher RI; Kuderer N; Lyman GH.

J Clin Oncol. 2006; .

Clinical Use of Plasma and Plasma Fractions

Blumberg N; Francis CW; Heal J.

Baillier's Best Practice & Research: Clinical Haematology. 2006; .

Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study.

Khorana AA, Francis CW, Culakova E, Lyman GH

Cancer.. 2005 December 15104 (12):2822-9. Epub 1900 01 01.

Endothelial cell activation by IL-1beta in the presence of fibrinogen requires alphavbeta3.

Sahni A, Sahni SK, Francis CW

Arteriosclerosis, thrombosis, and vascular biology.. 2005 October 25 (10):2222-7. Epub 08/25/2005.

Oral direct thrombin inhibitor ximelagatran compared with warfarin for the prevention of venous thromboembolism after total knee arthroplasty.

Colwell CW, Berkowitz SD, Lieberman JR, Comp PC, Ginsberg JS, Paiement G, McElhattan J, Roth AW, Francis CW,

The Journal of bone and joint surgery. American volume.. 2005 October 87 (10):2169-77. Epub 1900 01 01.

Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction.

Moss AJ, Ryan D, Oakes D, Goldstein RE, Greenberg H, Bodenheimer MM, Brown MW, Case RB, Dwyer EM, Eberly SW, Francis CW, Gillespie JA, Krone RJ, Lichstein E, MacCluer JW, Marcus FI, McCarthy J, Sparks CE, Zareba W

The American journal of cardiology.. 2005 July 1596 (2):177-82. Epub 1900 01 01.

Venous thrombosis and stenosis after implantation of pacemakers and defibrillators.

Rozmus G, Daubert JP, Huang DT, Rosero S, Hall B, Francis C

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing.. 2005 June 13 (1):9-19. Epub 1900 01 01.

Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: a randomized trial.

Fiessinger JN, Huisman MV, Davidson BL, Bounameaux H, Francis CW, Eriksson H, Lundström T, Berkowitz SD, Nyström P, Thorsén M, Ginsberg JS,

JAMA.. 2005 February 9293 (6):681-9. Epub 1900 01 01.

Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires avB3.

Sahni A; Sahni S; Francis CW.

ATVB. 2005; .

Ximelagatran vs. low molecular weight heparin and warfarin for the treatment of deep vein thrombosis: a randomized controlled trial

Fiessinger JN; Huisman MV; Davidson BL; Bounameaux H; Francis CW.

JAMA. 2005; .

FGF-2 binding to fibrin(ogen) is required for augmented angiogenesis

Sahni A; Khorana AA; Baggs RB; Peng H; Francis CW.

Blood. 2005; .

Direct thrombin inhibitors for treatment of heparin induced thrombocytopenia, deep vein thrombosis and atrial fibrillation.

Francis CW

Current pharmaceutical design.. 2005 11 (30):3931-41. Epub 1900 01 01.

Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3.

Sahni A, Francis CW

Blood.. 2004 December 1104 (12):3635-41. Epub 08/05/2004.

Ultrasound energy improves myocardial perfusion in the presence of coronary occlusion.

Siegel RJ, Suchkova VN, Miyamoto T, Luo H, Baggs RB, Neuman Y, Horzewski M, Suorsa V, Kobal S, Thompson T, Echt D, Francis CW

Journal of the American College of Cardiology.. 2004 October 644 (7):1454-8. Epub 1900 01 01.

Fibrinogen regulates the expression of inflammatory chemokines through NF-kappaB activation of endothelial cells.

Guo M, Sahni SK, Sahni A, Francis CW

Thrombosis and haemostasis.. 2004 October 92 (4):858-66. Epub 1900 01 01.

Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes.

Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP

Blood.. 2004 September 1104 (5):1361-8. Epub 05/06/2004.

Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells.

Sahni A, Sahni SK, Simpson-Haidaris PJ, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2004 September 2 (9):1629-36. Epub 1900 01 01.

Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form.

Sahni A, Guo M, Sahni SK, Francis CW

Blood.. 2004 July 15104 (2):409-14. Epub 03/23/2004.

NF-kappaB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and anti-apoptotic proteins.

Joshi SG, Francis CW, Silverman DJ, Sahni SK

FEMS microbiology letters.. 2004 May 15234 (2):333-41. Epub 1900 01 01.

Effects of lipids and lipid-lowering therapy on hemostatic factors in patients with myocardial infarction.

Kaba NK, Francis CW, Moss AJ, Zareba W, Oakes D, Knox KL, Fernández ID, Rainwater DL,

Journal of thrombosis and haemostasis : JTH.. 2004 May 2 (5):718-25. Epub 1900 01 01.

Low-intensity ultrasound increases endothelial cell nitric oxide synthase activity and nitric oxide synthesis.

Altland OD, Dalecki D, Suchkova VN, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2004 April 2 (4):637-43. Epub 1900 01 01.

Identification of a binding site on human FGF-2 for fibrinogen.

Peng H, Sahni A, Fay P, Bellum S, Prudovsky I, Maciag T, Francis CW

Blood.. 2004 March 15103 (6):2114-20. Epub 11/20/2003.

Ximelagatran: a new oral anticoagulant.

Francis CW

Best practice & research. Clinical haematology.. 2004 March 17 (1):139-52. Epub 1900 01 01.

Comparison of the Oral Direct Thrombin Inhibitor Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism Following total Knee Replacement

Francis CW; Berkowitz SD; Comp PC.

NEJM. 2004; 349: 1703-1712.

Interluekin-1B but not IL-1a Binds t Fibrinogen and Fibrin and has Enhanced Activity in the Bound Form

Sahni A; Guo M; Sahni SK; Francis CW.

Blood. 2004; .

Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of uPA, uPAR, and PAI-1 in endothelial cells.

Sahni A; Sahni SK; Simpson-Haidaris PJ; Francis CW.

J Thromb Haemost. 2004; .

Human bone marrow megakaryocytes and platelets express PPARy and PPARy agonists blunt platelet release of CD40 ligand and thromboxanes

Akbiyik F; Ray DM; Gettings KF; Blumberg N; Francis CW and Phipps RP;.

Blood. 2004; .

Fibrinogen regulates the expression of inflammatory chemokines through NF-kB activation of endothelial cells

Guo M; Sahni SK; Sahni A; Francis CW;.

J Thromb Haemost. 2004; .

Ultrasound Energy Improves Myocardial Perfusion in the Presence of Coronary Occlusion

Siegel RJ; Suchkova VN; Miyamoto T; Luo H; Baggs RB; Neuman Y; Horzewski M; Francis CW; et al.

JACC. 2004; .

Heparin inhibition of endothelial cell proliferation and organization is dependent on molecular weight.

Khorana AA, Sahni A, Altland OD, Francis CW

Arteriosclerosis, thrombosis, and vascular biology.. 2003 November 123 (11):2110-5. Epub 08/14/2003.

Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement.

Francis CW, Berkowitz SD, Comp PC, Lieberman JR, Ginsberg JS, Paiement G, Peters GR, Roth AW, McElhattan J, Colwell CW,

The New England journal of medicine.. 2003 October 30349 (18):1703-12. Epub 1900 01 01.

Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study.

Colwell CW, Berkowitz SD, Davidson BL, Lotke PA, Ginsberg JS, Lieberman JR, Neubauer J, McElhattan JL, Peters GR, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2003 October 1 (10):2119-30. Epub 1900 01 01.

Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity.

Joshi SG, Francis CW, Silverman DJ, Sahni SK

Infection and immunity.. 2003 July 71 (7):4127-36. Epub 1900 01 01.

Plasmic degradation modulates activity of fibrinogen-bound fibroblast growth factor-2.

Sahni A, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2003 June 1 (6):1271-7. Epub 1900 01 01.

FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth.

Sahni A, Altland OD, Francis CW

Journal of thrombosis and haemostasis : JTH.. 2003 June 1 (6):1304-10. Epub 1900 01 01.

Protein S declines during winter respiratory infections.

Kaba NK, Francis CW, Hall WJ, Falsey AR, Smith BH

Journal of thrombosis and haemostasis : JTH.. 2003 April 1 (4):729-34. Epub 1900 01 01.

Randomized prospective study comparing routine versus selective use of sonography of the complete calf in patients with suspected deep venous thrombosis.

Gottlieb RH, Voci SL, Syed L, Shyu C, Fultz PJ, Rubens DJ, Strang JG, Carson N, DiGrazio WJ, Francis CW

AJR. American journal of roentgenology.. 2003 January 180 (1):241-5. Epub 1900 01 01.

Nuclear Factor kB protects against Host Cell Apoptosis during Rickettsia rickettsii iinfection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity

Joshi S; Francis CW; Silverman DJ; Sahni S.

Infection and Immunity. 2003; .

Evaluation of platelet activation, fibrinolysis and hemostatic activation during high dose dobutamine stress echocardiography

Shammas NW; Pennell BJ; Rossen J; Francis CW; et al.

Journal of Angiology. 2003; 12: 162-165.

FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth

Sahni A; Altland O; Francis CW.

J Thromb Hemost. 2003; 1: 1304-1310.

Protein S declines during winter respiratory infections

Kaba NK; Francis CW; Hall WJ; Falsey AF; Smith BH.

J Thromb and Haemost. 2003; 1: 729-732.

Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study

Colwell CW; Berkowitz SD; Davidson BL; Lotke PA; Francis CW; et al.

J Thromb Hemost. 2003; 1: 2119-2130.

Oral direct thrombin inhibitor ximelagatran compared with warfarin for prevention of venous thromboembolism after total knee replacement

Colwell CW; Francis CW; Berkowitz SE; et al.

J Thromb Haemost. 2003; .

Consultations on patients with venous or arterial diseases.

Alving BM, Francis CW, Hiatt WR, Jackson MR

Hematology. 2003 :540-58. Epub 1900 01 01.

Factor XIII polymorphisms and venous thromboembolism.

Francis CW

Archives of pathology & laboratory medicine.. 2002 November 126 (11):1391-3. Epub 1900 01 01.

Plasminogen activator inhibitor-1 levels and polymorphisms.

Francis CW

Archives of pathology & laboratory medicine.. 2002 November 126 (11):1401-4. Epub 1900 01 01.

Ultrasound improves tissue perfusion in ischemic tissue through a nitric oxide dependent mechanism.

Suchkova VN, Baggs RB, Sahni SK, Francis CW

Thrombosis and haemostasis.. 2002 November 88 (5):865-70. Epub 1900 01 01.

Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trial.

Francis CW, Davidson BL, Berkowitz SD, Lotke PA, Ginsberg JS, Lieberman JR, Webster AK, Whipple JP, Peters GR, Colwell CW

Annals of internal medicine.. 2002 October 15137 (8):648-55. Epub 1900 01 01.

Neuropathologic findings in a Guillain-Barré patient with strokes after IVIg therapy.

Byrne NP, Henry JC, Herrmann DN, Abdelhalim AN, Shrier DA, Francis CW, Powers JM

Neurology.. 2002 August 1359 (3):458-61. Epub 1900 01 01.

Direct thrombin inhibitors.

Kaplan KL, Francis CW

Seminars in hematology.. 2002 July 39 (3):187-96. Epub 1900 01 01.

Ultrasound enhancement of fibrinolysis at frequencies of 27 to 100 kHz.

Suchkova V, Carstensen EL, Francis CW

Ultrasound in medicine & biology.. 2002 March 28 (3):377-82. Epub 1900 01 01.

Ultrasound enhancement of fibrinolysis at frequencies of 27 to 100 kHz

Suchkova VN; Carstensen EL; Francis CW.

Ultrasound in Med & Biol. 2002; 28: 377-382.

Fibrin degradation products, fibrin monomer and soluble fibrin in disseminated intravascular coagulation.

Horan JT, Francis CW

Seminars in thrombosis and hemostasis.. 2001 December 27 (6):657-66. Epub 1900 01 01.

Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study.

Heit JA, Colwell CW, Francis CW, Ginsberg JS, Berkowitz SD, Whipple J, Peters G,

Archives of internal medicine.. 2001 October 8161 (18):2215-21. Epub 1900 01 01.

Timing of initial administration of low-molecular-weight heparin prophylaxis against deep vein thrombosis in patients following elective hip arthroplasty: a systematic review.

Hull RD, Pineo GF, Stein PD, Mah AF, MacIsaac SM, Dahl OE, Ghali WA, Butcher MS, Brant RF, Bergqvist D, Hamulyák K, Francis CW, Marder VJ, Raskob GE

Archives of internal medicine.. 2001 September 10161 (16):1952-60. Epub 1900 01 01.

Posttransfusion purpura secondary to an alloantibody reactive with HPA-5a (Br(b)).

Anolik JH, Blumberg N, Snider J, Francis CW

Transfusion.. 2001 May 41 (5):633-6. Epub 1900 01 01.

Response of C-reactive protein and serum amyloid A to influenza A infection in older adults.

Falsey AR, Walsh EE, Francis CW, Looney RJ, Kolassa JE, Hall WJ, Abraham GN

The Journal of infectious diseases.. 2001 April 1183 (7):995-9. Epub 02/23/2001.

Ultrasound-enhanced thrombolysis.

Francis CW

Echocardiography.. 2001 April 18 (3):239-46. Epub 1900 01 01.

Prothrombotic changes in hemostatic parameters and C-reactive protein in the elderly with winter acute respiratory tract infections.

Horan JT, Francis CW, Falsey AR, Kolassa J, Smith BH, Hall WJ

Thrombosis and haemostasis.. 2001 February 85 (2):245-9. Epub 1900 01 01.

Response of C-reactive protein (CRP) and serum amyloid A (SAA) to influenza A infections in older adults

Falsey AR; Walsh EE; Francis CW; et al.

J Infec Dis. 2001; 183: 995-999.

Timing of initial administration of low-molecular-weight heparin prophylaxis against deep vein thrombosis in patients following elective hip arthroplasty: a systemic review

Hull RD; Pinieo GF; Stein PD; Mah AF; Francis CW; et al.

Arch Intern Med. 2001; 16: 1852-1960.

Ultrasound and thrombolysis.

Francis CW, Suchkova VN

Vascular medicine.. 2001 6 (3):181-7. Epub 1900 01 01.

Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation.

Sahni A, Francis CW

Blood.. 2000 December 196 (12):3772-8. Epub 1900 01 01.

Anticardiolipin antibodies and recurrent coronary events: a prospective study of 1150 patients. Thrombogenic Factors, and Recurrent Coronary Events Investigators.

Bili A, Moss AJ, Francis CW, Zareba W, Watelet LF, Sanz I

Circulation.. 2000 September 12102 (11):1258-63. Epub 1900 01 01.

Cavitational mechanisms in ultrasound-accelerated thrombolysis at 1 MHz.

Everbach EC, Francis CW

Ultrasound in medicine & biology.. 2000 September 26 (7):1153-60. Epub 1900 01 01.

Effect of 40-kHz ultrasound on acute thrombotic ischemia in a rabbit femoral artery thrombosis model: enhancement of thrombolysis and improvement in capillary muscle perfusion.

Suchkova VN, Baggs RB, Francis CW

Circulation.. 2000 May 16101 (19):2296-301. Epub 1900 01 01.

Fibrinogen and fibrin protect fibroblast growth factor-2 from proteolytic degradation.

Sahni A, Baker CA, Sporn LA, Francis CW

Thrombosis and haemostasis.. 2000 May 83 (5):736-41. Epub 1900 01 01.

A double-blind, randomized comparison of low-molecular weight heparin prophylaxis using dalteparin extended out of hospital versus warfarin-placebo in hip-arthroplasty patients

Hull R; Pineo G; Francis CW; Bergquist D; et al.

Arch Int Med. 2000; 160: 2208-2215.

Reactivity of soluble fibrin assays with plasmic degradation products of fibrin and in patients receiving fibrinolytic therapy.

McCarron BI, Marder VJ, Francis CW

Thrombosis and haemostasis.. 1999 December 82 (6):1722-9. Epub 1900 01 01.

Thrombolytic therapy for arterial thrombosis.

Shortell CK, Francis CW

Current opinion in hematology.. 1999 September 6 (5):309-13. Epub 1900 01 01.

Structural studies of fibrinolysis by electron and light microscopy.

Weisel JW, Veklich Y, Collet JP, Francis CW

Thrombosis and haemostasis.. 1999 August 82 (2):277-82. Epub 1900 01 01.

A soluble fibrin standard: comparable dose-response with immunologic and functional assays.

McCarron BI, Marder VJ, Kanouse JJ, Francis CW

Thrombosis and haemostasis.. 1999 July 82 (1):145-8. Epub 1900 01 01.

Potentiation of endothelial cell proliferation by fibrin(ogen)-bound fibroblast growth factor-2.

Sahni A, Sporn LA, Francis CW

The Journal of biological chemistry.. 1999 May 21274 (21):14936-41. Epub 1900 01 01.

Bench- and pilot-scale studies relating to the removal of uranium from uranium-contaminated soils using carbonate and citrate lixiviants.

Francis CW, Timpson ME, Wilson JH

Journal of hazardous materials.. 1999 April 2366 (1-2):67-87. Epub 1900 01 01.

Heparin-induced thrombocytopenia.

Kaplan KL, Francis CW

Blood reviews.. 1999 March 13 (1):1-7. Epub 1900 01 01.

A pharmacoeconomic evaluation of low-molecular-wweight heparin in patients after total hip-replacement surgery

Francis CW; Pleil AM; Reinhart SP;.

P&T. 1999; 24: 136-145.

Structural studies of fibrinolysis by electron microscopy.

Veklich Y, Francis CW, White J, Weisel JW

Blood.. 1998 December 1592 (12):4721-9. Epub 1900 01 01.

Enhancement of fibrinolysis with 40-kHz ultrasound.

Suchkova V, Siddiqi FN, Carstensen EL, Dalecki D, Child S, Francis CW

Circulation.. 1998 September 898 (10):1030-5. Epub 1900 01 01.

Disseminated intravascular coagulation and status epilepticus.

Felcher A, Commichau C, Cao Q, Brown MJ, Torres A, Francis CW

Neurology.. 1998 August 51 (2):629-31. Epub 1900 01 01.

Binding of basic fibroblast growth factor to fibrinogen and fibrin.

Sahni A, Odrljin T, Francis CW

The Journal of biological chemistry.. 1998 March 27273 (13):7554-9. Epub 1900 01 01.

Binding of tissue-plasminogen activator to fibrin: effect of ultrasound.

Siddiqi F, Odrljin TM, Fay PJ, Cox C, Francis CW

Blood.. 1998 March 1591 (6):2019-25. Epub 1900 01 01.

Relation of factor V Leiden genotype to risk for acute deep venous thrombosis after joint replacement surgery.

Ryan DH, Crowther MA, Ginsberg JS, Francis CW

Annals of internal medicine.. 1998 February 15128 (4):270-6. Epub 1900 01 01.

Effect of acoustic cavitation on platelets in the presence of an echo-contrast agent.

Everbach EC, Makin IR, Francis CW, Meltzer RS

Ultrasound in medicine & biology.. 1998 January 24 (1):129-36. Epub 1900 01 01.

Ultrasound reversibly disaggregates fibrin fibers.

Braaten JV, Goss RA, Francis CW

Thrombosis and haemostasis.. 1997 September 78 (3):1063-8. Epub 1900 01 01.

Prevention of deep-vein thrombosis after total hip arthroplasty. Comparison of warfarin and dalteparin.

Francis CW, Pellegrini VD, Totterman S, Boyd AD, Marder VJ, Liebert KM, Stulberg BN, Ayers DC, Rosenberg A, Kessler C, Johanson NA

The Journal of bone and joint surgery. American volume.. 1997 September 79 (9):1365-72. Epub 1900 01 01.

Reversal of multiorgan system dysfunction in sickle cell disease with plasma exchange.

Geigel EJ, Francis CW

Acta anaesthesiologica Scandinavica.. 1997 May 41 (5):647-50. Epub 1900 01 01.

Ultrasound enhancement of rabbit femoral artery thrombolysis.

Riggs PN, Francis CW, Bartos SR, Penney DP

Cardiovascular surgery : official journal of the International Society for Cardiovascular Surgery.. 1997 April 5 (2):201-7. Epub 1900 01 01.

Primary fibrinolysis during supraceliac aortic clamping.

Illig KA, Green RM, Ouriel K, Riggs PN, Bartos S, Whorf R, DeWeese JA, Chhibber A, Marder VJ, Francis CW

Journal of vascular surgery.. 1997 February 25 (2):244-51; discussion 252-4. Epub 1900 01 01.

Thrombin activity associated with indwelling central venous catheters.

Francis CW, Felcher AH, White J, Braaten JV, Goss R

Thrombosis and haemostasis.. 1997 January 77 (1):48-52. Epub 1900 01 01.

Ultrasound reversibly disaggregates fibrin fibers

Braaten JV; Goss RA; Francis CW.

Thrombosis Haemost. 1997; 78: 1063-1068.

Effect of acoustic cavitation on platelets in the presence of an echo-contrast agent

Everbach EC; Makin IR; Francis CW; et al.

Ultrasound Med Biol. 1997; 24: 129-136.

Hemolysis in vivo from exposure to pulsed ultrasound.

Dalecki D, Raeman CH, Child SZ, Cox C, Francis CW, Meltzer RS, Carstensen EL

Ultrasound in medicine & biology.. 1997 23 (2):307-13. Epub 1900 01 01.

Heparin-binding domain of fibrin mediates its binding to endothelial cells.

Odrljin TM, Francis CW, Sporn LA, Bunce LA, Marder VJ, Simpson-Haidaris PJ

Arteriosclerosis, thrombosis, and vascular biology.. 1996 December 16 (12):1544-51. Epub 1900 01 01.

Calcium modulates plasmin cleavage of the fibrinogen D fragment gamma chain N-terminus: mapping of monoclonal antibody J88B to a plasmin sensitive domain of the gamma chain.

Odrljin TM, Rybarczyk BJ, Francis CW, Lawrence SO, Hamaguchi M, Simpson-Haidaris PJ

Biochimica et biophysica acta.. 1996 November 141298 (1):69-77. Epub 1900 01 01.

Transport processes in fibrinolysis and fibrinolytic therapy.

Blinc A, Francis CW

Thrombosis and haemostasis.. 1996 October 76 (4):481-91. Epub 1900 01 01.

Comparison of two warfarin regimens in the prevention of venous thrombosis following total knee replacement.

Francis CW, Pellegrini VD, Leibert KM, Totterman S, Azodo MV, Harris CM, Cox C, Marder VJ

Thrombosis and haemostasis.. 1996 May 75 (5):706-11. Epub 1900 01 01.

Heparin binding domain of fibrin mediates its binding to endothelial cells

Odrljin TM; Francis CW; Sporn LA; et al.

Arterioscl Thrombosis & Vasc Biol. 1996; 16: 1544-1551.

Cell proliferation on fibrin: modulation by fibrinopeptide cleavage.

Sporn LA, Bunce LA, Francis CW

Blood.. 1995 September 186 (5):1802-10. Epub 1900 01 01.

Magnetic resonance imaging of deep vein thrombi correlates with response to thrombolytic therapy.

Francis CW, Totterman S

Thrombosis and haemostasis.. 1995 March 73 (3):386-91. Epub 1900 01 01.

Ultrasound increases flow through fibrin gels.

Siddiqi F, Blinc A, Braaten J, Francis CW

Thrombosis and haemostasis.. 1995 March 73 (3):495-8. Epub 1900 01 01.

Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots.

Francis CW, Blinc A, Lee S, Cox C

Ultrasound in medicine & biology.. 1995 21 (3):419-24. Epub 1900 01 01.

Acceleration of fibrinolysis by ultrasound in a rabbit ear model of small vessel injury.

Kashyap A, Blinc A, Marder VJ, Penney DP, Francis CW

Thrombosis research.. 1994 December 176 (5):475-85. Epub 1900 01 01.

Markers of hemostatic activation in affected coronary arteries during angioplasty.

Shammas NW, Cunningham MJ, Pomerantz RM, Francis CW

Thrombosis and haemostasis.. 1994 November 72 (5):672-5. Epub 1900 01 01.

Plasmic degradation of fibrin rapidly decreases platelet adhesion and spreading.

Hamaguchi M, Bunce LA, Sporn LA, Francis CW

Blood.. 1994 August 1584 (4):1143-50. Epub 1900 01 01.

Evaluation of mild bleeding disorders and easy bruising.

Sham RL, Francis CW

Blood reviews.. 1994 June 8 (2):98-104. Epub 1900 01 01.

A comparison of thrombolytic therapy with operative revascularization in the initial treatment of acute peripheral arterial ischemia.

Ouriel K, Shortell CK, DeWeese JA, Green RM, Francis CW, Azodo MV, Gutierrez OH, Manzione JV, Cox C, Marder VJ

Journal of vascular surgery.. 1994 June 19 (6):1021-30. Epub 1900 01 01.

Ultrasound accelerates urokinase-induced thrombolysis and reperfusion.

Harpaz D, Chen X, Francis CW, Meltzer RS

American heart journal.. 1994 May 127 (5):1211-9. Epub 1900 01 01.

Nomenclature of quantities and units in thrombosis and haemostasis (recommendation 1993). A Collaborative project of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (ISTH/SSC) and the Commission/Committee on Quantities and Units (in Clinical Chemistry) of the International Union of Pure and Applied Chemistry-International Federation of Clinical Chemistry (IUPAC-IFCC/CQU(CC)).

Blombäck M, Abildgaard U, van den Besselaar AM, Clementson KJ, Dahlbäck B, Exner T, Francis CW, Gaffney P, Gralnick H, Hoyer LW

Thrombosis and haemostasis.. 1994 March 71 (3):375-94. Epub 1900 01 01.

Flow through clots determines the rate and pattern of fibrinolysis.

Blinc A, Kennedy SD, Bryant RG, Marder VJ, Francis CW

Thrombosis and haemostasis.. 1994 February 71 (2):230-5. Epub 1900 01 01.

Flow through clots determines the rate and pattern of fibrinolysis

Blinc A; Francis CW; Kennedy SD; et al.

Thrombo Haemost. 1994; 71: 230-235.

Onundarson PT; Haraldsson HM; Bermann L; Francis CW; et al

Onundarson PT; Haraldsson HM; Bermann L; Francis CW; et al.

Thromb Haemost. 1994; 70: 998-1004.

Plasminogen depletion during streptokinase treatment or two-chain urokinase incubation correlates with decreased clot lysability ex vivo and in vitro.

Onundarson PT, Haraldsson HM, Bergmann L, Francis CW, Marder VJ

Thrombosis and haemostasis.. 1993 December 2070 (6):998-1004. Epub 1900 01 01.

Determination of the topology of factor XIIIa-induced fibrin gamma-chain cross-links by electron microscopy of ligated fragments.

Weisel JW, Francis CW, Nagaswami C, Marder VJ

The Journal of biological chemistry.. 1993 December 15268 (35):26618-24. Epub 1900 01 01.

Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma.

Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ

Blood.. 1993 October 1582 (8):2406-13. Epub 1900 01 01.

Embolic complications of calf thrombosis following total hip arthroplasty.

Pellegrini VD, Langhans MJ, Totterman S, Marder VJ, Francis CW

The Journal of arthroplasty.. 1993 October 8 (5):449-57. Epub 1900 01 01.

Comparison of native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant prophylaxis.

Kornberg A, Francis CW, Pellegrini VD, Gabriel KR, Marder VJ

Circulation.. 1993 August 88 (2):454-60. Epub 1900 01 01.

Characterization of ultrasound-potentiated fibrinolysis in vitro.

Blinc A, Francis CW, Trudnowski JL, Carstensen EL

Blood.. 1993 May 1581 (10):2636-43. Epub 1900 01 01.

Spreading of platelets on fibrin is mediated by the amino terminus of the beta chain including peptide beta 15-42.

Hamaguchi M, Bunce LA, Sporn LA, Francis CW

Blood.. 1993 May 181 (9):2348-56. Epub 1900 01 01.

Ultrasound enhancement of thrombolysis and reperfusion in vitro.

Harpaz D, Chen X, Francis CW, Marder VJ, Meltzer RS

Journal of the American College of Cardiology.. 1993 May 21 (6):1507-11. Epub 1900 01 01.

Principles of access to health care. Access to Health Care Task Force, American Heart Association.

Dustan HP, Francis CW, Allen HD, Cunningham SL, Dulany W, Hay J, Kaiser GA, Lee TH, Mattson P, Ness DA

Circulation.. 1993 February 87 (2):657-8. Epub 1900 01 01.

Endothelial cell responses to fibrin mediated by FPB cleavage and the amino terminus of the beta chain.

Francis CW, Bunce LA, Sporn LA

Blood cells. 1993 19 (2):291-306; discussion 306-7. Epub 1900 01 01.

Fibrinogen- and fibrin-degradation products during fibrinolytic therapy.

Francis CW, Kornberg A

Annals of the New York Academy of Sciences.. 1992 December 4667 :310-23. Epub 1900 01 01.

Enhancement of fibrinolysis in vitro by ultrasound.

Francis CW, Onundarson PT, Carstensen EL, Blinc A, Meltzer RS, Schwarz K, Marder VJ

The Journal of clinical investigation.. 1992 November 90 (5):2063-8. Epub 1900 01 01.

Plasma crosslinked fibrin polymers: quantitation based on tissue plasminogen activator conversion to D-dimer and measurement in normal and patients with acute thrombotic disorders.

Kornberg A, Francis CW, Marder VJ

Blood.. 1992 August 180 (3):709-17. Epub 1900 01 01.

Depletion of plasminogen in vitro or during thrombolytic therapy limits fibrinolytic potential.

Onundarson PT, Francis CW, Marder VJ

The Journal of laboratory and clinical medicine.. 1992 July 120 (1):120-8. Epub 1900 01 01.

Comparison of warfarin and external pneumatic compression in prevention of venous thrombosis after total hip replacement.

Francis CW, Pellegrini VD, Marder VJ, Totterman S, Harris CM, Gabriel KR, Azodo MV, Leibert KM

JAMA.. 1992 June 3267 (21):2911-5. Epub 1900 01 01.

Comparison of dosage schedules of rt-PA in the treatment of proximal deep vein thrombosis.

Marder VJ, Brenner B, Totterman S, Francis CW, Rubin R, Rao AK, Kessler CM, Kwaan HC, Sharma GV, Fong KL

The Journal of laboratory and clinical medicine.. 1992 May 119 (5):485-95. Epub 1900 01 01.

Response to plasma exchange and splenectomy in thrombotic thrombocytopenic purpura. A 10-year experience at a single institution.

Onundarson PT, Rowe JM, Heal JM, Francis CW

Archives of internal medicine.. 1992 April 152 (4):791-6. Epub 1900 01 01.

Endothelial cell spreading on fibrin requires fibrinopeptide B cleavage and amino acid residues 15-42 of the beta chain.

Bunce LA, Sporn LA, Francis CW

The Journal of clinical investigation.. 1992 March 89 (3):842-50. Epub 1900 01 01.

Effects of ionic and nonionic radiographic contrast agents on endothelial cells in vitro.

Owens MR, Ribes JA, Marder VJ, Francis CW

The Journal of laboratory and clinical medicine.. 1992 March 119 (3):315-9. Epub 1900 01 01.

Response to plasma exchange and splenectomy in thrombotic thrombocytopenic purpura: a ten year experience at a single institution.

Onundarson PT; Rose JM; Heal JM; Francis CW.

Arch Int Med. 1992; 152: 791-796.

Fibrinogen and fibrin degradation products during fibrinolytic therapy.

Francis CW; Kornberg A.

Proc New York Acad Sci. 1992; 667: 310-323.

Angioedema during therapy with recombinant tissue plasminogen activator.

Francis CW, Brenner B, Leddy JP, Marder VJ

British journal of haematology.. 1991 April 77 (4):562-3. Epub 1900 01 01.

Prophylaxis of venous thrombosis following total hip and total knee replacement using antithrombin III and heparin.

Francis CW, Pellegrini VD, Harris CM, Stulberg B, Gabriel KR, Marder VJ

Seminars in hematology.. 1991 January 28 (1):39-45. Epub 1900 01 01.

Angioedema during therapy with recombinant tissue plasminogen activator

Francis CW; Brenner B; Leddy JP; Marder VJ.

Brit J Hematol. 1991; 77.

Fibrinolytic therapy for venous thrombosis.

Francis CW, Marder VJ

Progress in cardiovascular diseases.. 1991 34 (3):193-204. Epub 1900 01 01.

Magnetic resonance imaging of blood and clots in vitro.

Blackmore CC, Francis CW, Bryant RG, Brenner B, Marder VJ

Investigative radiology.. 1990 December 25 (12):1316-24. Epub 1900 01 01.

Prevention of venous thrombosis after total knee arthroplasty. Comparison of antithrombin III and low-dose heparin with dextran.

Francis CW, Pellegrini VD, Stulberg BN, Miller ML, Totterman S, Marder VJ

The Journal of bone and joint surgery. American volume.. 1990 August 72 (7):976-82. Epub 1900 01 01.

Quantitation of venous clot lysis with the D-dimer immunoassay during fibrinolytic therapy requires correction for soluble fibrin degradation.

Brenner B, Francis CW, Totterman S, Kessler CM, Rao AK, Rubin R, Kwaan HC, Gabriel KR, Marder VJ

Circulation.. 1990 June 81 (6):1818-25. Epub 1900 01 01.

Multimer size dependence of von Willebrand factor binding to crosslinked or noncrosslinked fibrin.

Ribes JA, Francis CW

Blood.. 1990 April 175 (7):1460-5. Epub 1900 01 01.

Skin necrosis associated with acquired protein C deficiency in patients with renal failure and calciphylaxis.

Mehta RL, Scott G, Sloand JA, Francis CW

The American journal of medicine.. 1990 March 88 (3):252-7. Epub 1900 01 01.

Diagnosis of femoropopliteal venous thrombosis with MR imaging: a comparison of four MR pulse sequences.

Totterman S, Francis CW, Foster TH, Brenner B, Marder VJ, Bryant RG

AJR. American journal of roentgenology.. 1990 January 154 (1):175-8. Epub 1900 01 01.

Magnetic relaxation in blood and blood clots

Bryant, RG; Marill, K; Blackmore, CC; Francis, CW.

Magnetic Resonance in Med. 1990; 13: 133-144.

Prevention of venous thrombosis following total knee arthroplasty

Francis, CW; Pellegrini, VD; Stulberg, BN; et al.

J Bone & Joint Surg. 1990; 72-A: 976-982.

The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin.

Haidaris PJ, Peerschke EI, Marder VJ, Francis CW

Blood.. 1989 November 1574 (7):2437-44. Epub 1900 01 01.

Antithrombin III/low-dose heparin in the prevention of deep-vein thrombosis after total knee arthroplasty. A preliminary report.

Stulberg BN, Francis CW, Pellegrini VD, Miller ML, Shull S, deSwart R, Easley K, Totterman S, Marder VJ

Clinical orthopaedics and related research.. 1989 November (248):152-7. Epub 1900 01 01.

Terminology for fibrinogen gamma-chains differing in carboxyl terminal amino acid sequence.

Francis CW, Mosesson MW

Thrombosis and haemostasis.. 1989 September 2962 (2):813-4. Epub 1900 01 01.

Antithrombin III prophylaxis of venous thromboembolic disease after total hip or total knee replacement.

Francis CW, Pellegrini VD, Harris CM, Marder VJ

The American journal of medicine.. 1989 September 1187 (3B):61S-66S. Epub 1900 01 01.

Megakaryocyte and hepatocyte origins of human fibrinogen biosynthesis exhibit hepatocyte-specific expression of gamma chain-variant polypeptides.

Haidaris PJ, Francis CW, Sporn LA, Arvan DS, Collichio FA, Marder VJ

Blood.. 1989 August 174 (2):743-50. Epub 1900 01 01.

Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain.

Ribes JA, Ni F, Wagner DD, Francis CW

The Journal of clinical investigation.. 1989 August 84 (2):435-42. Epub 1900 01 01.

The role of soluble cross-linked fibrin in D dimer immunoreactivity of plasmic digests.

Brenner B, Francis CW, Marder VJ

The Journal of laboratory and clinical medicine.. 1989 June 113 (6):682-8. Epub 1900 01 01.

Relation of plasma D-dimer concentrations to coronary artery reperfusion before and after thrombolytic treatment in patients with acute myocardial infarction.

Brenner B, Francis CW, Fitzpatrick PG, Rothbard RL, Cox C, Hackworthy RA, Anderson JL, Sorensen SG, Marder VJ

The American journal of cardiology.. 1989 May 1563 (17):1179-84. Epub 1900 01 01.

Increased immunoreactivity of plasma after fibrinolytic activation in an anti-DD ELISA system. Role of soluble crosslinked fibrin polymers.

Francis CW, Doughney K, Brenner B, Klingbiel K, Marder VJ

Circulation.. 1989 March 79 (3):666-73. Epub 1900 01 01.

Prevention of venous thrombosis after total hip arthroplasty. Antithrombin III and low-dose heparin compared with dextran 40.

Francis CW, Pellegrini VD, Marder VJ, Harris CM, Totterman S, Gabriel KR, Baughman DJ, Roemer S, Burke J, Goodman TL

The Journal of bone and joint surgery. American volume.. 1989 March 71 (3):327-35. Epub 1900 01 01.

Monitoring of therapy for deep vein thrombosis using magnetic resonance imaging

Francis, CW; Foster, TH; Totterman, S; et al.

Acta Radiologica. 1989; 4: 445-446.

Antithrombin III/low dose heparin in the prevention of deep-vein thrombosis following total knee arthroplasty

Stulberg, BN; Francis, CW; Pellegrini, VD; et al.

Clin Ortho Rel Res. 1989; 248: 152-157.

Monitoring of therapy for deep vein thrombosis using magnetic resonance imaging.

Francis CW, Foster TH, Totterman S, Brenner B, Marder VJ, Bryant RG

Acta radiologica.. 1989 30 (4):445-6. Epub 1900 01 01.

Long-term clinical observations and venous functional abnormalities after asymptomatic venous thrombosis following total hip or knee arthroplasty.

Francis CW, Ricotta JJ, Evarts CM, Marder VJ

Clinical orthopaedics and related research.. 1988 July (232):271-8. Epub 1900 01 01.

Increased resistance to plasmic degradation of fibrin with highly crosslinked alpha-polymer chains formed at high factor XIII concentrations.

Francis CW, Marder VJ

Blood.. 1988 May 71 (5):1361-5. Epub 1900 01 01.

Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen.

Francis CW, Müller E, Henschen A, Simpson PJ, Marder VJ

Proceedings of the National Academy of Sciences of the United States of America.. 1988 May 85 (10):3358-62. Epub 1900 01 01.

Prolonged remission after life-threatening gastrointestinal hemorrhage from coexistent angiodysplasia and acquired bleeding diathesis.

Woodlock TJ, Francis CW, Rowe JM, Brown MJ, Marder VJ

American journal of hematology.. 1988 February 27 (2):125-31. Epub 1900 01 01.

Long term clinical findings and venous functional abnormalities after asymptomatic total hip and knee replacement

Francis, CW; Ricotta, JJ; Evarts, CM; Marder, VJ.

Clin Orth Rel Res. 1988; 232: 271-278.

Rapid formation of large molecular weight alpha-polymers in cross-linked fibrin induced by high factor XIII concentrations. Role of platelet factor XIII.

Francis CW, Marder VJ

The Journal of clinical investigation.. 1987 November 80 (5):1459-65. Epub 1900 01 01.

Increased plasma concentration of cross-linked fibrin polymers in acute myocardial infarction.

Francis CW, Connaghan DG, Scott WL, Marder VJ

Circulation.. 1987 June 75 (6):1170-7. Epub 1900 01 01.

Physiologic regulation and pathologic disorders of fibrinolysis.

Francis CW, Marder VJ

Human pathology.. 1987 March 18 (3):263-74. Epub 1900 01 01.

Terminology for macromolecular plasmic derivatives of crosslinked fibrin.

Francis CW, Alkjaersig N, Galanakis DK, Graeff H, Owen J, Gaffney P, Marder VJ

Thrombosis and haemostasis.. 1987 February 357 (1):110-1. Epub 1900 01 01.

Fibrin induces release of von Willebrand factor from endothelial cells.

Ribes JA, Francis CW, Wagner DD

The Journal of clinical investigation.. 1987 January 79 (1):117-23. Epub 1900 01 01.

Two-step warfarin therapy for the prophylaxis of venous thrombosis after elective surgery

Marder, VJ; Francis, CW.

Avd Exp Med Biol. 1987; 214: 159-163.

Dose-ranging studies of anisoylated plasminogen streptokinase activator complex. Studies in healthy volunteers and in patients with acute myocardial infarction.

Marder VJ, Rothbard RL, Fitzpatrick PG, Francis CW, Norry EC

Drugs.. 1987 33 Suppl 3 :124-32. Epub 1900 01 01.

Physiological balance of haemostasis and bleeding.

Marder VJ, Francis CW

Drugs.. 1987 33 Suppl 3 :13-21. Epub 1900 01 01.

Two-step warfarin therapy for the prophylaxis of venous thrombosis after elective surgery.

Mader VJ, Francis CW

Advances in experimental medicine and biology.. 1987 214 :159-63. Epub 1900 01 01.

Assessment of fibrin degradation products during fibrinolytic therapy for acute myocardial infarction.

Francis CW, Connaghan DG, Marder VJ

Circulation.. 1986 November 74 (5):1027-36. Epub 1900 01 01.

Prevalence and clinical implications of heparin-associated false positive tests for serum fibrin(ogen) degradation products.

Connaghan DG, Francis CW, Ryan DH, Marder VJ

American journal of clinical pathology.. 1986 September 86 (3):304-10. Epub 1900 01 01.

Specific identification of urinary fibrinogen, fibrinogen degradation products, and cross-linked fibrin degradation products in renal diseases and after renal allotransplantation.

Scott WL, Francis CW, Knutson DW, Marder VJ

The Journal of laboratory and clinical medicine.. 1986 June 107 (6):534-43. Epub 1900 01 01.

Lower risk of thromboembolic disease after total hip replacement with non-cemented than with cemented prostheses.

Francis CW, Marder VJ, Evarts CM

Lancet.. 1986 April 51 (8484):769-71. Epub 1900 01 01.

Degradation of cross-linked fibrin by human leukocyte proteases.

Francis CW, Marder VJ

The Journal of laboratory and clinical medicine.. 1986 April 107 (4):342-52. Epub 1900 01 01.

Rapid lysis of coronary artery thrombi with anisoylated plasminogen: streptokinase activator complex. Treatment by bolus intravenous injection.

Marder VJ, Rothbard RL, Fitzpatrick PG, Francis CW

Annals of internal medicine.. 1986 March 104 (3):304-10. Epub 1900 01 01.

Fibrinogen binding to human blood platelets: effect of gamma chain carboxyterminal structure and length.

Peerschke EI, Francis CW, Marder VJ

Blood.. 1986 February 67 (2):385-90. Epub 1900 01 01.

Degradation of crosslinked fibrin by human leukocyte proteases

Francis, CW; Marder, VJ.

J Lab Clin Med. 1986; 107.

Concepts of clot lysis.

Francis CW, Marder VJ

Annual review of medicine.. 1986 37 :187-204. Epub 1900 01 01.

Comparison of a chromogenic prothrombin time with clotting prothrombin time in the assessment of clinical coagulation deficiencies.

Francis CW, Malone JE, Marder VJ

American journal of clinical pathology.. 1985 December 84 (6):724-9. Epub 1900 01 01.

Thrombotic thrombocytopenic purpura: recovery after splenectomy associated with persistence of abnormally large von Willebrand factor multimers.

Rowe JM, Francis CW, Cyran EM, Marder VJ

American journal of hematology.. 1985 October 20 (2):161-8. Epub 1900 01 01.

Specific identification of fibrin polymers, fibrinogen degradation products, and crosslinked fibrin degradation products in plasma and serum with a new sensitive technique.

Connaghan DG, Francis CW, Lane DA, Marder VJ

Blood.. 1985 March 65 (3):589-97. Epub 1900 01 01.

Relationship of the lytic state to successful reperfusion with standard- and low-dose intracoronary streptokinase.

Rothbard RL, Fitzpatrick PG, Francis CW, Caton DM, Hood WB, Marder VJ

Circulation.. 1985 March 71 (3):562-70. Epub 1900 01 01.

Thrombolytic therapy for acute transmural myocardial infarction. Intracoronary versus intravenous.

Marder VJ, Francis CW

The American journal of medicine.. 1984 November 77 (5):921-8. Epub 1900 01 01.

Comparison of structures of various human fibrinogens and a derivative thereof by a study of the kinetics of release of fibrinopeptides.

Hanna LS, Scheraga HA, Francis CW, Marder VJ

Biochemistry.. 1984 September 2523 (20):4681-7. Epub 1900 01 01.

Demonstration of in situ fibrin degradation in pathologic thrombi.

Francis CW, Markham RE, Marder VJ

Blood.. 1984 May 63 (5):1216-24. Epub 1900 01 01.

Purification of three gamma-chains with different molecular weights from normal human plasma fibrinogen.

Francis CW, Keele EM, Marder VJ

Biochimica et biophysica acta.. 1984 March 1797 (3):328-35. Epub 1900 01 01.

Plasma and platelet fibrinogen differ in gamma chain content.

Francis CW, Nachman RL, Marder VJ

Thrombosis and haemostasis.. 1984 February 2851 (1):84-8. Epub 1900 01 01.

An assessment of regional versus systemic thrombolytic treatment of peripheral and coronary artery thrombosis.

Marder VJ, Francis CW

Progress in hemostasis and thrombosis. 1984 7 :325-56. Epub 1900 01 01.

Potentiation of wheat germ agglutinin aggregation of platelets by von Willebrand protein and by a 116,000 molecular weight tryptic fragment.

Martin SE, Francis CW, Marder VJ

Thrombosis research.. 1983 August 131 (3):437-49. Epub 1900 01 01.

Thrombin activity of fibrin thrombi and soluble plasmic derivatives.

Francis CW, Markham RE, Barlow GH, Florack TM, Dobrzynski DM, Marder VJ

The Journal of laboratory and clinical medicine.. 1983 August 102 (2):220-30. Epub 1900 01 01.

Plasmin degradation of cross-linked fibrin.

Marder VJ, Francis CW

Annals of the New York Academy of Sciences.. 1983 June 27408 :397-406. Epub 1900 01 01.

Heterogeneity of normal human fibrinogen due to two high molecular weight variant gamma chains.

Francis CW, Marder VJ

Annals of the New York Academy of Sciences.. 1983 June 27408 :118-20. Epub 1900 01 01.

Structural and chromatographic heterogeneity of normal plasma fibrinogen associated with the presence of three gamma-chain types with distinct molecular weights.

Francis CW, Kraus DH, Marder VJ

Biochimica et biophysica acta.. 1983 April 28744 (2):155-64. Epub 1900 01 01.

Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding.

Francis CW, Marder VJ, Evarts CM, Yaukoolbodi S

JAMA.. 1983 January 21249 (3):374-8. Epub 1900 01 01.

Potentiation of wheat germ aggultinin aggregation of platelets by von Willebrand protein and by a 116,000 molecular weight tryptic fragment

Martin, SE; Francis, CW; Marder, VJ.

Thromb Res. 1983; 31: 437-449.

Secretion of plasminogen activator by the human macrophage-like cell line, GCT: separation from colony-stimulating and erythropoiesis-enhancing activities.

Barlow GH, Brennan JK, Abboud CN, Francis CW, Lichtman AH, Lichtman MA

British journal of haematology.. 1982 December 52 (4):645-55. Epub 1900 01 01.

A molecular model of plasmic degradation of crosslinked fibrin.

Francis CW, Marder VJ

Seminars in thrombosis and hemostasis.. 1982 January 8 (1):25-35. Epub 1900 01 01.

On the conversion of high molecular weight urokinase to the low molecular weight form by plasmin.

Barlow GH, Francis CW, Marder VJ

Thrombosis research.. 1981 September 1523 (6):541-7. Epub 1900 01 01.

Structural studies of the functional heterogeneity of von Willebrand protein polymers.

Martin SE, Marder VJ, Francis CW, Barlow GH

Blood.. 1981 February 57 (2):313-23. Epub 1900 01 01.

A molecular model of plasmic degradation of crosslinked fibrin

Francis, CW; Marder, VJ.

Sem Thromb Haemost. 1981; : 25-35.

Plasmic degradation of crosslinked fibrin. Characterization of new macromolecular soluble complexes and a model of their structure.

Francis CW, Marder VJ, Barlow GH

The Journal of clinical investigation.. 1980 November 66 (5):1033-43. Epub 1900 01 01.

Plasmic degradation of crosslinked fibrin. I. Structural analysis of the particulate clot and identification of new macromolecular-soluble complexes.

Francis CW, Marder VJ, Martin SE

Blood.. 1980 September 56 (3):456-64. Epub 1900 01 01.

Demonstration of a large molecular weight variant of the gamma chain of normal human plasma fibrinogen.

Francis CW, Marder VJ, Martin SE

The Journal of biological chemistry.. 1980 June 25255 (12):5599-604. Epub 1900 01 01.

Enzymatic degradation of the factor-VIII-von-Willebrand protein: a unique tryptic fragment with ristocetin cofactor activity.

Martin SE, Marder VJ, Francis CW, Loftus LS, Barlow GH

Blood.. 1980 May 55 (5):848-58. Epub 1900 01 01.

Detection of circulating crosslinked fibrin derivatives by a heat extraction-SDS gradient gel electrophoretic technique.

Francis CW, Marder VJ, Martin SE

Blood.. 1979 December 54 (6):1282-95. Epub 1900 01 01.

Geologic migration potentials of technetium-99 and neptunium-237.

Bondietti EA, Francis CW

Science.. 1979 March 30203 (4387):1337-40. Epub 1900 01 01.

The relative uptake of 237Pu(IV) and Pu(VI) oxidation states from water by bush beans.

Delaney MS, Francis CW

Health physics.. 1978 May 34 (5):492-4. Epub 1900 01 01.

Radioisotope techniques in delineation of the environmental behavior of cadmium.

Van Hook RI, Blaylock BG, Bondietti EA, Francis CW, Huckabee JW, Reichle DE, Sweeton FH, Witherspoon JP

Environmental quality and safety. 1976 5 :167-82. Epub 1900 01 01.

Polonium-210 analyses of vegetables, cured and uncured tobacco, and associated soils.

Berger KC, Erhardt WH, Francis CW

Science.. 1965 December 24150 (3704):1738-9. Epub 1900 01 01.

Comparison of ximelegatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement.

Colwell CW; Berkowitz SD; Davidson BL; Lotke PA; Ginsberg JS; Francis CW.

J Thromb Hemost. .

Heparin inhhibition of endothelial cell proliferation and organization is dependent on nolecular weight

Khorana AA; Sahni A; Altland OD; Francis CW.

Arterioscler Thromb Vasc Biol. .

Identification of a binding site on human FGF-2 for fibrinogen

Peng H; Sahni A; Fay P; Bellum S; Prudosky I; Maciag T; Francis CW.

Blood. .

Comparison of the Oral Direct Thrombin Inhibitor Ximelagatran with Warfarin for the Prevention of Venous Thromboembolism Following Total Knee Replacement: EXULT A. N.

Francis CW; Berkowitz SD; Comp PC.

N. Eng. J. Med. .

Low-intensity ultrasound increases endothelial cell nitric oxide synthase activity and nitric oxide synthase activity and nitric oxide synthesis

Altand OD; Dalecki D; Suchkova VN; Francis CW.

J Thromb Haemost. .

Effects of lipids and lipid-lowering therapy on hemostatic factors in patients with myocardial infarction

Kaba NK; Francis CW; Moss AJ; Zareba W; Oakes D; Knox KL; Fernandez ID; et al.

J Thromb Haemost. .

NF-kB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and antiapoptotic proteins.

Joshi SG; Francis CW; Silverman DJ; Sahni SK.

FEMS Microbiology Letters. .

Interluekin-1B but not IL-1a Binds t Fibrinogen and Fibrin and has Enhanced Activity in the Bound form.

Sahni A; Guo M; Sahni SK; Francis CW.

Blood. .

Coronary disease-related risk genotypes and reduction in recurrent coronary events after myocardial infarction

Moss AJ; Ryan D; Oakes D; Goldstein RE; Greenberg H; Bodenheimer MM; Brown MW; Case RB; Francis CW; et al.

JACC. .

Venous thromboembolism in patients with diffuse large B cell lymphoma

Komrokji RS; Uppal NP; Khorana AA; Lyman GH; Kaplan KK; Fisher RI; Francis CW.

Leukemia and Lymphoma. .

15-deoxy-(delta)12, 14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis

O'Brien JJ; Baglole CJ; Garcia-Bates TM; Blumberg N; Francis CW, Phipps RP.

Thromb Haemost. .

Venous Thromboembolism Prophylaxis and Treatment in Patients with Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update.

Treatment of Venous Thromboembolism in cancer patients with dalteparin for up to twelve months. The Daltecan Study

C.. Francis.

JTH. .

"Thrombosis in Cancer: Research Priorities Identified by a National Cancer Institute/National Heart, Lung, and Blood Institute Strategic Working Group"

Nigel S. Key, Alok A. Khorana, Nigel Mackman, Owen J.T. McCarty, Gilbert C. White, Charles W. Francis, Keith R. McCrae, Joseph S. Palumbo, Gary E. Raskob, Andrew T. Chan, Anil K. Sood.

Cancer Research – submitted November 2015. .

Books

Clinical Hematology (2006)

Chapter: Venous and arterial thrombosis

Authors: Francis CW; Kaplan K

Publisher: MOSBY Elsevier 2006

Hemostasis and Thrombosis: Basic Prin. & Clinical Prac. (2006)

Chapter: Clinical disorders of fibrinolysis

Authors: Francis CW; Marder VJ

Publisher: Lippincott Wlliams & Wilkins 2006

Williams Hematology 7th Ed. (2005)

Chapter: Principles of Anticoagulant Therapy

Authors: Francis CW; Kaplan K

Publisher: McGraw Hill 2005

Hemostasis & Thrombosis: Basic Prin. & Clin. Prac. (2005)

Chapter: Physiologic regulation and pathologic disorders of fibrinolysis

Authors: Francis CW; Marder VJ

Publisher: Lippincott Williams & Wilkens 2005

Williams Hematology (2005)

Chapter: Fibrinolysis and Thrombolysis

Authors: Hajjar KA; Francis CW

Publisher: McGraw Hill 2005

New Findings in Cancer-associated Thrombosis (2005)

Chapter: Who's at risk for VTE? Strategies for risk stratifying cancer patients.

Authors: Rao, MN; Francis, CW; Khorana, AA.

Publisher: Informa Healthcare 2005

Best Practice & Research Clinical Hematology (2004)

Chapter: Ximelagatran: a new oral anticoagulant

Authors: Francis CW

Publisher: Elsevier Ltd. 2004

New Therapeutic Agents in Thrombosis and Thrombolysis (2003)

Chapter: Thrombolysis and Ultrasound

Authors: Francis CW; Suchkova VN

Publisher: Marcel Dekker, Inc. 2003

Thrombosis and Hemorrhage (2003)

Chapter: Prevention and Treatment of Venous Thromboembolic Disease

Authors: Francis CW

Publisher: Lippincott Williams & Wilkins 2003

Hemostasis and Thrombosis: Basic Principles and Clin. Prac. (2001)

Authors: Hantgan RR; Simpson-Haidaris PJ; Francis CW; et al

Publisher: Lippincott-Raven 2001

Hemostasis and Thrombosis: Basic Princ. and Clin. Prac. (2001)

Chapter: Physiologic regulation and pathologic disorders of fibrinolysis

Authors: Francis CW; Marder VJ

Publisher: Lippincott-Raven 2001

Thrombolytic Therapy for Peripheral Vascular Disease (1995)

Chapter: The fibrinolytic system: Physiology and Pathophysiology

Authors: Francis CW

Publisher: J. B. Lippincott 1995

Hematology: Basic Principles and Practice, 2nd ed. (1995)

Chapter: Hematology problems in the surgical patient: Bleeding and Thrombosis

Authors: Francis CW

Publisher: Churchill Livingstone 1995

Hematology. Basic principles and Practice (1991)

Chapter: Hematologic problems in the surgical patient: Bleeding and Thrombosis

Authors: Francis CW

Publisher: Churchill Livingstone 1991

Hemostasis and Thrombosis (1987)

Chapter: Fibrinogen structure and physiology

Authors: Hantgan RR; Francis CW; et al

Publisher: J. B. Lippincott 1987

Hemostasis and Thrombosis (1987)

Chapter: Consumptive thrombohemorrhagic disorders

Authors: Marder VJ; Martin SE; Francis CW; et al

Publisher: J. B. Lippincott 1987

Hemostasis and Thrombosis: Basic principles and clinical prac (1982)

Chapter: Fibrinogen structure and physiology

Authors: Marder VJ; Francis CW; Doolittle RF

Publisher: JB Lippincott Co. 1982