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M. Kerry O'Banion, M.D., Ph.D.

M. Kerry O'Banion, M.D., Ph.D.

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About Me

EDUCATION:

1976 – 1980 University of Illinois, College of Liberal Arts and Sciences - B.S. with honors in Biology (summa cum laude). Research training with Dr. Sue Carter-Porges, Department of Neural and Behavioral Biology.
1980 – 1987 University of Illinois, College of Liberal Arts and S...
EDUCATION:

1976 – 1980 University of Illinois, College of Liberal Arts and Sciences - B.S. with honors in Biology (summa cum laude). Research training with Dr. Sue Carter-Porges, Department of Neural and Behavioral Biology.
1980 – 1987 University of Illinois, College of Liberal Arts and Sciences - M.S., Ph.D. in Microbiology.
1980 – 1987 University of Illinois, School of Medicine, Urbana, Illinois - M.D. with honors.
1987 – 1990 Postdoctoral Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine & Dentistry.

FACULTY APPOINTMENTS:

1990 – 1991 Instructor and Fellow, Departments of Medicine and Biochemistry, University of Rochester School of Medicine & Dentistry
1991 – 1997 Assistant Professor, Departments of Neurology and of Neurobiology and Anatomy, University of Rochester School of Medicine & Dentistry
1997 – 2000 Associate Professor, Departments of Neurology and of Neurobiology and Anatomy, University of Rochester School of Medicine & Dentistry
2000 – Present Associate Professor (Tenured in 2002), Departments of Neurobiology and Anatomy and of Neurology, University of Rochester School of Medicine & Dentistry

HONORS, AWARDS AND FELLOWSHIPS:

1977 – 1980 Edmund J. James Scholar
1980 Phi Kappa Phi (Honorary Society)
1980 B.S. with honors (summa cum laude); Bronze Tablet Recipient
1980 University of Illinois Life Sciences Predoctoral Fellowship
1982 Excellence in Undergraduate Teaching Award
1984 Otto Saphir Memorial Award in Pathology
1984 Alpha Omega Alpha (Honorary Medical Society)
1986 University of Illinois College of Medicine Predoctoral Fellowship
1987 M.D. with honors; Valedictorian Address, Medical School Commencement
1987 Lange Book Award
1988 Proficiency in Pediatrics Book Award
1987 – 1989 NIH Postdoctoral Training Fellow in Endocrinology and Metabolism, University of Rochester
1988 – 1991 Wilmot Cancer Research Postdoctoral Fellowship, University of Rochester
1990 – 1991 New York State Health Research Council Postdoctoral Fellowship for Diabetes Research
1996 – 1999 George W. Corner Dean's Teaching Scholar
1998 Graduate Student Society Faculty Teaching Award

Faculty Appointments

Professor - Department of Neuroscience (SMD)

Vice Chair - Department of Neuroscience (SMD)

Professor - Department of Neurology (SMD) - Joint

Credentials

Post-doctoral Training & Residency

New York State Health Research Council Fellowship for Diabetes Research. 1990 - 1991

Wilmot Cancer Research Postdoctoral Fellowship,
University of Rochester. 1988 - 1991

Postdoctoral Fellow,
Departments of Medicine and Biochemistry,
University of Rochester School of Medicine.
Trained with Dr. D. A. Young. 1987 - 1990

Education

PhD | Univ of Illinois-Urbana. Microbiology. 1987

MD | Univ of Illinois Coll Medicine. Medicine. 1987

BS | Univ of Illinois-Urbana. Biology. 1980

Awards

Graduate Student Society Faculty Teaching Award. 1998

George W. Corner Dean's Teaching Scholar. 1996 - 1999

Proficiency in Pediatrics Book Award. 1988

M.D. with honors; Valedictorian Address. 1987

Lange Book Award. 1987

Otto Saphir Memorial Award in Pathology. 1984

Alpha Omega Alpha (Honorary Medical Society). 1984

Excellence in Undergraduate Teaching Award. 1982

Phi Kappa Phi (Honorary Society). 1980

B.S. with honors (summa cum laude); Bronze Tablet Recipient. 1980

Edmund J. James Scholar. 1977 - 1980

Research

RESEARCH: Neuroinflammation in CNS Injury and Alzheimer's Disease.

Twenty years ago evidence from epidemiological studies and investigations of human brain pathology suggested the hypothesis that innate immune activation of the brain, a term now referred to as neuroinflammation, might contri...
RESEARCH: Neuroinflammation in CNS Injury and Alzheimer's Disease.

Twenty years ago evidence from epidemiological studies and investigations of human brain pathology suggested the hypothesis that innate immune activation of the brain, a term now referred to as neuroinflammation, might contribute to the pathogenesis of Alzheimer's and other brain diseases. Based on our pioneering work in the area of cyclooxygenase-2 and inflammation, we initiated a research program that focuses on understanding the role of neuroinflammation in Alzheimer's and other neurodegenerative diseases. Studies conducted in the laboratory with human brain tissue, neuronal cell culture models and mouse models of acute injury and neurodegeneration have pointed to a prominent role for specific proinflammatory cytokines and bioactive prostaglandins in promoting neuroinflammation. Interestingly, our current work in Alzheimer's disease has revealed a potential protective role for neuroinflammation and has led to a focus on the influence of glial expressed cytokines and infiltrating peripheral cells on brain pathology, utilizing genetic and pharmacological approaches in a variety of mouse models. In complementary work, we also have active preclinical projects in the area of brain radiation injury, a critical problem for individuals receiving radiotherapy for brain tumors or bone marrow transplantation. The main goal is to understand the role of neuroinflammation and oxidative stress in promoting injury and to determine whether therapeutic interventions targeting these processes can alleviate late radiation effects, including cognitive changes

RECENT PUBLICATIONS:

Cherry, J.D., B. Liu, J.L. Frost, C.A. Lemere, J.P. Williams, J.A. Olschowka and M.K. O'Banion. 2012. Galactic cosmic radiation leads to cognitive impairment and increased Ab plaque accumulation in a mouse model of Alzheimer's disease. PLOS ONE 7:e53275. PMCID in process.

Dilmanian, F.A., A.L. Jenkins, J. Olschowka, Z. Zhong, J.Y. Park, N.R. Desnoyers, S. Sobotka, G.R. Fois, C.R. Messina, M. Morales, S.D. Hurley, L.A. Trojanczyk, S. Ahmad, N. Shahrabi, P.K. Coyle, A.G. Meek and M.K. O'Banion. 2012. X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function. Rad. Res. Dec 5 [Epub ahead of print]. PMCID in process.

Wu, M.D., A.M. Hein, M.J. Moravan, S.S. Shaftel, J.A. Olschowka and M.K. O'Banion. 2012. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1? and not rescued by voluntary running. Brain Behav. Immun. 26:292-300. PMCID: PMC3258353

Matousek, S.B., S. Ghosh, S.S. Shaftel, S. Kyrkanides, J.A. Olschowka and M.K. O'Banion. 2012. Chronic IL-1?-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J. Neuroimmune Pharmacol. 7:156-164. PMCID: PMC3302720

Hein, A. M., T. J. Zarcone, D. B. Parfitt, S. B. Matousek, D. M. Carbonari, J. A. Olschowka and M. K. O'Banion. 2012. Behavioral, structural and molecular changes following long-term hippocampal IL-1? overexpression in transgenic mice. J. Neuroimmune Pharmacol. 7:145-155. PMCID: PMC3214690

Kyrkanides S., R.H. Tallents, J.N. Miller, M.E. Olschowka, R. Johnson, M. Yang, J.A. Olschowka, S.M. Brouxhon and M.K. O'Banion. 2011. Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice. J. Neuroinflammation 8:112. PMCID: PMC3179730

Moravan, M.J., D.A. Olschowka, J.P. Williams and M.K. O'Banion. 2011. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat. Res. 176:459-473. PMCID: PMC3191189.

Patents

Mammalian Prostaglandin H Synthase-2

Issue date: September 15, 1998

Patent #: 5,807,733

Country: United States

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Screening Assays for Inhibitors of Mammalian Prostaglandin H Synthase-2

Issue date: November 17, 1998

Patent #: 5,837,479

Country: United States

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transfromed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: July 02, 1998

Patent #: 688282

Country: Australia

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: 0667911

Country: Europe

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: February 12, 2000

Patent #: 1013106

Country: Hong Kong

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: February 20, 1998

Patent #: 256,776

Country: New Zealand

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Mammalian Prostaglandin H Synthase-2

Issue date: April 11, 2000

Patent #: 6,048,850

Country: United States

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: DE0667911

Country: Germany

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion

Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: FR0667911

Country: France

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: LU0667911

Country: Luxembourg

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: BE0667911

Country: Belgium

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: MC0667911

Country: Monaco

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: IE0667911

Country: Ireland

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: GB0667911

Country: United Kingdom

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: CH0667911

Country: Switzerland/Liechtenstein

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: AT179756

Country: Austria

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: DK0667911

Country: Denmark

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: ES0667911

Country: Spain

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: GR0667911

Country: Greece

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: IT0667911

Country: Italy

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: PT0667911

Country: Portugal

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: SE0667911

Country: Sweden

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Stably-Transformed Mammalian Cells Expressing a Regulated, Inflammatory Cyclooxygenase

Issue date: May 06, 1999

Patent #: NL0667911

Country: Netherlands

Inventors: Virginia Dragonne-Winn, M. Kerry O'Banion, Donald A Young

Publications

Journal Articles

DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in C. elegans amyloid ? proteotoxicity.

Peng W, Chung KB, Lawrence BP, O'Banion MK, Dirksen RT, Wojtovich AP, Onukwufor JO

Free radical biology & medicine.. 2024 September 22 Epub 09/22/2024.

DMT1 knockout abolishes ferroptosis induced mitochondrial dysfunction in amyloid ? proteotoxicity.

Peng W, Chung KB, Lawrence BP, O'Banion MK, Dirksen RT, Wojtovich AP, Onukwufor JO

bioRxiv : the preprint server for biology.. 2024 August 9 Epub 08/09/2024.

Pharmacologic Manipulation of Complement Receptor 3 Prevents Dendritic Spine Loss and Cognitive Impairment After Acute Cranial Radiation.

Hinkle JJ, Olschowka JA, Williams JP, O'Banion MK

International journal of radiation oncology, biology, physics.. 2024 July 1119 (3):912-923. Epub 12/23/2023.

Cranial irradiation disrupts homeostatic microglial dynamic behavior.

Strohm AO, Johnston C, Hernady E, Marples B, O'Banion MK, Majewska AK

Journal of neuroinflammation.. 2024 April 321 (1):82. Epub 04/03/2024.

Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial ?2 adrenergic receptors.

Majewska A, Le L, Feidler A, Li H, Kara-Pabani K, Lamantia C, O'Banion MK

Research square.. 2024 February 26 Epub 02/26/2024.

Radiotherapy for non-cancer diseases: benefits and long-term risks.

Thariat J, Little MP, Zablotska LB, Samson P, O'Banion MK, Leuraud K, Bergom C, Girault G, Azimzadeh O, Bouffler S, Hamada N

International journal of radiation biology.. 2024 100 (4):505-526. Epub 01/05/2024.

Noradrenergic signaling controls Alzheimer's disease pathology via activation of microglial ?2 adrenergic receptors.

Le L, Feidler AM, Li H, Kara-Pabani K, Lamantia C, O'Banion MK, Majewska KA

bioRxiv : the preprint server for biology.. 2023 December 4 Epub 12/04/2023.

Correction: Gas6 induces infammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease.

Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK

Journal of neuroinflammation.. 2023 November 620 (1):254. Epub 11/06/2023.

Inconsistent Effects of Glatiramer Acetate Treatment in the 5xFAD Mouse Model of Alzheimer's Disease.

Karaahmet B, Olschowka JA, O'Banion MK

Pharmaceutics.. 2023 June 2415 (7)Epub 06/24/2023.

High-Energy, Whole-Body Proton Irradiation Differentially Alters Long-Term Brain Pathology and Behavior Dependent on Sex and Alzheimer's Disease Mutations.

Hinshaw RG, Schroeder MK, Ciola J, Varma C, Colletti B, Liu B, Liu GG, Shi Q, Williams JP, O'Banion MK, Caldarone BJ, Lemere CA

International journal of molecular sciences.. 2023 February 1024 (4)Epub 02/10/2023.

Radiation and CNS effects: summary of evidence from a recent symposium of the Radiation Research Society.

Zablotska LB, Zupunski L, Leuraud K, Lopes J, Hinkle J, Pugeda T, Delgado T, Olschowka J, Williams J, O'Banion MK, Boice JD, Cohen SS, Mumma MT, Dauer LT, Britten RA, Stephenson S

International journal of radiation biology.. 2023 99 (9):1332-1342. Epub 11/11/2022.

AAV gene therapy vectors in the TMJ.

Brouxhon SM, O'Banion MK, Kyrkanides S

Clinical and experimental dental research.. 2022 December 8 (6):1561-1566. Epub 07/24/2022.

Alzheimer's disease and related dementias: From risk factors to disease pathogenesis.

Porsteinsson AP, Rangaraju S, Spires-Jones TL, O'Banion MK

The European journal of neuroscience.. 2022 November 56 (9):5337-5341. Epub 11/10/2022.

Calcitonin gene-related peptide: An intra-articular therapeutic target for TMJ disorders.

Brouxhon SM, O'Banion MK, Dickerson IM, Kyrkanides S

Clinical and experimental dental research.. 2022 October 8 (5):1158-1166. Epub 06/14/2022.

Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology.

Karaahmet B, Le L, Mendes MS, Majewska AK, O'Banion MK

Journal of neuroinflammation.. 2022 July 419 (1):173. Epub 07/04/2022.

Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease.

Owlett LD, Karaahmet B, Le L, Belcher EK, Dionisio-Santos D, Olschowka JA, Elliott MR, O'Banion MK

Journal of neuroinflammation.. 2022 February 719 (1):38. Epub 02/07/2022.

Long-Term Sex- and Genotype-Specific Effects of Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice.

Schroeder MK, Liu B, Hinshaw RG, Park MA, Wang S, Dubey S, Liu GG, Shi Q, Holton P, Reiser V, Jones PA, Trigg W, Di Carli MF, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA

International journal of molecular sciences.. 2021 December 1022 (24)Epub 12/10/2021.

In Vivo Imaging of the Microglial Landscape After Whole Brain Radiation Therapy.

Whitelaw BS, Tanny S, Johnston CJ, Majewska AK, O'Banion MK, Marples B

International journal of radiation oncology, biology, physics.. 2021 November 15111 (4):1066-1071. Epub 07/24/2021.

Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer's disease in the 3xTgAD mouse model.

Herr D, Jew K, Wong C, Kennell A, Gelein R, Chalupa D, Raab A, Oberdörster G, Olschowka J, O'Banion MK, Elder A

Neurotoxicology.. 2021 May 84 :172-183. Epub 03/29/2021.

Evaluating Effects of Glatiramer Acetate Treatment on Amyloid Deposition and Tau Phosphorylation in the 3xTg Mouse Model of Alzheimer's Disease.

Dionisio-Santos DA, Karaahmet B, Belcher EK, Owlett LD, Trojanczyk LA, Olschowka JA, O'Banion MK

Frontiers in neuroscience.. 2021 15 :758677. Epub 10/22/2021.

Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease.

Owlett L, Belcher EK, Dionisio-Santos DA, Williams JP, Olschowka JA, O'Banion MK

Life sciences in space research.. 2020 November 27 :89-98. Epub 08/03/2020.

Retrospective analysis of the hemodynamic consequences of prehospital supplemental oxygen in acute stroke.

Dylla L, Cushman JT, Abar B, Benesch C, Jones CMC, O'Banion MK, Adler DH

The American journal of emergency medicine.. 2020 October 38 (10):2125-2129. Epub 07/11/2020.

Cranial irradiation acutely and persistently impairs injury-induced microglial proliferation.

Belcher EK, Sweet TB, Karaahmet B, Dionisio-Santos DA, Owlett LD, Leffler KA, Janelsins MC, Williams JP, Olschowka JA, O'Banion MK

Brain, behavior, & immunity - health.. 2020 April 4 :100057. Epub 03/06/2020.

Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer's disease.

Chockanathan U, Warner EJ, Turpin L, O'Banion MK, Padmanabhan K

Scientific reports.. 2020 January 2310 (1):1077. Epub 01/23/2020.

Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer's Disease.

Dionisio-Santos DA, Behrouzi A, Olschowka JA, O'Banion MK

Frontiers in neuroscience.. 2020 14 :441. Epub 05/14/2020.

Cognitively supernormal older adults maintain a unique structural connectome that is resistant to Alzheimer's pathology.

Chen Q, Baran TM, Rooks B, O'Banion MK, Mapstone M, Zhang Z, Lin F,

NeuroImage. Clinical.. 2020 28 :102413. Epub 09/08/2020.

Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice.

Hinkle JJ, Olschowka JA, Love TM, Williams JP, O'Banion MK

Scientific reports.. 2019 December 119 (1):18899. Epub 12/11/2019.

IL-1?-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia.

Rivera-Escalera F, Pinney JJ, Owlett L, Ahmed H, Thakar J, Olschowka JA, Elliott MR, O'Banion MK

Journal of neuroinflammation.. 2019 December 1016 (1):261. Epub 12/10/2019.

Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer's disease mice.

Jew K, Herr D, Wong C, Kennell A, Morris-Schaffer K, Oberdörster G, O'Banion MK, Cory-Slechta DA, Elder A

Particle and fibre toxicology.. 2019 November 2616 (1):45. Epub 11/26/2019.

Space-like Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer's-like transgenic mice.

Liu B, Hinshaw RG, Le KX, Park MA, Wang S, Belanger AP, Dubey S, Frost JL, Shi Q, Holton P, Trojanczyk L, Reiser V, Jones PA, Trigg W, Di Carli MF, Lorello P, Caldarone BJ, Williams JP, O'Banion MK, Lemere CA

Scientific reports.. 2019 August 209 (1):12118. Epub 08/20/2019.

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer's disease.

Dionisio-Santos DA, Olschowka JA, O'Banion MK

Journal of neuroinflammation.. 2019 April 516 (1):74. Epub 04/05/2019.

Fractionation enhances acute oligodendrocyte progenitor cell radiation sensitivity and leads to long term depletion.

Begolly S, Olschowka JA, Love T, Williams JP, O'Banion MK

Glia.. 2018 April 66 (4):846-861. Epub 12/30/2017.

Reduced activation and proliferation of human lymphocytes exposed to respiratory syncytial virus compared to cells exposed to influenza virus.

Fleming EH, Ochoa EE, Nichols JE, O'Banion MK, Salkind AR, Roberts NJ

Journal of medical virology.. 2018 January 90 (1):26-33. Epub 09/26/2017.

Neurogenic Effects of Low-Dose Whole-Body HZE (Fe) Ion and Gamma Irradiation.

Sweet TB, Hurley SD, Wu MD, Olschowka JA, Williams JP, O'Banion MK

Radiation research.. 2016 December 186 (6):614-623. Epub 12/01/2016.

Fractionation Spares Mice From Radiation-Induced Reductions in Weight Gain But Does Not Prevent Late Oligodendrocyte Lineage Side Effects.

Begolly S, Shrager PG, Olschowka JA, Williams JP, O'Banion MK

International journal of radiation oncology, biology, physics.. 2016 October 196 (2):449-457. Epub 05/12/2016.

Targeting innate immunity for neurodegenerative disorders of the central nervous system.

Heneka M, Andreasson KI, Bachstetter AD, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee DC, Low D, Lynch MA, Monsonego A, O'Banion MK, Pekny M, Puschmann T, Russek-Blum N, Sandusky LA, Selenica MB, Takata K, Teeling J, Town T, Van Eldik LJ, Schulz JB

Journal of neurochemistry.. 2016 September 138 (5):653-93. Epub 1900 01 01.

Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury.

Williams JP, Calvi L, Chakkalakal JV, Finkelstein JN, O'Banion MK, Puzas E

Radiation research.. 2016 July 186 (1):1-16. Epub 06/22/2016.

Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling.

Moravan MJ, Olschowka JA, Williams JP, O'Banion MK

Journal of neuroinflammation.. 2016 February 313 :30. Epub 02/03/2016.

Arginase 1+ microglia reduce A? plaque deposition during IL-1?-dependent neuroinflammation.

Cherry JD, Olschowka JA, O'Banion MK

Journal of neuroinflammation.. 2015 November 412 :203. Epub 11/04/2015.

Characterization of binge-dosed methamphetamine-induced neurotoxicity and neuroinflammation.

McConnell SE, O'Banion MK, Cory-Slechta DA, Olschowka JA, Opanashuk LA

Neurotoxicology.. 2015 September 50 :131-41. Epub 08/15/2015.

Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers.

Brouxhon SM, Kyrkanides S, Teng X, O'Banion MK, Clarke R, Byers S, Ma L

Molecular carcinogenesis.. 2014 November 53 (11):893-906. Epub 06/18/2013.

Interleukin-1? mediated amyloid plaque clearance is independent of CCR2 signaling in the APP/PS1 mouse model of Alzheimer's disease.

Rivera-Escalera F, Matousek SB, Ghosh S, Olschowka JA, Kerry O'Banion M

Neurobiology of disease.. 2014 September 69 :124-33. Epub 05/27/2014.

Does peripheral inflammation contribute to Alzheimer disease? Evidence from animal models.

O'Banion MK

Neurology.. 2014 August 583 (6):480-1. Epub 07/02/2014.

Central nervous system effects of whole-body proton irradiation.

Sweet TB, Panda N, Hein AM, Das SL, Hurley SD, Olschowka JA, Williams JP, O'Banion MK

Radiation research.. 2014 July 182 (1):18-34. Epub 06/17/2014.

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.

Cherry JD, Olschowka JA, O Banion MK

Journal of neuroinflammation.. 2014 June 311 :98. Epub 06/03/2014.

Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling.

Brouxhon SM, Kyrkanides S, Teng X, Athar M, Ghazizadeh S, Simon M, O'Banion MK, Ma L

Oncogene.. 2014 January 933 (2):225-35. Epub 01/14/2013.

Are "resting" microglia more "m2"?

Cherry JD, Olschowka JA, O'Banion MK

Frontiers in immunology.. 2014 5 :594. Epub 11/18/2014.

Thermal injury lowers the threshold for radiation-induced neuroinflammation and cognitive dysfunction.

Cherry JD, Williams JP, O'Banion MK, Olschowka JA

Radiation research.. 2013 October 180 (4):398-406. Epub 09/23/2013.

It may take more than a shot: alternatives to immunotherapy for Alzheimer's disease.

O'Banion MK

Biological psychiatry.. 2013 September 174 (5):316-7. Epub 1900 01 01.

Sustained IL-1? expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells.

Wu MD, Montgomery SL, Rivera-Escalera F, Olschowka JA, Kerry O'Banion M

Brain, behavior, and immunity.. 2013 August 32 :9-18. Epub 03/16/2013.

Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways.

Brouxhon SM, Kyrkanides S, Teng X, Raja V, O'Banion MK, Clarke R, Byers S, Silberfeld A, Tornos C, Ma L

Clinical cancer research : an official journal of the American Association for Cancer Research.. 2013 June 1519 (12):3234-46. Epub 04/25/2013.

Chronic neuron- and age-selective down-regulation of TNF receptor expression in triple-transgenic Alzheimer disease mice leads to significant modulation of amyloid- and Tau-related pathologies.

Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ

The American journal of pathology.. 2013 June 182 (6):2285-97. Epub 04/06/2013.

Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory.

Latchney SE, Hein AM, O'Banion MK, Dicicco-Bloom E, Opanashuk LA

Journal of neurochemistry.. 2013 May 125 (3):430-45. Epub 01/07/2013.

Sustained interleukin-1? overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, Laferla FM, Olschowka JA, O'Banion MK

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 March 1333 (11):5053-64. Epub 1900 01 01.

X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function.

Dilmanian FA, Jenkins AL, Olschowka J, Zhong Z, Park JY, Desnoyers NR, Sobotka S, Fois GR, Messina CR, Morales M, Hurley SD, Trojanczyk L, Ahmad S, Shahrab N, Coyle PK, Meek AG, O'Banion MK

Radiation research.. 2013 January 179 (1):76-88. Epub 12/05/2012.

Interleaved carbon minibeams: an experimental radiosurgery method with clinical potential.

Dilmanian FA, Rusek A, Fois GR, Olschowka J, Desnoyers NR, Park JY, Dioszegi I, Dane B, Wang R, Tomasi D, Lee H, Hurley SD, Coyle PK, Meek AG, O'Banion MK

International journal of radiation oncology, biology, physics.. 2012 October 184 (2):514-9. Epub 02/17/2012.

Conditional expression of human ?-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation.

Kyrkanides S, Brouxhon SM, Tallents RH, Miller JN, Olschowka JA, O'Banion MK

Journal of neuroinflammation.. 2012 August 49 :186. Epub 08/04/2012.

Behavioral, structural and molecular changes following long-term hippocampal IL-1? overexpression in transgenic mice.

Hein AM, Zarcone TJ, Parfitt DB, Matousek SB, Carbonari DM, Olschowka JA, O'Banion MK

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2012 March 7 (1):145-55. Epub 07/12/2011.

Chronic IL-1?-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration.

Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O'Banion MK

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2012 March 7 (1):156-64. Epub 12/16/2011.

Neuroinflammation and cognitive dysfunction in chronic disease and aging.

Hein AM, O'Banion MK

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2012 March 7 (1):3-6. Epub 01/18/2012.

Adult murine hippocampal neurogenesis is inhibited by sustained IL-1? and not rescued by voluntary running.

Wu MD, Hein AM, Moravan MJ, Shaftel SS, Olschowka JA, O'Banion MK

Brain, behavior, and immunity.. 2012 February 26 (2):292-300. Epub 09/29/2011.

Chronic IL-1?-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration.

Matousek, S. B., S. Ghosh, S. S. Shaftel, S. Kyrkanides, J. A. Olschowka and M. K. O'Banion.

Journal of Neuroimmune Pharmacology. 2012; 7: 156-64.

Conditional expression of human ?-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation.

Kyrkanides, S., S. M. Brouxhon, R. H. Tallents, J. N. Miller, J. A. Olschowka and M. K. O'Banion.

Journal of Neuroinflammation. 2012; 9: 186.

X-ray microbeam irradiation of the contusion-injured rat spinal cored temporarily improves hind-limb function.

Dilmanian, F. A., A. L. Jenkins III, J. A. Olschowka, Z. Zhong, J. Y. Park, N. R. Desnoyers, S. Sobotka, G. R. Fois, C. R. Messina, M. Morales, S. D. Hurley, L. A. Trojanczyk, S. Ahmed, N. Shahrab, P. K. Coyle, A. G. Meek and M. K. O'Banion.

Radiation Research. 2012; .

Galactic cosmic radiation leads to cognitive impairment and increased A? plaque accumulation in a mouse model of Alzheimer's disease

Cherry, J. D., B. Liu, J. L. Frost, C. A. Lemere, J. P. Williams, J. A. Olschowka and M. K. O'Banion.

PLOS ONE. 2012; 7: e53275.

Deletion or activation of the aryl hydrocarbon receptor (AhR) alters adult hippocampal neurogenesis and contextual fear memory.

Latchney, S. E., A. M. Hein, M. K. O'Banion, E. DiCicco-Bloom and L. A. Opanashuk.

Journal of Neurochemistry. 2012; .

Soluble E-cadherin: a critical oncogene modulating receptor tyrosine kinases, MAPK and PI3K/Akt/mTOR signaling.

Brouxhon, S. M., S. Kyrkanides, X. Teng, M. Athar, S. Ghazizadeh, M. Simon, M. K. O'Banion and L. Ma.

Oncogene. 2012; .

Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: Involvement of the HER/PI3K/Akt/mTOR and IAP pathways.

Brouxhon, S., S. Kyrkanides, X. Teng, R. Veena, M .K. O'Banion, R. Clark, S. Byers, A. Silberfeld, C. Tornos and L. Ma.

Clinical Cancer Research. 2012; .

Sustained interleukin-1? overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model.

Ghosh, S., M. D. Wu, S. S. Shaftel, S. Kyrkanides, F. M. LaFerla, J. A. Olschowka and M. K. O'Banion.

Journal of Neuroscience,. 2012; .

Sustained IL-1? expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin+ neural precursor cells.

Wu, M. D., S. L. Montgomery, J. A. Olschowka and M. K. O'Banion.

Brain Behavior and Immunity. 2012; .

Galactic cosmic radiation leads to cognitive impairment and increased a? plaque accumulation in a mouse model of Alzheimer's disease.

Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK

PloS one.. 2012 7 (12):e53275. Epub 12/31/2012.

Acute neuroinflammation and neurogenesis: a role for microglial COX-1.

O'Banion MK

Cell cycle.. 2011 November 1510 (22):3819-20. Epub 11/15/2011.

Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain.

Moravan MJ, Olschowka JA, Williams JP, O'Banion MK

Radiation research.. 2011 October 176 (4):459-73. Epub 07/25/2011.

Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice.

Kyrkanides S, Tallents RH, Miller JN, Olschowka ME, Johnson R, Yang M, Olschowka JA, Brouxhon SM, O'Banion MK

Journal of neuroinflammation.. 2011 September 78 :112. Epub 09/07/2011.

Medical Scientist Training Programs: federal funding offers support and drives innovation.

Andersen OS, O'Banion MK

Academic medicine : journal of the Association of American Medical Colleges.. 2010 October 85 (10):1559. Epub 1900 01 01.

Neuroinflammatory processes in Alzheimer's disease.

Heneka MT, O'Banion MK, Terwel D, Kummer MP

Journal of neural transmission.. 2010 August 117 (8):919-47. Epub 07/15/2010.

Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression.

Matousek SB, Hein AM, Shaftel SS, Olschowka JA, Kyrkanides S, O'Banion MK

Journal of neurochemistry.. 2010 July 114 (1):247-58. Epub 04/19/2010.

Prostaglandin E2 synthases in neurologic homeostasis and disease.

O'Banion MK

Prostaglandins & other lipid mediators.. 2010 April 91 (3-4):113-7. Epub 04/22/2009.

Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice.

Hein AM, Stasko MR, Matousek SB, Scott-McKean JJ, Maier SF, Olschowka JA, Costa AC, O'Banion MK

Brain, behavior, and immunity.. 2010 February 24 (2):243-53. Epub 10/13/2009.

Sustained expression of interleukin-1beta in mouse hippocampus impairs spatial memory.

Moore AH, Wu M, Shaftel SS, Graham KA, O'Banion MK

Neuroscience.. 2009 December 29164 (4):1484-95. Epub 09/08/2009.

Neuroinflammation and memory: the role of prostaglandins.

Hein AM, O'Banion MK

Molecular neurobiology.. 2009 August 40 (1):15-32. Epub 04/14/2009.

Restructuring MD-PhD programs: career training or broad education?

Ahn J, Nguyen FT, Mann JR, O'Banion MK

Academic medicine : journal of the Association of American Medical Colleges.. 2009 April 84 (4):407; author reply 407-8. Epub 1900 01 01.

Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration.

Kyrkanides S, Miller AW, Miller JN, Tallents RH, Brouxhon SM, Olschowka ME, O'Banion MK, Olschowka JA

Journal of neuroimmunology.. 2008 October 15203 (1):50-7. Epub 1900 01 01.

Spinal interleukin-1beta in a mouse model of arthritis and joint pain.

Fiorentino PM, Tallents RH, Miller JN, Brouxhon SM, O'Banion MK, Puzas JE, Kyrkanides S

Arthritis and rheumatism.. 2008 October 58 (10):3100-9. Epub 1900 01 01.

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration.

Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O'Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV

Nature neuroscience.. 2008 April 11 (4):420-2. Epub 03/16/2008.

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective.

Shaftel SS, Griffin WS, O'Banion MK

Journal of neuroinflammation.. 2008 February 265 :7. Epub 02/26/2008.

Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration.

Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 August 2927 (35):9301-9. Epub 1900 01 01.

Sequential down-regulation of E-cadherin with squamous cell carcinoma progression: loss of E-cadherin via a prostaglandin E2-EP2 dependent posttranslational mechanism.

Brouxhon S, Kyrkanides S, O'Banion MK, Johnson R, Pearce DA, Centola GM, Miller JN, McGrath KH, Erdle B, Scott G, Schneider S, VanBuskirk J, Pentland AP

Cancer research.. 2007 August 1567 (16):7654-64. Epub 1900 01 01.

Amelioration of pain and histopathologic joint abnormalities in the Col1-IL-1beta(XAT) mouse model of arthritis by intraarticular induction of mu-opioid receptor into the temporomandibular joint.

Kyrkanides S, Fiorentino PM, Miller JN, Gan Y, Lai YC, Shaftel SS, Puzas JE, Piancino MG, O'Banion MK, Tallents RH

Arthritis and rheumatism.. 2007 June 56 (6):2038-48. Epub 1900 01 01.

Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology.

Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK

The Journal of clinical investigation.. 2007 June 117 (6):1595-604. Epub 1900 01 01.

Inflammatory processes in Alzheimer's disease.

Heneka MT, O'Banion MK

Journal of neuroimmunology.. 2007 March 184 (1-2):69-91. Epub 01/12/2007.

Cytosolic prostaglandin E2 synthase (cPGES) expression is decreased in discrete cortical regions in psychiatric disease.

Maida ME, Hurley SD, Daeschner JA, Moore AH, O'Banion MK

Brain research.. 2006 August 41103 (1):164-72. Epub 06/27/2006.

Enhanced cyclooxygenase-2 expression in olfactory-limbic forebrain following kainate-induced seizures.

Joseph SA, Lynd-Balta E, O'Banion MK, Rappold PM, Daschner J, Allen A, Padowski J

Neuroscience.. 2006 July 7140 (3):1051-65. Epub 05/04/2006.

Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain.

Lai YC, Shaftel SS, Miller JN, Tallents RH, Chang Y, Pinkert CA, Olschowka JA, Dickerson IM, Puzas JE, O'Banion MK, Kyrkanides S

Arthritis and rheumatism.. 2006 April 54 (4):1184-97. Epub 1900 01 01.

Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.

Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'Banion K, Klockgether T, Van Leuven F, Landreth GE

Brain : a journal of neurology.. 2005 June 128 (Pt 6):1442-53. Epub 04/07/2005.

The role of COX-1 and COX-2 in Alzheimer's disease pathology and the therapeutic potentials of non-steroidal anti-inflammatory drugs.

Hoozemans JJ, O'Banion MK

Current drug targets. CNS and neurological disorders. 2005 June 4 (3):307-15. Epub 1900 01 01.

Regulation of prostaglandin E2 synthesis after brain irradiation.

Moore AH, Olschowka JA, Williams JP, Okunieff P, O'Banion MK

International journal of radiation oncology, biology, physics.. 2005 May 162 (1):267-72. Epub 1900 01 01.

Regulation of prostaglandin E2 synthesis after brain irradiation.

Moore, A. H.; J. A. Olschowka; J. P. Williams; P. Okunieff; M. K. O'Banion.

Int. J. Rad. Oncol. Biol. Phys. 2005; 62: 267-272.

Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain.

Moore AH, Olschowka JA, O'Banion MK

Journal of neuroimmunology.. 2004 March 148 (1-2):32-40. Epub 1900 01 01.

Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain.

Moore AH, Olschowka JA, Williams JP, Paige SL, O'Banion MK

Radiation research.. 2004 February 161 (2):153-60. Epub 1900 01 01.

Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys.

Hurley SD, O'Banion MK, Song DD, Arana FS, Olschowka JA, Haber SN

Experimental neurology.. 2003 December 184 (2):659-68. Epub 1900 01 01.

COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells.

Shaftel SS, Olschowka JA, Hurley SD, Moore AH, O'Banion MK

Brain research. Molecular brain research.. 2003 November 26119 (2):213-5. Epub 1900 01 01.

Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.

Heneka MT, Gavrilyuk V, Landreth GE, O'Banion MK, Weinberg G, Feinstein DL

Journal of neurochemistry.. 2003 April 85 (2):387-98. Epub 1900 01 01.

Neuroinflammation and anti-inflammatory therapy for Alzheimer's disease.

Moore AH, O'Banion MK

Advanced drug delivery reviews.. 2002 December 754 (12):1627-56. Epub 1900 01 01.

Viral disease transmitted by laser-generated plume (aerosol).

Garden JM, O'Banion MK, Bakus AD, Olson C

Archives of dermatology.. 2002 October 138 (10):1303-7. Epub 1900 01 01.

Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury.

Kyrkanides S, Moore AH, Olschowka JA, Daeschner JC, Williams JP, Hansen JT, Kerry O'Banion M

Brain research. Molecular brain research.. 2002 August 15104 (2):159-69. Epub 1900 01 01.

Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.

Heneka MT, Galea E, Gavriluyk V, Dumitrescu-Ozimek L, Daeschner J, O'Banion MK, Weinberg G, Klockgether T, Feinstein DL

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 April 122 (7):2434-42. Epub 1900 01 01.

Cyclooxygenase inhibition as a strategy to ameliorate brain injury.

Hurley SD, Olschowka JA, O'Banion MK

Journal of neurotrauma.. 2002 January 19 (1):1-15. Epub 1900 01 01.

Selective inhibition of cyclooxygenase-2 attenuates expression of inflammation-related genes in CNS injury.

O'Banion MK, Kyrkanides S, Olschowka JA

Advances in experimental medicine and biology.. 2002 507 :155-60. Epub 1900 01 01.

Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury.

Kyrkanides S, O'Banion MK, Whiteley PE, Daeschner JC, Olschowka JA

Journal of neuroimmunology.. 2001 October 1119 (2):269-77. Epub 1900 01 01.

Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease.

Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K

The American journal of pathology.. 2001 April 158 (4):1345-54. Epub 1900 01 01.

Two-dimensional gel analysis of secreted proteins induced by interleukin-1 beta in rat astrocytes.

Chang JW, Young DA, Coleman PD, O'Banion MK

Neurochemistry international.. 2001 39 (5-6):349-59. Epub 1900 01 01.

Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease.

Yermakova AV, O'Banion MK

Neurobiology of aging.. 2001 22 (6):823-36. Epub 1900 01 01.

Cyclooxygenases in the central nervous system: implications for treatment of neurological disorders.

Yermakova A, O'Banion MK

Current pharmaceutical design.. 2000 November 6 (17):1755-76. Epub 1900 01 01.

Nonsteroidal anti-inflammatory drugs in orthodontic tooth movement: metalloproteinase activity and collagen synthesis by endothelial cells.

Kyrkanides S, O'Banion MK, Subtelny JD

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.. 2000 August 118 (2):203-9. Epub 1900 01 01.

Non-steroidal anti-inflammatory drugs in orthodontic tooth movement: metalloproteinase activity and collagen synthesis by endothelial cells.

Kyrkanides, S.; M. K. O'Banion; J. D. Subtelny.

Am. J. Orthod. Dentofacial Orthoped. 2000; 118: 203-209.

Inflammation and Alzheimer's disease.

Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T

Neurobiology of aging.. 2000 21 (3):383-421. Epub 1900 01 01.

Cyclooxygenase-1 in human Alzheimer and control brain: quantitative analysis of expression by microglia and CA3 hippocampal neurons.

Yermakova AV, Rollins J, Callahan LM, Rogers J, O'Banion MK

Journal of neuropathology and experimental neurology.. 1999 November 58 (11):1135-46. Epub 1900 01 01.

COX-2 and Alzheimer's disease: potential roles in inflammation and neurodegeneration.

O'Banion MK

Expert opinion on investigational drugs.. 1999 October 8 (10):1521-1536. Epub 1900 01 01.

Adenovirus-mediated transgene expression in nonhuman primate brain.

Bohn MC, Choi-Lundberg DL, Davidson BL, Leranth C, Kozlowski DA, Smith JC, O'Banion MK, Redmond DE

Human gene therapy.. 1999 May 110 (7):1175-84. Epub 1900 01 01.

TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury.

Kyrkanides S, Olschowka JA, Williams JP, Hansen JT, O'Banion MK

Journal of neuroimmunology.. 1999 March 195 (1-2):95-106. Epub 1900 01 01.

Adenovirus-mediated transgene expression in non-human primate brain.

Bohn, M. C.; D. L. Choi-Lundberg; B. L. Davidson; C. Leranth; D. A. Kozlowski; J. C. Smith; M. K. O'Banion; D. E. Redmond, Jr.

Human Gene Therapy 10:. 1999; : 1175-1184.

Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology.

O'Banion MK

Critical reviews in neurobiology. 1999 13 (1):45-82. Epub 1900 01 01.

Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry.

O'Banion MK, Olschowka JA

Methods in molecular biology.. 1999 120 :55-66. Epub 1900 01 01.

Interleukin-1 beta and tumor necrosis factor-alpha suppress dexamethasone induction of glutamine synthetase in primary mouse astrocytes.

Huang TL, O'Banion MK

Journal of neurochemistry.. 1998 October 71 (4):1436-42. Epub 1900 01 01.

Developmental regulation and PKC dependence of Alzheimer's-type tau phosphorylations in cultured fetal rat hippocampal neurons.

Combs CK, Coleman PD, O'Banion MK

Brain research. Developmental brain research.. 1998 April 17107 (1):143-58. Epub 1900 01 01.

Developmental regulation and protein kinase C dependence of Alzheimer's type tau phosphorylation in fetal rat hippocampal neuron cultures.

Combs, C. K.; P. D. Coleman; M. K. O'Banion.

Dev. Brain Res. 1998; 107: 143-158.

ICAM-1 induction in the mouse CNS following irradiation.

Olschowka JA, Kyrkanides S, Harvey BK, O'Banion MK, Williams JP, Rubin P, Hansen JT

Brain, behavior, and immunity.. 1997 December 11 (4):273-85. Epub 1900 01 01.

Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor.

Kaplan MD, Olschowka JA, O'Banion MK

The Journal of biological chemistry.. 1997 July 25272 (30):18534-7. Epub 1900 01 01.

Bovine papillomavirus E5 oncogene stimulates DNA synthesis in C127 fibroblasts without general effects on growth factor responsive protein phosphorylations.

Wheeler TT, O'Banion MK, Colasurdo AM, Young DA

Archives of virology.. 1997 142 (5):953-64. Epub 1900 01 01.

Decreased expression of prostaglandin G/H synthase-2 (PGHS-2) in Alzheimer's disease brain.

O'Banion MK, Chang JW, Coleman PD

Advances in experimental medicine and biology.. 1997 407 :171-7. Epub 1900 01 01.

Glial and neuronal expression of cyclooxygenase-2: relevance to Alzheimer's disease.

O'Banion MK, Chang JW, Kaplan MD, Yermakova A, Coleman PD

Advances in experimental medicine and biology.. 1997 433 :177-80. Epub 1900 01 01.

Interleukin-1 beta induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures.

O'Banion MK, Miller JC, Chang JW, Kaplan MD, Coleman PD

Journal of neurochemistry.. 1996 June 66 (6):2532-40. Epub 1900 01 01.

Inflammatory mechanisms and anti-inflammatory therapy in Alzheimer's disease.

O'Banion MK, Finch CE

Neurobiology of aging.. 1996 17 (5):669-71. Epub 1900 01 01.

Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease.

Chang JW, Coleman PD, O'Banion MK

Neurobiology of aging.. 1996 17 (5):801-8. Epub 1900 01 01.

In vitro studies of glucocorticoid effects on neurons and astrocytes.

Bohn MC, O'Banion MK, Young DA, Giuliano R, Hussain S, Dean DO, Cunningham LA

Annals of the New York Academy of Sciences.. 1994 November 30746 :243-58; discussion 258-9, 289-93. Epub 1900 01 01.

Induction of cyclooxygenase-2 in rat vascular smooth muscle cells in vitro and in vivo.

Pritchard KA, O'Banion MK, Miano JM, Vlasic N, Bhatia UG, Young DA, Stemerman MB

The Journal of biological chemistry.. 1994 March 18269 (11):8504-9. Epub 1900 01 01.

Corticosterone-responsive mRNAs in primary rat astrocytes.

O'Banion MK, Young DA, Bohn MC

Brain research. Molecular brain research.. 1994 March 22 (1-4):57-68. Epub 1900 01 01.

Genetic definition of a new bovine papillomavirus type 1 open reading frame, E5B, that encodes a hydrophobic protein involved in altering host-cell protein processing.

O'Banion MK, Winn VD, Settleman J, Young DA

Journal of virology.. 1993 June 67 (6):3427-34. Epub 1900 01 01.

Anti-inflammatory glucocorticoid action: inhibition of griPGHS, a new cyclooxygenase.

Winn VD, O'Banion MK, Young DA

Journal of lipid mediators. 1993 6 (1-3):101-11. Epub 1900 01 01.

Glucocorticoid modulation of transformed cell proliferation is oncogene specific and correlates with effects on c-myc levels.

O'Banion MK, Levenson RM, Brinckmann UG, Young DA

Molecular endocrinology.. 1992 September 6 (9):1371-80. Epub 1900 01 01.

cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.

O'Banion MK, Winn VD, Young DA

Proceedings of the National Academy of Sciences of the United States of America.. 1992 June 189 (11):4888-92. Epub 1900 01 01.

Molecular cloning and partial characterization of a parrot papillomavirus.

O'Banion MK, Jacobson ER, Sundberg JP

Intervirology.. 1992 33 (2):91-6. Epub 1900 01 01.

A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.

O'Banion MK, Sadowski HB, Winn V, Young DA

The Journal of biological chemistry.. 1991 December 5266 (34):23261-7. Epub 1900 01 01.

Bovine papillomavirus type 1 alters the processing of host glucose- and calcium-modulated endoplasmic reticulum proteins.

O'Banion MK, Young DA

Journal of virology.. 1991 July 65 (7):3481-8. Epub 1900 01 01.

Papillomavirus-associated inductions of cellular proteins in mouse C127 cells: correlation with the presence of open reading frame E2.

Levenson RM, Brinckmann UG, O'Banion MK, Androphy EJ, Schiller JT, Tabatabai F, Turek LP, Neary K, Chin MT, Broker TR

Virology.. 1989 September 172 (1):170-9. Epub 1900 01 01.

Papillomas and carcinomas associated with a papillomavirus in European harvest mice (Micromys minutus).

Sundberg JP, O'Banion MK, Shima A, Knupp C, Reichmann ME

Veterinary pathology.. 1988 September 25 (5):356-61. Epub 1900 01 01.

Papillary squamous cell carcinoma in three young dogs.

Ogilvie GK, Sundberg JP, O'Banion MK, Badertscher RR, Wheaton LG, Reichmann ME

Journal of the American Veterinary Medical Association.. 1988 April 1192 (7):933-6. Epub 1900 01 01.

Papillomavirus in the vapor of carbon dioxide laser-treated verrucae.

Garden JM, O'Banion MK, Shelnitz LS, Pinski KS, Bakus AD, Reichmann ME, Sundberg JP

JAMA.. 1988 February 26259 (8):1199-202. Epub 1900 01 01.

Cloning and characterization of a papillomavirus associated with papillomas and carcinomas in the European harvest mouse (Micromys minutus).

O'Banion MK, Reichmann ME, Sundberg JP

Journal of virology.. 1988 January 62 (1):226-33. Epub 1900 01 01.

Cloning and molecular characterization of an oral papillomavirus of domestic rabbits.

O'Banion MK, Cialkowski ME, Reichmann ME, Sundberg JP

Virology.. 1988 January 162 (1):221-31. Epub 1900 01 01.

Papillomavirus genomes in experimentally induced fibromas in white-tailed deer.

O'Banion MK, Sundberg JP

American journal of veterinary research.. 1987 October 48 (10):1453-5. Epub 1900 01 01.

Mouse papillomavirus: pathology and characterization of the virus.

Sundberg, J. P.; M. K. O'Banion; M. E. Reichmann.

Cancer Cells 5. 1987; : 373-379.

Cross-hybridization and relationships of various papillomavirus DNAs at different degrees of stringency.

O'Banion MK, Sundberg JP, Reszka AA, Reichmann ME

Intervirology.. 1987 28 (2):114-21. Epub 1900 01 01.

Venereal papilloma and papillomavirus in a colobus monkey (Colobus guereza).

O'Banion MK, Sundberg JP, Shima AL, Reichmann ME

Intervirology.. 1987 28 (4):232-7. Epub 1900 01 01.

Cutaneous papillomas associated with a herpesvirus-like infection in a herd of captive African elephants.

Jacobson ER, Sundberg JP, Gaskin JM, Kollias GV, O'Banion MK

Journal of the American Veterinary Medical Association.. 1986 November 1189 (9):1075-8. Epub 1900 01 01.

Polyp in the urogenital canal of an African elephant.

Munson L, Heuschele W, O'Banion MK, Sundberg JP, Oosterhuis JE

Journal of the American Veterinary Medical Association.. 1986 November 1189 (9):1190-1. Epub 1900 01 01.

Cloning and characterization of an equine cutaneous papillomavirus.

O'Banion MK, Reichmann ME, Sundberg JP

Virology.. 1986 July 15152 (1):100-9. Epub 1900 01 01.

Cloning and characterization of a canine oral papillomavirus.

Sundberg JP, O'Banion MK, Schmidt-Didier E, Reichmann ME

American journal of veterinary research.. 1986 May 47 (5):1142-4. Epub 1900 01 01.

Cloacal papillomas in psittacines.

Sundberg JP, Junge RE, O'Banion MK, Basgall EJ, Harrison G, Herron AJ, Shivaprasad HL

American journal of veterinary research.. 1986 April 47 (4):928-32. Epub 1900 01 01.

Effect of intracellular vesicular stomatitis virus mRNA concentration on the inhibition of host cell protein synthesis.

Schnitzlein WM, O'Banion MK, Poirot MK, Reichmann ME

Journal of virology.. 1983 January 45 (1):206-14. Epub 1900 01 01.

Papillary squamous cell carcinoma in three young dogs.

Olgilvie, G. K.; J. P. Sundberg; M. K. O'Banion; R. R. Badertscher; L. G. Wheaton; M. E. Reichmann.

J. Am. Vet. Med. Assoc. 192: 933-936.

Books

Inflammatory Events in Neurodegeneration (2001)

Chapter: The cyclooxygenases in neuroinflammation and neurodegeneration: emerging perspectives.

Authors: Maida, M. E.; M. K. O'Banion

Publisher: Prominent Press, Scottsdale, AZ. 2001

Eicosanoid Protocols (1999)

Chapter: Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry.

Authors: O'Banion, M. K.; J. A. Olschowka

Publisher: Academic Press, New York 1999

Recent Advances in Prostaglandin, Thromboxane and Leukotriene Research (1998)

Chapter: Glial and neuronal expression of cyclooxygenase-2: relevance to Alzheimer's disease.

Authors: O'Banion, M. K.; A. Yermakova; J. W. Chang; M. D. Kaplan; P. D. Coleman

Publisher: Plenum, New York 1998

Clinical Significance and Potential of Selective COX-2 Inhibitors. (1998)

Chapter: COX-2 in Alzheimer's disease

Authors: O'Banion, M. K.

Publisher: William Harvey Press, London 1998

Eicosanoids & Other Bioactive Lipids in Cancer, Inflammation & Radiation Injury (1997)

Chapter: Decreased expression of prostaglandin G/H synthase (PGHS-2) in Alzheimer's disease brain.

Authors: O'Banion, M. K.; J. W. Chang; P. D. Coleman

Publisher: Adv. Exp. Med. Biol. 1997

Neuronal Death in Health and Disease. (1994)

Chapter: Regional neuronal loss in aging and Alzheimer's disease: a brief review.

Authors: O'Banion, M. K.; P. D. Coleman; L. D. Callahan.

Publisher: Academic Press Ltd., London 1994

Brain Corticosteroid Receptors: Studies on the Mechanism, Function and Neurotox (1994)

Chapter: In vitro studies of glucocorticoid effects on neurons and astrocytes.

Authors: Bohn, M. C.; M. K. O'Banion; D. A. Young; R. Giuliano; S. Hussain; D. O. Dean; L. A. Cunningham

Publisher: Ann. NY Acad. Sci. 1994

Prostaglandins, Thromboxanes, Leukotrienes, and Related Compounds (1993)

Chapter: Anti-inflammatory glucocorticoid action: inhibition of griPGHS, a new cyclooxygenase.

Authors: Winn, V. D., M. K. O'Banion, and D. A. Young

Publisher: Elsevier Science Publishers, Amsterdam 1993

Alzheimer's Disease: Advances in Clinical and Basic Research. (1993)

Chapter: Responses of surviving cells to the death of their neighbor neurons.

Authors: Coleman, P. D.; D. G. Flood; M. K. O'Banion; J. R. Slemmon; T. Wengenack; M. R. Martzen.

Publisher: John Wiley & Sons, Ltd., Sussex 1993

Advances in Viral Oncology (1989)

Chapter: Animal papillomaviruses associated with malignant tumors.

Authors: Sundberg, J. P.; M. K. O'Banion

Publisher: Raven Press, New York 1989