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Mahin D. Maines, Ph.D.

Mahin D. Maines, Ph.D.

About Me

Faculty Appointments

Professor Emeritus - Department of Biochemistry and Biophysics (SMD)

Credentials

Education

PhD | Univ of Missouri System Office. Pharmacology. 1970

MA | Ball State University. Biology. 1967

BS | Ball State University. Biology. 1964

Research

The protein kinases mediate eukaryotic cells' response to internal and external stimuli such as a growth and differentiation factors, hormones, drugs and chemicals. The cell signaling pathways that transduce stimuli depend on cascades of phosphorylation /dephosphorylation events and kinase activitie...
The protein kinases mediate eukaryotic cells' response to internal and external stimuli such as a growth and differentiation factors, hormones, drugs and chemicals. The cell signaling pathways that transduce stimuli depend on cascades of phosphorylation /dephosphorylation events and kinase activities. The heme metabolic pathway, which converts, sequentially, heme to biliverdin plus CO, and bilirubin, reflects activities of heme oxygenase (HO) isozymes 1,2and 3, which constitute the HSP32 (heat shock/stress protein) family of proteins, and biliverdin reductase (BVR). Our recent studies have identified the heme metabolic pathway as a component of the cell signal transduction pathways.We have described CO as a signaling molecule; HO proteins as an intracellular sink for NO and potentially an intracellular oxygen sensor, bilirubin and biliverdin as modulators of protein phosphorylation. We have recently described biliverdin reductase as a new member of the dual specificity kinase (serine/threonine/tyrosine kinase) family, a leucine zipper-type transcription factor for cAMP and AP-1 regulated genes and an inhibitor of apoptosis. We are further investigating how the HO/BVR pathway modulates cell signaling and cell cycle processes.

Patents

Methods of Modifying Cell Structure and Remodeling Tissue

Issue date: November 29, 2005

Patent #: 6,969,610

Country: United States

Inventors: Mahin D Maines

Methods of Modulating Heme Oxygenase-1 Expression and Treating Heme Oxygenase-1 Mediated Conditions

Issue date: May 29, 2008

Patent #: 2002360742

Country: Australia

Inventors: Mahin D Maines

Methods of Modifying Insulin Signaling Using Biliverdin Reductase

Issue date: June 04, 2013

Patent #: 8,455,427

Country: United States

Inventors: Mahin D Maines

Use of Human Biliverdin Reductase and Fragments Thereof Protein Kinase C-Delta and ERK Related Conditions

Issue date: July 14, 2015

Patent #: 9,078,913

Country: United States

Inventors: Mahin D Maines

Use of Human Biliverdin Reductase and Fragments Thereof for the Treatment of Protein Kinase C-Delta and ERK Related Conditions

Issue date: March 21, 2017

Patent #: 9,598,677

Country: United States

Inventors: Mahin D Maines

Approach to Treatment of Hyperglycemia Using a Nano-Particle-Encapsulated Peptide

Issue date: March 06, 2018

Patent #: 9,907,853

Country: United States

Inventors: Mahin D Maines

Publications

Journal Articles

Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation.

Miralem T, Lerner-Marmarosh N, Gibbs PE, Jenkins JL, Heimiller C, Maines MD

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 August 30 (8):2926-44. Epub 05/10/2016.

Cysteine-independent activation/inhibition of heme oxygenase-2.

Vukomanovic D, Rahman MN, Maines MD, Ozolinš TR, Szarek WA, Jia Z, Nakatsu K

Medical gas research. 2016 March 6 (1):10-13. Epub 04/04/2016.

Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice.

Gibbs PE, Miralem T, Lerner-Marmarosh N, Maines MD

Journal of diabetes research.. 2016 2016 :4712053. Epub 05/17/2016.

Biliverdin reductase: a target for cancer therapy?

Gibbs PE, Miralem T, Maines MD

Frontiers in pharmacology.. 2015 6 :119. Epub 06/03/2015.

Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor.

Gibbs PE, Lerner-Marmarosh N, Poulin A, Farah E, Maines MD

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2014 June 28 (6):2478-91. Epub 02/25/2014.

The human biliverdin reductase-based peptide fragments and biliverdin regulate protein kinase C? activity: the peptides are inhibitors or substrate for the protein kinase C.

Miralem T, Lerner-Marmarosh N, Gibbs PE, Tudor C, Hagen FK, Maines MD

The Journal of biological chemistry.. 2012 July 13287 (29):24698-712. Epub 05/14/2012.

Formation of ternary complex of human biliverdin reductase-protein kinase C?-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-?B, and inducible nitric-oxidase synthase (iNOS).

Gibbs PE, Miralem T, Lerner-Maramarosh N, Tudor C, Maines MD

The Journal of biological chemistry.. 2012 January 6287 (2):1066-79. Epub 11/07/2011.

Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C.

Gibbs PE, Tudor C, Maines MD

Frontiers in pharmacology.. 2012 3 :31. Epub 03/13/2012.

The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity, and cytoprotection.

Kapitulnik J, Maines MD

Frontiers in pharmacology.. 2012 3 :136. Epub 07/13/2012.

The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ?-adrenergic receptor ligand-mediated cardiac dysfunction.

Ding B, Gibbs PE, Brookes PS, Maines MD

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2011 January 25 (1):301-13. Epub 09/27/2010.

Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings.

Maines MD

Current drug targets.. 2010 December 11 (12):1586-94. Epub 1900 01 01.

Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB.

Gibbs PE, Miralem T, Maines MD

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2010 September 24 (9):3239-54. Epub 04/21/2010.

Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression.

Miralem T, Gibbs PE, Revert F, Saus J, Maines MD

The Journal of biological chemistry.. 2010 April 23285 (17):12551-8. Epub 02/22/2010.

Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin.

Kapitulnik J, Maines MD

Trends in pharmacological sciences.. 2009 March 30 (3):129-37. Epub 02/11/2009.

Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin.

Tudor C, Lerner-Marmarosh N, Engelborghs Y, Gibbs PE, Maines MD

The Biochemical journal.. 2008 August 1413 (3):405-16. Epub 1900 01 01.

Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling.

Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD

Proceedings of the National Academy of Sciences of the United States of America.. 2008 May 13105 (19):6870-5. Epub 05/07/2008.

Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase.

Gibbs PE, Maines MD

International journal of cancer.. 2007 December 1121 (11):2567-74. Epub 1900 01 01.

Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase.

Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2007 December 21 (14):3949-62. Epub 07/17/2007.

Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways.

Maines MD

Antioxidants & redox signaling.. 2007 December 9 (12):2187-95. Epub 1900 01 01.

Human biliverdin reductase, a previously unknown activator of protein kinase C betaII.

Maines MD, Miralem T, Lerner-Marmarosh N, Shen J, Gibbs PE

The Journal of biological chemistry.. 2007 March 16282 (11):8110-22. Epub 01/16/2007.

Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response.

Ewing JF, Maines MD

Journal of neural transmission.. 2006 April 113 (4):439-54. Epub 02/16/2006.

Antiaging medicine: antioxidants and aging.

Calabrese V, Maines MD

Antioxidants & redox signaling.. 2006 8 (3-4):362-4. Epub 1900 01 01.

Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity.

Calabrese V, Butterfield DA, Scapagnini G, Stella AM, Maines MD

Antioxidants & redox signaling.. 2006 8 (3-4):444-77. Epub 1900 01 01.

30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events.

Maines MD, Gibbs PE

Biochemical and biophysical research communications.. 2005 December 9338 (1):568-77. Epub 08/24/2005.

New insights into biliverdin reductase functions: linking heme metabolism to cell signaling.

Maines MD

Physiology.. 2005 December 20 :382-9. Epub 1900 01 01.

Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity.

Lerner-Marmarosh N, Shen J, Torno MD, Kravets A, Hu Z, Maines MD

Proceedings of the National Academy of Sciences of the United States of America.. 2005 May 17102 (20):7109-14. Epub 05/03/2005.

Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells.

Miralem T, Hu Z, Torno MD, Lelli KM, Maines MD

The Journal of biological chemistry.. 2005 April 29280 (17):17084-92. Epub 02/28/2005.

The heme oxygenase system: update 2005.

Maines MD

Antioxidants & redox signaling.. 2005 7 (11-12):1761-6. Epub 1900 01 01.

The heme oxygenase system: past, present, and future.

Maines MD

Antioxidants & redox signaling.. 2004 October 6 (5):797-801. Epub 1900 01 01.

Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1.

Kravets A, Hu Z, Miralem T, Torno MD, Maines MD

The Journal of biological chemistry.. 2004 May 7279 (19):19916-23. Epub 02/25/2004.

Nitric oxide inhibitor N omega -nitro-l-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: a novel mechanism for regulation of the oxygenase.

Mayer RD, Wang X, Maines MD

The Journal of pharmacology and experimental therapeutics.. 2003 July 306 (1):43-50. Epub 04/03/2003.

Neotrofin increases heme oxygenase-1 selectively in neurons.

Wang X, Hauptmann N, Taylor E, Foreman M, Khawli LA, Maines MD

Brain research.. 2003 February 7962 (1-2):1-14. Epub 1900 01 01.

Bile pigments: newcomers to the cell signaling arena.

Maines MD

Toxicological sciences : an official journal of the Society of Toxicology.. 2003 January 71 (1):9-10. Epub 1900 01 01.

Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex.

Whitby FG, Phillips JD, Hill CP, McCoubrey W, Maines MD

Journal of molecular biology.. 2002 June 21319 (5):1199-210. Epub 1900 01 01.

Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress.

Ahmad Z, Salim M, Maines MD

The Journal of biological chemistry.. 2002 March 15277 (11):9226-32. Epub 12/31/2001.

The heme oxygenase system and cellular defense mechanisms: Do HO-1 and HO-2 have different functions? Hypoxia from Genese to the Bedside

Maines, M.D.; Panahian, N.;.

Advances in Experimental Medicine and Biology (Roach, R.C., Wagner, P.G., Hackett, P.H. eds.) Kluwer Academic/Plenum Pub., New York. 2002; 502(3): 249-271.

Heme oxygenase 1 transgenic mice as a model to study neuroprotection.

Maines MD

Methods in enzymology.. 2002 353 :374-88. Epub 1900 01 01.

Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifs.

Huang TJ, McCoubrey WK, Maines MD

Antioxidants & redox signaling.. 2001 August 3 (4):685-96. Epub 1900 01 01.

Overview of heme degradation pathway.

Maines MD

Current protocols in toxicology. 2001 May Chapter 9 :Unit 9.1. Epub 1900 01 01.

Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation.

Salim M, Brown-Kipphut BA, Maines MD

The Journal of biological chemistry.. 2001 April 6276 (14):10929-34. Epub 01/17/2001.

Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1.

Maines MD, Ewing JF, Huang TJ, Panahian N

The Journal of pharmacology and experimental therapeutics.. 2001 March 296 (3):1091-7. Epub 1900 01 01.

Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms?

Panahian N, Maines MD

Journal of neurochemistry.. 2001 January 76 (2):539-54. Epub 1900 01 01.

The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions?

Maines MD, Panahian N

Advances in experimental medicine and biology.. 2001 502 :249-72. Epub 1900 01 01.

Assessment of induction of biliverdin reductase in a mouse model of middle cerebral artery occlusion.

Panahian N, Maines MD

Brain research. Brain research protocols. 2000 November 6 (1-2):53-70. Epub 1900 01 01.

Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death.

Chen K, Gunter K, Maines MD

Journal of neurochemistry.. 2000 July 75 (1):304-13. Epub 1900 01 01.

The heme oxygenase system and its functions in the brain.

Maines MD

Cellular and molecular biology.. 2000 May 46 (3):573-85. Epub 1900 01 01.

Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38.

Chen K, Maines MD

Cellular and molecular biology.. 2000 May 46 (3):609-17. Epub 1900 01 01.

Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression.

Liu N, Wang X, McCoubrey WK, Maines MD

Gene.. 2000 January 4241 (1):175-83. Epub 1900 01 01.

Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia.

Panahian N, Huang T, Maines MD

Brain research.. 1999 December 11850 (1-2):1-13. Epub 1900 01 01.

Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury.

Maines MD, Raju VS, Panahian N

The Journal of pharmacology and experimental therapeutics.. 1999 November 291 (2):911-9. Epub 1900 01 01.

The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma--pH and cofactor-specific increase in activity.

Maines MD, Mayer RD, Erturk E, Huang TJ, Disantagnese A

The Journal of urology.. 1999 October 162 (4):1467-72. Epub 1900 01 01.

Interaction of heme oxygenase-2 with nitric oxide donors. Is the oxygenase an intracellular 'sink' for NO?

Ding Y, McCoubrey WK, Maines MD

European journal of biochemistry. 1999 September 264 (3):854-61. Epub 1900 01 01.

Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice.

Panahian N, Yoshiura M, Maines MD

Journal of neurochemistry.. 1999 March 72 (3):1187-203. Epub 1900 01 01.

Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1.

Morgan D, Holcomb L, Saad I, Gordon M, Mahin Maines

Brain research.. 1998 October 12808 (1):110-2. Epub 1900 01 01.

Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32).

Woo J, Iyer S, Cornejo MC, Mori N, Gao L, Sipos I, Maines M, Buelow R

Transplant immunology.. 1998 June 6 (2):84-93. Epub 1900 01 01.

Neuronal overexpression of heme oxygenase-1 correlates with an attenuated exploratory behavior and causes an increase in neuronal NADPH diaphorase staining.

Maines MD, Polevoda B, Coban T, Johnson K, Stoliar S, Huang TJ, Panahian N, Cory-Slechta DA, McCoubrey WK

Journal of neurochemistry.. 1998 May 70 (5):2057-69. Epub 1900 01 01.

Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum.

Farrugia G, Miller SM, Rich A, Liu X, Maines MD, Rae JL, Szurszewski JH

American journal of physiology. Gastrointestinal and liver physiology.. 1998 February 1274 (2):G350-G358. Epub 1900 01 01.

Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine.

Miller SM, Farrugia G, Schmalz PF, Ermilov LG, Maines MD, Szurszewski JH

Gastroenterology.. 1998 February 114 (2):239-44. Epub 1900 01 01.

Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum.

Farrugia G, Miller SM, Rich A, Liu X, Maines MD, Rae JL, Szurszewski JH

The American journal of physiology.. 1998 February 274 (2):G350-8. Epub 1900 01 01.

Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1.

Iyer S, Woo J, Cornejo MC, Gao L, McCoubrey W, Maines M, Buelow R

The Journal of biological chemistry.. 1998 January 30273 (5):2692-7. Epub 1900 01 01.

Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3.

McCoubrey WK, Huang TJ, Maines MD

European journal of biochemistry. 1997 July 15247 (2):725-32. Epub 1900 01 01.

Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis.

McCoubrey WK, Huang TJ, Maines MD

The Journal of biological chemistry.. 1997 May 9272 (19):12568-74. Epub 1900 01 01.

Regulation of photomorphogenesis by expression of mammalian biliverdin reductase in transgenic Arabidopsis plants.

Lagarias DM, Crepeau MW, Maines MD, Lagarias JC

The Plant cell.. 1997 May 9 (5):675-88. Epub 1900 01 01.

Histochemical localization of heme oxygenase-2 protein and mRNA expression in rat brain.

Ewing JF, Maines MD

Brain research. Brain research protocols. 1997 May 1 (2):165-74. Epub 1900 01 01.

Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element.

Raju VS, McCoubrey WK, Maines MD

Biochimica et biophysica acta.. 1997 March 201351 (1-2):89-104. Epub 1900 01 01.

The heme oxygenase system and carbon monoxide production: A non-radical approach to cell signaling

Ewing, J.F.; Maines, M.D.;.

Porphyrins. 1997; 6(3): 1-13.

The heme oxygenase system: a regulator of second messenger gases.

Maines MD

Annual review of pharmacology and toxicology.. 1997 37 :517-54. Epub 1900 01 01.

Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain.

Geddes JW, Pettigrew LC, Holtz ML, Craddock SD, Maines MD

Neuroscience letters.. 1996 June 7210 (3):205-8. Epub 1900 01 01.

Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart.

Raju VS, Maines MD

The Journal of pharmacology and experimental therapeutics.. 1996 June 277 (3):1814-22. Epub 1900 01 01.

Corticosterone promotes increased heme oxygenase-2 protein and transcript expression in the newborn rat brain.

Maines MD, Eke BC, Zhao X

Brain research.. 1996 May 25722 (1-2):83-94. Epub 1900 01 01.

Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution.

Maines MD, Abrahamsson PA

Urology.. 1996 May 47 (5):727-33. Epub 1900 01 01.

Stress response of the rat testis: in situ hydridization and immunohistochemical analysis of heme oxygenase-1 (HSP32) induction by hyperthermia.

Maines MD, Ewing JF

Biology of reproduction.. 1996 May 54 (5):1070-9. Epub 1900 01 01.

Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes.

Maines MD, Polevoda BV, Huang TJ, McCoubrey WK

European journal of biochemistry. 1996 January 15235 (1-2):372-81. Epub 1900 01 01.

Carbon monoxide and nitric oxide homology: differential modulation of heme oxygenases in brain and detection of protein and activity.

Maines M

Methods in enzymology.. 1996 268 :473-88. Epub 1900 01 01.

Multiple transcripts encoding heme oxygenase-2 in rat testis: developmental and cell-specific regulation of transcripts and protein.

McCoubrey WK, Eke B, Maines MD

Biology of reproduction.. 1995 December 53 (6):1330-8. Epub 1900 01 01.

The structure, organization and differential expression of the rat gene encoding biliverdin reductase.

McCoubrey WK, Cooklis MA, Maines MD

Gene.. 1995 July 28160 (2):235-40. Epub 1900 01 01.

Distribution of constitutive (HO-2) and heat-inducible (HO-1) heme oxygenase isozymes in rat testes: HO-2 displays stage-specific expression in germ cells.

Ewing JF, Maines MD

Endocrinology.. 1995 May 136 (5):2294-302. Epub 1900 01 01.

Corticosterone has a permissive effect on expression of heme oxygenase-1 in CA1-CA3 neurons of hippocampus in thermal-stressed rats.

Maines MD, Eke BC, Weber CM, Ewing JF

Journal of neurochemistry.. 1995 April 64 (4):1769-79. Epub 1900 01 01.

Immunohistochemical localization of biliverdin reductase in rat brain: age related expression of protein and transcript.

Ewing JF, Maines MD

Brain research.. 1995 February 20672 (1-2):29-41. Epub 1900 01 01.

Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons.

Vincent SR, Das S, Maines MD

Neuroscience.. 1994 November 63 (1):223-31. Epub 1900 01 01.

Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isozyme of the brain and testes.

Rublevskaya I, Maines MD

The Journal of biological chemistry.. 1994 October 21269 (42):26390-5. Epub 1900 01 01.

Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3':5'-guanosine monophosphate.

Ewing JF, Raju VS, Maines MD

The Journal of pharmacology and experimental therapeutics.. 1994 October 271 (1):408-14. Epub 1900 01 01.

Corticosterone regulates heme oxygenase-2 and NO synthase transcription and protein expression in rat brain.

Weber CM, Eke BC, Maines MD

Journal of neurochemistry.. 1994 September 63 (3):953-62. Epub 1900 01 01.

Site-directed mutagenesis of cysteine residues in biliverdin reductase. Roles in substrate and cofactor binding.

McCoubrey WK, Maines MD

European journal of biochemistry. 1994 June 1222 (2):597-603. Epub 1900 01 01.

Coordinated expression and mechanism of induction of HSP32 (heme oxygenase-1) mRNA by hyperthermia in rat organs.

Raju VS, Maines MD

Biochimica et biophysica acta.. 1994 April 61217 (3):273-80. Epub 1900 01 01.

The structure, organization and differential expression of the gene encoding rat heme oxygenase-2.

McCoubrey WK, Maines MD

Gene.. 1994 February 25139 (2):155-61. Epub 1900 01 01.

Inactivation of phytochrome- and phycobiliprotein-chromophore precursors by rat liver biliverdin reductase.

Terry MJ, Maines MD, Lagarias JC

The Journal of biological chemistry.. 1993 December 15268 (35):26099-106. Epub 1900 01 01.

Carbon Monoxide: An Emerging Regulator of cGMP in the Brain.

Maines MD

Molecular and cellular neurosciences.. 1993 October 4 (5):389-97. Epub 1900 01 01.

Heme Oxygenase, a Likely Regulator of cGMP Production in the Brain: Induction in Vivo of HO-1 Compensates for Depression in NO Synthase Activity.

Maines MD, Mark JA, Ewing JF

Molecular and cellular neurosciences.. 1993 October 4 (5):396-405. Epub 1900 01 01.

Biliverdin reductase is heat resistant and coexpressed with constitutive and heat shock forms of heme oxygenase in brain.

Ewing JF, Weber CM, Maines MD

Journal of neurochemistry.. 1993 September 61 (3):1015-23. Epub 1900 01 01.

Domains of rat heme oxygenase-2: the amino terminus and histidine 151 are required for heme oxidation.

McCoubrey WK, Maines MD

Archives of biochemistry and biophysics.. 1993 May 302 (2):402-8. Epub 1900 01 01.

Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain.

Ewing JF, Maines MD

Journal of neurochemistry.. 1993 April 60 (4):1512-9. Epub 1900 01 01.

Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein by ischemia/reperfusion: possible role of heme as both promotor of tissue damage and regulator of HSP32.

Maines MD, Mayer RD, Ewing JF, McCoubrey WK

The Journal of pharmacology and experimental therapeutics.. 1993 January 264 (1):457-62. Epub 1900 01 01.

Purification and characterization of human biliverdin reductase.

Maines MD, Trakshel GM

Archives of biochemistry and biophysics.. 1993 January 300 (1):320-6. Epub 1900 01 01.

Heme oxygenase, a likely regulator of cGMP production in the brain: induction in vivo of HO-1 compensates for depression in NO synthase activity

Maines, M.D.; Mark, J.; Ewing, J.;.

Molecular and Cellular Neuroscience. 1993; 4(3): 398-405.

Carbon Monoxide: An emerging regulator of cGMP in the brain (invited review)

Maines, M.D.;.

Molecular and Cellular Neuroscience. 1993; 4(3): 389-397.

In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2.

Ewing JF, Maines MD

Molecular and cellular neurosciences.. 1992 December 3 (6):559-70. Epub 1900 01 01.

Tin-protoporphyrin-mediated disruption in vivo of heme oxygenase-2 protein integrity and activity in rat brain.

Mark JA, Maines MD

Pediatric research.. 1992 September 32 (3):324-9. Epub 1900 01 01.

Differential regulation of heme oxygenase isozymes by Sn- and Zn-protoporphyrins: possible relevance to suppression of hyperbilirubinemia.

Maines MD, Trakshel GM

Biochimica et biophysica acta.. 1992 June 151131 (2):166-74. Epub 1900 01 01.

Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal.

McCoubrey WK, Ewing JF, Maines MD

Archives of biochemistry and biophysics.. 1992 May 15295 (1):13-20. Epub 1900 01 01.

Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein.

Ewing JF, Haber SN, Maines MD

Journal of neurochemistry.. 1992 March 58 (3):1140-9. Epub 1900 01 01.

Expression and characterization of a cDNA for rat kidney biliverdin reductase. Evidence suggesting the liver and kidney enzymes are the same transcript product.

Fakhrai H, Maines MD

The Journal of biological chemistry.. 1992 February 25267 (6):4023-9. Epub 1900 01 01.

Tin-protoporphyrin: a potent inhibitor of hemoprotein-dependent steroidogenesis in rat adrenals and testes.

Maines MD, Trakshel GM

The Journal of pharmacology and experimental therapeutics.. 1992 February 260 (2):909-16. Epub 1900 01 01.

Comparative effects of tin- and zinc-protoporphyrin on steroidogenesis: tin-protoporphyrin is a potent inhibitor of cytochrome P-450-dependent activities in the rat adrenals.

Trakshel GM, Sluss PM, Maines MD

Pediatric research.. 1992 February 31 (2):196-201. Epub 1900 01 01.

In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: differential distribution of isozyme 1 and 2

Ewing, J.F.; aines, M.D.;.

Molecular and Cellular Neuroscience. 1992; 3(3): 559-570.

Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: possible heme-binding site?

Rotenberg MO, Maines MD

Archives of biochemistry and biophysics.. 1991 November 1290 (2):336-44. Epub 1900 01 01.

Cyclosporin-mediated depression of luteinizing hormone receptors and heme biosynthesis in rat testes: a possible mechanism for decrease in serum testosterone.

Krueger BA, Trakshel GM, Sluss PM, Maines MD

Endocrinology.. 1991 November 129 (5):2647-54. Epub 1900 01 01.

Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells.

Saunders EL, Maines MD, Meredith MJ, Freeman ML

Archives of biochemistry and biophysics.. 1991 August 1288 (2):368-73. Epub 1900 01 01.

Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.

Ewing JF, Maines MD

Proceedings of the National Academy of Sciences of the United States of America.. 1991 June 1588 (12):5364-8. Epub 1900 01 01.

Heterogeneity of haem oxygenase 1 and 2 isoenzymes. Rat and primate transcripts for isoenzyme 2 differ in number and size.

Trakshel GM, Ewing JF, Maines MD

The Biochemical journal.. 1991 April 1275 ( Pt 1) (Pt 1):159-64. Epub 1900 01 01.

Heme oxygenase-2 mRNA: developmental expression in the rat liver and response to cobalt chloride.

Sun Y, Maines MD

Archives of biochemistry and biophysics.. 1990 November 1282 (2):340-5. Epub 1900 01 01.

Multiple forms of biliverdin reductase: age-related change in pattern of expression in rat liver and brain.

Maines MD

Molecular pharmacology.. 1990 October 38 (4):481-5. Epub 1900 01 01.

Regional and subcellular distribution of cytochrome P-450-dependent drug metabolism in monkey brain: the olfactory bulb and the mitochondrial fraction have high levels of activity.

Iscan M, Reuhl K, Weiss B, Maines MD

Biochemical and biophysical research communications.. 1990 June 29169 (3):858-63. Epub 1900 01 01.

Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected.

Sun Y, Rotenberg MO, Maines MD

The Journal of biological chemistry.. 1990 May 15265 (14):8212-7. Epub 1900 01 01.

Promotion of trans-platinum in vivo effects on renal heme and hemoprotein metabolism by D,L-buthionine-S,R-sulfoximine. Possible role of glutathione.

Mayer RD, Maines MD

Biochemical pharmacology.. 1990 May 1539 (10):1565-71. Epub 1900 01 01.

Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

Rotenberg MO, Maines MD

The Journal of biological chemistry.. 1990 May 5265 (13):7501-6. Epub 1900 01 01.

cis-platinum-mediated decrease in serum testosterone is associated with depression of luteinizing hormone receptors and cytochrome P-450scc in rat testis.

Maines MD, Sluss PM, Iscan M

Endocrinology.. 1990 May 126 (5):2398-406. Epub 1900 01 01.

Differential regulation of heme and drug metabolism in rat testis and prostate: response to cis-platinum and human chorionic gonadotropin.

Iscan M, Maines MD

The Journal of pharmacology and experimental therapeutics.. 1990 April 253 (1):73-9. Epub 1900 01 01.

Bromobenzene-mediated alteration in activity and electrophoretic pattern of biliverdin reductase variants in rat kidney.

Huang TJ, Maines MD

Molecular pharmacology.. 1990 January 37 (1):25-9. Epub 1900 01 01.

Effect of cis-platinum on heme, drug, and steroid metabolism pathways: possible involvement in nephrotoxicity and infertility.

Maines MD

Critical reviews in toxicology.. 1990 21 (1):1-20. Epub 1900 01 01.

Microheterogeneity of biliverdin reductase in rat liver and spleen: selective suppression of enzyme variants in liver by bromobenzene.

Huang TJ, Trakshel GM, Maines MD

Archives of biochemistry and biophysics.. 1989 November 1274 (2):617-25. Epub 1900 01 01.

Detection of 10 variants of biliverdin reductase in rat liver by two-dimensional gel electrophoresis.

Huang TJ, Trakshel GM, Maines MD

The Journal of biological chemistry.. 1989 May 15264 (14):7844-9. Epub 1900 01 01.

Multiple forms of biliverdin reductase: modification of the pattern of expression in rat liver by bromobenzene.

Huang TJ, Trakshel GM, Maines MD

Archives of biochemistry and biophysics.. 1989 May 1270 (2):513-20. Epub 1900 01 01.

Differential effects of cyclosporin on hepatic and renal heme, cytochrome P-450 and drug metabolism. Possible role in nephrotoxicity of the drug.

Mayer RD, Berman S, Cockett AT, Maines MD

Biochemical pharmacology.. 1989 March 1538 (6):1001-7. Epub 1900 01 01.

Multiplicity of heme oxygenase isozymes. HO-1 and HO-2 are different molecular species in rat and rabbit.

Trakshel GM, Maines MD

The Journal of biological chemistry.. 1989 January 15264 (2):1323-8. Epub 1900 01 01.

Selective induction of heme oxygenase-1 isozyme in rat testis by human chorionic gonadotropin.

Kutty RK, Maines MD

Archives of biochemistry and biophysics.. 1989 January 268 (1):100-7. Epub 1900 01 01.

Manganese-mediated increase in the rat brain mitochondrial cytochrome P-450 and drug metabolism activity: susceptibility of the striatum.

Liccione JJ, Maines MD

The Journal of pharmacology and experimental therapeutics.. 1989 January 248 (1):222-8. Epub 1900 01 01.

Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese.

Liccione JJ, Maines MD

The Journal of pharmacology and experimental therapeutics.. 1988 October 247 (1):156-61. Epub 1900 01 01.

Detection of two heme oxygenase isoforms in the human testis.

Trakshel GM, Maines MD

Biochemical and biophysical research communications.. 1988 July 15154 (1):285-91. Epub 1900 01 01.

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.

Maines MD

FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 1988 July 2 (10):2557-68. Epub 1900 01 01.

Kinetic properties and regulation of biliverdin reductase.

Bell JE, Maines MD

Archives of biochemistry and biophysics.. 1988 May 15263 (1):1-9. Epub 1900 01 01.

Characterization of glutathione S-transferases in rat kidney. Alteration of composition by cis-platinum.

Trakshel GM, Maines MD

The Biochemical journal.. 1988 May 15252 (1):127-36. Epub 1900 01 01.

Evidence suggesting that the two forms of heme oxygenase are products of different genes.

Cruse I, Maines MD

The Journal of biological chemistry.. 1988 March 5263 (7):3348-53. Epub 1900 01 01.

Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase.

Kutty RK, Daniel RF, Ryan DE, Levin W, Maines MD

Archives of biochemistry and biophysics.. 1988 February 1260 (2):638-44. Epub 1900 01 01.

Resolution of the rat brain heme oxygenase activity: absence of a detectable amount of the inducible form (HO-1).

Trakshel GM, Kutty RK, Maines MD

Archives of biochemistry and biophysics.. 1988 February 1260 (2):732-9. Epub 1900 01 01.

Characterization of an NADH-dependent haem-degrading system in ox heart mitochondria.

Kutty RK, Maines MD

The Biochemical journal.. 1987 September 1246 (2):467-74. Epub 1900 01 01.

Regulation of the activity of heme degradative enzymes in K562 erythroleukemic cells: induction by thymidine.

Trakshel GM, Rowley PT, Maines MD

Experimental hematology.. 1987 September 15 (8):859-63. Epub 1900 01 01.

Differential effect of cadmium on GSH-peroxidase activity in the Leydig and the Sertoli cells of rat testis. Suppression by selenium and the possible relationship to heme concentration.

Chung AS, Maines MD

Biochemical pharmacology.. 1987 April 1536 (8):1367-72. Epub 1900 01 01.

Characterization of two heme oxygenase isoforms in rat spleen: comparison with the hematin-induced and constitutive isoforms of the liver.

Braggins PE, Trakshel GM, Kutty RK, Maines MD

Biochemical and biophysical research communications.. 1986 December 15141 (2):528-33. Epub 1900 01 01.

Cadmium-mediated inhibition of testicular heme oxygenase activity: the role of NADPH-cytochrome c (P-450) reductase.

Trakshel GM, Kutty RK, Maines MD

Archives of biochemistry and biophysics.. 1986 November 15251 (1):175-87. Epub 1900 01 01.

Regulatory effect of copper on rat adrenal cytochrome P-450 and steroid metabolism.

Veltman JC, Maines MD

Biochemical pharmacology.. 1986 September 135 (17):2903-9. Epub 1900 01 01.

Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform.

Trakshel GM, Kutty RK, Maines MD

The Journal of biological chemistry.. 1986 August 25261 (24):11131-7. Epub 1900 01 01.

Differential effect of cis-platinum (cis-diamminedichloroplatinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes.

Maines MD

The Biochemical journal.. 1986 August 1237 (3):713-21. Epub 1900 01 01.

Alterations of heme, cytochrome P-450, and steroid metabolism by mercury in rat adrenal.

Veltman JC, Maines MD

Archives of biochemistry and biophysics.. 1986 August 1248 (2):467-78. Epub 1900 01 01.

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

Maines MD, Trakshel GM, Kutty RK

The Journal of biological chemistry.. 1986 January 5261 (1):411-9. Epub 1900 01 01.

Sex difference in adrenal heme and cytochrome P-450 metabolism: evidence for the repressive regulatory role of testosterone.

Veltman JC, Maines MD

The Journal of pharmacology and experimental therapeutics.. 1985 October 235 (1):71-5. Epub 1900 01 01.

Effect of cis-platinum on kidney cytochrome P-450 and heme metabolism: evidence for the regulatory role of the pituitary hormones.

Jollie DR, Maines MD

Archives of biochemistry and biophysics.. 1985 July 240 (1):51-9. Epub 1900 01 01.

Inhibition of testicular cytochrome P-450-dependent steroid biosynthesis by cis-platinum. Reversal by human chorionic gonadotropin.

Maines MD, Mayer RD

The Journal of biological chemistry.. 1985 May 25260 (10):6063-8. Epub 1900 01 01.

Regulation of heme and drug metabolism activities in the brain by manganese.

Qato MK, Maines MD

Biochemical and biophysical research communications.. 1985 April 16128 (1):18-24. Epub 1900 01 01.

Prevention of neonatal hyperbilirubinaemia in non-human primates by Zn-protoporphyrin.

Qato MK, Maines MD

The Biochemical journal.. 1985 February 15226 (1):51-7. Epub 1900 01 01.

Effects of induction of heme oxygenase by cobalt and tin on the in vivo degradation of myoglobin.

Kutty RK, Maines MD

Biochemical pharmacology.. 1984 September 1533 (18):2924-6. Epub 1900 01 01.

Dissociation of heme metabolic activities from the microsomal cytochrome P-450 turnover in testis of hypophysectomized rats.

Maines MD, Jollie DR

The Journal of biological chemistry.. 1984 August 10259 (15):9557-62. Epub 1900 01 01.

Hepatic heme metabolism: possible role of biliverdin in the regulation of heme oxygenase activity.

Kutty RK, Maines MD

Biochemical and biophysical research communications.. 1984 July 18122 (1):40-6. Epub 1900 01 01.

Characterization of heme oxygenase activity in Leydig and Sertoli cells of the rat testes. Differential distribution of activity and response to cadmium.

Maines MD

Biochemical pharmacology.. 1984 May 133 (9):1493-502. Epub 1900 01 01.

Phenylhydrazine-mediated induction of haem oxygenase activity in rat liver and kidney and development of hyperbilirubinaemia. Inhibition by zinc-protoporphyrin.

Maines MD, Veltman JC

The Biochemical journal.. 1984 January 15217 (2):409-17. Epub 1900 01 01.

New developments in the regulation of heme metabolism and their implications.

Maines MD

Critical reviews in toxicology.. 1984 12 (3):241-314. Epub 1900 01 01.

Differential response of testicular and ovarian heme oxygenase activity to metal ions.

Maines MD, Kutty RK

Archives of biochemistry and biophysics.. 1983 October 1226 (1):134-44. Epub 1900 01 01.

Biliverdin reductase: characterization in the rat kidney and the inhibition of activity by mercuric chloride.

Kutty RK, Maines MD

Biochemical pharmacology.. 1983 July 132 (13):2095-102. Epub 1900 01 01.

The inhibition of testicular heme oxygenase activity by cadmium. A novel cellular response.

Maines MD, Chung AS, Kutty RK

The Journal of biological chemistry.. 1982 December 10257 (23):14116-21. Epub 1900 01 01.

Inhibition of the enzymes of glutathione metabolism by mercuric chloride in the rat kidney: reversal by selenium.

Chung AS, Maines MD, Reynolds WA

Biochemical pharmacology.. 1982 October 131 (19):3093-100. Epub 1900 01 01.

Oxidation of heme c derivatives by purified heme oxygenase. Evidence for the presence of one molecular species of heme oxygenase in the rat liver.

Kutty RK, Maines MD

The Journal of biological chemistry.. 1982 September 10257 (17):9944-52. Epub 1900 01 01.

Enhancement and inhibition of enzymes of heme metabolism by diethyl maleate in the rat kidney.

Maines MD

Archives of biochemistry and biophysics.. 1982 June 216 (1):17-26. Epub 1900 01 01.

Effect of selenium on glutathione metabolism. Induction of gamma-glutamylcysteine synthetase and glutathione reductase in the rat liver.

Chung AS, Maines MD

Biochemical pharmacology.. 1981 December 130 (23):3217-23. Epub 1900 01 01.

Host heme biosynthesis and degradation in schistosomiasis.

Maines MD, Senft AW

The American journal of tropical medicine and hygiene.. 1981 September 30 (5):1010-9. Epub 1900 01 01.

Purification and characterization of biliverdin reductase from rat liver.

Kutty RK, Maines MD

The Journal of biological chemistry.. 1981 April 25256 (8):3956-62. Epub 1900 01 01.

Effect of allylisopropylacetamide on glutathione metabolism in the rat liver. The possible role of glutathione in the induction of 5-aminolaevulinate synthase.

Maines MD

The Biochemical journal.. 1981 April 15196 (1):285-92. Epub 1900 01 01.

Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat.

Maines MD

Biochimica et biophysica acta.. 1981 March 18673 (3):339-50. Epub 1900 01 01.

Enzymatic basis of metal ion alterations of cellular heme and glutathione metabolism.

Maines MD

Fundamental and applied toxicology : official journal of the Society of Toxicology.. 1981 1 (5):358-67. Epub 1900 01 01.

Regional distribution of the enzymes of haem biosynthesis and the inhibition of 5-aminolaevulinate synthase by manganese in the rat brain.

Maines MD

The Biochemical journal.. 1980 August 15190 (2):315-21. Epub 1900 01 01.

Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver.

Maines MD

The International journal of biochemistry. 1980 12 (5-6):781-5. Epub 1900 01 01.

Role of trace metals in regulation of cellular heme and hemoprotein metabolism: sensitizing effects of chronic iron treatment on acute gold toxicity.

Maines MD

Drug metabolism reviews.. 1979 9 (2):237-55. Epub 1900 01 01.

Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation.

Maines MD, Kappas A

The Journal of biological chemistry.. 1978 April 10253 (7):2321-6. Epub 1900 01 01.

Effect of cobalt on enzymes of porphyrin and heme synthesis in the rat kidney and the inhibition by cobalt of 3, 5-dicarbethoxy-1, 4-dihydrocollidine and allyl- isopropyl-acetamide induction of liver d-aminolevulinate synthetase activity

Maines, M.D.; Tomio, J.M.; Janousek, V.;.

Journal of Clinical Chemistry and Clinical Biochemistry. 1978; 16(3): 30-32.

Metals as regulators of heme metabolism.

Maines MD, Kappas A

Science.. 1977 December 23198 (4323):1215-21. Epub 1900 01 01.

Enzymes of heme metabolism in the kidney: regulation by trace metals which do not form heme complexes.

Maines MD, Kappas A

The Journal of experimental medicine.. 1977 November 1146 (5):1286-93. Epub 1900 01 01.

Regulation of cytochrome P-450-dependent microsomal drug-metabolizing enzymes by nickel, cobalt, and iron.

Maines MD, Kappas A

Clinical pharmacology and therapeutics.. 1977 November 22 (5 Pt 2):780-90. Epub 1900 01 01.

Solubilization and partial purification of heme oxygenase from rat liver.

Maines MD, Ibrahim NG, Kappas A

The Journal of biological chemistry.. 1977 August 25252 (16):5900-3. Epub 1900 01 01.

Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols.

Maines MD, Kappas A

Proceedings of the National Academy of Sciences of the United States of America.. 1977 May 74 (5):1875-8. Epub 1900 01 01.

Bile pigment formation by skin heme oxygenase: studies on the response of the enzyme to heme compounds and tissue injury.

Maines MD, Cohn J

The Journal of experimental medicine.. 1977 April 1145 (4):1054-9. Epub 1900 01 01.

Enzymatic oxidation of cobalt protoporphyrin IX: observations on the mechanism of heme oxygenase action.

Maines MD, Kappas A

Biochemistry.. 1977 February 816 (3):419-23. Epub 1900 01 01.

Cobalt regulation of heme synthesis and degradation in avian embryo liver cell culture.

Maines MD, Sinclair P

The Journal of biological chemistry.. 1977 January 10252 (1):219-23. Epub 1900 01 01.

Evidence for the catabolism of polychlorinated biphenyl-induced cytochrome P-448 by microsomal heme oxygenase, and the inhibition of delta-aminolevulinate dehydratase by polychlorinated biphenyls.

Maines MD

The Journal of experimental medicine.. 1976 December 1144 (6):1509-19. Epub 1900 01 01.

Selenium regulation of hepatic heme metabolism: induction of delta-aminolevulinate synthase and heme oxygenase.

Maines MD, Kappas A

Proceedings of the National Academy of Sciences of the United States of America.. 1976 December 73 (12):4428-31. Epub 1900 01 01.

Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver.

Maines MD, Janous?k V, Tomio JM, Kappas A

Proceedings of the National Academy of Sciences of the United States of America.. 1976 May 73 (5):1499-503. Epub 1900 01 01.

Tin: a potent inducer of heme oxygenase in kidney.

Kappas A, Maines MD

Science.. 1976 April 2192 (4234):60-2. Epub 1900 01 01.

Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions.

Maines MD, Kappas A

The Biochemical journal.. 1976 January 15154 (1):125-31. Epub 1900 01 01.

Trace Metal regulation of heme and hemoprotein oxidation

Maines, M.D.; Kappas, A.;.

Hoppe-Seyler's Zeitschrift fur Physiologische Chemie. 1976; 357(3): 1038-1039.

The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase.

Maines MD, Kappas A

Annals of clinical research.. 1976 8 Suppl 17 :39-46. Epub 1900 01 01.

Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450.

Maines MD, Kappas A

The Journal of biological chemistry.. 1975 June 10250 (11):4171-7. Epub 1900 01 01.

Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period.

Maines MD, Kappas A

The Journal of experimental medicine.. 1975 June 1141 (6):1400-10. Epub 1900 01 01.

The degradative effects of porphyrins and heme compounds on components of the microsomal mixed function oxidase system.

Maines MD, Kappas A

The Journal of biological chemistry.. 1975 March 25250 (6):2363-9. Epub 1900 01 01.

Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity.

Maines MD, Kappas A

Proceedings of the National Academy of Sciences of the United States of America.. 1974 November 71 (11):4293-7. Epub 1900 01 01.

Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins.

Maines MD, Anders MW, Muller-Eberhard U

Molecular pharmacology.. 1974 March 10 (2):204-13. Epub 1900 01 01.

Characterization of the heme of cytochrome P-450 using gas chromatography-mass spectrometry.

Maines MD, Anders MW

Archives of biochemistry and biophysics.. 1973 November 159 (1):201-5. Epub 1900 01 01.

Reconstitution of carbon monoxide-binding particles after removal of heme by serum albumin.

Maines MD, Anders MW

Molecular pharmacology.. 1973 March 9 (2):219-28. Epub 1900 01 01.

The possible implication of heme transfer from cytochrome P-420 to albumin in the metabolism of cytochrome P-450.

Maines MD, Anders MW

Drug metabolism and disposition : the biological fate of chemicals.. 1973 1 (1):293-8. Epub 1900 01 01.

Preparation of hepatic microsomal fraction for drug metabolism studies by rapid decompression homogenization.

Short CR, Maines MD, Davis LE

Proceedings of the Society for Experimental Biology and Medicine.. 1972 May 140 (1):58-65. Epub 1900 01 01.

Postnatal development of drug-metabolizing enzyme activity in liver and extrahepatic tissues of swine.

Short CR, Maines MD, Westfall BA

Biology of the neonate.. 1972 21 (1):54-68. Epub 1900 01 01.

Sex difference in the metabolism of hexobarbital in the mongolian gerbil (Meriones unguiculatus).

Maines MD, Westfall BA

Proceedings of the Society for Experimental Biology and Medicine.. 1971 December 138 (3):820-2. Epub 1900 01 01.

Effect of water deprivation on the metabolism of hexobarbital in the Mongolian gerbil (Meriones unguiculatus).

Maines MD, Westfall BA

Comparative and general pharmacology. 1971 September 2 (7):311-6. Epub 1900 01 01.

An autoradiographic study of the distribution and excretion of 14C-dicoumarol in the rat.

Maines MD, Wosilait WD

Comparative and general pharmacology. 1971 June 2 (6):184-8. Epub 1900 01 01.