Home Home Randy N. Rosier, M.D., Ph.D.

Randy N. Rosier, M.D., Ph.D.

Contact

Appointment (585) 275-5321

Office (585) 341-9236

Fax (585) 340-3051

About Me
Credentials
Publications

About Me

Faculty Appointments

Professor Emeritus - Department of Orthopaedics (SMD)

Credentials

Post-doctoral Training & Residency

Research Fellow in Department of Orthopaedics
the University of Iowa.
Project Title: Investigation of the role of mitochondria in
endochondral calcification. 1982 - 1983

Internship at the University of Iowa 1978 - 1979

Education

PhD | University of Rochester School of Medicine and Dentistry. Biophysics. 1979

MD | University of Rochester School of Medicine and Dentistry. Medicine. 1978

MS | University of Rochester School of Medicine and Dentistry. Biophysics. 1976

BS | Dickinson College. Physics. 1972

Awards

The Alfred R. Shands Jr, MD Award. 2009

Best Doctors in America for Tumor Surgery. 2009

Dean's Professorship. 1998

Kappa Delta Award for outstanding orthopaedic research. 1995

Honorary member, Holdsworth Orthopaedic Club. 1992

American Orthopaedic Association: American-British Traveling Fellowship. 1991

Shannon Award. 1991

Outstanding Teacher Award. 1989

Sigma Xi (scientific research society). 1979

Phi Beta Kappa. 1972

Sigma Pi Sigma (physics honorary). 1971

Dana Award Scholar. 1970 - 1972

Publications

Journal Articles

Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis.

Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH

Oncogene.. 2008 June 527 (25):3605-14. Epub 01/28/2008.

Regulation of embryonic endochondral ossification by Smurf2.

Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2008 May 26 (5):704-12. Epub 1900 01 01.

Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition.

Eliseev RA, Filippov G, Velos J, VanWinkle B, Goldman A, Rosier RN, Gunter TE

Neurobiology of aging.. 2007 October 28 (10):1532-42. Epub 07/31/2006.

Overexpression of Smurf2 Stimulates Endochondral Ossification Through Upregulation of beta-Catenin

Wu,Q.; Chen,D.; Zuscik,M. J.; O'Keefe,R. J.; Rosier,R. N.;.

J.Bone Miner.Res. 2007; .

Continuing competency in orthopaedics: the future of recertification.

Rosier RN

Clinical orthopaedics and related research.. 2006 August 449 :72-5. Epub 1900 01 01.

Institutional barriers to the orthopaedic clinician-scientist.

Rosier RN

Clinical orthopaedics and related research.. 2006 August 449 :159-64. Epub 1900 01 01.

American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, certification examination case mix.

Garrett WE, Swiontkowski MF, Weinstein JN, Callaghan J, Rosier RN, Berry DJ, Harrast J, Derosa GP

The Journal of bone and joint surgery. American volume.. 2006 March 88 (3):660-7. Epub 1900 01 01.

Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB.

Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN

Experimental cell research.. 2006 January 1312 (1):40-50. Epub 11/02/2005.

Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2006 January 21 (1):4-16. Epub 09/19/2005.

A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival.

Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN

FEBS letters.. 2005 December 19579 (30):6814-20. Epub 11/28/2005.

Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase.

Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN

Journal of cellular biochemistry.. 2005 December 1596 (6):1262-73. Epub 1900 01 01.

Molecular biology in orthopaedics: the advent of molecular orthopaedics.

Evans CH, Rosier RN

The Journal of bone and joint surgery. American volume.. 2005 November 87 (11):2550-64. Epub 1900 01 01.

Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency.

Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM

Environmental health perspectives.. 2005 June 113 (6):749-55. Epub 1900 01 01.

Case report: Bone metastases from fallopian tube carcinoma.

Courville XF, Cortés Z, Katzman PJ, Rosier RN

Clinical orthopaedics and related research.. 2005 May (434):278-81. Epub 1900 01 01.

Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone.

Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE

Cancer research.. 2005 April 1565 (8):3209-17. Epub 1900 01 01.

Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists.

Andela VB, Altuwaijri S, Wood J, Rosier RN

FEBS letters.. 2005 March 14579 (7):1765-9. Epub 1900 01 01.

An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma.

Andela VB, Siddiqui F, Groman A, Rosier RN

Journal of clinical pathology.. 2005 March 58 (3):328-30. Epub 1900 01 01.

Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB.

Eliseev RA, Vanwinkle B, Rosier RN, Gunter TE

The Journal of biological chemistry.. 2004 November 5279 (45):46748-54. Epub 08/23/2004.

PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling.

Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ

Experimental cell research.. 2004 October 15300 (1):159-69. Epub 1900 01 01.

Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway.

Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H

Experimental cell research.. 2004 September 10299 (1):128-36. Epub 1900 01 01.

The association between environmental lead exposure and bone density in children.

Campbell JR, Rosier RN, Novotny L, Puzas JE

Environmental health perspectives.. 2004 August 112 (11):1200-3. Epub 1900 01 01.

5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes.

Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN

Journal of cellular biochemistry.. 2004 May 1592 (2):316-31. Epub 1900 01 01.

Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation.

Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ

Bone.. 2004 May 34 (5):809-17. Epub 1900 01 01.

The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids.

Andela VB, Rosier RN

Molecular cancer.. 2004 March 223 :8. Epub 03/22/2004.

CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter.

Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ

Journal of cellular physiology.. 2004 March 198 (3):428-40. Epub 1900 01 01.

PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway.

Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2004 January 22 (1):6-12. Epub 1900 01 01.

Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes.

Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ

Journal of cellular biochemistry.. 2003 December 1590 (6):1287-98. Epub 1900 01 01.

The mevalonate synthesis pathway as a therapeutic target in cancer.

Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN

Clinical orthopaedics and related research.. 2003 October (415 Suppl):S59-66. Epub 1900 01 01.

NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone.

Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ

Clinical orthopaedics and related research.. 2003 October (415 Suppl):S75-85. Epub 1900 01 01.

Smad6 is induced by BMP-2 and modulates chondrocyte differentiation.

Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2003 September 21 (5):908-13. Epub 1900 01 01.

ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development.

Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2003 September 18 (9):1593-604. Epub 1900 01 01.

ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation.

Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ

Experimental cell research.. 2003 August 1288 (1):198-207. Epub 1900 01 01.

Altered negative regulation of transforming growth factor beta signaling in scleroderma: potential involvement of SMURF2 in disease.

Zuscik MJ, Rosier RN, Schwarz EM

Arthritis and rheumatism.. 2003 July 48 (7):1779-80. Epub 1900 01 01.

Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5.

Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ

Endocrinology.. 2003 June 144 (6):2514-23. Epub 1900 01 01.

Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB.

Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN

Cancer letters.. 2003 May 8194 (1):37-43. Epub 1900 01 01.

A phage display technique identifies a novel regulator of cell differentiation.

Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE

The Journal of biological chemistry.. 2003 January 3278 (1):438-43. Epub 10/25/2002.

Parathyroid hormone-related Peptide expression in cartilaginous tumors.

Pateder DB, Gish MW, O'Keefe RJ, Hicks DG, Teot LA, Rosier RN

Clinical orthopaedics and related research.. 2002 October (403):198-204. Epub 1900 01 01.

Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB.

Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN

Biochemical and biophysical research communications.. 2002 September 20297 (2):237-41. Epub 1900 01 01.

Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A.

Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 September 20 (5):1079-90. Epub 1900 01 01.

The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles.

Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 July 20 (4):714-22. Epub 1900 01 01.

Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes.

Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 July 20 (4):811-8. Epub 1900 01 01.

Growth plate chondrocyte maturation is regulated by basal intracellular calcium.

Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN

Experimental cell research.. 2002 June 10276 (2):310-9. Epub 1900 01 01.

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair.

Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ

The Journal of clinical investigation.. 2002 June 109 (11):1405-15. Epub 1900 01 01.

Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae.

Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 May 17 (5):915-22. Epub 1900 01 01.

Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles.

Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ

Arthritis and rheumatism.. 2002 May 46 (5):1298-308. Epub 1900 01 01.

Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis.

Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN

Clinical orthopaedics and related research.. 2002 April (397):228-39. Epub 1900 01 01.

Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors.

Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN

Journal of surgical oncology.. 2002 March 79 (3):174-9. Epub 1900 01 01.

Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis.

Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 March 20 (2):169-73. Epub 1900 01 01.

In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis.

Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 February 17 (2):192-9. Epub 1900 01 01.

A role for the BMP antagonist chordin in endochondral ossification.

Zhang D, Ferguson CM, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2002 February 17 (2):293-300. Epub 1900 01 01.

Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes.

Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN

Radiation research.. 2002 January 157 (1):62-8. Epub 1900 01 01.

COX-1 and COX-2 expression in osteoid osteomas.

Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2002 January 20 (1):159-62. Epub 1900 01 01.

PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling.

Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ

Journal of cellular physiology.. 2001 September 188 (3):343-51. Epub 1900 01 01.

From oranges and lemons to glucosamine and chondroitin sulfate: clinical observations stimulate basic research.

Buckwalter JA, Callaghan JJ, Rosier RN

The Journal of bone and joint surgery. American volume.. 2001 August 83 (8):1266-8. Epub 1900 01 01.

Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components.

Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ

The Journal of bone and joint surgery. American volume.. 2001 July 83 (7):1057-61. Epub 1900 01 01.

The role of autocrine growth factors in radiation damage to the epiphyseal growth plate.

Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN

Radiation research.. 2001 June 155 (6):847-57. Epub 1900 01 01.

The increasing need for nonoperative treatment of patients with osteoarthritis.

Buckwalter JA, Stanish WD, Rosier RN, Schenck RC, Dennis DA, Coutts RD

Clinical orthopaedics and related research.. 2001 April (385):36-45. Epub 1900 01 01.

Expanding the role of the orthopaedic surgeon in the treatment of osteoporosis.

Rosier RN

Clinical orthopaedics and related research.. 2001 April (385):57-67. Epub 1900 01 01.

Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis.

Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 2001 April 16 (4):660-70. Epub 1900 01 01.

Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB.

Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN

Cancer research.. 2000 December 160 (23):6557-62. Epub 1900 01 01.

Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation.

Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ

Endocrinology.. 2000 December 141 (12):4728-35. Epub 1900 01 01.

Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis.

Schwarz EM, Benz EB, Lu AP, Goater JJ, Mollano AV, Rosier RN, Puzas JE, Okeefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 November 18 (6):849-55. Epub 1900 01 01.

Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo.

Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR

Molecular and cellular biology.. 2000 September 20 (17):6496-507. Epub 1900 01 01.

Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues.

Reynolds SD, Zhang D, Puzas JE, O'Keefe RJ, Rosier RN, Reynolds PR

Gene.. 2000 May 2248 (1-2):233-43. Epub 1900 01 01.

PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes.

Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ

Experimental cell research.. 2000 May 1256 (2):555-62. Epub 1900 01 01.

Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis.

Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2000 May 18 (3):472-80. Epub 1900 01 01.

Hyaluronic acid therapy.

Rosier RN, O'Keefe RJ

Instructional course lectures.. 2000 49 :495-502. Epub 1900 01 01.

Pelvic reconstruction for severe periacetabular metastatic disease.

Vena VE, Hsu J, Rosier RN, O'Keefe RJ

Clinical orthopaedics and related research.. 1999 May (362):171-80. Epub 1900 01 01.

BMP-6 is an autocrine stimulator of chondrocyte differentiation.

Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Reynolds PR, Rosier RN, O'Keefe RJ

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1999 April 14 (4):475-82. Epub 1900 01 01.

Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19.

Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR

Genomics.. 1999 March 1556 (3):324-36. Epub 1900 01 01.

Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway.

Pollice PF, Hsu J, Hicks DG, Bukata S, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1998 November 16 (6):697-704. Epub 1900 01 01.

Functional outcome after soft-tissue reconstruction for limb salvage after sarcoma surgery.

Serletti JM, Carras AJ, O'Keefe RJ, Rosier RN

Plastic and reconstructive surgery.. 1998 October 102 (5):1576-83; discussion 1584-5. Epub 1900 01 01.

The potential role of transforming growth factor beta in fracture healing.

Rosier RN, O'Keefe RJ, Hicks DG

Clinical orthopaedics and related research.. 1998 October (355 Suppl):S294-300. Epub 1900 01 01.

Breakout session. 6: Regional gene therapy.

Rosier RN

Clinical orthopaedics and related research.. 1998 October (355 Suppl):S361-3. Epub 1900 01 01.

Stimulation of bone formation in vivo by insulin-like growth factor-II in rats.

Ishibe M, Ishibashi T, Kaneda K, Koda T, Rosier RN, Puzas JE

Calcified tissue international.. 1998 July 63 (1):36-8. Epub 1900 01 01.

Treatment of multifocal lymphoma of bone with intensified ProMACE-CytaBOM chemotherapy and involved field radiotherapy.

Rapoport AP, Constine LS, Packman CH, Rosier RN, O'Keefe R, Hicks DG, Rubin SJ, Rowe JM

American journal of hematology.. 1998 May 58 (1):1-7. Epub 1900 01 01.

HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation.

Romano PR, Wang J, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR

Journal of cell science.. 1998 March 111 ( Pt 6) :803-13. Epub 1900 01 01.

Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation.

Grimsrud CD, Rosier RN, Puzas JE, Reynolds PR, Reynolds SD, Hicks DG, O'Keefe RJ

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1998 March 16 (2):247-55. Epub 1900 01 01.

Autocrine regulation of articular cartilage.

Rosier RN, O'Keefe RJ

Instructional course lectures.. 1998 47 :469-75. Epub 1900 01 01.

Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction.

O'Keefe RJ, Rosier RN, Teot LA, Stewart JM, Hicks DG

The Iowa orthopaedic journal.. 1998 18 :26-34. Epub 1900 01 01.

Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms.

Blaine TA, Pollice PF, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ

The Journal of bone and joint surgery. American volume.. 1997 October 79 (10):1519-28. Epub 1900 01 01.

P-glycoprotein expression in cartilaginous tumors.

Rosier RN, O'Keefe RJ, Teot LA, Fox EJ, Nester TA, Puzas JE, Reynolds PR, Hicks DG

Journal of surgical oncology.. 1997 June 65 (2):95-105. Epub 1900 01 01.

Characterization of voltage-sensitive calcium channels in growth plate chondrocytes.

Zuscik MJ, Gunter TE, Puzas JE, Rosier RN

Biochemical and biophysical research communications.. 1997 May 19234 (2):432-8. Epub 1900 01 01.

Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study.

O'Keefe RJ, Teot LA, Singh D, Puzas JE, Rosier RN, Hicks DG

Laboratory investigation; a journal of technical methods and pathology.. 1997 April 76 (4):457-65. Epub 1900 01 01.

Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes.

O'Keefe RJ, Loveys LS, Hicks DG, Reynolds PR, Crabb ID, Puzas JE, Rosier RN

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1997 March 15 (2):162-74. Epub 1900 01 01.

Effects of lead on growth plate chondrocyte phenotype.

Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A, Rosier RN

Toxicology and applied pharmacology.. 1996 September 140 (1):164-72. Epub 1900 01 01.

Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles.

Blaine TA, Rosier RN, Puzas JE, Looney RJ, Reynolds PR, Reynolds SD, O'Keefe RJ

The Journal of bone and joint surgery. American volume.. 1996 August 78 (8):1181-92. Epub 1900 01 01.

Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy.

Reynolds SD, Johnston C, Leboy PS, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR

Experimental cell research.. 1996 July 10226 (1):197-207. Epub 1900 01 01.

Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation.

Teot LA, O'Keefe RJ, Rosier RN, O'Connell JX, Fox EJ, Hicks DG

Human pathology.. 1996 July 27 (7):625-32. Epub 1900 01 01.

Alternative splicing of a chondrocyte-specific gene.

Reynolds PR, Reynolds SD, O'Keefe RJ, Puzas JE, Rosier RN

Annals of the New York Academy of Sciences.. 1996 June 8785 :321-4. Epub 1900 01 01.

Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages.

Hicks DG, Judkins AR, Sickel JZ, Rosier RN, Puzas JE, O'Keefe RJ

The Journal of bone and joint surgery. American volume.. 1996 April 78 (4):482-96. Epub 1900 01 01.

Mastocytosis presenting as a skeletal disorder.

Delsignore JL, Dvoretsky PM, Hicks DG, O'Keefe RJ, Rosier RN

The Iowa orthopaedic journal.. 1996 16 :126-34. Epub 1900 01 01.

17 beta-estradiol increases the receptor number and modulates the action of 1,25-dihydroxyvitamin D3 in human osteosarcoma-derived osteoblast-like cells.

Ishibe M, Nojima T, Ishibashi T, Koda T, Kaneda K, Rosier RN, Puzas JE

Calcified tissue international.. 1995 December 57 (6):430-5. Epub 1900 01 01.

Identification of functional insulin-like growth factor-II/mannose-6-phosphate receptors in isolated bone cells.

Martinez DA, Zuscik MJ, Ishibe M, Rosier RN, Romano PR, Cushing JE, Puzas JE

Journal of cellular biochemistry.. 1995 October 59 (2):246-57. Epub 1900 01 01.

Comparison of the type-2 insulin-like growth factor receptor in normal osteoblasts and osteosarcoma-derived osteoblast-like cells.

Ishibe M, Nojima T, Ishibashi T, Koda T, Rosier RN, Puzas JE, Kaneda K

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1995 September 13 (5):643-8. Epub 1900 01 01.

Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus.

Hughes SS, Hicks DG, O'Keefe RJ, Hurwitz SR, Crabb ID, Krasinskas AM, Loveys L, Puzas JE, Rosier RN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1995 April 10 (4):533-44. Epub 1900 01 01.

Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells.

Hicks DG, Gokan T, O'Keefe RJ, Totterman SM, Fultz PJ, Judkins AR, Meyers SP, Rubens DJ, Sickel JZ, Rosier RN

Cancer.. 1995 February 1575 (4):973-80. Epub 1900 01 01.

The mandibular condylar growth center: separation and characterization of the cellular elements.

Landesberg R, Proctor RL, Rosier RN, Puzas JE

Calcified tissue international.. 1995 January 56 (1):71-7. Epub 1900 01 01.

Multiple drug resistance in osteosarcoma.

Rosier RN, Teot LA, Hicks DG, Schwartz C, O'Keefe RJ, Puzas JE

The Iowa orthopaedic journal.. 1995 15 :66-73. Epub 1900 01 01.

Cyclic-AMP-dependent protein kinase activity is not required by parathyroid hormone to stimulate phosphoinositide signaling in chondrocytes but is required to transduce the hormone's proliferative effect.

Zuscik MJ, Puzas JE, Rosier RN, Gunter KK, Gunter TE

Archives of biochemistry and biophysics.. 1994 December 315 (2):352-61. Epub 1900 01 01.

Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: rapid induction of type X collagen in culture.

O'Keefe RJ, Puzas JE, Loveys L, Hicks DG, Rosier RN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1994 November 9 (11):1713-22. Epub 1900 01 01.

Activation of phosphoinositide metabolism by parathyroid hormone in growth plate chondrocytes.

Zuscik MJ, Gunter TE, Rosier RN, Gunter KK, Puzas JE

Cell calcium.. 1994 August 16 (2):112-22. Epub 1900 01 01.

Comparative effects of growth factors on fibroblasts of Dupuytren's tissue and normal palmar fascia.

Alioto RJ, Rosier RN, Burton RI, Puzas JE

The Journal of hand surgery.. 1994 May 19 (3):442-52. Epub 1900 01 01.

Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I.

O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1994 May 12 (3):299-310. Epub 1900 01 01.

Low content of estrogen receptors in human giant cell tumors of bone.

Ishibe M, Ishibe Y, Ishibashi T, Nojima T, Rosier RN, Puzas JE, Kaneda K

Archives of orthopaedic and trauma surgery.. 1994 113 (2):106-9. Epub 1900 01 01.

Effects of parathyroid hormone-related peptide on chick growth plate chondrocytes.

Loveys LS, Gelb D, Hurwitz SR, Puzas JE, Rosier RN

Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 1993 November 11 (6):884-91. Epub 1900 01 01.

Preliminary findings on the effects of sex hormones on bone metabolism in anorexia nervosa.

Kreipe RE, Hicks DG, Rosier RN, Puzas JE

The Journal of adolescent health : official publication of the Society for Adolescent Medicine.. 1993 June 14 (4):319-24. Epub 1900 01 01.

Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm.

Kramer K, Hicks DG, Palis J, Rosier RN, Oppenheimer J, Fallon MD, Cohen HJ

Cancer.. 1993 May 1571 (10):2977-82. Epub 1900 01 01.

The human auricular chondrocyte. Responses to growth factors.

Quatela VC, Sherris DA, Rosier RN

Archives of otolaryngology--head & neck surgery.. 1993 January 119 (1):32-7. Epub 1900 01 01.

Nonradioactive in situ hybridization using digoxigenin-labeled oligonucleotides. Applications to musculoskeletal tissues.

Crabb ID, Hughes SS, Hicks DG, Puzas JE, Tsao GJ, Rosier RN

The American journal of pathology.. 1992 September 141 (3):579-89. Epub 1900 01 01.

Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes.

O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1992 April 7 (4):397-404. Epub 1900 01 01.

Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes.

Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN

Calcified tissue international.. 1992 January 50 (1):61-6. Epub 1900 01 01.

Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells.

Ishibe M, Rosier RN, Puzas JE

The Journal of clinical endocrinology and metabolism.. 1991 October 73 (4):785-92. Epub 1900 01 01.

Heterotopic ossification: clinical and cellular aspects.

Sawyer JR, Myers MA, Rosier RN, Puzas JE

Calcified tissue international.. 1991 September 49 (3):208-15. Epub 1900 01 01.

Activation of osteoblast insulin-like growth factor-II/cation-independent mannose-6-phosphate receptors by specific phosphorylated sugars and antibodies induce insulin-like growth factor-II effects.

Ishibe M, Rosier RN, Puzas JE

Endocrine research.. 1991 17 (3-4):357-66. Epub 1900 01 01.

Synergistic effect of transforming growth factor beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes.

Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.. 1990 November 5 (11):1105-12. Epub 1900 01 01.

The production of transforming growth factor-beta by chick growth plate chondrocytes in short term monolayer culture.

Gelb DE, Rosier RN, Puzas JE

Endocrinology.. 1990 October 127 (4):1941-7. Epub 1900 01 01.

Cytosolic free calcium concentrations in avian growth plate chondrocytes.

Gunter TE, Zuscik MJ, Puzas JE, Gunter KK, Rosier RN

Cell calcium.. 1990 August 11 (7):445-57. Epub 1900 01 01.

Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes.

O'Keefe RJ, Rosier RN, Puzas JE

Connective tissue research.. 1990 24 (1):53-66. Epub 1900 01 01.

Pathologic bone formation.

Puzas JE, Miller MD, Rosier RN

Clinical orthopaedics and related research.. 1989 August (245):269-81. Epub 1900 01 01.